A549_SGI-1776 free base_1µM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description SGI-1776 free base 1µM perturbation in A549 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the A549_SGI-1776 free base_1µM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.184666
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.124551
PKM pyruvate kinase, muscle 0.115304
AKR1C2 aldo-keto reductase family 1, member C2 0.105259
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.0929594
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.0929321
NRCAM neuronal cell adhesion molecule 0.0736898
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0715021
DST dystonin 0.0710718
ACTN4 actinin, alpha 4 0.0708263
SQSTM1 sequestosome 1 0.0651817
MGST1 microsomal glutathione S-transferase 1 0.0637213
ENO1 enolase 1, (alpha) 0.0624077
MUSK muscle, skeletal, receptor tyrosine kinase 0.0619041
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 0.0617862
GCLM glutamate-cysteine ligase, modifier subunit 0.0580007
CLU clusterin 0.0578571
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0577922
PHGDH phosphoglycerate dehydrogenase 0.0536443
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.0518747
KPNB1 karyopherin (importin) beta 1 0.0502041
PDE4D phosphodiesterase 4D, cAMP-specific 0.0443126
CTSD cathepsin D 0.0441457
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0437251
MTUS1 microtubule associated tumor suppressor 1 0.0429762
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0429675
AKR1C1 aldo-keto reductase family 1, member C1 0.0429292
TXN2 thioredoxin 2 0.0427166
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0415321
TXNRD1 thioredoxin reductase 1 0.0414899
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0412544
CAPNS1 calpain, small subunit 1 0.0411603
IGFBP4 insulin-like growth factor binding protein 4 0.0410996
ABTB3 ankyrin repeat and BTB domain containing 3 0.0403026
AKR1C3 aldo-keto reductase family 1, member C3 0.0395397
CLSPN claspin 0.0390346
NAMPT nicotinamide phosphoribosyltransferase 0.0389601
ANXA4 annexin A4 0.038106
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0377812
PRKCA protein kinase C, alpha 0.0377762
RPL13A ribosomal protein L13a 0.0376329
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0372521
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0362494
PDIA6 protein disulfide isomerase family A, member 6 0.0361949
CA12 carbonic anhydrase XII 0.0361374
RPL18 ribosomal protein L18 0.0360866
DLG5 discs, large homolog 5 (Drosophila) 0.0360708
CCDC88A coiled-coil domain containing 88A 0.0358058
IQGAP1 IQ motif containing GTPase activating protein 1 0.0357103
S100A6 S100 calcium binding protein A6 0.0353117
PDLIM5 PDZ and LIM domain 5 0.035013
PKP4 plakophilin 4 0.0347018
FBXL20 F-box and leucine-rich repeat protein 20 0.0344309
HACD3 3-hydroxyacyl-CoA dehydratase 3 0.0343847
PTPRA protein tyrosine phosphatase, receptor type, A 0.0341625
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0338925
ZFR zinc finger RNA binding protein 0.0337206
POLK polymerase (DNA directed) kappa 0.0336808
RPLP1 ribosomal protein, large, P1 0.0331759
MPG N-methylpurine-DNA glycosylase 0.0330398
S100A4 S100 calcium binding protein A4 0.0328943
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0327443
AVPI1 arginine vasopressin-induced 1 0.0326396
KRT7 keratin 7, type II 0.0324212
PTMS parathymosin 0.0319606
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0312971
TM4SF1 transmembrane 4 L six family member 1 0.0312854
BRCA1 breast cancer 1, early onset 0.0312127
SMC4 structural maintenance of chromosomes 4 0.0309782
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0308948
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0308879
AKAP13 A kinase (PRKA) anchor protein 13 0.0308204
FBXL17 F-box and leucine-rich repeat protein 17 0.030713
DHCR7 7-dehydrocholesterol reductase 0.0304676
TMSB10 thymosin beta 10 0.0300753
TOB1 transducer of ERBB2, 1 0.0298744
DSCAM Down syndrome cell adhesion molecule 0.0297653
RNFT2 ring finger protein, transmembrane 2 0.0294622
FLII flightless I homolog (Drosophila) 0.0294542
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0292594
BPTF bromodomain PHD finger transcription factor 0.0291765
METTL15 methyltransferase like 15 0.0288431
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0287906
FADS2 fatty acid desaturase 2 0.0283893
KNTC1 kinetochore associated 1 0.0282883
UGDH UDP-glucose 6-dehydrogenase 0.0280683
DSPP dentin sialophosphoprotein 0.0279469
NRP2 neuropilin 2 0.0277377
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0275
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0271937
CD81 CD81 molecule 0.0271428
TRAM1 translocation associated membrane protein 1 0.0271346
VDAC2 voltage-dependent anion channel 2 0.0271109
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0270864
ANKRD28 ankyrin repeat domain 28 0.0263896
NOTCH3 notch 3 0.0261107
RICTOR RPTOR independent companion of MTOR, complex 2 0.0256997
DIAPH2 diaphanous-related formin 2 0.0256663
BTBD7 BTB (POZ) domain containing 7 0.0256322
MRTFB myocardin related transcription factor B 0.0254968
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.0253254
TSKU tsukushi, small leucine rich proteoglycan 0.0253155
R3HDM2 R3H domain containing 2 0.0253081
SYNJ2BP synaptojanin 2 binding protein 0.0252978
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0251307
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.0250978
VIM vimentin 0.025048
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0250308
CAMKMT calmodulin-lysine N-methyltransferase 0.0250117
RPL27 ribosomal protein L27 0.0249543
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) 0.0249107
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.0248924
KMT2C lysine (K)-specific methyltransferase 2C 0.0246796
FMN1 formin 1 0.0245672
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 0.0245653
RPS11 ribosomal protein S11 0.0245414
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) 0.0245064
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.0243338
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0243002
CEP350 centrosomal protein 350kDa 0.024291
LDHA lactate dehydrogenase A 0.0242742
VCAN versican 0.0242634
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0242423
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0241322
CLIP2 CAP-GLY domain containing linker protein 2 0.0241012
TM7SF3 transmembrane 7 superfamily member 3 0.024027
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0239716
PTGR1 prostaglandin reductase 1 0.0236579
ZNF367 zinc finger protein 367 0.0235909
PGRMC2 progesterone receptor membrane component 2 0.0235085
EPB41 erythrocyte membrane protein band 4.1 0.0234582
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0233926
MACF1 microtubule-actin crosslinking factor 1 0.023385
RPL29 ribosomal protein L29 0.0233783
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0233488
RTN3 reticulon 3 0.0233398
RBL1 retinoblastoma-like 1 0.0232973
SLC38A7 solute carrier family 38, member 7 0.0232675
ACACA acetyl-CoA carboxylase alpha 0.0231722
RPL8 ribosomal protein L8 0.0231193
AGR2 anterior gradient 2 0.0230322
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0229199
AHNAK2 AHNAK nucleoprotein 2 0.0229102
ALCAM activated leukocyte cell adhesion molecule 0.0228875
CLPTM1 cleft lip and palate associated transmembrane protein 1 0.0228654
CDK6 cyclin-dependent kinase 6 0.0228362
PLCE1 phospholipase C, epsilon 1 0.0227554
ZDHHC5 zinc finger, DHHC-type containing 5 0.0227457
EFNA5 ephrin-A5 0.0226843
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0226291
CCT7 chaperonin containing TCP1, subunit 7 (eta) 0.0226251
DIAPH1 diaphanous-related formin 1 0.0226011
CHD3 chromodomain helicase DNA binding protein 3 0.022577
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0224177
TPI1 triosephosphate isomerase 1 0.0223799
GNS glucosamine (N-acetyl)-6-sulfatase 0.0223625
M6PR mannose-6-phosphate receptor (cation dependent) 0.0222595
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0222232
RBBP7 retinoblastoma binding protein 7 0.0221846
BMP6 bone morphogenetic protein 6 0.0220726
SRSF4 serine/arginine-rich splicing factor 4 0.0220088
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.021956
PFN1 profilin 1 0.0219383
NPTN neuroplastin 0.0218944
ABHD2 abhydrolase domain containing 2 0.0218798
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.0217511
CD44 CD44 molecule (Indian blood group) 0.0216291
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0214654
TUBGCP2 tubulin, gamma complex associated protein 2 0.0214581
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.0214323
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0214081
CSNK1D casein kinase 1, delta 0.0213213
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0213097
RPS2 ribosomal protein S2 0.0213026
MAP1B microtubule-associated protein 1B 0.0212385
TSPAN3 tetraspanin 3 0.0211979
PCYOX1 prenylcysteine oxidase 1 0.0210405
WASHC4 WASH complex subunit 4 0.0210357
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.0209593
AREG amphiregulin 0.0209587
FAM168B family with sequence similarity 168, member B 0.0207942
CEACAM19 carcinoembryonic antigen-related cell adhesion molecule 19 0.0207355
METTL8 methyltransferase like 8 0.0207222
EXOC6B exocyst complex component 6B 0.0206955
CLASP1 cytoplasmic linker associated protein 1 0.0206126
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0205891
DNMBP dynamin binding protein 0.0205775
CENPF centromere protein F, 350/400kDa 0.0205398
ARHGAP35 Rho GTPase activating protein 35 0.020483
SETD5 SET domain containing 5 0.02047
TRRAP transformation/transcription domain-associated protein 0.0204694
RAB2A RAB2A, member RAS oncogene family 0.0204392
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0204266
PLEC plectin 0.0204145
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 0.0203897
NRIP1 nuclear receptor interacting protein 1 0.020352
CCT2 chaperonin containing TCP1, subunit 2 (beta) 0.0202394
ARL4C ADP-ribosylation factor-like 4C 0.0202315
LDHB lactate dehydrogenase B 0.0202104
CLCN3 chloride channel, voltage-sensitive 3 0.0201795
TRIM28 tripartite motif containing 28 0.0201266
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0200987
INVS inversin 0.0200505
MYH9 myosin, heavy chain 9, non-muscle 0.0200362
RPS6 ribosomal protein S6 0.0200118
PBX3 pre-B-cell leukemia homeobox 3 0.019918
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0198478
CENPE centromere protein E, 312kDa 0.0198117
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 0.0197918
CALU calumenin 0.0197498
CD63 CD63 molecule 0.0197332
C19ORF53 chromosome 19 open reading frame 53 0.0196482
RAB33B RAB33B, member RAS oncogene family 0.0196428
SUMO2 small ubiquitin-like modifier 2 0.0195085
RPS23 ribosomal protein S23 0.0194961
CENPK centromere protein K 0.0194714
UBA1 ubiquitin-like modifier activating enzyme 1 0.019434
NUAK2 NUAK family, SNF1-like kinase, 2 0.0193809
JUP junction plakoglobin 0.0193796
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0191999
PITPNA phosphatidylinositol transfer protein, alpha 0.0191777
LRP6 low density lipoprotein receptor-related protein 6 0.0191215
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0190926
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0190337
TUBA1B tubulin, alpha 1b 0.0189537
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0189088
UTRN utrophin 0.0188297
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.018827
ATG7 autophagy related 7 0.0188014
CST3 cystatin C 0.0187814
LARP1 La ribonucleoprotein domain family, member 1 0.0187477
PBRM1 polybromo 1 0.0187464
POGZ pogo transposable element with ZNF domain 0.0187272
FARSB phenylalanyl-tRNA synthetase, beta subunit 0.0186282
MATN2 matrilin 2 0.0186272
ULK1 unc-51 like autophagy activating kinase 1 0.0185906
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0185738
SETBP1 SET binding protein 1 0.0185712
TMEM209 transmembrane protein 209 0.0185632
SYNGR2 synaptogyrin 2 0.0185461
DOCK1 dedicator of cytokinesis 1 0.018425
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.01842
TRIM44 tripartite motif containing 44 0.018417
LRIF1 ligand dependent nuclear receptor interacting factor 1 0.0184096
TASOR2 transcription activation suppressor family member 2 0.0183691
BCAS4 breast carcinoma amplified sequence 4 0.0183455
USP37 ubiquitin specific peptidase 37 0.018301
CCDC66 coiled-coil domain containing 66 0.0182441
SSH2 slingshot protein phosphatase 2 0.0181293
NVL nuclear VCP-like 0.0180913
MGME1 mitochondrial genome maintenance exonuclease 1 0.0180815
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0180453
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0180259
HCFC1 host cell factor C1 0.0179926
STK4 serine/threonine kinase 4 0.0179895
WDHD1 WD repeat and HMG-box DNA binding protein 1 0.0179314
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0178847
FTH1 ferritin, heavy polypeptide 1 0.017805
FA2H fatty acid 2-hydroxylase 0.0177737
LONP2 lon peptidase 2, peroxisomal 0.0177352
LRMDA leucine rich melanocyte differentiation associated 0.0176155
SYPL1 synaptophysin-like 1 0.017586
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0174673
RAB28 RAB28, member RAS oncogene family 0.0174621
ATAD5 ATPase family, AAA domain containing 5 0.0174494
CENPP centromere protein P 0.0173836
TACC3 transforming, acidic coiled-coil containing protein 3 0.0173556
RAD54L2 RAD54-like 2 (S. cerevisiae) 0.0173158
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.017274
EMC3 ER membrane protein complex subunit 3 0.0172654
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0172445
EGFR epidermal growth factor receptor 0.0172125
RPS3 ribosomal protein S3 0.0171602
DOCK10 dedicator of cytokinesis 10 0.0171203
PRR11 proline rich 11 0.0171134
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0170276
ZNF251 zinc finger protein 251 0.0169772
SOCS6 suppressor of cytokine signaling 6 0.0169331
FAF1 Fas (TNFRSF6) associated factor 1 0.016798
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0167787
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) 0.0167581
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 0.0167511
NQO2 NAD(P)H dehydrogenase, quinone 2 0.0167289
INTS6 integrator complex subunit 6 0.0167249
GANAB glucosidase, alpha; neutral AB 0.0166664
ARF1 ADP-ribosylation factor 1 0.0166502
PDIA4 protein disulfide isomerase family A, member 4 0.0165666
RIPK2 receptor-interacting serine-threonine kinase 2 0.01653
INTU inturned planar cell polarity protein 0.0165177
KIF24 kinesin family member 24 0.0164823
KDM3B lysine (K)-specific demethylase 3B 0.0164626
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0164386
SKIC3 SKI3 subunit of superkiller complex 0.0164184
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 0.0164064
ZBTB44 zinc finger and BTB domain containing 44 0.0163832
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 0.0163532
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.0162966
SKA2 spindle and kinetochore associated complex subunit 2 0.0162855
IGFBP3 insulin-like growth factor binding protein 3 0.0162512
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 0.0162207
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0161923
PBK PDZ binding kinase 0.0161733
SPAG9 sperm associated antigen 9 0.0161719
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0161388
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0161331
KHSRP KH-type splicing regulatory protein 0.016115
GTF2A2 general transcription factor IIA, 2, 12kDa 0.0160947
RPL32 ribosomal protein L32 0.0160873
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0160521
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.016042
IFI6 interferon, alpha-inducible protein 6 0.0160345
ACADVL acyl-CoA dehydrogenase, very long chain 0.0160273
ABHD12 abhydrolase domain containing 12 0.0160157
UBXN7 UBX domain protein 7 0.0160109
DARS1 aspartyl-tRNA synthetase 1 0.015996
TMED2 transmembrane emp24 domain trafficking protein 2 0.0159796
WWC2 WW and C2 domain containing 2 0.015971
MGST3 microsomal glutathione S-transferase 3 0.0159532
PHTF2 putative homeodomain transcription factor 2 0.0159275
TMEM131 transmembrane protein 131 0.0158766
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 0.015868
PGAP1 post-GPI attachment to proteins 1 0.0158538
MKI67 marker of proliferation Ki-67 0.0158232
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0157956
ELOVL5 ELOVL fatty acid elongase 5 0.0156993
GDE1 glycerophosphodiester phosphodiesterase 1 0.0156966
ANLN anillin, actin binding protein 0.0156922
RAD51B RAD51 paralog B 0.0156911
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0156756
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0156432
HELZ helicase with zinc finger 0.0156054
RUSC2 RUN and SH3 domain containing 2 0.0155957
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0155798
LDLR low density lipoprotein receptor 0.0155625
FANCL Fanconi anemia, complementation group L 0.0155179
EVA1C eva-1 homolog C (C. elegans) 0.0154818
RPL37 ribosomal protein L37 0.0154755
STRA6 stimulated by retinoic acid 6 0.0154057
SORT1 sortilin 1 0.0153999
NIPBL Nipped-B homolog (Drosophila) 0.0153915
PRRC2C proline-rich coiled-coil 2C 0.0153646
SDF4 stromal cell derived factor 4 0.0153578
SETX senataxin 0.0153394
MICU1 mitochondrial calcium uptake 1 0.0153191
PPP2R2D protein phosphatase 2, regulatory subunit B, delta 0.0152988
KDM2B lysine (K)-specific demethylase 2B 0.0152648
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0152056
ZBTB2 zinc finger and BTB domain containing 2 0.0151593
CNOT7 CCR4-NOT transcription complex, subunit 7 0.0151588
SELENOI selenoprotein I 0.0151477
VWA8 von Willebrand factor A domain containing 8 0.0151419
PEX14 peroxisomal biogenesis factor 14 0.015132
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0151123
EIF4B eukaryotic translation initiation factor 4B 0.0151046
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.0150956
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0150907
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0150842
BCL9L B-cell CLL/lymphoma 9-like 0.0150446
CRTAP cartilage associated protein 0.0150179
IFT81 intraflagellar transport 81 0.0149935
NECTIN3 nectin cell adhesion molecule 3 0.0149691
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.0149571
NCEH1 neutral cholesterol ester hydrolase 1 0.0148525
PIAS1 protein inhibitor of activated STAT, 1 0.0148137
NMRAL1 NmrA-like family domain containing 1 0.0148131
DUSP5 dual specificity phosphatase 5 0.0147939
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.0147794
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0147775
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.0147693
DCAF17 DDB1 and CUL4 associated factor 17 0.0147563
PARN poly(A)-specific ribonuclease 0.0147256
NUP214 nucleoporin 214kDa 0.0147101
CUL2 cullin 2 0.0147061
SOS1 son of sevenless homolog 1 (Drosophila) 0.0146708
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0146559
LIN52 lin-52 DREAM MuvB core complex component 0.0146316
IPO5 importin 5 0.014613
THRA thyroid hormone receptor, alpha 0.0146056
SCAI suppressor of cancer cell invasion 0.0145443
WARS1 tryptophanyl-tRNA synthetase 1 0.0144799
IGF2R insulin-like growth factor 2 receptor 0.0144699
PRCP prolylcarboxypeptidase (angiotensinase C) 0.0144046
ADAR adenosine deaminase, RNA-specific 0.0143786
ZFP36L2 ZFP36 ring finger protein-like 2 0.0143768
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 0.0143619
PUM1 pumilio RNA-binding family member 1 0.014358
RPL30 ribosomal protein L30 0.0143482
NLN neurolysin (metallopeptidase M3 family) 0.0143411
FMNL2 formin-like 2 0.0143409
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0143383
ADAM23 ADAM metallopeptidase domain 23 0.0143255
SMC6 structural maintenance of chromosomes 6 0.0143075
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.014295
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 0.0142727
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0142674
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 0.0142638
DHCR24 24-dehydrocholesterol reductase 0.0142145
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.0141986
ZC3H3 zinc finger CCCH-type containing 3 0.0141933
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0141796
MYPOP Myb-related transcription factor, partner of profilin 0.0141734
TPR translocated promoter region, nuclear basket protein 0.01417
RND1 Rho family GTPase 1 0.0141609
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0141482
NAT14 N-acetyltransferase 14 (GCN5-related, putative) 0.0141446
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0141278
ERRFI1 ERBB receptor feedback inhibitor 1 0.0141247
SCARB2 scavenger receptor class B, member 2 0.0140708
RPS9 ribosomal protein S9 0.0140666
ARHGAP32 Rho GTPase activating protein 32 0.0140391
CSRP1 cysteine and glycine-rich protein 1 0.014029
C1S complement component 1, s subcomponent 0.014024
NUCB2 nucleobindin 2 0.0140222
CENPA centromere protein A 0.0140131
MAP2K2 mitogen-activated protein kinase kinase 2 0.0139904
MICU2 mitochondrial calcium uptake 2 0.0139581
JAK1 Janus kinase 1 0.0139455
SEPTIN7 septin 7 0.0139148
ANKRD11 ankyrin repeat domain 11 0.0139003
DCAF1 DDB1 and CUL4 associated factor 1 0.0138602
APLP2 amyloid beta (A4) precursor-like protein 2 0.0138396
CXXC5 CXXC finger protein 5 0.0138174
RBM15 RNA binding motif protein 15 0.0138068
MARCHF6 membrane associated ring-CH-type finger 6 0.0137993
MED29 mediator complex subunit 29 0.0137802
RPGRIP1L RPGRIP1-like 0.0137498
CREBRF CREB3 regulatory factor 0.0137319
ICE1 interactor of little elongation complex ELL subunit 1 0.0137225
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0137215
LPIN1 lipin 1 0.0136888
ENOX2 ecto-NOX disulfide-thiol exchanger 2 0.0136788
IWS1 IWS1 homolog (S. cerevisiae) 0.0136687
CD151 CD151 molecule (Raph blood group) 0.0136538
ETF1 eukaryotic translation termination factor 1 0.0136521
LRRC8A leucine rich repeat containing 8 family, member A 0.0136113
H2AZ2 H2A.Z variant histone 2 0.0135975
ZDHHC9 zinc finger, DHHC-type containing 9 0.0135972
PRDX5 peroxiredoxin 5 0.0135819
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.0135614
ATG14 autophagy related 14 0.0135304
PDIA3 protein disulfide isomerase family A, member 3 0.0135151
CDIN1 CDAN1 interacting nuclease 1 0.0134885
BFSP1 beaded filament structural protein 1, filensin 0.0134523
SEC23IP SEC23 interacting protein 0.0134184
FOXK2 forkhead box K2 0.0133864
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0133844
ORAI2 ORAI calcium release-activated calcium modulator 2 0.0133729
CDK19 cyclin-dependent kinase 19 0.0133612
CANX calnexin 0.0133423
UBASH3B ubiquitin associated and SH3 domain containing B 0.0133364
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 0.0133072
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0132884
SERTAD2 SERTA domain containing 2 0.0132856
ACOD1 aconitate decarboxylase 1 0.0132528
KDSR 3-ketodihydrosphingosine reductase 0.0132395
MSL1 male-specific lethal 1 homolog (Drosophila) 0.013228
SSRP1 structure specific recognition protein 1 0.0132241
LGALS12 lectin, galactoside-binding, soluble, 12 0.0132034
NFE2L1 nuclear factor, erythroid 2-like 1 0.0131492
UBL4A ubiquitin-like 4A 0.0131411
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0131037
LEMD2 LEM domain containing 2 0.0131009
TM9SF4 transmembrane 9 superfamily protein member 4 0.0130989
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 0.0130938
SAR1A secretion associated, Ras related GTPase 1A 0.013092
SPICE1 spindle and centriole associated protein 1 0.0130742
DGLUCY D-glutamate cyclase 0.0130535
NARS1 asparaginyl-tRNA synthetase 1 0.0130469
ZNF236 zinc finger protein 236 0.01304
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 0.0130363
SCGB1D1 secretoglobin, family 1D, member 1 0.0130275
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0130143
ZNF407 zinc finger protein 407 0.0129776
SLC38A10 solute carrier family 38, member 10 0.012959
ZNF704 zinc finger protein 704 0.0129154
ZBTB38 zinc finger and BTB domain containing 38 0.0129014
RPL15 ribosomal protein L15 0.0128899
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 0.0128767
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 0.0128736
IKBIP IKBKB interacting protein 0.0128733
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0128692
ATF4 activating transcription factor 4 0.0128561
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 0.0128254
DUSP18 dual specificity phosphatase 18 0.0128044
MTREX Mtr4 exosome RNA helicase 0.0127896
GOLGA1 golgin A1 0.0127748
LPCAT3 lysophosphatidylcholine acyltransferase 3 0.0127508
SOX4 SRY (sex determining region Y)-box 4 0.0127148
MYO9B myosin IXB 0.0126805
ACO2 aconitase 2, mitochondrial 0.0126415
CNTNAP3 contactin associated protein-like 3 0.0126384
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.0126234
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.0126181
DNM1L dynamin 1-like 0.0126083
XPO5 exportin 5 0.0125788
RAB3B RAB3B, member RAS oncogene family 0.0125719
TMCO1 transmembrane and coiled-coil domains 1 0.0125508
IDI1 isopentenyl-diphosphate delta isomerase 1 0.0125477
MAP7 microtubule-associated protein 7 0.0125271
CXXC1 CXXC finger protein 1 0.0124979

decreased expression

Symbol Name Standardized Value
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.156998
ZBTB20 zinc finger and BTB domain containing 20 -0.0893556
PDE8A phosphodiesterase 8A -0.0838026
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0823312
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0783789
JMJD1C jumonji domain containing 1C -0.0735597
EHBP1 EH domain binding protein 1 -0.0725892
BIRC6 baculoviral IAP repeat containing 6 -0.0708435
NRG1 neuregulin 1 -0.0641227
PTK2 protein tyrosine kinase 2 -0.0640363
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0637969
CMIP c-Maf inducing protein -0.0628999
GRAMD1B GRAM domain containing 1B -0.0626817
PCDH9 protocadherin 9 -0.0600157
MAML3 mastermind-like 3 (Drosophila) -0.0591737
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0586932
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0573041
RAB10 RAB10, member RAS oncogene family -0.0563423
DENND5B DENN/MADD domain containing 5B -0.0560552
DOCK5 dedicator of cytokinesis 5 -0.0531287
THSD7A thrombospondin, type I, domain containing 7A -0.053083
BCAS3 breast carcinoma amplified sequence 3 -0.0530579
CSNK2A2 casein kinase 2, alpha prime polypeptide -0.0485319
CNTNAP3B contactin associated protein-like 3B -0.0474486
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.046248
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0457244
CP ceruloplasmin (ferroxidase) -0.0452714
TNS3 tensin 3 -0.0448666
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0443932
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0438708
TACC2 transforming, acidic coiled-coil containing protein 2 -0.0438419
ANKRD17 ankyrin repeat domain 17 -0.043718
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0434537
WWOX WW domain containing oxidoreductase -0.0423612
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 -0.0414055
MED13 mediator complex subunit 13 -0.0407852
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0407376
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0403792
SMAD2 SMAD family member 2 -0.0400209
WWP1 WW domain containing E3 ubiquitin protein ligase 1 -0.0399964
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0395234
NRP1 neuropilin 1 -0.0392392
MED13L mediator complex subunit 13-like -0.0379501
MYADM myeloid-associated differentiation marker -0.0377481
PDE4B phosphodiesterase 4B, cAMP-specific -0.0372717
NCOA2 nuclear receptor coactivator 2 -0.036131
GIGYF2 GRB10 interacting GYF protein 2 -0.0360892
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.0353904
USP32 ubiquitin specific peptidase 32 -0.0353416
NBAS neuroblastoma amplified sequence -0.0349615
ARHGAP26 Rho GTPase activating protein 26 -0.0348536
FN1 fibronectin 1 -0.0348202
TTC28 tetratricopeptide repeat domain 28 -0.0347923
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0347725
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0347475
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0347448
USP9X ubiquitin specific peptidase 9, X-linked -0.0346381
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0345572
TTC3 tetratricopeptide repeat domain 3 -0.0343108
NCOA3 nuclear receptor coactivator 3 -0.0343005
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0337458
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0335375
RAI14 retinoic acid induced 14 -0.0334315
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0333215
FOSL1 FOS-like antigen 1 -0.0332706
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0331002
SPIDR scaffolding protein involved in DNA repair -0.0327814
ZFAND3 zinc finger, AN1-type domain 3 -0.0326467
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0325522
USP34 ubiquitin specific peptidase 34 -0.0325348
MYO10 myosin X -0.032383
GMDS GDP-mannose 4,6-dehydratase -0.0323828
STK24 serine/threonine kinase 24 -0.0322098
MLPH melanophilin -0.0319028
MYOF myoferlin -0.0318893
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0317825
PARD3 par-3 family cell polarity regulator -0.0317305
RBM6 RNA binding motif protein 6 -0.0317036
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0316433
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0314559
MACROD2 MACRO domain containing 2 -0.0314539
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0312761
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0311927
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0311278
KIF13A kinesin family member 13A -0.0309439
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0307231
SMG6 SMG6 nonsense mediated mRNA decay factor -0.0306805
PDE10A phosphodiesterase 10A -0.0305452
HIP1 huntingtin interacting protein 1 -0.0303583
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0302891
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0302188
COL4A5 collagen, type IV, alpha 5 -0.0298125
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0298093
GLG1 golgi glycoprotein 1 -0.0297108
BMPR1B bone morphogenetic protein receptor, type IB -0.0295881
NCOR2 nuclear receptor corepressor 2 -0.029511
FCGBP Fc fragment of IgG binding protein -0.0295032
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0294695
PALLD palladin, cytoskeletal associated protein -0.0292128
LRRK2 leucine-rich repeat kinase 2 -0.0291153
SMAD6 SMAD family member 6 -0.0291079
DGKD diacylglycerol kinase, delta 130kDa -0.0290292
PSD3 pleckstrin and Sec7 domain containing 3 -0.0290037
IGF1R insulin-like growth factor 1 receptor -0.0289337
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0288475
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0286117
RPS21 ribosomal protein S21 -0.0285808
NCOA6 nuclear receptor coactivator 6 -0.0285131
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0284975
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -0.0284455
RPTOR regulatory associated protein of MTOR, complex 1 -0.0284248
SOGA1 suppressor of glucose, autophagy associated 1 -0.0283666
FTO fat mass and obesity associated -0.0283663
RNPS1 RNA binding protein S1, serine-rich domain -0.0282813
STX8 syntaxin 8 -0.0281965
EML4 echinoderm microtubule associated protein like 4 -0.028125
PUM2 pumilio RNA-binding family member 2 -0.0281027
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0280295
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0280028
OLA1 Obg-like ATPase 1 -0.0279659
TNPO3 transportin 3 -0.0279378
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.0277925
ASPH aspartate beta-hydroxylase -0.0277881
PTPRK protein tyrosine phosphatase, receptor type, K -0.0275828
AVL9 AVL9 homolog (S. cerevisiase) -0.0275618
PKN2 protein kinase N2 -0.0274746
TNRC18 trinucleotide repeat containing 18 -0.0273847
HM13 histocompatibility (minor) 13 -0.0273391
ADGRG6 adhesion G protein-coupled receptor G6 -0.0273291
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0273211
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0271061
EEF2 eukaryotic translation elongation factor 2 -0.0270725
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 -0.0269004
FCHSD2 FCH and double SH3 domains 2 -0.0268678
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.026734
VEZT vezatin, adherens junctions transmembrane protein -0.0266383
PPP1R9A protein phosphatase 1, regulatory subunit 9A -0.0266332
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0265391
GRAMD1A GRAM domain containing 1A -0.0264487
TP53 tumor protein p53 -0.0264304
LIMCH1 LIM and calponin homology domains 1 -0.0264001
EDN1 endothelin 1 -0.0263979
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0262817
DNAAF9 dynein axonemal assembly factor 9 -0.0261885
ATAD2B ATPase family, AAA domain containing 2B -0.0261629
SCAPER S-phase cyclin A-associated protein in the ER -0.0261224
RAB1A RAB1A, member RAS oncogene family -0.0261138
CERS6 ceramide synthase 6 -0.0261069
TCF12 transcription factor 12 -0.0260805
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0260799
SMAD3 SMAD family member 3 -0.0259131
UNC13B unc-13 homolog B (C. elegans) -0.0258447
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0258107
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.025689
PLD5 phospholipase D family, member 5 -0.0256879
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.025687
NINL ninein-like -0.025498
YAP1 Yes-associated protein 1 -0.0254884
CNKSR3 CNKSR family member 3 -0.0254573
CPT1A carnitine palmitoyltransferase 1A (liver) -0.0253774
TUT4 terminal uridylyl transferase 4 -0.0252913
TUBD1 tubulin, delta 1 -0.0251895
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.0250802
TSPAN14 tetraspanin 14 -0.0250198
METTL16 methyltransferase like 16 -0.024803
PHF21A PHD finger protein 21A -0.0246947
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0246709
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.024559
DENND5A DENN/MADD domain containing 5A -0.0245485
PRKCSH protein kinase C substrate 80K-H -0.0245443
MARCHF7 membrane associated ring-CH-type finger 7 -0.0244727
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0243445
MORF4L1 mortality factor 4 like 1 -0.024294
HOMER2 homer scaffolding protein 2 -0.0240106
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0239683
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0239134
ANTXR1 anthrax toxin receptor 1 -0.0238502
FGA fibrinogen alpha chain -0.0238279
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0237943
BLTP2 bridge-like lipid transfer protein family member 2 -0.0237658
FOCAD focadhesin -0.0237196
FNDC3B fibronectin type III domain containing 3B -0.0236142
ARRB1 arrestin, beta 1 -0.0235663
STRN striatin, calmodulin binding protein -0.0235378
VCP valosin containing protein -0.0234279
SAE1 SUMO1 activating enzyme subunit 1 -0.023374
NPAS2 neuronal PAS domain protein 2 -0.0233682
USP36 ubiquitin specific peptidase 36 -0.0233496
UBAP2 ubiquitin associated protein 2 -0.0231801
NCOR1 nuclear receptor corepressor 1 -0.0231414
LARP4 La ribonucleoprotein domain family, member 4 -0.0230571
TSPAN4 tetraspanin 4 -0.0229692
RNF216 ring finger protein 216 -0.0228699
MISP mitotic spindle positioning -0.0228158
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0226193
RBM39 RNA binding motif protein 39 -0.0226018
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0225695
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 -0.022569
UBA2 ubiquitin-like modifier activating enzyme 2 -0.0224926
SIK3 SIK family kinase 3 -0.0224258
RABGAP1 RAB GTPase activating protein 1 -0.0223122
LARP1B La ribonucleoprotein domain family, member 1B -0.0223041
TNRC6A trinucleotide repeat containing 6A -0.0220481
CST1 cystatin SN -0.0220416
BRD4 bromodomain containing 4 -0.0219657
ATE1 arginyltransferase 1 -0.0219484
ARHGAP12 Rho GTPase activating protein 12 -0.0219042
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase -0.0218513
SLC71A2 solute carrier family 71 member 2 -0.0218144
ARB2A ARB2 cotranscriptional regulator A -0.0216868
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0216321
COL5A2 collagen, type V, alpha 2 -0.0214411
RIOK3 RIO kinase 3 -0.0214244
RAP1GAP2 RAP1 GTPase activating protein 2 -0.021381
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0213769
SGMS1 sphingomyelin synthase 1 -0.0212968
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0212435
VMP1 vacuole membrane protein 1 -0.0211949
CHD9 chromodomain helicase DNA binding protein 9 -0.0211316
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0210797
AMBRA1 autophagy/beclin-1 regulator 1 -0.021067
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0210441
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0210297
ATXN3 ataxin 3 -0.0210182
MAP2K4 mitogen-activated protein kinase kinase 4 -0.0209267
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0209202
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -0.0209006
PLCH1 phospholipase C, eta 1 -0.0207647
GOLGA4 golgin A4 -0.0207055
MVP major vault protein -0.0206307
EFTUD2 elongation factor Tu GTP binding domain containing 2 -0.0205881
TRIM27 tripartite motif containing 27 -0.0204792
PDLIM1 PDZ and LIM domain 1 -0.0204199
WDR44 WD repeat domain 44 -0.0203897
GSE1 Gse1 coiled-coil protein -0.0202613
PTCD3 pentatricopeptide repeat domain 3 -0.0202032
FOXN2 forkhead box N2 -0.020168
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0201106
KLF13 Kruppel-like factor 13 -0.0200819
SREBF2 sterol regulatory element binding transcription factor 2 -0.0200787
CCNT1 cyclin T1 -0.0200765
HDGFL3 HDGF like 3 -0.0200736
GPC1 glypican 1 -0.0200542
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 -0.0199357
NOP58 NOP58 ribonucleoprotein -0.0198232
CLIP1 CAP-GLY domain containing linker protein 1 -0.0197933
ADAM9 ADAM metallopeptidase domain 9 -0.0197897
OPHN1 oligophrenin 1 -0.0197453
WWC1 WW and C2 domain containing 1 -0.019617
BBX bobby sox homolog (Drosophila) -0.019603
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0195662
CCM2 cerebral cavernous malformation 2 -0.0195269
THSD4 thrombospondin, type I, domain containing 4 -0.0194577
PCNX1 pecanex 1 -0.0193894
ATM ATM serine/threonine kinase -0.019369
FAM107B family with sequence similarity 107, member B -0.019337
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0193282
AUTS2 autism susceptibility candidate 2 -0.0192605
SERGEF secretion regulating guanine nucleotide exchange factor -0.0192186
ZNF518A zinc finger protein 518A -0.019136
GPATCH1 G patch domain containing 1 -0.0191249
SMAP1 small ArfGAP 1 -0.0191208
MAU2 MAU2 sister chromatid cohesion factor -0.0190964
AKAP12 A kinase (PRKA) anchor protein 12 -0.0189984
ACTN1 actinin, alpha 1 -0.0189683
BCL2L1 BCL2-like 1 -0.018941
SNX6 sorting nexin 6 -0.0189034
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -0.0188557
USP47 ubiquitin specific peptidase 47 -0.0188518
ATL2 atlastin GTPase 2 -0.0188443
APP amyloid beta (A4) precursor protein -0.018775
SLC45A4 solute carrier family 45, member 4 -0.0187286
CSDE1 cold shock domain containing E1, RNA-binding -0.0186698
TENT4B terminal nucleotidyltransferase 4B -0.0186606
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0186594
RPLP0 ribosomal protein, large, P0 -0.0186557
LAPTM4A lysosomal protein transmembrane 4 alpha -0.0186305
CERT1 ceramide transporter 1 -0.0185943
MTDH metadherin -0.0185774
TRIM33 tripartite motif containing 33 -0.0185544
ADAM17 ADAM metallopeptidase domain 17 -0.018549
MORF4L2 mortality factor 4 like 2 -0.0185133
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0184872
TENT2 terminal nucleotidyltransferase 2 -0.0184842
UBAP1 ubiquitin associated protein 1 -0.0184717
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0184701
GDNF glial cell derived neurotrophic factor -0.0184692
PRDX1 peroxiredoxin 1 -0.0184535
PBX1 pre-B-cell leukemia homeobox 1 -0.0183689
SLC38A6 solute carrier family 38, member 6 -0.0183327
SYMPK symplekin -0.018323
GOLGB1 golgin B1 -0.0183169
GATAD2A GATA zinc finger domain containing 2A -0.0183008
NUP210 nucleoporin 210kDa -0.0182697
ATXN10 ataxin 10 -0.0182548
CCDC12 coiled-coil domain containing 12 -0.0182296
STXBP4 syntaxin binding protein 4 -0.0182182
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.018112
KMT2E lysine (K)-specific methyltransferase 2E -0.018088
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.018078
LMNA lamin A/C -0.0180571
RANBP17 RAN binding protein 17 -0.0180487
SEPTIN9 septin 9 -0.0180434
MYO1D myosin ID -0.0180127
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0180077
ARHGAP17 Rho GTPase activating protein 17 -0.0179842
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -0.0179678
WDR72 WD repeat domain 72 -0.0179159
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0179089
ANKRD44 ankyrin repeat domain 44 -0.0178789
TOM1L1 target of myb1 (chicken)-like 1 -0.0178348
PCED1B PC-esterase domain containing 1B -0.0177999
PCNX2 pecanex 2 -0.0177933
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 -0.0177923
THRAP3 thyroid hormone receptor associated protein 3 -0.0177673
API5 apoptosis inhibitor 5 -0.0177615
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0177449
NRF1 nuclear respiratory factor 1 -0.0176837
SBF2 SET binding factor 2 -0.0176476
RABGAP1L RAB GTPase activating protein 1-like -0.0176272
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0175958
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32 -0.0175811
USP3 ubiquitin specific peptidase 3 -0.0175787
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) -0.0175744
PARVA parvin, alpha -0.0174331
FLNA filamin A, alpha -0.0174311
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0174097
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0174095
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 -0.0173763
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0173572
ATAD1 ATPase family, AAA domain containing 1 -0.0173542
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0172995
LPP LIM domain containing preferred translocation partner in lipoma -0.0172906
PHF20 PHD finger protein 20 -0.0172762
PHIP pleckstrin homology domain interacting protein -0.0172218
CADPS2 Ca++-dependent secretion activator 2 -0.0171511
IST1 increased sodium tolerance 1 homolog (yeast) -0.0171482
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0171385
TNPO1 transportin 1 -0.0171283
ITGB4 integrin, beta 4 -0.0170856
LPIN2 lipin 2 -0.0170838
CUL4A cullin 4A -0.0170808
MPHOSPH9 M-phase phosphoprotein 9 -0.0170699
UBE2K ubiquitin-conjugating enzyme E2K -0.0170392
RNF217 ring finger protein 217 -0.0170333
PTAR1 protein prenyltransferase alpha subunit repeat containing 1 -0.0170181
CNTN1 contactin 1 -0.0170144
PAWR PRKC, apoptosis, WT1, regulator -0.0169959
TAOK3 TAO kinase 3 -0.0169214
SATB2 SATB homeobox 2 -0.0169039
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0168959
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 -0.0168809
CDC123 cell division cycle 123 -0.0168379
REV1 REV1, polymerase (DNA directed) -0.0168219
PKN1 protein kinase N1 -0.0168168
ZNF326 zinc finger protein 326 -0.0167816
GARRE1 granule associated Rac and RHOG effector 1 -0.0167498
KCNK5 potassium channel, two pore domain subfamily K, member 5 -0.0167186
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.016686
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) -0.0166805
SLC39A11 solute carrier family 39, member 11 -0.0166688
EXOC6 exocyst complex component 6 -0.0166301
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0166288
PTGES2 prostaglandin E synthase 2 -0.0166112
NCAPG non-SMC condensin I complex, subunit G -0.0165575
TXNL4A thioredoxin-like 4A -0.0165193
NLK nemo-like kinase -0.016497
TPT1 tumor protein, translationally-controlled 1 -0.016491
LMBR1 limb development membrane protein 1 -0.0164715
RSU1 Ras suppressor protein 1 -0.0164168
CUL3 cullin 3 -0.0163838
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0163604
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0163384
SHOC2 soc-2 suppressor of clear homolog (C. elegans) -0.0163353
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0163035
SLC25A43 solute carrier family 25, member 43 -0.0162989
GTF2IRD1 GTF2I repeat domain containing 1 -0.0162927
SPPL3 signal peptide peptidase like 3 -0.0162505
SF1 splicing factor 1 -0.016248
IPO7 importin 7 -0.0162442
EZR ezrin -0.0162421
FGFR1 fibroblast growth factor receptor 1 -0.0161963
ATG4B autophagy related 4B, cysteine peptidase -0.0161872
SPG11 spastic paraplegia 11 (autosomal recessive) -0.01618
EPS15 epidermal growth factor receptor pathway substrate 15 -0.0161777
EXOC5 exocyst complex component 5 -0.0161398
NUCB1 nucleobindin 1 -0.0161023
CDKL5 cyclin-dependent kinase-like 5 -0.0160921
MBTPS1 membrane-bound transcription factor peptidase, site 1 -0.0160714
TMCC1 transmembrane and coiled-coil domain family 1 -0.0160621
TACC1 transforming, acidic coiled-coil containing protein 1 -0.0160102
TBL1X transducin (beta)-like 1X-linked -0.0159455
KDM4B lysine (K)-specific demethylase 4B -0.0159014
SNX1 sorting nexin 1 -0.015901
RPL28 ribosomal protein L28 -0.015814
MTRFR mitochondrial translation release factor in rescue -0.0158137
MIPOL1 mirror-image polydactyly 1 -0.0158129
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0158008
ANGPTL4 angiopoietin-like 4 -0.0157898
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0157348
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0157218
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 -0.0157118
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0156972
DYM dymeclin -0.0156525
CARMIL1 capping protein regulator and myosin 1 linker 1 -0.0156487
KIAA1671 KIAA1671 -0.0156302
MTCH2 mitochondrial carrier 2 -0.0156176
TRIO trio Rho guanine nucleotide exchange factor -0.01561
RUFY1 RUN and FYVE domain containing 1 -0.0155671
HNRNPL heterogeneous nuclear ribonucleoprotein L -0.0155506
ELOVL6 ELOVL fatty acid elongase 6 -0.0155423
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0154938
GPR39 G protein-coupled receptor 39 -0.0154705
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D -0.0154559
ZC3H7A zinc finger CCCH-type containing 7A -0.0154412
UBQLN1 ubiquilin 1 -0.0154295
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 -0.0153903
LRP5 low density lipoprotein receptor-related protein 5 -0.01538
EYA3 EYA transcriptional coactivator and phosphatase 3 -0.0153137
SKP1 S-phase kinase-associated protein 1 -0.0153014
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase -0.0152849
SNX29 sorting nexin 29 -0.0152616
ARID1A AT rich interactive domain 1A (SWI-like) -0.0152554
RBPMS RNA binding protein with multiple splicing -0.0152506
TRIM16 tripartite motif containing 16 -0.0152029
RPH3AL rabphilin 3A-like (without C2 domains) -0.015189
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0151889
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0151791
BMPR1A bone morphogenetic protein receptor, type IA -0.0151653
XPC xeroderma pigmentosum, complementation group C -0.0151499
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -0.0151436
KAT6B K(lysine) acetyltransferase 6B -0.0151414
AHNAK AHNAK nucleoprotein -0.0151172
SNRPA1 small nuclear ribonucleoprotein polypeptide A' -0.015098
ELMOD3 ELMO/CED-12 domain containing 3 -0.0150738
KDM5A lysine (K)-specific demethylase 5A -0.0150395
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0150223
UNC13A unc-13 homolog A (C. elegans) -0.01502
PPCDC phosphopantothenoylcysteine decarboxylase -0.0149637
RPL14 ribosomal protein L14 -0.0148444
GOLGA3 golgin A3 -0.0148342
GIPC1 GIPC PDZ domain containing family, member 1 -0.0148099
TATDN3 TatD DNase domain containing 3 -0.0148037
TTC13 tetratricopeptide repeat domain 13 -0.014768
AXL AXL receptor tyrosine kinase -0.0147607
MSN moesin -0.0147158
STARD7 StAR-related lipid transfer (START) domain containing 7 -0.0147081
INO80 INO80 complex subunit -0.0147009
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0146972
MRE11 MRE11 homolog, double strand break repair nuclease -0.0146829
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial -0.0146774
PGM2L1 phosphoglucomutase 2-like 1 -0.0146728
PNISR PNN-interacting serine/arginine-rich protein -0.0146614
HEATR1 HEAT repeat containing 1 -0.0146308
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0146278
DNAH14 dynein, axonemal, heavy chain 14 -0.0146227
RIC1 RAB6A GEF complex partner 1 -0.0146227
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) -0.0145831
STRN3 striatin, calmodulin binding protein 3 -0.0145541
INSR insulin receptor -0.0145404
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0145173
TFCP2 transcription factor CP2 -0.0145167
TTC39B tetratricopeptide repeat domain 39B -0.0145156
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha -0.0144867
TMEM263 transmembrane protein 263 -0.0144682
MAPK8 mitogen-activated protein kinase 8 -0.0144542
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0144168
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit -0.0144114
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0144012
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0143662
PLD3 phospholipase D family, member 3 -0.0143597
CDC42SE2 CDC42 small effector 2 -0.0143536
FBXL5 F-box and leucine-rich repeat protein 5 -0.0143349
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0143343
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0143134
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0143071
NUP93 nucleoporin 93kDa -0.0142887
VDAC1 voltage-dependent anion channel 1 -0.0142842
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -0.0142816
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 -0.0142623
SCAF11 SR-related CTD-associated factor 11 -0.0142622
SSBP1 single-stranded DNA binding protein 1, mitochondrial -0.0142434
TRAP1 TNF receptor-associated protein 1 -0.0142374
KANK1 KN motif and ankyrin repeat domains 1 -0.014228
SOCS5 suppressor of cytokine signaling 5 -0.014215
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0142136
CFH complement factor H -0.0142026
SRP68 signal recognition particle 68kDa -0.0141679
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit -0.0141163
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -0.0141015
PCGF5 polycomb group ring finger 5 -0.0140504
DENND4A DENN/MADD domain containing 4A -0.0140077
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 -0.0139914
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0139867
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.013984
PSIP1 PC4 and SFRS1 interacting protein 1 -0.0139768
POLR1A polymerase (RNA) I polypeptide A, 194kDa -0.0139497
CHD6 chromodomain helicase DNA binding protein 6 -0.0139474
PPP6R2 protein phosphatase 6, regulatory subunit 2 -0.0139234
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0139186