A549_SGI-1776 free base_10µM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description SGI-1776 free base 10µM perturbation in A549 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the A549_SGI-1776 free base_10µM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.335657
MUSK muscle, skeletal, receptor tyrosine kinase 0.246771
CA12 carbonic anhydrase XII 0.136605
SQSTM1 sequestosome 1 0.135667
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.127247
FTL ferritin, light polypeptide 0.105077
CLU clusterin 0.100009
FADS2 fatty acid desaturase 2 0.0987005
RPLP1 ribosomal protein, large, P1 0.0948681
THSD4 thrombospondin, type I, domain containing 4 0.075122
TXNRD1 thioredoxin reductase 1 0.0744476
CTSD cathepsin D 0.0740455
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.0711892
ACACA acetyl-CoA carboxylase alpha 0.0695763
FDPS farnesyl diphosphate synthase 0.0686697
ELOVL6 ELOVL fatty acid elongase 6 0.0681664
UBL4A ubiquitin-like 4A 0.0681155
RPL15 ribosomal protein L15 0.0659972
SQLE squalene epoxidase 0.0643042
DHCR7 7-dehydrocholesterol reductase 0.0633288
RPL13A ribosomal protein L13a 0.0620582
LDLR low density lipoprotein receptor 0.0601088
AKR1C1 aldo-keto reductase family 1, member C1 0.0597741
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0592393
ABTB3 ankyrin repeat and BTB domain containing 3 0.0586942
AHNAK2 AHNAK nucleoprotein 2 0.0585576
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0571253
GCLM glutamate-cysteine ligase, modifier subunit 0.0553936
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0514045
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0512568
FASN fatty acid synthase 0.0504533
CXXC1 CXXC finger protein 1 0.0500411
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.049116
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0490041
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 0.0489979
RPS19 ribosomal protein S19 0.0486375
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0482165
PCDHB16 protocadherin beta 16 0.0475382
FTH1 ferritin, heavy polypeptide 1 0.0472616
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0469604
ACSS2 acyl-CoA synthetase short-chain family member 2 0.0449291
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 0.0444466
KRT8 keratin 8, type II 0.04363
RAB10 RAB10, member RAS oncogene family 0.0433714
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 0.0429558
SLC38A1 solute carrier family 38, member 1 0.0427217
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.0426473
SFTPA2 surfactant protein A2 0.0415237
FHIT fragile histidine triad 0.0384567
TMEM156 transmembrane protein 156 0.0379911
MAML3 mastermind-like 3 (Drosophila) 0.0371665
ABHD3 abhydrolase domain containing 3 0.0367863
ALCAM activated leukocyte cell adhesion molecule 0.0367133
MPG N-methylpurine-DNA glycosylase 0.0366638
LPIN1 lipin 1 0.0362405
TXN2 thioredoxin 2 0.0358228
RPLP0 ribosomal protein, large, P0 0.035601
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0355484
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0353122
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0351008
PHGDH phosphoglycerate dehydrogenase 0.0350019
PKM pyruvate kinase, muscle 0.0346104
CALD1 caldesmon 1 0.033633
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0333632
S100A6 S100 calcium binding protein A6 0.0332649
CTSL cathepsin L 0.0326945
PRXL2A peroxiredoxin like 2A 0.0326414
NAMPT nicotinamide phosphoribosyltransferase 0.0318646
RPL37A ribosomal protein L37a 0.0318106
GOLGA4 golgin A4 0.031792
ITGB5 integrin, beta 5 0.0316032
RHOQ ras homolog family member Q 0.0315036
TRIB3 tribbles pseudokinase 3 0.0292167
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0291564
SMG6 SMG6 nonsense mediated mRNA decay factor 0.0290061
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0288467
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.028835
SHTN1 shootin 1 0.0286868
FMNL2 formin-like 2 0.0285608
IDI1 isopentenyl-diphosphate delta isomerase 1 0.0279537
AKR1C2 aldo-keto reductase family 1, member C2 0.0279014
IER5L immediate early response 5-like 0.0277596
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0277592
RTN4RL2 reticulon 4 receptor-like 2 0.027718
RDH10 retinol dehydrogenase 10 (all-trans) 0.0275946
RPS20 ribosomal protein S20 0.0274309
RPL23 ribosomal protein L23 0.0272165
PCYOX1 prenylcysteine oxidase 1 0.0271175
ITM2B integral membrane protein 2B 0.0270869
DPYSL2 dihydropyrimidinase-like 2 0.0270731
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0269209
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0267339
NRIP1 nuclear receptor interacting protein 1 0.0264708
TNS3 tensin 3 0.0264113
INSIG1 insulin induced gene 1 0.0264042
MAP1B microtubule-associated protein 1B 0.0262008
LAMP2 lysosomal-associated membrane protein 2 0.0258937
MLEC malectin 0.0257509
PDIA6 protein disulfide isomerase family A, member 6 0.0257332
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 0.0256803
LDHB lactate dehydrogenase B 0.0254725
LOC112694756 uncharaterized LOC112694756 0.0252062
RPS14 ribosomal protein S14 0.0251106
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0249986
RFX7 regulatory factor X, 7 0.0249528
RPL7A ribosomal protein L7a 0.0249058
GLIS3 GLIS family zinc finger 3 0.0248736
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 0.0246733
WNT7B wingless-type MMTV integration site family, member 7B 0.0246299
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.024612
SNX8 sorting nexin 8 0.0245115
ENAH enabled homolog (Drosophila) 0.0244496
RAB3B RAB3B, member RAS oncogene family 0.024233
ABHD12 abhydrolase domain containing 12 0.0242012
GPX2 glutathione peroxidase 2 0.0241378
RPL10A ribosomal protein L10a 0.0241284
BLTP2 bridge-like lipid transfer protein family member 2 0.0240064
SHLD2 shieldin complex subunit 2 0.0237093
LMBR1 limb development membrane protein 1 0.0236114
SOAT2 sterol O-acyltransferase 2 0.0235387
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 0.0234688
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0233024
RPL28 ribosomal protein L28 0.0230937
MSMO1 methylsterol monooxygenase 1 0.0230717
MLF2 myeloid leukemia factor 2 0.0230658
CEP89 centrosomal protein 89kDa 0.0229332
PHB1 prohibitin 1 0.0228772
GATAD2B GATA zinc finger domain containing 2B 0.0228751
PCDH9 protocadherin 9 0.0228727
MVD mevalonate (diphospho) decarboxylase 0.0228345
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0224476
OSGIN2 oxidative stress induced growth inhibitor family member 2 0.0221499
EEF2 eukaryotic translation elongation factor 2 0.0218257
MON2 MON2 homolog (S. cerevisiae) 0.0218245
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0217597
ZFHX3 zinc finger homeobox 3 0.0217061
TGIF1 TGFB-induced factor homeobox 1 0.0216538
NPC2 Niemann-Pick disease, type C2 0.0215445
RPS16 ribosomal protein S16 0.0215217
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0215188
KRT19 keratin 19, type I 0.0214577
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 0.0212989
SH3D19 SH3 domain containing 19 0.0211747
RPS6 ribosomal protein S6 0.0210272
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0209235
ACBD3 acyl-CoA binding domain containing 3 0.0207294
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 0.0206451
ARL15 ADP-ribosylation factor-like 15 0.0205074
NCOA2 nuclear receptor coactivator 2 0.0204936
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0204617
DHCR24 24-dehydrocholesterol reductase 0.0204577
TMEM97 transmembrane protein 97 0.0204373
ANKMY1 ankyrin repeat and MYND domain containing 1 0.0203639
EGLN1 egl-9 family hypoxia-inducible factor 1 0.020126
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0200194
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.019957
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0199178
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 0.0197593
ECH1 enoyl CoA hydratase 1, peroxisomal 0.0197385
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0197002
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0195705
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 0.0195653
SERF2 small EDRK-rich factor 2 0.0194907
MAGT1 magnesium transporter 1 0.0194542
TPR translocated promoter region, nuclear basket protein 0.0193766
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0193127
AP1M2 adaptor-related protein complex 1, mu 2 subunit 0.0190051
FRMD5 FERM domain containing 5 0.0189668
LARP1 La ribonucleoprotein domain family, member 1 0.0189269
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0187428
SPAG9 sperm associated antigen 9 0.018673
RAI14 retinoic acid induced 14 0.0185664
SUMF1 sulfatase modifying factor 1 0.0185285
LNPEP leucyl/cystinyl aminopeptidase 0.0183869
PDZD8 PDZ domain containing 8 0.0181741
RPL18 ribosomal protein L18 0.0181403
PRDX1 peroxiredoxin 1 0.0181374
MYOF myoferlin 0.0180974
M6PR mannose-6-phosphate receptor (cation dependent) 0.0178467
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0178205
SCARB1 scavenger receptor class B, member 1 0.0178001
ARID1B AT rich interactive domain 1B (SWI1-like) 0.017722
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.0177207
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.0176788
RTN3 reticulon 3 0.0176663
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0175716
RACK1 receptor for activated C kinase 1 0.0175695
CCDC57 coiled-coil domain containing 57 0.017562
GPAA1 glycosylphosphatidylinositol anchor attachment 1 0.0175379
RPS9 ribosomal protein S9 0.017527
HEATR5A HEAT repeat containing 5A 0.0174748
MEGF9 multiple EGF-like-domains 9 0.0174617
METTL15 methyltransferase like 15 0.017418
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 0.0174052
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0174044
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0173497
NIN ninein (GSK3B interacting protein) 0.017343
AMIGO2 adhesion molecule with Ig-like domain 2 0.017205
HLA-E major histocompatibility complex, class I, E 0.0171979
LITAF lipopolysaccharide-induced TNF factor 0.0171546
BAG1 BCL2-associated athanogene 0.0171441
GOLPH3L golgi phosphoprotein 3-like 0.0171275
HLTF helicase-like transcription factor 0.0170004
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0169909
IGF2R insulin-like growth factor 2 receptor 0.0169347
RIPK2 receptor-interacting serine-threonine kinase 2 0.0168947
RSPO3 R-spondin 3 0.0168947
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0168634
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0168023
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 0.0167613
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 0.0166596
RPL38 ribosomal protein L38 0.0166405
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 0.0166287
RPS2 ribosomal protein S2 0.0165374
MTA3 metastasis associated 1 family, member 3 0.0165157
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.0164652
CKAP4 cytoskeleton-associated protein 4 0.0164617
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 0.0164399
EXOC6B exocyst complex component 6B 0.016356
RPL31 ribosomal protein L31 0.0163268
MTDH metadherin 0.016274
CLDN2 claudin 2 0.0162356
ACD adrenocortical dysplasia homolog (mouse) 0.0162331
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0161934
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0161742
THSD7A thrombospondin, type I, domain containing 7A 0.0160868
TOB1 transducer of ERBB2, 1 0.0160813
GIPC1 GIPC PDZ domain containing family, member 1 0.0160569
NUCB2 nucleobindin 2 0.0160285
KMT2D lysine (K)-specific methyltransferase 2D 0.0159846
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.0159811
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0159597
TBC1D16 TBC1 domain family, member 16 0.0157835
MAST2 microtubule associated serine/threonine kinase 2 0.0157678
RPS18 ribosomal protein S18 0.0157522
EXT2 exostosin glycosyltransferase 2 0.0157358
PUM1 pumilio RNA-binding family member 1 0.0157091
XRN2 5'-3' exoribonuclease 2 0.015678
KIAA1549 KIAA1549 0.0156371
CTSA cathepsin A 0.0156082
UTRN utrophin 0.0155544
SCAMP3 secretory carrier membrane protein 3 0.0155419
AKR1C3 aldo-keto reductase family 1, member C3 0.0154362
TM4SF20 transmembrane 4 L six family member 20 0.0154221
DENND1B DENN/MADD domain containing 1B 0.0153054
STAG2 stromal antigen 2 0.0152503
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.0152411
KLF7 Kruppel-like factor 7 (ubiquitous) 0.015233
RPS11 ribosomal protein S11 0.0152229
WDR45 WD repeat domain 45 0.0152175
ITSN2 intersectin 2 0.0152046
RNASE3 ribonuclease, RNase A family, 3 0.0151045
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0150644
ADAR adenosine deaminase, RNA-specific 0.0150526
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0149855
KRT18 keratin 18, type I 0.0149573
SLC38A9 solute carrier family 38, member 9 0.0149279
OSBPL1A oxysterol binding protein-like 1A 0.0148917
ERBIN erbb2 interacting protein 0.0148759
PKD1L2 polycystic kidney disease 1-like 2 (gene/pseudogene) 0.0148705
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 0.0148341
CHKA choline kinase alpha 0.0148252
AFF4 AF4/FMR2 family, member 4 0.0148175
RPS29 ribosomal protein S29 0.0147422
RPL37 ribosomal protein L37 0.0147421
WDFY1 WD repeat and FYVE domain containing 1 0.0146976
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0146884
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0146803
LIMS1 LIM and senescent cell antigen-like domains 1 0.0146298
SKAP2 src kinase associated phosphoprotein 2 0.0145358
PLD3 phospholipase D family, member 3 0.0145309
CLCN7 chloride channel, voltage-sensitive 7 0.0145189
STK24 serine/threonine kinase 24 0.0145144
NIBAN2 niban apoptosis regulator 2 0.0144893
RPS8 ribosomal protein S8 0.0144249
ATRN attractin 0.0143913
DEK DEK proto-oncogene 0.014366
CHD6 chromodomain helicase DNA binding protein 6 0.014363
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.0143404
DOCK10 dedicator of cytokinesis 10 0.0142829
RNF103-CHMP3 RNF103-CHMP3 readthrough 0.0142768
RGS17 regulator of G-protein signaling 17 0.0142468
UGDH UDP-glucose 6-dehydrogenase 0.014193
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.0141742
CUTA cutA divalent cation tolerance homolog (E. coli) 0.0141475
QKI QKI, KH domain containing, RNA binding 0.0141294
CST3 cystatin C 0.0141223
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0141102
RFWD3 ring finger and WD repeat domain 3 0.0140838
GOLM1 golgi membrane protein 1 0.0140814
MYH14 myosin, heavy chain 14, non-muscle 0.0140785
LRP10 low density lipoprotein receptor-related protein 10 0.0140673
MANBA mannosidase, beta A, lysosomal 0.0140562
ANKRD11 ankyrin repeat domain 11 0.0140385
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0140272
CANX calnexin 0.0140264
TACC2 transforming, acidic coiled-coil containing protein 2 0.014018
QSER1 glutamine and serine rich 1 0.0139293
MRPL13 mitochondrial ribosomal protein L13 0.0139159
PTPRM protein tyrosine phosphatase, receptor type, M 0.0139063
RPL26 ribosomal protein L26 0.0138951
CHMP2A charged multivesicular body protein 2A 0.0138891
STX6 syntaxin 6 0.0138215
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 0.0137722
RPL27 ribosomal protein L27 0.0137691
ZBTB38 zinc finger and BTB domain containing 38 0.0137671
FLVCR1 feline leukemia virus subgroup C cellular receptor 1 0.0137267
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.0136898
SETD5 SET domain containing 5 0.0136825
MATN2 matrilin 2 0.0136235
PALB2 partner and localizer of BRCA2 0.0136112
SETD2 SET domain containing 2 0.0135853
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.0135732
DIAPH2 diaphanous-related formin 2 0.0135708
ANXA4 annexin A4 0.0135299
SHKBP1 SH3KBP1 binding protein 1 0.0135214
RPS24 ribosomal protein S24 0.0134434
EFR3A EFR3 homolog A (S. cerevisiae) 0.0134292
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.0134199
CBR1 carbonyl reductase 1 0.0134115
RNF130 ring finger protein 130 0.0134083
RPL30 ribosomal protein L30 0.0134031
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0133736
STX5 syntaxin 5 0.0133066
TKT transketolase 0.0132989
ARHGAP10 Rho GTPase activating protein 10 0.0132854
EGFL7 EGF-like-domain, multiple 7 0.01326
ABLIM1 actin binding LIM protein 1 0.0132043
ZFP64 ZFP64 zinc finger protein 0.0131945
SMC3 structural maintenance of chromosomes 3 0.013182
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.0131748
NFE2L1 nuclear factor, erythroid 2-like 1 0.0131604
RPS21 ribosomal protein S21 0.013136
OSBPL9 oxysterol binding protein-like 9 0.0131254
ARSL arylsulfatase L 0.0131136
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.0131118
UBAP1 ubiquitin associated protein 1 0.0130947
MPZL1 myelin protein zero-like 1 0.0130801
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 0.0130779
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae) 0.01306
CD63 CD63 molecule 0.0130182
VRK2 vaccinia related kinase 2 0.012996
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0129861
NARS1 asparaginyl-tRNA synthetase 1 0.0129749
NIPSNAP1 nipsnap homolog 1 (C. elegans) 0.0129715
MTUS1 microtubule associated tumor suppressor 1 0.0129323
SPIDR scaffolding protein involved in DNA repair 0.0129193
MAML2 mastermind-like 2 (Drosophila) 0.0128707
TRIP4 thyroid hormone receptor interactor 4 0.012853
ODR4 odr-4 GPCR localization factor homolog 0.012786
PHAX phosphorylated adaptor for RNA export 0.0126931
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 0.0126787
ELOVL5 ELOVL fatty acid elongase 5 0.0126641
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.0126626
RB1CC1 RB1-inducible coiled-coil 1 0.0126536
PNPLA3 patatin-like phospholipase domain containing 3 0.0126406
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 0.0126343
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0126324
CERS6 ceramide synthase 6 0.0126157
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa 0.012602
DNM2 dynamin 2 0.0126006
DARS1 aspartyl-tRNA synthetase 1 0.0125724
RESF1 retroelement silencing factor 1 0.0125635
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0125329
RBM15 RNA binding motif protein 15 0.0125291
ZFAND5 zinc finger, AN1-type domain 5 0.0125214
TMEM135 transmembrane protein 135 0.0124825
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 0.0124497
APLP2 amyloid beta (A4) precursor-like protein 2 0.0124232
MPV17 MpV17 mitochondrial inner membrane protein 0.0124212
GNPDA1 glucosamine-6-phosphate deaminase 1 0.012393
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.0123826
SOGA1 suppressor of glucose, autophagy associated 1 0.0123474
GSTP1 glutathione S-transferase pi 1 0.0123257
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 0.0123142
SLC22A23 solute carrier family 22, member 23 0.0122855
PES1 pescadillo ribosomal biogenesis factor 1 0.0122817
CORO1B coronin, actin binding protein, 1B 0.0122691
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 0.0122616
UBN2 ubinuclein 2 0.0122426
FLOT2 flotillin 2 0.0122248
GOLIM4 golgi integral membrane protein 4 0.0122089
EPB41 erythrocyte membrane protein band 4.1 0.012198
PLAAT3 phospholipase A and acyltransferase 3 0.012155
TEAD2 TEA domain family member 2 0.0121269
MGST1 microsomal glutathione S-transferase 1 0.0121209
KTN1 kinectin 1 (kinesin receptor) 0.0120832
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0120746
FAM227A family with sequence similarity 227, member A 0.0120699
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 0.012068
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0119918
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like 0.0119479
H2AZ2 H2A.Z variant histone 2 0.0119246
PRRC1 proline-rich coiled-coil 1 0.0119237
HELZ helicase with zinc finger 0.0119237
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 0.0118805
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0118781
CLTC clathrin, heavy chain (Hc) 0.0118728
CCT2 chaperonin containing TCP1, subunit 2 (beta) 0.0118485
MFSD11 major facilitator superfamily domain containing 11 0.0118172
ARHGAP32 Rho GTPase activating protein 32 0.0118082
GSE1 Gse1 coiled-coil protein 0.0118011
MRPL12 mitochondrial ribosomal protein L12 0.0117989
RBM47 RNA binding motif protein 47 0.0117983
ARHGAP5 Rho GTPase activating protein 5 0.0116941
SEC62 SEC62 homolog (S. cerevisiae) 0.0116855
SUMO2 small ubiquitin-like modifier 2 0.0116647
PIGF phosphatidylinositol glycan anchor biosynthesis, class F 0.011636
RYK receptor-like tyrosine kinase 0.0116204
RPL19 ribosomal protein L19 0.0115629
PERP PERP, TP53 apoptosis effector 0.0115341
RAP1GAP RAP1 GTPase activating protein 0.0115181
NDRG1 N-myc downstream regulated 1 0.0115097
COPA coatomer protein complex, subunit alpha 0.0115094
CXXC5 CXXC finger protein 5 0.0114779
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.011475
PHF12 PHD finger protein 12 0.0114556
NUAK2 NUAK family, SNF1-like kinase, 2 0.0114467
CHPT1 choline phosphotransferase 1 0.0114401
NAGLU N-acetylglucosaminidase, alpha 0.0114214
HOXB3 homeobox B3 0.0114195
DOCK1 dedicator of cytokinesis 1 0.0113992
RPL39 ribosomal protein L39 0.0113981
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0113766
RPL3 ribosomal protein L3 0.0113349
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0113273
MAP2K5 mitogen-activated protein kinase kinase 5 0.0113132
SPDEF SAM pointed domain containing ETS transcription factor 0.0113124
DNHD1 dynein heavy chain domain 1 0.0113115
MACO1 macoilin 1 0.0112945
TRIO trio Rho guanine nucleotide exchange factor 0.0112847
RNF145 ring finger protein 145 0.0112682
SCGB1D1 secretoglobin, family 1D, member 1 0.0112677
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.0112605
ZDHHC12 zinc finger, DHHC-type containing 12 0.0112555
WDR12 WD repeat domain 12 0.0112387
FMN1 formin 1 0.0112313
BZW2 basic leucine zipper and W2 domains 2 0.0112027
DEGS1 delta(4)-desaturase, sphingolipid 1 0.011188
FNBP4 formin binding protein 4 0.0111681
CALCOCO2 calcium binding and coiled-coil domain 2 0.0111467
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0111255
RAI1 retinoic acid induced 1 0.0111026
JUP junction plakoglobin 0.0111023
TJP3 tight junction protein 3 0.0110796
GTF2I general transcription factor IIi 0.0110521
DCTN6 dynactin 6 0.0110317
MICU1 mitochondrial calcium uptake 1 0.0110304
COL4A5 collagen, type IV, alpha 5 0.0110054
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0109968
TRIM44 tripartite motif containing 44 0.0109944
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0109937
MAP7 microtubule-associated protein 7 0.0109801
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.0109789
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0109585
MGA MGA, MAX dimerization protein 0.0109533
DENR density-regulated protein 0.0109249
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0109245
RPL4 ribosomal protein L4 0.0108809
STRBP spermatid perinuclear RNA binding protein 0.0108736
RABL6 RAB, member RAS oncogene family-like 6 0.0108731
CCNI cyclin I 0.0108718
SERBP1 SERPINE1 mRNA binding protein 1 0.0108699
ATP11B ATPase, class VI, type 11B 0.0108661
FBXL20 F-box and leucine-rich repeat protein 20 0.0108559
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0108436
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.0108332
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0108136
NUBP2 nucleotide binding protein 2 0.0108069
MAP2K2 mitogen-activated protein kinase kinase 2 0.0108037
TRAPPC6A trafficking protein particle complex 6A 0.010794
NF2 neurofibromin 2 (merlin) 0.0107788
EXOC5 exocyst complex component 5 0.0107608
ARFGEF3 ARFGEF family member 3 0.0107607
PEX14 peroxisomal biogenesis factor 14 0.0107585
ALG3 ALG3, alpha-1,3- mannosyltransferase 0.0107567
MAPRE2 microtubule-associated protein, RP/EB family, member 2 0.010737
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 0.0107169
BTG1 B-cell translocation gene 1, anti-proliferative 0.0106931
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 0.0106865
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) 0.0106827
SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33 0.0106599
PCSK9 proprotein convertase subtilisin/kexin type 9 0.0106576
ZSWIM6 zinc finger, SWIM-type containing 6 0.0106515
MRPS34 mitochondrial ribosomal protein S34 0.0106494
PCNX4 pecanex 4 0.0106449
EPHA2 EPH receptor A2 0.010641
NR2C2 nuclear receptor subfamily 2, group C, member 2 0.0106312
LRRC58 leucine rich repeat containing 58 0.0105853
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 0.0105816
TSPO translocator protein (18kDa) 0.0105786
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 0.0105771
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 0.0105189
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0105068
INF2 inverted formin, FH2 and WH2 domain containing 0.0105012
ARMH1 armadillo like helical domain containing 1 0.0104998
SRPX2 sushi-repeat containing protein, X-linked 2 0.0104914
EGLN2 egl-9 family hypoxia-inducible factor 2 0.0104753
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0104718
TMEM106B transmembrane protein 106B 0.0104616

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.215377
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.125092
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0778223
MKI67 marker of proliferation Ki-67 -0.0698121
NCOA3 nuclear receptor coactivator 3 -0.0680552
PDE10A phosphodiesterase 10A -0.0674506
CUX1 cut-like homeobox 1 -0.064045
CNTN1 contactin 1 -0.0630192
ARHGAP26 Rho GTPase activating protein 26 -0.0625134
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0583943
CTBP2 C-terminal binding protein 2 -0.0566694
CMIP c-Maf inducing protein -0.054295
KRT81 keratin 81, type II -0.0528275
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0497719
VMP1 vacuole membrane protein 1 -0.0476117
FLNA filamin A, alpha -0.0475685
ASPH aspartate beta-hydroxylase -0.0465392
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0455447
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.041789
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0417183
GRAMD1A GRAM domain containing 1A -0.0408708
AK1 adenylate kinase 1 -0.0405153
ZFR zinc finger RNA binding protein -0.0401943
PDE8A phosphodiesterase 8A -0.0392173
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0385446
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0384297
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0380575
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0377658
BCAS3 breast carcinoma amplified sequence 3 -0.0377548
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.037696
TMOD3 tropomodulin 3 (ubiquitous) -0.0374768
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0356612
PLD5 phospholipase D family, member 5 -0.0355546
HDAC8 histone deacetylase 8 -0.035479
PARD3 par-3 family cell polarity regulator -0.0351925
SPATS2 spermatogenesis associated, serine-rich 2 -0.0350994
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0350507
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0348583
BCL2L1 BCL2-like 1 -0.033531
BSG basigin (Ok blood group) -0.0331822
TPI1 triosephosphate isomerase 1 -0.0330946
BICC1 BicC family RNA binding protein 1 -0.0329606
AOPEP aminopeptidase O (putative) -0.0329
DENND5B DENN/MADD domain containing 5B -0.0328844
WWC1 WW and C2 domain containing 1 -0.032858
MYO1E myosin IE -0.0323169
NFIA nuclear factor I/A -0.0320848
SSH2 slingshot protein phosphatase 2 -0.031955
HM13 histocompatibility (minor) 13 -0.031464
GPC6 glypican 6 -0.031424
DOCK5 dedicator of cytokinesis 5 -0.030772
LIMCH1 LIM and calponin homology domains 1 -0.0307545
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0304743
POTEF POTE ankyrin domain family, member F -0.0301333
ZFAND3 zinc finger, AN1-type domain 3 -0.0300768
TPX2 TPX2, microtubule-associated -0.0300065
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0299713
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0299381
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0297616
PDE4B phosphodiesterase 4B, cAMP-specific -0.0296898
THRB thyroid hormone receptor, beta -0.0292167
SEPTIN9 septin 9 -0.0278341
CENPF centromere protein F, 350/400kDa -0.0276158
INVS inversin -0.0274571
MCU mitochondrial calcium uniporter -0.0272978
USP3 ubiquitin specific peptidase 3 -0.0272594
MAPK8 mitogen-activated protein kinase 8 -0.027221
KIF1B kinesin family member 1B -0.027148
FGA fibrinogen alpha chain -0.0270771
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0269374
BRCA1 breast cancer 1, early onset -0.0266954
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0266924
CD44 CD44 molecule (Indian blood group) -0.0266777
IGF1R insulin-like growth factor 1 receptor -0.0265333
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 -0.0264819
PON2 paraoxonase 2 -0.026462
FOXP1 forkhead box P1 -0.0264479
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0264342
TOP2A topoisomerase (DNA) II alpha 170kDa -0.026432
LCLAT1 lysocardiolipin acyltransferase 1 -0.0264209
PRKCA protein kinase C, alpha -0.026223
PRKCE protein kinase C, epsilon -0.0261524
FNDC3B fibronectin type III domain containing 3B -0.0261381
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0261134
DGKD diacylglycerol kinase, delta 130kDa -0.0260064
MPHOSPH9 M-phase phosphoprotein 9 -0.0259483
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0256521
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 -0.02543
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase -0.025425
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0252582
TUBB tubulin, beta class I -0.0252471
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0252275
WWP1 WW domain containing E3 ubiquitin protein ligase 1 -0.0251636
BBX bobby sox homolog (Drosophila) -0.0250794
SMAD3 SMAD family member 3 -0.0250581
TBL1X transducin (beta)-like 1X-linked -0.024989
NIPBL Nipped-B homolog (Drosophila) -0.0246713
MACROD2 MACRO domain containing 2 -0.0246432
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.0246395
DST dystonin -0.0246051
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0245823
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.024582
WWOX WW domain containing oxidoreductase -0.0245615
MPRIP myosin phosphatase Rho interacting protein -0.0244843
SRSF4 serine/arginine-rich splicing factor 4 -0.0244172
AKAP13 A kinase (PRKA) anchor protein 13 -0.0243589
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.024266
SENP6 SUMO1/sentrin specific peptidase 6 -0.0241723
DHDDS dehydrodolichyl diphosphate synthase -0.0240881
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0239954
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0239536
FN1 fibronectin 1 -0.0237449
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0236449
RPTOR regulatory associated protein of MTOR, complex 1 -0.0234841
LASP1 LIM and SH3 protein 1 -0.0233993
GMDS GDP-mannose 4,6-dehydratase -0.0233421
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0232838
EVA1C eva-1 homolog C (C. elegans) -0.0229963
CKAP5 cytoskeleton associated protein 5 -0.0229883
LMNA lamin A/C -0.0228262
METTL16 methyltransferase like 16 -0.0227872
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.022742
MORC4 MORC family CW-type zinc finger 4 -0.0226487
EHBP1 EH domain binding protein 1 -0.0226429
MBD5 methyl-CpG binding domain protein 5 -0.0225282
NUP160 nucleoporin 160kDa -0.0225009
RAP1GAP2 RAP1 GTPase activating protein 2 -0.0223829
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0223521
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -0.0221991
PCED1B PC-esterase domain containing 1B -0.0221839
PSD3 pleckstrin and Sec7 domain containing 3 -0.0221103
NPAS2 neuronal PAS domain protein 2 -0.0217764
DENND1A DENN/MADD domain containing 1A -0.0216863
NOP58 NOP58 ribonucleoprotein -0.0216651
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -0.0216544
GPRIN3 GPRIN family member 3 -0.0215926
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0214941
RGS3 regulator of G-protein signaling 3 -0.0214768
ICE2 interactor of little elongation complex ELL subunit 2 -0.0214679
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0213586
RBM39 RNA binding motif protein 39 -0.021352
IGSF1 immunoglobulin superfamily, member 1 -0.0213284
RBMX RNA binding motif protein, X-linked -0.0213028
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) -0.0212706
ELL2 elongation factor, RNA polymerase II, 2 -0.0212297
ACTG1 actin gamma 1 -0.0212212
PATJ PATJ crumbs cell polarity complex component -0.0210285
KDM6A lysine (K)-specific demethylase 6A -0.0209793
DENND4A DENN/MADD domain containing 4A -0.0209688
PTPRF protein tyrosine phosphatase, receptor type, F -0.0208182
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0207952
PLEKHA7 pleckstrin homology domain containing, family A member 7 -0.0207566
ATXN1 ataxin 1 -0.0207254
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0206041
CLIP2 CAP-GLY domain containing linker protein 2 -0.0204516
ESYT2 extended synaptotagmin-like protein 2 -0.0204464
RAB1A RAB1A, member RAS oncogene family -0.0203685
GLG1 golgi glycoprotein 1 -0.0203444
MRTFA myocardin related transcription factor A -0.0203169
PPP1R12B protein phosphatase 1, regulatory subunit 12B -0.0202584
TFCP2 transcription factor CP2 -0.0201491
HIP1 huntingtin interacting protein 1 -0.020115
R3HDM1 R3H domain containing 1 -0.020078
SNX14 sorting nexin 14 -0.0200685
GDNF glial cell derived neurotrophic factor -0.0200523
PLPP1 phospholipid phosphatase 1 -0.0200348
CHD9 chromodomain helicase DNA binding protein 9 -0.0199889
TM4SF4 transmembrane 4 L six family member 4 -0.0199754
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0199522
DLG5 discs, large homolog 5 (Drosophila) -0.0199001
ARRB1 arrestin, beta 1 -0.0197086
KIF14 kinesin family member 14 -0.0197033
SDC1 syndecan 1 -0.0195366
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0195064
LMTK2 lemur tyrosine kinase 2 -0.0193563
CLMN calmin (calponin-like, transmembrane) -0.019352
PLS3 plastin 3 -0.0192441
SKIL SKI-like proto-oncogene -0.0192441
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 -0.0192178
RNF149 ring finger protein 149 -0.0191719
MYO9A myosin IXA -0.0190352
TATDN1 TatD DNase domain containing 1 -0.0189766
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0189658
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0189335
RRBP1 ribosome binding protein 1 -0.0188891
VCAN versican -0.018823
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0188193
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0187871
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0187704
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0186953
PUS7 pseudouridylate synthase 7 (putative) -0.0186698
POC1B POC1 centriolar protein B -0.0186122
SNAP25 synaptosomal-associated protein, 25kDa -0.0185998
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.0185686
USP53 ubiquitin specific peptidase 53 -0.0184914
USP34 ubiquitin specific peptidase 34 -0.0184871
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0184509
NFX1 nuclear transcription factor, X-box binding 1 -0.0184496
NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.0184337
BASP1 brain abundant, membrane attached signal protein 1 -0.0184117
PDLIM5 PDZ and LIM domain 5 -0.0184033
SVIL supervillin -0.0182834
FGB fibrinogen beta chain -0.0181323
AVPI1 arginine vasopressin-induced 1 -0.0180751
TUBA1B tubulin, alpha 1b -0.0179941
TUBB4B tubulin, beta 4B class IVb -0.0179777
SMC4 structural maintenance of chromosomes 4 -0.0179639
GTF2IRD1 GTF2I repeat domain containing 1 -0.0179606
ZNF367 zinc finger protein 367 -0.0179039
CNKSR2 connector enhancer of kinase suppressor of Ras 2 -0.0178933
RAP1B RAP1B, member of RAS oncogene family -0.0178637
CAMKMT calmodulin-lysine N-methyltransferase -0.0178462
ITCH itchy E3 ubiquitin protein ligase -0.0178442
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.0178103
ANXA1 annexin A1 -0.0177628
AGO2 argonaute RISC catalytic component 2 -0.0177567
USP32 ubiquitin specific peptidase 32 -0.017692
AHI1 Abelson helper integration site 1 -0.0176086
IQGAP2 IQ motif containing GTPase activating protein 2 -0.0175712
NEMF nuclear export mediator factor -0.0175598
ARHGAP11B Rho GTPase activating protein 11B -0.0175473
KMT5B lysine methyltransferase 5B -0.0174566
DROSHA drosha, ribonuclease type III -0.0174334
IWS1 IWS1 homolog (S. cerevisiae) -0.0174318
TRAPPC9 trafficking protein particle complex 9 -0.0173867
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -0.0173611
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 -0.0172614
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0172594
JMJD1C jumonji domain containing 1C -0.0172502
XPO1 exportin 1 -0.0172324
PPP1R9A protein phosphatase 1, regulatory subunit 9A -0.0172286
CHD4 chromodomain helicase DNA binding protein 4 -0.0171959
HSPG2 heparan sulfate proteoglycan 2 -0.0171679
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.0170506
NEBL nebulette -0.0170427
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0170174
GGNBP2 gametogenetin binding protein 2 -0.0169917
PTCD3 pentatricopeptide repeat domain 3 -0.0169873
PPP1R21 protein phosphatase 1, regulatory subunit 21 -0.0169848
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 -0.0169505
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0168787
RCOR1 REST corepressor 1 -0.0168628
PCNX2 pecanex 2 -0.0167413
MAP2K4 mitogen-activated protein kinase kinase 4 -0.0166719
PHACTR4 phosphatase and actin regulator 4 -0.016665
PTGES2 prostaglandin E synthase 2 -0.0166602
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0166244
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -0.0166081
SLC30A5 solute carrier family 30 (zinc transporter), member 5 -0.0165891
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -0.0165807
MYO5C myosin VC -0.0165804
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -0.0165461
EZR ezrin -0.0165401
RNGTT RNA guanylyltransferase and 5'-phosphatase -0.0165329
KNTC1 kinetochore associated 1 -0.016462
BIRC6 baculoviral IAP repeat containing 6 -0.016446
DIAPH1 diaphanous-related formin 1 -0.0163337
C5 complement component 5 -0.0163322
PLEC plectin -0.0162956
PLCB4 phospholipase C, beta 4 -0.0162811
ARID1A AT rich interactive domain 1A (SWI-like) -0.0162788
SPC25 SPC25, NDC80 kinetochore complex component -0.0161519
HOOK3 hook microtubule-tethering protein 3 -0.0160579
PRIM2 primase, DNA, polypeptide 2 (58kDa) -0.0160562
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0160308
MCPH1 microcephalin 1 -0.0159981
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 -0.0159817
CCDC14 coiled-coil domain containing 14 -0.0159372
WAC WW domain containing adaptor with coiled-coil -0.0159244
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0158939
WDR43 WD repeat domain 43 -0.0158719
PAWR PRKC, apoptosis, WT1, regulator -0.015862
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 -0.0158617
NUP107 nucleoporin 107kDa -0.0158493
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.015842
ZMPSTE24 zinc metallopeptidase STE24 -0.015784
LDHA lactate dehydrogenase A -0.0157557
FOSL1 FOS-like antigen 1 -0.0157377
THOC2 THO complex 2 -0.0157159
SGMS1 sphingomyelin synthase 1 -0.0156747
SESTD1 SEC14 and spectrin domains 1 -0.0156741
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.0156695
PRPF8 pre-mRNA processing factor 8 -0.0156419
ARHGAP35 Rho GTPase activating protein 35 -0.0155989
OGA O-GlcNAcase -0.0155758
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0155385
NHSL1 NHS-like 1 -0.0154974
CTPS2 CTP synthase 2 -0.015465
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -0.015436
NUP155 nucleoporin 155kDa -0.015414
GEN1 GEN1 Holliday junction 5' flap endonuclease -0.0153782
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -0.0153743
MARCHF6 membrane associated ring-CH-type finger 6 -0.0153732
RNF115 ring finger protein 115 -0.0153132
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0153021
H4C3 H4 clustered histone 3 -0.015302
ANKRD28 ankyrin repeat domain 28 -0.0152899
MELK maternal embryonic leucine zipper kinase -0.0152269
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -0.0152046
RREB1 ras responsive element binding protein 1 -0.015121
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0151102
ARL4C ADP-ribosylation factor-like 4C -0.0150884
KPNA6 karyopherin alpha 6 (importin alpha 7) -0.0150406
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.0150304
TNRC18 trinucleotide repeat containing 18 -0.0150171
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0149645
SON SON DNA binding protein -0.0149607
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.0149415
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0148959
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0147961
COL5A2 collagen, type V, alpha 2 -0.014793
FAF2 Fas associated factor family member 2 -0.0147853
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0147676
CDK19 cyclin-dependent kinase 19 -0.0147644
ARHGAP12 Rho GTPase activating protein 12 -0.0147592
TASOR2 transcription activation suppressor family member 2 -0.0147552
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 -0.0146912
SP3 Sp3 transcription factor -0.0146718
NUP98 nucleoporin 98kDa -0.0146413
MAGED1 melanoma antigen family D1 -0.0145946
PHF21A PHD finger protein 21A -0.0145727
INTS6 integrator complex subunit 6 -0.0145507
CD151 CD151 molecule (Raph blood group) -0.0145427
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) -0.0145214
LTBP1 latent transforming growth factor beta binding protein 1 -0.0144906
ANO6 anoctamin 6 -0.0144818
AATF apoptosis antagonizing transcription factor -0.0144778
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.01444
CLASP1 cytoplasmic linker associated protein 1 -0.0143761
FAM222B family with sequence similarity 222, member B -0.014349
ANAPC5 anaphase promoting complex subunit 5 -0.0143241
TASOR transcription activation suppressor -0.0142994
EXT1 exostosin glycosyltransferase 1 -0.0142937
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0142856
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0142788
PHKB phosphorylase kinase, beta -0.0141745
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0141728
MED13L mediator complex subunit 13-like -0.0141416
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -0.0141327
YARS1 tyrosyl-tRNA synthetase 1 -0.0141132
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0141012
ANLN anillin, actin binding protein -0.0140781
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0139484
CPLX2 complexin 2 -0.0139412
CENPK centromere protein K -0.013906
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -0.0138952
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0138779
SLC25A43 solute carrier family 25, member 43 -0.0138346
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.013805
KRIT1 KRIT1, ankyrin repeat containing -0.0137715
ATAD2 ATPase family, AAA domain containing 2 -0.0137643
FAM13A family with sequence similarity 13, member A -0.013754
WDR44 WD repeat domain 44 -0.0137424
LRRC28 leucine rich repeat containing 28 -0.0137261
TBC1D5 TBC1 domain family, member 5 -0.013693
AAK1 AP2 associated kinase 1 -0.0136631
TENT2 terminal nucleotidyltransferase 2 -0.0136563
DIPK1A divergent protein kinase domain 1A -0.013647
ANXA2 annexin A2 -0.0136007
PTER phosphotriesterase related -0.0135955
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0135546
VCP valosin containing protein -0.0135417
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -0.0134196
VCL vinculin -0.0133776
KIF11 kinesin family member 11 -0.0133679
THADA thyroid adenoma associated -0.013352
PTPRG protein tyrosine phosphatase, receptor type, G -0.0133178
PDS5A PDS5 cohesin associated factor A -0.0132983
TOPBP1 topoisomerase (DNA) II binding protein 1 -0.0132786
IARS1 isoleucyl-tRNA synthetase 1 -0.0131986
SRRM1 serine/arginine repetitive matrix 1 -0.013197
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0131582
INTS7 integrator complex subunit 7 -0.0131553
ANKRD44 ankyrin repeat domain 44 -0.0131507
FRMD3 FERM domain containing 3 -0.0131376
SPACA6 sperm acrosome associated 6 -0.0131334
HSDL2 hydroxysteroid dehydrogenase like 2 -0.0131322
FBXO11 F-box protein 11 -0.0131297
PROS1 protein S (alpha) -0.01309
TANK TRAF family member-associated NFKB activator -0.0130831
CENPE centromere protein E, 312kDa -0.0130595
RAB11FIP3 RAB11 family interacting protein 3 (class II) -0.01305
WDHD1 WD repeat and HMG-box DNA binding protein 1 -0.0130193
GTSE1 G-2 and S-phase expressed 1 -0.0130113
KANK1 KN motif and ankyrin repeat domains 1 -0.0129711
NOL10 nucleolar protein 10 -0.0129423
TPST1 tyrosylprotein sulfotransferase 1 -0.0128955
IRS1 insulin receptor substrate 1 -0.012872
DCAF10 DDB1 and CUL4 associated factor 10 -0.0128386
PKP4 plakophilin 4 -0.0128185
CPNE1 copine I -0.0127785
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0127101
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0127007
EEF2K eukaryotic elongation factor 2 kinase -0.0126981
TUT4 terminal uridylyl transferase 4 -0.0126968
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0126955
NCOR1 nuclear receptor corepressor 1 -0.0126793
PIBF1 progesterone immunomodulatory binding factor 1 -0.0126564
CCAR1 cell division cycle and apoptosis regulator 1 -0.0126513
ZDHHC17 zinc finger, DHHC-type containing 17 -0.0126494
SATB2 SATB homeobox 2 -0.0126491
UBE3C ubiquitin protein ligase E3C -0.0126473
RIC8B RIC8 guanine nucleotide exchange factor B -0.012642
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 -0.0126399
IREB2 iron-responsive element binding protein 2 -0.0126198
CCM2 cerebral cavernous malformation 2 -0.0125786
ELMO1 engulfment and cell motility 1 -0.0124794
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0124515
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0124506
CAND1 cullin-associated and neddylation-dissociated 1 -0.0124427
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) -0.0124329
QRICH1 glutamine-rich 1 -0.0123325
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0123312
SRP72 signal recognition particle 72kDa -0.0123277
PM20D1 peptidase M20 domain containing 1 -0.012311
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0122961
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0122958
KIF18B kinesin family member 18B -0.0122639
ULK4 unc-51 like kinase 4 -0.0122635
GARNL3 GTPase activating Rap/RanGAP domain-like 3 -0.0122587
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0122496
RAB6A RAB6A, member RAS oncogene family -0.0122484
ZNF207 zinc finger protein 207 -0.0122466
NECTIN2 nectin cell adhesion molecule 2 -0.0122431
CUEDC1 CUE domain containing 1 -0.0121645
DYNLRB1 dynein, light chain, roadblock-type 1 -0.0121467
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0121302
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0121159
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0121115
IQGAP1 IQ motif containing GTPase activating protein 1 -0.012088
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0120802
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0120586
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -0.0120517
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0120442
TTC7A tetratricopeptide repeat domain 7A -0.0120296
ZEB1 zinc finger E-box binding homeobox 1 -0.0120204
DIAPH3 diaphanous-related formin 3 -0.0119919
UBE2K ubiquitin-conjugating enzyme E2K -0.0119828
SYNJ2 synaptojanin 2 -0.0119634
WDR20 WD repeat domain 20 -0.0119353
KIF18A kinesin family member 18A -0.0119319
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 -0.0119235
ZC3H13 zinc finger CCCH-type containing 13 -0.0119072
EVL Enah/Vasp-like -0.0119012
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.0118598
WDR62 WD repeat domain 62 -0.0118486
CCDC12 coiled-coil domain containing 12 -0.0117933
CEP83 centrosomal protein 83kDa -0.0117824
ORC3 origin recognition complex, subunit 3 -0.0117715
TRA2A transformer 2 alpha homolog (Drosophila) -0.0117333
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 -0.0117305
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0117277
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0117226
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0117182
ETV6 ets variant 6 -0.0116928
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0116656
DAPK1 death-associated protein kinase 1 -0.011643
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0116351
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 -0.011617
DMXL1 Dmx-like 1 -0.011577
GPATCH8 G patch domain containing 8 -0.0115606
CNTNAP3B contactin associated protein-like 3B -0.011552
SETX senataxin -0.011549
NEB nebulin -0.0115318
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) -0.0115138
IQCB1 IQ motif containing B1 -0.0115118
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -0.0115047
DCAKD dephospho-CoA kinase domain containing -0.0115028
KATNAL1 katanin p60 subunit A-like 1 -0.0114806
TMPO thymopoietin -0.0114638
STIL SCL/TAL1 interrupting locus -0.01146
LPCAT3 lysophosphatidylcholine acyltransferase 3 -0.0114409
RUVBL2 RuvB-like AAA ATPase 2 -0.0114198
RBM6 RNA binding motif protein 6 -0.0114195
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 -0.011415
GIGYF2 GRB10 interacting GYF protein 2 -0.0113752
IGSF11 immunoglobulin superfamily, member 11 -0.0113544
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.0113515
SGO2 shugoshin 2 -0.0113407
NUP88 nucleoporin 88kDa -0.0113323
AQR aquarius intron-binding spliceosomal factor -0.0113192
KHSRP KH-type splicing regulatory protein -0.0112866
ECE1 endothelin converting enzyme 1 -0.0112864
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa -0.0112845
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa -0.0112637
MAVS mitochondrial antiviral signaling protein -0.0112632
RPL7L1 ribosomal protein L7-like 1 -0.0112163
CCNF cyclin F -0.0112151
NRG1 neuregulin 1 -0.0111983
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -0.011163
ZZZ3 zinc finger, ZZ-type containing 3 -0.0111447
TFPI2 tissue factor pathway inhibitor 2 -0.0111279
CARMIL1 capping protein regulator and myosin 1 linker 1 -0.0111162
BRCA2 breast cancer 2, early onset -0.0111109
TPD52 tumor protein D52 -0.0111013
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 -0.0110911
KLF3 Kruppel-like factor 3 (basic) -0.0110898
RABEPK Rab9 effector protein with kelch motifs -0.0110775
PBX1 pre-B-cell leukemia homeobox 1 -0.0110761
EFNA5 ephrin-A5 -0.0110406