A549_SGI-1776 free base_10nM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description SGI-1776 free base 10nM perturbation in A549 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the A549_SGI-1776 free base_10nM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.164515
PKM pyruvate kinase, muscle 0.163142
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.132988
ACTN4 actinin, alpha 4 0.132618
KRT8 keratin 8, type II 0.0999556
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0972322
AKR1C2 aldo-keto reductase family 1, member C2 0.0971168
AKR1C3 aldo-keto reductase family 1, member C3 0.0891142
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0859297
ENO1 enolase 1, (alpha) 0.0802396
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.073545
ACACA acetyl-CoA carboxylase alpha 0.0698393
ACTG1 actin gamma 1 0.0692905
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0684384
RAB10 RAB10, member RAS oncogene family 0.0683108
PRRC2C proline-rich coiled-coil 2C 0.0635969
KRT81 keratin 81, type II 0.061846
AKR1C1 aldo-keto reductase family 1, member C1 0.0604973
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0536489
CALR calreticulin 0.0494255
UBL4A ubiquitin-like 4A 0.0491267
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0465884
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0425693
CENPF centromere protein F, 350/400kDa 0.0411413
LOC112694756 uncharaterized LOC112694756 0.0402388
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.0401289
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0398634
KTN1 kinectin 1 (kinesin receptor) 0.0395627
NRCAM neuronal cell adhesion molecule 0.0393555
FTL ferritin, light polypeptide 0.0391629
ANXA1 annexin A1 0.0390769
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0388651
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0379214
MKI67 marker of proliferation Ki-67 0.037627
ENAH enabled homolog (Drosophila) 0.0361634
RPS19 ribosomal protein S19 0.0361419
MUSK muscle, skeletal, receptor tyrosine kinase 0.0359551
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0354916
PFN1 profilin 1 0.0354663
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 0.035397
FADS2 fatty acid desaturase 2 0.0353422
PDIA6 protein disulfide isomerase family A, member 6 0.0347922
BCL2L1 BCL2-like 1 0.0347417
RRBP1 ribosome binding protein 1 0.0343237
KPNB1 karyopherin (importin) beta 1 0.0335816
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0335654
RPL10A ribosomal protein L10a 0.0335072
FTH1 ferritin, heavy polypeptide 1 0.0333602
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0332573
KIF5B kinesin family member 5B 0.03312
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0329351
MGST1 microsomal glutathione S-transferase 1 0.0329228
RTN4 reticulon 4 0.0323576
THADA thyroid adenoma associated 0.0320625
VIM vimentin 0.0319666
TKT transketolase 0.0317882
CKAP4 cytoskeleton-associated protein 4 0.0308364
MPG N-methylpurine-DNA glycosylase 0.0304169
CLPTM1 cleft lip and palate associated transmembrane protein 1 0.0302929
ATAD2 ATPase family, AAA domain containing 2 0.0300376
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0299824
TRIM28 tripartite motif containing 28 0.029869
ZBTB38 zinc finger and BTB domain containing 38 0.0297515
KRT18 keratin 18, type I 0.0294594
HIPK2 homeodomain interacting protein kinase 2 0.0293735
LDHA lactate dehydrogenase A 0.0289879
CDYL chromodomain protein, Y-like 0.028983
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0284816
MPHOSPH9 M-phase phosphoprotein 9 0.0284649
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0284046
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0281415
DSPP dentin sialophosphoprotein 0.0276543
FNDC3B fibronectin type III domain containing 3B 0.0275565
MYLK myosin light chain kinase 0.0273477
MTDH metadherin 0.0273157
SMOX spermine oxidase 0.0270866
MRPS27 mitochondrial ribosomal protein S27 0.0267727
CAPN2 calpain 2, (m/II) large subunit 0.026668
TUT4 terminal uridylyl transferase 4 0.0266474
GIPC1 GIPC PDZ domain containing family, member 1 0.0266324
CANX calnexin 0.026513
CNTLN centlein, centrosomal protein 0.0265065
PTMS parathymosin 0.0264248
NOTCH3 notch 3 0.0263791
SETD2 SET domain containing 2 0.0263028
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.026259
TLK1 tousled-like kinase 1 0.0262435
PAWR PRKC, apoptosis, WT1, regulator 0.0261612
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0260388
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0260313
SLC35F3 solute carrier family 35, member F3 0.025974
WNK1 WNK lysine deficient protein kinase 1 0.0258309
SETX senataxin 0.0254083
BSG basigin (Ok blood group) 0.0254009
NAP1L1 nucleosome assembly protein 1-like 1 0.0253206
EREG epiregulin 0.0252637
ANLN anillin, actin binding protein 0.0247187
NRIP1 nuclear receptor interacting protein 1 0.0244717
UBTF upstream binding transcription factor, RNA polymerase I 0.0241084
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.0239693
PLS3 plastin 3 0.0238406
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0237151
S100A4 S100 calcium binding protein A4 0.0236026
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 0.0235894
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0235835
STAG2 stromal antigen 2 0.0233929
TSPAN14 tetraspanin 14 0.0233892
COASY CoA synthase 0.0233492
TUBB4B tubulin, beta 4B class IVb 0.0233392
IPO7 importin 7 0.0232994
CENPE centromere protein E, 312kDa 0.0232906
DLG1 discs, large homolog 1 (Drosophila) 0.0231856
MRPS34 mitochondrial ribosomal protein S34 0.0230093
ABTB3 ankyrin repeat and BTB domain containing 3 0.0229821
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0228676
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0228543
SRRM2 serine/arginine repetitive matrix 2 0.0227982
ANXA2 annexin A2 0.02278
MED13L mediator complex subunit 13-like 0.0225725
AHCTF1 AT hook containing transcription factor 1 0.0224798
CBX5 chromobox homolog 5 0.0224714
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0222778
DENND1A DENN/MADD domain containing 1A 0.0222663
CCDC47 coiled-coil domain containing 47 0.0221395
CXXC1 CXXC finger protein 1 0.0220643
PTMA prothymosin, alpha 0.0220393
JUP junction plakoglobin 0.0220064
SRPK1 SRSF protein kinase 1 0.0219503
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0219463
HSPH1 heat shock 105kDa/110kDa protein 1 0.0218915
SH3RF2 SH3 domain containing ring finger 2 0.0218822
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 0.0218432
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0217925
EDN1 endothelin 1 0.0217719
KMT2A lysine (K)-specific methyltransferase 2A 0.0217319
VEZT vezatin, adherens junctions transmembrane protein 0.0217259
FANCI Fanconi anemia, complementation group I 0.0216912
PUF60 poly-U binding splicing factor 60KDa 0.0216868
DHRS7B dehydrogenase/reductase (SDR family) member 7B 0.0216446
ESYT2 extended synaptotagmin-like protein 2 0.0214268
ZRANB3 zinc finger, RAN-binding domain containing 3 0.0214132
SNX17 sorting nexin 17 0.0213203
SUSD1 sushi domain containing 1 0.021271
DIAPH1 diaphanous-related formin 1 0.0209904
SEPTIN10 septin 10 0.0209212
NCAPG2 non-SMC condensin II complex, subunit G2 0.0208926
NEBL nebulette 0.0208366
BRCA1 breast cancer 1, early onset 0.0208336
MMS22L MMS22-like, DNA repair protein 0.0208267
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0208186
TMPO thymopoietin 0.0207856
SPC25 SPC25, NDC80 kinetochore complex component 0.020656
SMC4 structural maintenance of chromosomes 4 0.0206518
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 0.0205581
RANBP2 RAN binding protein 2 0.0205267
CCSER2 coiled-coil serine-rich protein 2 0.0204177
ARHGAP24 Rho GTPase activating protein 24 0.0203389
LBR lamin B receptor 0.02033
ACLY ATP citrate lyase 0.0202033
HJURP Holliday junction recognition protein 0.0201914
MAPK1 mitogen-activated protein kinase 1 0.0201879
VRK1 vaccinia related kinase 1 0.0201638
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 0.0201426
PBRM1 polybromo 1 0.0200074
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 0.0199612
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0199558
SH3KBP1 SH3-domain kinase binding protein 1 0.0199454
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0198216
TALDO1 transaldolase 1 0.0198131
SRRM1 serine/arginine repetitive matrix 1 0.019801
PDCD7 programmed cell death 7 0.0197705
TPI1 triosephosphate isomerase 1 0.01946
TBC1D4 TBC1 domain family, member 4 0.0194396
RBL1 retinoblastoma-like 1 0.0192739
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0192298
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0191863
KIF18A kinesin family member 18A 0.019143
CRLF3 cytokine receptor-like factor 3 0.0190999
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) 0.0190321
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0190205
SERINC3 serine incorporator 3 0.0190177
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0189769
AREG amphiregulin 0.0188514
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 0.0188009
METTL16 methyltransferase like 16 0.0187658
KYAT1 kynurenine aminotransferase 1 0.0187482
KAT6A K(lysine) acetyltransferase 6A 0.01874
CENPP centromere protein P 0.018711
NRP2 neuropilin 2 0.0187074
ATP9B ATPase, class II, type 9B 0.0187047
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.018682
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0186739
VCL vinculin 0.0185597
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0185402
RPS28 ribosomal protein S28 0.0185161
ANXA8L1 annexin A8-like 1 0.0185088
KDM3B lysine (K)-specific demethylase 3B 0.0185085
THRAP3 thyroid hormone receptor associated protein 3 0.018486
RDX radixin 0.018448
DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33 0.0184416
AGR2 anterior gradient 2 0.0183734
PCM1 pericentriolar material 1 0.0183193
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa 0.0183037
APIP APAF1 interacting protein 0.0182891
AHNAK2 AHNAK nucleoprotein 2 0.0181941
CALU calumenin 0.018151
CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae) 0.0181225
DHCR7 7-dehydrocholesterol reductase 0.0181163
RPL23 ribosomal protein L23 0.0180865
S100A6 S100 calcium binding protein A6 0.0180557
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 0.018043
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.0178756
ZMYM1 zinc finger, MYM-type 1 0.0178722
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0178613
ERBIN erbb2 interacting protein 0.0178467
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 0.0177562
TPX2 TPX2, microtubule-associated 0.0177471
FBXW11 F-box and WD repeat domain containing 11 0.0177152
RNASEH1 ribonuclease H1 0.0176656
WDR7 WD repeat domain 7 0.0176644
TRAM1 translocation associated membrane protein 1 0.0176582
CAVIN1 caveolae associated protein 1 0.0176379
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 0.017623
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.0175997
PRDX3 peroxiredoxin 3 0.0175878
ZNF148 zinc finger protein 148 0.0174602
POLA2 polymerase (DNA directed), alpha 2, accessory subunit 0.0174507
FLII flightless I homolog (Drosophila) 0.0174426
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa 0.0174237
CSRP1 cysteine and glycine-rich protein 1 0.0174061
GCLC glutamate-cysteine ligase, catalytic subunit 0.0173345
ABHD2 abhydrolase domain containing 2 0.0173295
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0173109
CNKSR3 CNKSR family member 3 0.0172796
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.0172788
SLC22A23 solute carrier family 22, member 23 0.0172771
TUBA1B tubulin, alpha 1b 0.0171735
LTAP1 lipid transport auxiliary protein 1 0.0171296
WDR72 WD repeat domain 72 0.0171266
LRP6 low density lipoprotein receptor-related protein 6 0.0171262
PELP1 proline, glutamate and leucine rich protein 1 0.0170506
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0170005
TRIOBP TRIO and F-actin binding protein 0.0169784
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0169397
CD63 CD63 molecule 0.0168913
FANCC Fanconi anemia, complementation group C 0.016877
RPL31 ribosomal protein L31 0.0168588
APLP2 amyloid beta (A4) precursor-like protein 2 0.0168396
CSDE1 cold shock domain containing E1, RNA-binding 0.0168021
C1QBP complement component 1, q subcomponent binding protein 0.0167794
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0167451
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 0.0166786
SKIC3 SKI3 subunit of superkiller complex 0.0166765
SOCS6 suppressor of cytokine signaling 6 0.0166537
TENM3 teneurin transmembrane protein 3 0.0166245
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0165878
AGPS alkylglycerone phosphate synthase 0.0165652
RSL1D1 ribosomal L1 domain containing 1 0.0165638
RBM15 RNA binding motif protein 15 0.0164173
KMT2D lysine (K)-specific methyltransferase 2D 0.0163931
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.0163488
REXO2 RNA exonuclease 2 0.0162821
CYRIB CYFIP related Rac1 interactor B 0.0162778
HDAC4 histone deacetylase 4 0.0161523
PBX1 pre-B-cell leukemia homeobox 1 0.0161466
MAP4 microtubule-associated protein 4 0.0160796
FUBP1 far upstream element (FUSE) binding protein 1 0.0160453
IQGAP1 IQ motif containing GTPase activating protein 1 0.0160238
LARP4 La ribonucleoprotein domain family, member 4 0.016006
SLC38A10 solute carrier family 38, member 10 0.0160057
NOP56 NOP56 ribonucleoprotein 0.0159402
SLC4A2 solute carrier family 4 (anion exchanger), member 2 0.0159264
MYO1E myosin IE 0.0159242
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 0.0159054
TBX18 T-box 18 0.0158917
ENOX2 ecto-NOX disulfide-thiol exchanger 2 0.0158798
ARL4C ADP-ribosylation factor-like 4C 0.0158763
DYNC2I2 dynein 2 intermediate chain 2 0.015868
RPL37A ribosomal protein L37a 0.0158113
MYO19 myosin XIX 0.0157855
NUSAP1 nucleolar and spindle associated protein 1 0.0157486
ATXN10 ataxin 10 0.015714
GIGYF2 GRB10 interacting GYF protein 2 0.015685
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.0156764
LRP1B low density lipoprotein receptor-related protein 1B 0.0156638
LAMP2 lysosomal-associated membrane protein 2 0.0156525
PDCD11 programmed cell death 11 0.0156509
SNX5 sorting nexin 5 0.0156312
CHD8 chromodomain helicase DNA binding protein 8 0.0156191
RRM1 ribonucleotide reductase M1 0.0156172
ADAM9 ADAM metallopeptidase domain 9 0.015567
PSPC1 paraspeckle component 1 0.0155663
CLASP1 cytoplasmic linker associated protein 1 0.0155372
EIF5B eukaryotic translation initiation factor 5B 0.0155192
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.0155021
TMEM131 transmembrane protein 131 0.0154841
MTCL1 microtubule crosslinking factor 1 0.0154827
HELLS helicase, lymphoid-specific 0.0154546
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0154339
GTSE1 G-2 and S-phase expressed 1 0.0154318
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0154115
MBOAT7 membrane bound O-acyltransferase domain containing 7 0.0153486
TENT5A terminal nucleotidyltransferase 5A 0.0153419
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0153383
CLTC clathrin, heavy chain (Hc) 0.0153329
PSME3IP1 proteasome activator subunit 3 interacting protein 1 0.0153305
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.0153248
MYH9 myosin, heavy chain 9, non-muscle 0.0152865
DCLRE1C DNA cross-link repair 1C 0.015282
ZC3H15 zinc finger CCCH-type containing 15 0.0152816
TOPBP1 topoisomerase (DNA) II binding protein 1 0.0152582
FOXM1 forkhead box M1 0.0152535
EPS15 epidermal growth factor receptor pathway substrate 15 0.0152269
DCTN1 dynactin 1 0.0152024
BIRC5 baculoviral IAP repeat containing 5 0.0151842
STAU1 staufen double-stranded RNA binding protein 1 0.0151765
RPL5 ribosomal protein L5 0.0151754
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0151546
TAGLN2 transgelin 2 0.0151424
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0151146
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 0.0150861
MTIF2 mitochondrial translational initiation factor 2 0.0150376
RBM3 RNA binding motif (RNP1, RRM) protein 3 0.0149671
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0149582
MAP1B microtubule-associated protein 1B 0.0149556
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0149325
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0149236
FUBP3 far upstream element (FUSE) binding protein 3 0.014908
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0148912
EMSY EMSY transcriptional repressor, BRCA2 interacting 0.014864
METTL23 methyltransferase like 23 0.0148394
SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33 0.0148288
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0148233
NBDY negative regulator of P-body association 0.0148208
RPSA ribosomal protein SA 0.0148144
DPEP2 dipeptidase 2 0.0147997
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 0.0147881
NHP2 NHP2 ribonucleoprotein 0.0147633
CRTAP cartilage associated protein 0.0147525
PYGL phosphorylase, glycogen, liver 0.0147513
ASF1B anti-silencing function 1B histone chaperone 0.0147401
BORCS5 BLOC-1 related complex subunit 5 0.0147144
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0146691
RFC5 replication factor C (activator 1) 5, 36.5kDa 0.0146504
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.0146159
GSK3B glycogen synthase kinase 3 beta 0.0146138
RAB35 RAB35, member RAS oncogene family 0.0146117
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor 0.0145978
LRRC59 leucine rich repeat containing 59 0.0145919
HDLBP high density lipoprotein binding protein 0.0145623
DTNB dystrobrevin, beta 0.0145141
BDNF brain-derived neurotrophic factor 0.0145029
SAMD4B sterile alpha motif domain containing 4B 0.0144685
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) 0.0144476
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 0.0144433
IQCB1 IQ motif containing B1 0.0144255
NUP62 nucleoporin 62kDa 0.0144207
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 0.0144172
SMIM44 small integral membrane protein 44 0.0143852
ETF1 eukaryotic translation termination factor 1 0.0143619
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.0143099
TNPO2 transportin 2 0.0143025
NUAK2 NUAK family, SNF1-like kinase, 2 0.0142583
SEPTIN7 septin 7 0.0142354
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 0.0142283
SCAP SREBF chaperone 0.0142232
RNFT2 ring finger protein, transmembrane 2 0.0142116
ZC3H3 zinc finger CCCH-type containing 3 0.014176
GSTP1 glutathione S-transferase pi 1 0.0141748
LMNA lamin A/C 0.0141739
MARK2 MAP/microtubule affinity-regulating kinase 2 0.0141698
WAC WW domain containing adaptor with coiled-coil 0.0141624
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 0.0141609
MBTD1 mbt domain containing 1 0.0141428
TMEM43 transmembrane protein 43 0.01414
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0141171
COL5A2 collagen, type V, alpha 2 0.0141122
CDIN1 CDAN1 interacting nuclease 1 0.014106
EFTUD2 elongation factor Tu GTP binding domain containing 2 0.0140929
MPDU1 mannose-P-dolichol utilization defect 1 0.0139951
PTBP1 polypyrimidine tract binding protein 1 0.0139764
RPS12 ribosomal protein S12 0.013975
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 0.0139695
FOXO1 forkhead box O1 0.0139469
SECISBP2 SECIS binding protein 2 0.0139337
MBNL1 muscleblind-like splicing regulator 1 0.0139243
IWS1 IWS1 homolog (S. cerevisiae) 0.0139233
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae) 0.0139217
ZNF281 zinc finger protein 281 0.01392
ABI1 abl-interactor 1 0.0138477
CDC37 cell division cycle 37 0.0138187
PON2 paraoxonase 2 0.0138114
PHACTR4 phosphatase and actin regulator 4 0.0138014
FERMT2 fermitin family member 2 0.0137745
FBXO11 F-box protein 11 0.0137407
DARS2 aspartyl-tRNA synthetase 2, mitochondrial 0.0136847
HACD3 3-hydroxyacyl-CoA dehydratase 3 0.0136484
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 0.0136283
MELK maternal embryonic leucine zipper kinase 0.0136223
PITX1 paired-like homeodomain 1 0.0136172
PARD6B par-6 family cell polarity regulator beta 0.0135757
TRIB1 tribbles pseudokinase 1 0.0135329
SNF8 SNF8, ESCRT-II complex subunit 0.0135271
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) 0.0135214
BCLAF1 BCL2-associated transcription factor 1 0.0134928
BRD2 bromodomain containing 2 0.0134644
ZFP64 ZFP64 zinc finger protein 0.0134547
SPTBN4 spectrin, beta, non-erythrocytic 4 0.0134522
ZNHIT1 zinc finger, HIT-type containing 1 0.0134476
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.0134374
TCF20 transcription factor 20 (AR1) 0.01343
ADD2 adducin 2 (beta) 0.013411
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 0.0134016
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0133932
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 0.0133929
METTL8 methyltransferase like 8 0.0133686
RAB21 RAB21, member RAS oncogene family 0.0133496
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.013323
APRT adenine phosphoribosyltransferase 0.0133227
ARB2A ARB2 cotranscriptional regulator A 0.0132728
SMAD6 SMAD family member 6 0.013267
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0132603
GINM1 glycoprotein integral membrane 1 0.0132585
MARCHF5 membrane associated ring-CH-type finger 5 0.0132452
FNBP1L formin binding protein 1-like 0.0132317
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0132171
CENPK centromere protein K 0.0132096
EXOSC2 exosome component 2 0.0131657
BTN3A3 butyrophilin, subfamily 3, member A3 0.0131494
CLASRP CLK4-associating serine/arginine rich protein 0.0131106
TACC3 transforming, acidic coiled-coil containing protein 3 0.0130954
TUBB tubulin, beta class I 0.0130738
PHGDH phosphoglycerate dehydrogenase 0.0130674
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.0130664
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0130533
CD151 CD151 molecule (Raph blood group) 0.0130517
GSPT1 G1 to S phase transition 1 0.0130273
PLSCR4 phospholipid scramblase 4 0.0130158
SGMS1 sphingomyelin synthase 1 0.0130121
KIF2A kinesin heavy chain member 2A 0.0130021
CCDC57 coiled-coil domain containing 57 0.0129891
CD59 CD59 molecule, complement regulatory protein 0.0129687
RAN RAN, member RAS oncogene family 0.0129489
RAD9A RAD9 homolog A (S. pombe) 0.0129433
IRS2 insulin receptor substrate 2 0.0129424
AP2A1 adaptor-related protein complex 2, alpha 1 subunit 0.0129341
NTS neurotensin 0.0128775
TOR1AIP2 torsin A interacting protein 2 0.0128615
CDC25B cell division cycle 25B 0.0128565
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 0.0128516
IGHMBP2 immunoglobulin mu binding protein 2 0.012847
GNG12 guanine nucleotide binding protein (G protein), gamma 12 0.0128434
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 0.0128362
RPL34 ribosomal protein L34 0.0128348
FANCB Fanconi anemia, complementation group B 0.0128194
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like 0.0128011
CROT carnitine O-octanoyltransferase 0.0127881
ANKFY1 ankyrin repeat and FYVE domain containing 1 0.0127686
RPL11 ribosomal protein L11 0.0127572
TARBP1 TAR (HIV-1) RNA binding protein 1 0.0127394
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0127149
CLASP2 cytoplasmic linker associated protein 2 0.0127105
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0127104
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.0127086
HNF1A HNF1 homeobox A 0.0127029
USP48 ubiquitin specific peptidase 48 0.012662
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0126601
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.012656
ZC3H18 zinc finger CCCH-type containing 18 0.0126372
MACROH2A1 macroH2A.1 histone 0.0125997
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0125984
WWC1 WW and C2 domain containing 1 0.0125597
RAD51D RAD51 paralog D 0.0125012
WDR62 WD repeat domain 62 0.0124955
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0124679
RTF2 replication termination factor 2 0.0124569
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0124402
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 0.0124359
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.0124231
DAND5 DAN domain family member 5, BMP antagonist 0.0123972
COX20 COX20 cytochrome c oxidase assembly factor 0.0123574
GPR137 G protein-coupled receptor 137 0.0123431
MIDN midnolin 0.0123411
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) 0.0123327
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) 0.0123314
BLVRB biliverdin reductase B 0.0123308
OSGIN2 oxidative stress induced growth inhibitor family member 2 0.0123264
MALT1 MALT1 paracaspase 0.0123251
EIF3D eukaryotic translation initiation factor 3, subunit D 0.012318
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.0123079
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0122904
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.012276
EIF3I eukaryotic translation initiation factor 3, subunit I 0.0122639
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0122621
ASL argininosuccinate lyase 0.0122146
RNF170 ring finger protein 170 0.0121991
DOCK10 dedicator of cytokinesis 10 0.0121772
HUNK hormonally up-regulated Neu-associated kinase 0.0121758
ATP6V1E2 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2 0.012175
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0121724

decreased expression

Symbol Name Standardized Value
ZBTB20 zinc finger and BTB domain containing 20 -0.106748
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.106112
CA12 carbonic anhydrase XII -0.0959325
EHBP1 EH domain binding protein 1 -0.0833154
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0815213
THSD4 thrombospondin, type I, domain containing 4 -0.0787964
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0783602
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0770468
THSD7A thrombospondin, type I, domain containing 7A -0.0748443
PDE8A phosphodiesterase 8A -0.0745736
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0707802
VMP1 vacuole membrane protein 1 -0.0662266
KYNU kynureninase -0.0659026
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0648369
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0629393
R3HDM2 R3H domain containing 2 -0.0618792
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -0.0617021
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0611655
PTGR1 prostaglandin reductase 1 -0.0602176
PDE7A phosphodiesterase 7A -0.0598304
ARHGAP26 Rho GTPase activating protein 26 -0.0591258
PRKCA protein kinase C, alpha -0.0566791
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0560224
FN1 fibronectin 1 -0.0558407
PTK2 protein tyrosine kinase 2 -0.0550428
TNRC6B trinucleotide repeat containing 6B -0.054037
JMJD1C jumonji domain containing 1C -0.0539504
BCAS3 breast carcinoma amplified sequence 3 -0.0508896
DIAPH2 diaphanous-related formin 2 -0.0492937
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0488152
NRG1 neuregulin 1 -0.0462687
EFNA5 ephrin-A5 -0.0452198
FAM107B family with sequence similarity 107, member B -0.0450597
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0448833
GPATCH8 G patch domain containing 8 -0.0443237
NPAS2 neuronal PAS domain protein 2 -0.0410147
UBA2 ubiquitin-like modifier activating enzyme 2 -0.0401203
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0400258
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 -0.0394027
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 -0.0393081
CTSD cathepsin D -0.0389813
MLPH melanophilin -0.0387763
PALLD palladin, cytoskeletal associated protein -0.0387105
GLG1 golgi glycoprotein 1 -0.0383329
RPS2 ribosomal protein S2 -0.0381004
HIP1 huntingtin interacting protein 1 -0.0379275
FILIP1 filamin A interacting protein 1 -0.0369126
ANXA4 annexin A4 -0.036906
SH3D19 SH3 domain containing 19 -0.0367098
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A -0.0364793
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 -0.0362554
ATXN1 ataxin 1 -0.0358489
RNF145 ring finger protein 145 -0.0358458
EXOC6B exocyst complex component 6B -0.0357581
NF1 neurofibromin 1 -0.0357142
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0356728
BABAM2 BRISC and BRCA1 A complex member 2 -0.0356003
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0355908
AKAP13 A kinase (PRKA) anchor protein 13 -0.0355232
SLTM SAFB-like, transcription modulator -0.0354274
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0350862
PATJ PATJ crumbs cell polarity complex component -0.0350661
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0347273
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0346231
RORA RAR-related orphan receptor A -0.0337589
FLVCR1 feline leukemia virus subgroup C cellular receptor 1 -0.0334155
PCED1B PC-esterase domain containing 1B -0.0332483
LRMDA leucine rich melanocyte differentiation associated -0.0332076
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0330513
EXT1 exostosin glycosyltransferase 1 -0.0328826
LIMCH1 LIM and calponin homology domains 1 -0.0328071
MYO18A myosin XVIIIA -0.0326102
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0324584
ZNF609 zinc finger protein 609 -0.0324497
OLA1 Obg-like ATPase 1 -0.0322052
OSBPL10 oxysterol binding protein-like 10 -0.0321927
ECE1 endothelin converting enzyme 1 -0.0321832
GRAMD1B GRAM domain containing 1B -0.0319963
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0317419
BMPR1B bone morphogenetic protein receptor, type IB -0.0316837
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0316696
RPL19 ribosomal protein L19 -0.0316669
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0313465
DYM dymeclin -0.0312106
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0309122
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein -0.030855
NBEA neurobeachin -0.0304966
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0303481
CMIP c-Maf inducing protein -0.0303094
CP ceruloplasmin (ferroxidase) -0.0301462
ADNP activity-dependent neuroprotector homeobox -0.0300719
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -0.029754
ACYP2 acylphosphatase 2, muscle type -0.0296293
FSTL4 follistatin-like 4 -0.0295929
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0294619
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0294577
FCGBP Fc fragment of IgG binding protein -0.0290031
SPATS2 spermatogenesis associated, serine-rich 2 -0.028959
DENND4A DENN/MADD domain containing 4A -0.0287401
PRKCE protein kinase C, epsilon -0.028691
INVS inversin -0.0282716
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0279964
IGF1R insulin-like growth factor 1 receptor -0.0279948
RAB1A RAB1A, member RAS oncogene family -0.0279728
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0279579
AVL9 AVL9 homolog (S. cerevisiase) -0.0279265
PDE10A phosphodiesterase 10A -0.0277492
DNA2 DNA replication helicase/nuclease 2 -0.0277472
MAML3 mastermind-like 3 (Drosophila) -0.0277324
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0276762
UBE3C ubiquitin protein ligase E3C -0.0276707
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.02753
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0275251
APTX aprataxin -0.027441
PUM1 pumilio RNA-binding family member 1 -0.0273386
ATXN7L1 ataxin 7-like 1 -0.0271706
CERS6 ceramide synthase 6 -0.0270349
RPS16 ribosomal protein S16 -0.0269669
FRMD3 FERM domain containing 3 -0.0269546
CEP112 centrosomal protein 112kDa -0.0269164
TRIO trio Rho guanine nucleotide exchange factor -0.0268145
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0266312
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0265862
VRK2 vaccinia related kinase 2 -0.0265413
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -0.0263603
TNRC18 trinucleotide repeat containing 18 -0.0262741
SMAD2 SMAD family member 2 -0.0262736
TPM4 tropomyosin 4 -0.0261025
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.025958
SPPL3 signal peptide peptidase like 3 -0.0258597
FOXP1 forkhead box P1 -0.0257658
RACK1 receptor for activated C kinase 1 -0.0256731
REEP3 receptor accessory protein 3 -0.0254915
PTPRM protein tyrosine phosphatase, receptor type, M -0.0254654
RPLP2 ribosomal protein, large, P2 -0.025356
THRB thyroid hormone receptor, beta -0.0253116
HOMER2 homer scaffolding protein 2 -0.0251434
CDK13 cyclin-dependent kinase 13 -0.0250835
PCDH9 protocadherin 9 -0.0248962
MSI2 musashi RNA-binding protein 2 -0.0247847
TP53 tumor protein p53 -0.0247728
FHIT fragile histidine triad -0.0247404
QRICH1 glutamine-rich 1 -0.0246946
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0246632
MRTFB myocardin related transcription factor B -0.0245158
GOLPH3 golgi phosphoprotein 3 (coat-protein) -0.0244566
OGA O-GlcNAcase -0.0244126
SRPK2 SRSF protein kinase 2 -0.0242329
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0242319
SERF2 small EDRK-rich factor 2 -0.0240605
KDM5B lysine (K)-specific demethylase 5B -0.0239355
GRAMD1A GRAM domain containing 1A -0.0239008
PM20D1 peptidase M20 domain containing 1 -0.0238839
CCDC138 coiled-coil domain containing 138 -0.0238832
ATE1 arginyltransferase 1 -0.0238423
WWOX WW domain containing oxidoreductase -0.0237161
SYT1 synaptotagmin I -0.0237121
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0236105
PHC3 polyhomeotic homolog 3 (Drosophila) -0.0235865
WTAP Wilms tumor 1 associated protein -0.0235701
EML4 echinoderm microtubule associated protein like 4 -0.02357
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0235355
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0235014
GPC6 glypican 6 -0.0234903
STX8 syntaxin 8 -0.023439
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0234151
PDCD6IP programmed cell death 6 interacting protein -0.0233556
PAQR5 progestin and adipoQ receptor family member V -0.0232885
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0232513
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) -0.0231982
PTPRK protein tyrosine phosphatase, receptor type, K -0.0231446
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 -0.0231047
TASOR2 transcription activation suppressor family member 2 -0.0229767
NLK nemo-like kinase -0.0229013
RBL2 retinoblastoma-like 2 -0.0228371
PPP1R9A protein phosphatase 1, regulatory subunit 9A -0.0227803
FBXL17 F-box and leucine-rich repeat protein 17 -0.0227302
VEGFC vascular endothelial growth factor C -0.0226446
BIRC6 baculoviral IAP repeat containing 6 -0.0226206
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0225976
MEGF8 multiple EGF-like-domains 8 -0.0225564
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0224399
STK32B serine/threonine kinase 32B -0.022419
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -0.0224096
DENND5B DENN/MADD domain containing 5B -0.0223987
CNTNAP3B contactin associated protein-like 3B -0.0223943
DOCK1 dedicator of cytokinesis 1 -0.0223801
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0223635
UBE2H ubiquitin-conjugating enzyme E2H -0.0223114
SFXN5 sideroflexin 5 -0.0223095
UBAP2 ubiquitin associated protein 2 -0.0222637
NUP160 nucleoporin 160kDa -0.0222607
PARD3 par-3 family cell polarity regulator -0.0222495
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0222305
SLA2 Src-like-adaptor 2 -0.0222156
LITAF lipopolysaccharide-induced TNF factor -0.0221865
SSH2 slingshot protein phosphatase 2 -0.0220967
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0219941
WDFY3 WD repeat and FYVE domain containing 3 -0.0219663
UNC13B unc-13 homolog B (C. elegans) -0.0219214
LMTK2 lemur tyrosine kinase 2 -0.0218932
C19ORF12 chromosome 19 open reading frame 12 -0.0218324
PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase -0.0218008
MTA3 metastasis associated 1 family, member 3 -0.0217635
TP63 tumor protein p63 -0.0217508
USP32 ubiquitin specific peptidase 32 -0.0216636
FAM13A family with sequence similarity 13, member A -0.0216473
PRKCSH protein kinase C substrate 80K-H -0.0216347
RUNX1 runt-related transcription factor 1 -0.0216265
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0215805
UEVLD UEV and lactate/malate dehyrogenase domains -0.0215699
SMAD3 SMAD family member 3 -0.0214969
PDLIM5 PDZ and LIM domain 5 -0.0214738
AOPEP aminopeptidase O (putative) -0.0214068
RAP1GAP2 RAP1 GTPase activating protein 2 -0.0213656
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0212984
FOXK1 forkhead box K1 -0.0211788
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.0211578
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0211423
MAP7 microtubule-associated protein 7 -0.0211321
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -0.0210369
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -0.0209342
TTC19 tetratricopeptide repeat domain 19 -0.0209214
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0209021
DARS1 aspartyl-tRNA synthetase 1 -0.0207814
SCFD1 sec1 family domain containing 1 -0.020776
MGLL monoglyceride lipase -0.0206356
TXN2 thioredoxin 2 -0.0205844
PSEN1 presenilin 1 -0.0205811
DAPK1 death-associated protein kinase 1 -0.0205803
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0205219
WDR26 WD repeat domain 26 -0.0204459
GMDS GDP-mannose 4,6-dehydratase -0.0204394
FBXL20 F-box and leucine-rich repeat protein 20 -0.0203643
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0201544
SRC SRC proto-oncogene, non-receptor tyrosine kinase -0.0201478
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D -0.0201361
LAMB1 laminin, beta 1 -0.0200845
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -0.0200663
MYO1B myosin IB -0.0200322
CDK19 cyclin-dependent kinase 19 -0.0199865
GOLPH3L golgi phosphoprotein 3-like -0.019945
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0199366
ERGIC3 ERGIC and golgi 3 -0.0198774
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0197953
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0197799
PPP1R21 protein phosphatase 1, regulatory subunit 21 -0.0197793
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0197788
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0197693
MCU mitochondrial calcium uniporter -0.0196507
TSC22D1 TSC22 domain family, member 1 -0.0196345
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0196249
TRIP4 thyroid hormone receptor interactor 4 -0.0196211
ENOSF1 enolase superfamily member 1 -0.019568
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 -0.0195631
AFF1 AF4/FMR2 family, member 1 -0.0195599
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 -0.019524
CCNI cyclin I -0.0195138
DMXL2 Dmx-like 2 -0.0194996
NOVA1 neuro-oncological ventral antigen 1 -0.0194983
PIGL phosphatidylinositol glycan anchor biosynthesis, class L -0.0194953
AFG3L2 AFG3-like AAA ATPase 2 -0.0194295
PHF20 PHD finger protein 20 -0.0192922
AFF4 AF4/FMR2 family, member 4 -0.0191092
NINL ninein-like -0.0189995
NNMT nicotinamide N-methyltransferase -0.0189909
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 -0.0189694
MLXIP MLX interacting protein -0.0189691
SLF2 SMC5-SMC6 complex localization factor 2 -0.0189634
KCNT2 potassium channel, sodium activated subfamily T, member 2 -0.0189296
NCOR2 nuclear receptor corepressor 2 -0.0188583
NOSTRIN nitric oxide synthase trafficking -0.01885
STK24 serine/threonine kinase 24 -0.0188297
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0188097
CDKL5 cyclin-dependent kinase-like 5 -0.0188047
RAP1B RAP1B, member of RAS oncogene family -0.0187793
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0187443
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0186952
USP15 ubiquitin specific peptidase 15 -0.0186912
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) -0.0186733
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0186652
SETDB1 SET domain, bifurcated 1 -0.0186489
GTF2A2 general transcription factor IIA, 2, 12kDa -0.0186279
AHI1 Abelson helper integration site 1 -0.0185931
AKAP1 A kinase (PRKA) anchor protein 1 -0.0185909
AUTS2 autism susceptibility candidate 2 -0.0185766
SH3RF1 SH3 domain containing ring finger 1 -0.0185591
SEC14L1 SEC14-like 1 (S. cerevisiae) -0.0185242
MAP2K5 mitogen-activated protein kinase kinase 5 -0.0184773
IARS1 isoleucyl-tRNA synthetase 1 -0.0184716
AGO3 argonaute RISC catalytic component 3 -0.0184329
UBAC2 UBA domain containing 2 -0.0183329
TANK TRAF family member-associated NFKB activator -0.0181619
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.0180674
SPIDR scaffolding protein involved in DNA repair -0.0180441
TRAPPC12 trafficking protein particle complex 12 -0.0180368
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 -0.0180202
KCMF1 potassium channel modulatory factor 1 -0.0180095
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -0.0180021
ABI2 abl-interactor 2 -0.0180005
TPCN1 two pore segment channel 1 -0.0179887
SPIRE1 spire-type actin nucleation factor 1 -0.0179841
MPRIP myosin phosphatase Rho interacting protein -0.0179776
KDM4B lysine (K)-specific demethylase 4B -0.0179748
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) -0.0179677
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0179676
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 -0.0179474
PRR11 proline rich 11 -0.0178882
SINHCAF SIN3-HDAC complex associated factor -0.0178055
NUMB numb homolog (Drosophila) -0.0177663
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0177632
CDC27 cell division cycle 27 -0.0177474
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0176481
LTBP1 latent transforming growth factor beta binding protein 1 -0.0176198
EEF2K eukaryotic elongation factor 2 kinase -0.017559
MYO1D myosin ID -0.0175557
TPD52 tumor protein D52 -0.017537
TMOD3 tropomodulin 3 (ubiquitous) -0.0175305
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0175205
ANKRD11 ankyrin repeat domain 11 -0.0174256
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0174143
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -0.0174126
LIMD1 LIM domains containing 1 -0.0173999
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0173423
NCOR1 nuclear receptor corepressor 1 -0.0173376
TBC1D22A TBC1 domain family, member 22A -0.0173329
USP45 ubiquitin specific peptidase 45 -0.0173231
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.017298
NRDC nardilysin convertase -0.0172742
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.0172662
ZNF652 zinc finger protein 652 -0.0172067
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0172028
PDIA4 protein disulfide isomerase family A, member 4 -0.0171918
RAB6A RAB6A, member RAS oncogene family -0.0171519
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0170712
WDR70 WD repeat domain 70 -0.0170693
GPRIN3 GPRIN family member 3 -0.0170356
FAF1 Fas (TNFRSF6) associated factor 1 -0.0170043
TRIM56 tripartite motif containing 56 -0.017003
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0169961
SUMF1 sulfatase modifying factor 1 -0.0169833
ALCAM activated leukocyte cell adhesion molecule -0.0169692
SEPTIN6 septin 6 -0.0169607
CREBBP CREB binding protein -0.0169365
LCORL ligand dependent nuclear receptor corepressor-like -0.0169272
NEO1 neogenin 1 -0.0168544
STYXL1 serine/threonine/tyrosine interacting-like 1 -0.0168212
GLB1 galactosidase, beta 1 -0.0168126
TM9SF4 transmembrane 9 superfamily protein member 4 -0.0167698
TMEM245 transmembrane protein 245 -0.0167665
RBPMS RNA binding protein with multiple splicing -0.0167574
NRF1 nuclear respiratory factor 1 -0.0166777
SSH1 slingshot protein phosphatase 1 -0.01665
MAVS mitochondrial antiviral signaling protein -0.0166488
SDCCAG8 serologically defined colon cancer antigen 8 -0.0166308
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0166026
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.0165955
MTCH2 mitochondrial carrier 2 -0.0165772
RPS11 ribosomal protein S11 -0.016507
ACBD5 acyl-CoA binding domain containing 5 -0.0165051
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0164399
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.016422
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -0.0164096
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0164064
PTPRF protein tyrosine phosphatase, receptor type, F -0.0163884
ULK2 unc-51 like autophagy activating kinase 2 -0.0163448
BCAS1 breast carcinoma amplified sequence 1 -0.0163007
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 -0.0162634
LMBR1 limb development membrane protein 1 -0.0162356
LUC7L LUC7-like (S. cerevisiae) -0.0161994
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 -0.0161737
PNISR PNN-interacting serine/arginine-rich protein -0.016171
SEPTIN9 septin 9 -0.0161467
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.0161283
RANBP17 RAN binding protein 17 -0.0161088
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0160612
ANAPC11 anaphase promoting complex subunit 11 -0.016025
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0159217
DNM3 dynamin 3 -0.0159165
LNPEP leucyl/cystinyl aminopeptidase -0.0159118
FBXL2 F-box and leucine-rich repeat protein 2 -0.0158435
MYO6 myosin VI -0.0158414
SCAF8 SR-related CTD-associated factor 8 -0.0158386
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0158239
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 -0.0158043
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 -0.0157828
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0157689
GAPVD1 GTPase activating protein and VPS9 domains 1 -0.0157566
STRN striatin, calmodulin binding protein -0.0157563
RCOR1 REST corepressor 1 -0.0157441
DOCK5 dedicator of cytokinesis 5 -0.0157251
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -0.0157204
LASP1 LIM and SH3 protein 1 -0.0157173
DSCAM Down syndrome cell adhesion molecule -0.0156905
LRRC41 leucine rich repeat containing 41 -0.015687
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0156551
FYCO1 FYVE and coiled-coil domain containing 1 -0.0156237
KIAA0232 KIAA0232 -0.0156131
PDE1A phosphodiesterase 1A, calmodulin-dependent -0.0156096
FDPS farnesyl diphosphate synthase -0.015602
RCOR3 REST corepressor 3 -0.0155907
AKIRIN1 akirin 1 -0.0155267
ORC5 origin recognition complex, subunit 5 -0.01552
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0155072
SPPL2A signal peptide peptidase like 2A -0.0154837
CUL3 cullin 3 -0.0154836
MTUS1 microtubule associated tumor suppressor 1 -0.0154512
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0154283
RHOBTB1 Rho-related BTB domain containing 1 -0.0154212
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) -0.0154075
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 -0.0153838
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.015361
UNC13A unc-13 homolog A (C. elegans) -0.0153599
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.015356
SMIM14 small integral membrane protein 14 -0.0153527
SOCS5 suppressor of cytokine signaling 5 -0.0153373
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0153089
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.0153064
AHCYL2 adenosylhomocysteinase-like 2 -0.0152853
CFH complement factor H -0.0152795
CCNY cyclin Y -0.015272
PLS1 plastin 1 -0.0151655
LPCAT3 lysophosphatidylcholine acyltransferase 3 -0.0151174
MINK1 misshapen-like kinase 1 -0.0150535
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0150505
TGFBR3 transforming growth factor, beta receptor III -0.0150475
AMBRA1 autophagy/beclin-1 regulator 1 -0.0150397
ATF7IP activating transcription factor 7 interacting protein -0.0150366
BBX bobby sox homolog (Drosophila) -0.0149947
TBC1D14 TBC1 domain family, member 14 -0.0149453
RHEB Ras homolog enriched in brain -0.0149381
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0149317
ZP3 zona pellucida glycoprotein 3 (sperm receptor) -0.014889
C9ORF85 chromosome 9 open reading frame 85 -0.0148469
NEK1 NIMA-related kinase 1 -0.0148389
FANCL Fanconi anemia, complementation group L -0.0148155
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0147871
OSBPL9 oxysterol binding protein-like 9 -0.014782
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 -0.0147738
MACROD2 MACRO domain containing 2 -0.014671
SLPI secretory leukocyte peptidase inhibitor -0.0146174
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 -0.0145997
LARS2 leucyl-tRNA synthetase 2, mitochondrial -0.0145887
NFX1 nuclear transcription factor, X-box binding 1 -0.0145704
MCPH1 microcephalin 1 -0.0145542
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A -0.014549
TMEM135 transmembrane protein 135 -0.0145461
SKP1 S-phase kinase-associated protein 1 -0.0144868
KIAA1958 KIAA1958 -0.0144564
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0144272
SNAP25 synaptosomal-associated protein, 25kDa -0.0144239
TRIM2 tripartite motif containing 2 -0.0144018
ZFAND3 zinc finger, AN1-type domain 3 -0.0143957
UBE2N ubiquitin-conjugating enzyme E2N -0.0143517
ZFX zinc finger protein, X-linked -0.0143476
CLYBL citrate lyase beta like -0.0143342
RBM47 RNA binding motif protein 47 -0.0143298
CUEDC1 CUE domain containing 1 -0.0143258
ZNF260 zinc finger protein 260 -0.014319
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0143
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 -0.0142897
MBD5 methyl-CpG binding domain protein 5 -0.0142871
HNRNPF heterogeneous nuclear ribonucleoprotein F -0.0142742
RPS8 ribosomal protein S8 -0.0142398
ABHD18 abhydrolase domain containing 18 -0.0141633
SF1 splicing factor 1 -0.0141604
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0141026
PDGFD platelet derived growth factor D -0.0140989
POU2F1 POU class 2 homeobox 1 -0.0140702
ZFR zinc finger RNA binding protein -0.0140569
XPO4 exportin 4 -0.014019
PPIA peptidylprolyl isomerase A (cyclophilin A) -0.0140133
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0140106
KIAA2026 KIAA2026 -0.0140051
SKIL SKI-like proto-oncogene -0.0140009
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0139837
ADD3 adducin 3 (gamma) -0.0139831
NOL9 nucleolar protein 9 -0.0139563
FBXO33 F-box protein 33 -0.0139518
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0139335
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -0.0139208
COG7 component of oligomeric golgi complex 7 -0.0139043
PLCH1 phospholipase C, eta 1 -0.0138989
CABIN1 calcineurin binding protein 1 -0.013888
SIDT1 SID1 transmembrane family, member 1 -0.0138745
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -0.0138489
CHPT1 choline phosphotransferase 1 -0.0138352
PHKB phosphorylase kinase, beta -0.0138263
TOR1AIP1 torsin A interacting protein 1 -0.0138249
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0137846
PWWP2A PWWP domain containing 2A -0.0137807
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit -0.013774
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.013749
STXBP1 syntaxin binding protein 1 -0.0137414
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.01373
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0137296
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0137226
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0137136
NIN ninein (GSK3B interacting protein) -0.0137106
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0136949