A549_SNS-314 Mesylate_1µM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description SNS-314 Mesylate 1µM perturbation in A549 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the A549_SNS-314 Mesylate_1µM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.18543
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.173461
TXNRD1 thioredoxin reductase 1 0.135824
ABTB3 ankyrin repeat and BTB domain containing 3 0.131994
MYOF myoferlin 0.120152
TNS3 tensin 3 0.113059
ANXA4 annexin A4 0.112233
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.093961
CA12 carbonic anhydrase XII 0.0914014
MAP1B microtubule-associated protein 1B 0.0814576
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0773409
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0740934
AOPEP aminopeptidase O (putative) 0.0731684
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0693214
KRT8 keratin 8, type II 0.0688175
DST dystonin 0.0636289
MAML3 mastermind-like 3 (Drosophila) 0.0631011
IGF1R insulin-like growth factor 1 receptor 0.0620145
PCDH9 protocadherin 9 0.0612164
BCAS3 breast carcinoma amplified sequence 3 0.0587512
PLCB4 phospholipase C, beta 4 0.0575607
UBE2H ubiquitin-conjugating enzyme E2H 0.0561491
EFNA5 ephrin-A5 0.0558316
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0516426
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.0514688
TRAM1 translocation associated membrane protein 1 0.0484228
WWTR1 WW domain containing transcription regulator 1 0.0479886
PTPRJ protein tyrosine phosphatase, receptor type, J 0.047645
EXOC6B exocyst complex component 6B 0.047552
PTGR1 prostaglandin reductase 1 0.0468316
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0459301
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0449312
MAP7 microtubule-associated protein 7 0.0444588
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0435765
AHNAK2 AHNAK nucleoprotein 2 0.0434436
RBPMS RNA binding protein with multiple splicing 0.0433079
PDZD8 PDZ domain containing 8 0.0430031
SMAD3 SMAD family member 3 0.0427485
THSD4 thrombospondin, type I, domain containing 4 0.0415967
KRT18 keratin 18, type I 0.0414602
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0405957
GSK3B glycogen synthase kinase 3 beta 0.0404899
MSI2 musashi RNA-binding protein 2 0.0395337
EPB41L4A erythrocyte membrane protein band 4.1 like 4A 0.0387935
TPD52L1 tumor protein D52-like 1 0.0381081
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0379462
MBNL1 muscleblind-like splicing regulator 1 0.0378343
COL4A5 collagen, type IV, alpha 5 0.0377616
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0370703
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0367808
TBC1D5 TBC1 domain family, member 5 0.0362955
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 0.0357747
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0354107
PTPRM protein tyrosine phosphatase, receptor type, M 0.0351984
NCOA3 nuclear receptor coactivator 3 0.0351461
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.034804
NPAS2 neuronal PAS domain protein 2 0.0346996
FLNA filamin A, alpha 0.0345381
RAB10 RAB10, member RAS oncogene family 0.0343972
CCND3 cyclin D3 0.0339132
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.0336393
ACYP2 acylphosphatase 2, muscle type 0.0327511
TMEM131 transmembrane protein 131 0.0327481
NRCAM neuronal cell adhesion molecule 0.0327122
MBD5 methyl-CpG binding domain protein 5 0.0324201
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0323819
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0323581
SMIM14 small integral membrane protein 14 0.0321613
ASPH aspartate beta-hydroxylase 0.0318646
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0316451
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0316209
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.031516
RHOQ ras homolog family member Q 0.031492
ASTN2 astrotactin 2 0.031278
IKBIP IKBKB interacting protein 0.0312568
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0306561
CUEDC1 CUE domain containing 1 0.0304614
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0304415
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0303456
KMT2C lysine (K)-specific methyltransferase 2C 0.0302907
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0302615
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0302269
LPP LIM domain containing preferred translocation partner in lipoma 0.0300852
ZBTB20 zinc finger and BTB domain containing 20 0.0300288
WDR44 WD repeat domain 44 0.029752
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0297397
CAPN2 calpain 2, (m/II) large subunit 0.0295789
MEGF8 multiple EGF-like-domains 8 0.0295481
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 0.0295417
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0295246
ANXA2 annexin A2 0.0293557
BABAM2 BRISC and BRCA1 A complex member 2 0.0293226
AKR1C2 aldo-keto reductase family 1, member C2 0.0291522
NBEA neurobeachin 0.029119
CD81 CD81 molecule 0.028539
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.0285028
GLIS3 GLIS family zinc finger 3 0.0284853
XPR1 xenotropic and polytropic retrovirus receptor 1 0.0280857
ANO10 anoctamin 10 0.0280292
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.027805
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 0.0277566
PARD3 par-3 family cell polarity regulator 0.0275321
KYNU kynureninase 0.0273704
GATAD2B GATA zinc finger domain containing 2B 0.0271884
MYO10 myosin X 0.0270666
NT5C2 5'-nucleotidase, cytosolic II 0.0268448
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 0.0268356
CMIP c-Maf inducing protein 0.026425
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0262855
KRT7 keratin 7, type II 0.0262472
CYRIB CYFIP related Rac1 interactor B 0.0262305
MAPK14 mitogen-activated protein kinase 14 0.0261855
EVI5 ecotropic viral integration site 5 0.0261458
XPC xeroderma pigmentosum, complementation group C 0.0260285
FTL ferritin, light polypeptide 0.025939
AGR2 anterior gradient 2 0.0258899
SFTPA2 surfactant protein A2 0.0258694
TM7SF3 transmembrane 7 superfamily member 3 0.0258352
DOCK1 dedicator of cytokinesis 1 0.025817
ARHGAP24 Rho GTPase activating protein 24 0.0256729
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.0249373
ATXN10 ataxin 10 0.0248025
PTK2 protein tyrosine kinase 2 0.0247548
DNHD1 dynein heavy chain domain 1 0.0246759
PRSS23 protease, serine, 23 0.0245915
ZFAND3 zinc finger, AN1-type domain 3 0.0245254
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.0245246
NFIA nuclear factor I/A 0.0243278
ARB2A ARB2 cotranscriptional regulator A 0.0240568
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0239056
BLTP1 bridge-like lipid transfer protein family member 1 0.0238931
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.0238502
ANXA1 annexin A1 0.0236674
FMNL2 formin-like 2 0.0234694
EPB41 erythrocyte membrane protein band 4.1 0.0234293
MED13L mediator complex subunit 13-like 0.0233489
ATRN attractin 0.0233477
FRAS1 Fraser extracellular matrix complex subunit 1 0.0233173
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0232704
TMCC1 transmembrane and coiled-coil domain family 1 0.0228884
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0228613
ADGRG6 adhesion G protein-coupled receptor G6 0.0228302
SBF2 SET binding factor 2 0.0227617
AUTS2 autism susceptibility candidate 2 0.0227025
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0226569
ITFG1 integrin alpha FG-GAP repeat containing 1 0.0226086
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.0224283
CEP350 centrosomal protein 350kDa 0.0224248
RFX7 regulatory factor X, 7 0.0223676
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0221193
ALCAM activated leukocyte cell adhesion molecule 0.0221159
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0221034
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 0.0220013
RPS27L ribosomal protein S27-like 0.021773
DENND1A DENN/MADD domain containing 1A 0.0215809
EXOC4 exocyst complex component 4 0.0215259
YAP1 Yes-associated protein 1 0.0214624
LYRM4 LYR motif containing 4 0.021426
FOXK2 forkhead box K2 0.0213137
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0212956
USP49 ubiquitin specific peptidase 49 0.0212316
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0212248
NRG1 neuregulin 1 0.0211748
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 0.0211739
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.021164
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 0.0211533
SVIL supervillin 0.021079
LARP1 La ribonucleoprotein domain family, member 1 0.0210363
NBEAL1 neurobeachin-like 1 0.0209884
AFF1 AF4/FMR2 family, member 1 0.0209842
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0209177
FADS2 fatty acid desaturase 2 0.0208357
TP53BP1 tumor protein p53 binding protein 1 0.0207168
CANX calnexin 0.0206559
PACS1 phosphofurin acidic cluster sorting protein 1 0.0206172
PARD6B par-6 family cell polarity regulator beta 0.0205676
IDE insulin-degrading enzyme 0.0205257
RORA RAR-related orphan receptor A 0.0204389
FLNB filamin B, beta 0.0203785
CLEC16A C-type lectin domain family 16, member A 0.020376
PATJ PATJ crumbs cell polarity complex component 0.0203349
LRP6 low density lipoprotein receptor-related protein 6 0.0203169
KDM4C lysine (K)-specific demethylase 4C 0.020283
SPATS2 spermatogenesis associated, serine-rich 2 0.0202825
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0202763
MYEOV myeloma overexpressed 0.0201759
SH3D19 SH3 domain containing 19 0.0201659
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0200807
LATS1 large tumor suppressor kinase 1 0.0200237
RPL37A ribosomal protein L37a 0.0199617
CYFIP1 cytoplasmic FMR1 interacting protein 1 0.0198906
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0198155
CPPED1 calcineurin-like phosphoesterase domain containing 1 0.0197766
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.0197451
CALR calreticulin 0.0196957
NAT8 N-acetyltransferase 8 (GCN5-related, putative) 0.0196778
EGFR epidermal growth factor receptor 0.0196544
RPLP1 ribosomal protein, large, P1 0.0196541
PDGFD platelet derived growth factor D 0.0195924
HMOX1 heme oxygenase 1 0.0195549
AHCYL2 adenosylhomocysteinase-like 2 0.0195497
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.019498
BFAR bifunctional apoptosis regulator 0.0194932
N4BP2L2 NEDD4 binding protein 2-like 2 0.0194348
DLG1 discs, large homolog 1 (Drosophila) 0.0193768
PPP4R3B protein phosphatase 4 regulatory subunit 3B 0.0193599
TBCE tubulin folding cofactor E 0.0192983
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0192909
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0190831
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.0190248
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0190104
LASP1 LIM and SH3 protein 1 0.0189082
DRAM1 DNA-damage regulated autophagy modulator 1 0.0187957
KRCC1 lysine-rich coiled-coil 1 0.0187363
BAX BCL2-associated X protein 0.0186355
SMG6 SMG6 nonsense mediated mRNA decay factor 0.0186301
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.0184717
SESN2 sestrin 2 0.0183429
IFT81 intraflagellar transport 81 0.018338
NOL10 nucleolar protein 10 0.0182776
ARID4A AT rich interactive domain 4A (RBP1-like) 0.0182356
TRIM66 tripartite motif containing 66 0.0181976
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.0181665
ZMYND8 zinc finger, MYND-type containing 8 0.0181055
CEMIP2 cell migration inducing hyaluronidase 2 0.0180487
LDAH lipid droplet associated hydrolase 0.0180318
PCCA propionyl CoA carboxylase, alpha polypeptide 0.017995
KDM3B lysine (K)-specific demethylase 3B 0.0179303
BCL2L1 BCL2-like 1 0.0178602
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.0178556
PLCE1 phospholipase C, epsilon 1 0.0178512
SULF2 sulfatase 2 0.017839
PLD5 phospholipase D family, member 5 0.0178285
LAMA4 laminin, alpha 4 0.0178031
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0178011
RNF43 ring finger protein 43 0.0177602
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0177487
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0177282
DGKG diacylglycerol kinase, gamma 90kDa 0.0177043
SENP6 SUMO1/sentrin specific peptidase 6 0.0176993
ARHGAP22 Rho GTPase activating protein 22 0.0176989
AKAP13 A kinase (PRKA) anchor protein 13 0.0176815
ALPK2 alpha-kinase 2 0.0176466
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0176349
KRT19 keratin 19, type I 0.0176345
MYLK myosin light chain kinase 0.0175569
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0175454
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0174895
SKAP2 src kinase associated phosphoprotein 2 0.0174532
PBX1 pre-B-cell leukemia homeobox 1 0.0174185
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.0173926
LRP5 low density lipoprotein receptor-related protein 5 0.0173833
STIM1 stromal interaction molecule 1 0.0173535
R3HCC1L R3H domain and coiled-coil containing 1-like 0.0173113
LACTB2 lactamase, beta 2 0.0172949
NUDCD3 NudC domain containing 3 0.0172678
AGPS alkylglycerone phosphate synthase 0.0172405
ENOX2 ecto-NOX disulfide-thiol exchanger 2 0.0170596
LPIN1 lipin 1 0.0170516
PREPL prolyl endopeptidase-like 0.0170491
RNF13 ring finger protein 13 0.0170419
FBXW2 F-box and WD repeat domain containing 2 0.0170162
ARHGAP18 Rho GTPase activating protein 18 0.0170006
SDC1 syndecan 1 0.0169744
SH3PXD2B SH3 and PX domains 2B 0.0168662
CCNI cyclin I 0.0168655
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 0.016854
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.0168012
CES2 carboxylesterase 2 0.0167905
PDE4D phosphodiesterase 4D, cAMP-specific 0.0167443
BLVRB biliverdin reductase B 0.0166953
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0166928
DNAH14 dynein, axonemal, heavy chain 14 0.0166898
HSPG2 heparan sulfate proteoglycan 2 0.0166224
TP63 tumor protein p63 0.0165935
PARN poly(A)-specific ribonuclease 0.0165856
IGSF11 immunoglobulin superfamily, member 11 0.01657
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0165508
MARK4 MAP/microtubule affinity-regulating kinase 4 0.0165273
PTBP2 polypyrimidine tract binding protein 2 0.0164955
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.0164035
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 0.0163993
GSDME gasdermin E 0.0163498
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast) 0.0161881
AMBRA1 autophagy/beclin-1 regulator 1 0.0161856
MKRN1 makorin ring finger protein 1 0.0161648
SIK3 SIK family kinase 3 0.0161174
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 0.0160576
SQSTM1 sequestosome 1 0.0160477
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.0160414
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.0159872
RPAP2 RNA polymerase II associated protein 2 0.0159638
KDM4B lysine (K)-specific demethylase 4B 0.0159385
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0158695
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0158128
NCOA2 nuclear receptor coactivator 2 0.0157962
GOLGA4 golgin A4 0.0157587
RPL31 ribosomal protein L31 0.0156044
ACLY ATP citrate lyase 0.0154705
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 0.0154682
TSC2 tuberous sclerosis 2 0.015468
UBAP1 ubiquitin associated protein 1 0.0154495
STX12 syntaxin 12 0.0153891
FBXO16 F-box protein 16 0.0153665
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0152639
TRIML2 tripartite motif family-like 2 0.0152613
MINK1 misshapen-like kinase 1 0.0152326
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0151828
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.015166
GOLGA1 golgin A1 0.0151364
NLGN4Y neuroligin 4, Y-linked 0.0151104
GPC6 glypican 6 0.0150974
MAML2 mastermind-like 2 (Drosophila) 0.0150757
EPS15 epidermal growth factor receptor pathway substrate 15 0.0150574
KDM2B lysine (K)-specific demethylase 2B 0.0150418
HLA-E major histocompatibility complex, class I, E 0.0150068
WDR72 WD repeat domain 72 0.0150062
GPATCH2 G patch domain containing 2 0.0150021
FMN1 formin 1 0.0149726
TBCA tubulin folding cofactor A 0.0149705
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0149679
KIF1B kinesin family member 1B 0.0149576
AARS1 alanyl-tRNA synthetase 1 0.0149504
SLC39A6 solute carrier family 39 (zinc transporter), member 6 0.0149057
SUMF1 sulfatase modifying factor 1 0.0148955
CXXC1 CXXC finger protein 1 0.0148881
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 0.0148525
FBXO22 F-box protein 22 0.0148515
BMP1 bone morphogenetic protein 1 0.0147482
AEBP2 AE binding protein 2 0.0147478
TMEM135 transmembrane protein 135 0.0147454
TATDN3 TatD DNase domain containing 3 0.0147391
SLIT3 slit homolog 3 (Drosophila) 0.0147366
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0147152
IGF2R insulin-like growth factor 2 receptor 0.0146932
CAVIN1 caveolae associated protein 1 0.0146601
DENND2B DENN domain containing 2B 0.014608
EIF3I eukaryotic translation initiation factor 3, subunit I 0.0145991
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0145697
NEK9 NIMA-related kinase 9 0.0145636
ZRANB2 zinc finger, RAN-binding domain containing 2 0.0145478
DCDC1 doublecortin domain containing 1 0.0144937
TRAK1 trafficking protein, kinesin binding 1 0.0144887
ZSWIM6 zinc finger, SWIM-type containing 6 0.0144617
EPS8L2 EPS8-like 2 0.0144458
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 0.0144414
CUL2 cullin 2 0.0144235
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.0143907
ZNF48 zinc finger protein 48 0.0143829
PLCXD2 phosphatidylinositol-specific phospholipase C, X domain containing 2 0.0143806
GRN granulin 0.0143686
SYNJ2BP synaptojanin 2 binding protein 0.0143567
MAP4 microtubule-associated protein 4 0.0143534
MATN2 matrilin 2 0.0143513
FOXK1 forkhead box K1 0.0143445
CBX1 chromobox homolog 1 0.014309
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) 0.0143025
NUMB numb homolog (Drosophila) 0.0142868
TXNL1 thioredoxin-like 1 0.0142866
ADAM9 ADAM metallopeptidase domain 9 0.0142455
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0141647
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 0.0141644
YIPF4 Yip1 domain family, member 4 0.0141476
ZMYM2 zinc finger, MYM-type 2 0.0141261
YEATS2 YEATS domain containing 2 0.014114
CPNE4 copine IV 0.0140678
RBMS2 RNA binding motif, single stranded interacting protein 2 0.0140535
ANKIB1 ankyrin repeat and IBR domain containing 1 0.014047
PCED1B PC-esterase domain containing 1B 0.0140323
SEC31A SEC31 homolog A (S. cerevisiae) 0.0139993
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0139671
ZFP64 ZFP64 zinc finger protein 0.0138906
BBS4 Bardet-Biedl syndrome 4 0.0138841
MFSD6 major facilitator superfamily domain containing 6 0.013834
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0138264
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 0.0138215
IP6K2 inositol hexakisphosphate kinase 2 0.0137862
FUBP3 far upstream element (FUSE) binding protein 3 0.0137812
WDPCP WD repeat containing planar cell polarity effector 0.0137503
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.0137435
SLC38A6 solute carrier family 38, member 6 0.0137411
TBCK TBC1 domain containing kinase 0.0137091
PCNX2 pecanex 2 0.0136998
AKR1C1 aldo-keto reductase family 1, member C1 0.0136957
HACD3 3-hydroxyacyl-CoA dehydratase 3 0.0136753
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0136713
TRRAP transformation/transcription domain-associated protein 0.0136373
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0136134
EI24 etoposide induced 2.4 0.0135592
FGFR1 fibroblast growth factor receptor 1 0.0135544
USP32 ubiquitin specific peptidase 32 0.0135355
MRPL42 mitochondrial ribosomal protein L42 0.0134721
KATNBL1 katanin p80 subunit B-like 1 0.0134596
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.0133968
ANXA7 annexin A7 0.0133663
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0133557
MFGE8 milk fat globule-EGF factor 8 protein 0.0133523
NUBPL nucleotide binding protein-like 0.0133444
ORC4 origin recognition complex, subunit 4 0.0133438
DBN1 drebrin 1 0.0133335
LCLAT1 lysocardiolipin acyltransferase 1 0.0133329
STMP1 short transmembrane mitochondrial protein 1 0.0133282
ITGB4 integrin, beta 4 0.0133183
CNTRL centriolin 0.013298
ZP3 zona pellucida glycoprotein 3 (sperm receptor) 0.0132837
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 0.0132623
MRTFA myocardin related transcription factor A 0.013253
SIL1 SIL1 nucleotide exchange factor 0.0132518
CADPS2 Ca++-dependent secretion activator 2 0.0132416
ITCH itchy E3 ubiquitin protein ligase 0.0132078
GSTP1 glutathione S-transferase pi 1 0.0132023
SNX13 sorting nexin 13 0.0131987
ZFYVE16 zinc finger, FYVE domain containing 16 0.0131915
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.013183
TSEN2 TSEN2 tRNA splicing endonuclease subunit 0.0131778
CRTC3 CREB regulated transcription coactivator 3 0.0131368
BBS9 Bardet-Biedl syndrome 9 0.0131367
SCFD1 sec1 family domain containing 1 0.0131232
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0131126
ANXA5 annexin A5 0.0131013
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0131005
PDE7B phosphodiesterase 7B 0.0130776
CTSD cathepsin D 0.0130431
EDN1 endothelin 1 0.0130029
CEP83 centrosomal protein 83kDa 0.0129991
FBXW4 F-box and WD repeat domain containing 4 0.0129964
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0129758
CPNE8 copine VIII 0.0129744
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0129604
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0129222
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0129214
UBE3D ubiquitin protein ligase E3D 0.01292
ATXN7L1 ataxin 7-like 1 0.0129154
PYGB phosphorylase, glycogen; brain 0.0129153
AADAC arylacetamide deacetylase 0.0129132
SREBF2 sterol regulatory element binding transcription factor 2 0.0128886
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 0.0128727
KDM6A lysine (K)-specific demethylase 6A 0.01287
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.0128615
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0128503
KIAA0319L KIAA0319-like 0.0128426
ZNF367 zinc finger protein 367 0.0128353
COPA coatomer protein complex, subunit alpha 0.0128327
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0127052
SARS2 seryl-tRNA synthetase 2, mitochondrial 0.0126993
PLAAT3 phospholipase A and acyltransferase 3 0.0126982
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.0126949
TCP11L2 t-complex 11, testis-specific-like 2 0.0126719
TTC7A tetratricopeptide repeat domain 7A 0.0126668
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0126638
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 0.0126485
PNPLA7 patatin-like phospholipase domain containing 7 0.0125908
MZT2B mitotic spindle organizing protein 2B 0.0125326
KIAA0753 KIAA0753 0.0125324
TTBK2 tau tubulin kinase 2 0.0125312
MRTFB myocardin related transcription factor B 0.0125195
ACTA2 actin, alpha 2, smooth muscle, aorta 0.0125151
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase 0.0125016
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 0.0124826
TBC1D4 TBC1 domain family, member 4 0.0124776
CATSPERB catsper channel auxiliary subunit beta 0.0124719
PXDN peroxidasin 0.0124536
COL5A2 collagen, type V, alpha 2 0.0124424
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 0.0124349
XYLB xylulokinase homolog (H. influenzae) 0.0124286
NTN4 netrin 4 0.0123392
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.0123203
LNPEP leucyl/cystinyl aminopeptidase 0.0123022
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.012295
ZNF235 zinc finger protein 235 0.0122831
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0122193
SRP72 signal recognition particle 72kDa 0.0122103
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 0.0121912
WDR12 WD repeat domain 12 0.0121839
ARMH1 armadillo like helical domain containing 1 0.0121741
TTC23 tetratricopeptide repeat domain 23 0.012162
PGRMC2 progesterone receptor membrane component 2 0.012135
NME7 NME/NM23 family member 7 0.0121299
STX1A syntaxin 1A (brain) 0.0121247
FNBP4 formin binding protein 4 0.0121243
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0120935
TRERF1 transcriptional regulating factor 1 0.0120788
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.012078
MECR mitochondrial trans-2-enoyl-CoA reductase 0.0120761
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0120704
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0120621
INTS4 integrator complex subunit 4 0.0119827
FAM222B family with sequence similarity 222, member B 0.011976
RNF121 ring finger protein 121 0.0119611
CCDC80 coiled-coil domain containing 80 0.0119561
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) 0.0119536
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 0.0119502
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0119088
NLN neurolysin (metallopeptidase M3 family) 0.0119012
SLC38A7 solute carrier family 38, member 7 0.0119002
NPEPPS aminopeptidase puromycin sensitive 0.0118856
C18ORF25 chromosome 18 open reading frame 25 0.0118812
MBD4 methyl-CpG binding domain protein 4 0.0118749
ATP5MC1 ATP synthase membrane subunit c locus 1 0.0118746
NRP2 neuropilin 2 0.0118718

decreased expression

Symbol Name Standardized Value
MTUS1 microtubule associated tumor suppressor 1 -0.0927336
MKI67 marker of proliferation Ki-67 -0.0861154
TPM4 tropomyosin 4 -0.07539
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0717341
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0712377
CNTN1 contactin 1 -0.0708379
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0699745
JMJD1C jumonji domain containing 1C -0.0674991
CENPF centromere protein F, 350/400kDa -0.062363
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0591372
TOP2A topoisomerase (DNA) II alpha 170kDa -0.056577
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0549097
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0548859
PDLIM5 PDZ and LIM domain 5 -0.0521701
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.050508
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -0.0500467
PSD3 pleckstrin and Sec7 domain containing 3 -0.0486662
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.0485323
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0484882
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.048364
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0482861
PKM pyruvate kinase, muscle -0.0479586
FAF1 Fas (TNFRSF6) associated factor 1 -0.0465285
XPO1 exportin 1 -0.0459164
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0456262
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0448294
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0446574
VMP1 vacuole membrane protein 1 -0.0442906
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0440675
UBL4A ubiquitin-like 4A -0.0439976
SMC4 structural maintenance of chromosomes 4 -0.0429913
ACTG1 actin gamma 1 -0.0416959
ARHGAP26 Rho GTPase activating protein 26 -0.0406595
RPS5 ribosomal protein S5 -0.0404454
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0401219
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0398244
IRS2 insulin receptor substrate 2 -0.0394873
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0389844
RBL1 retinoblastoma-like 1 -0.038421
FN1 fibronectin 1 -0.038215
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0378896
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0377374
CUX1 cut-like homeobox 1 -0.0364892
BMPR1B bone morphogenetic protein receptor, type IB -0.0364603
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.036054
THSD7A thrombospondin, type I, domain containing 7A -0.0357778
MYO19 myosin XIX -0.0354743
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0354092
GSPT1 G1 to S phase transition 1 -0.0351914
CP ceruloplasmin (ferroxidase) -0.0351224
FCGBP Fc fragment of IgG binding protein -0.034997
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0349358
MCU mitochondrial calcium uniporter -0.0348458
TACC2 transforming, acidic coiled-coil containing protein 2 -0.0345063
USP36 ubiquitin specific peptidase 36 -0.0344962
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0344821
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0342965
WNK1 WNK lysine deficient protein kinase 1 -0.0340714
MCM4 minichromosome maintenance complex component 4 -0.0337215
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0329808
SGMS1 sphingomyelin synthase 1 -0.0329717
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0325181
SPIDR scaffolding protein involved in DNA repair -0.0321671
EML4 echinoderm microtubule associated protein like 4 -0.0320879
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0316641
RPS8 ribosomal protein S8 -0.0314213
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -0.0312113
EEF2 eukaryotic translation elongation factor 2 -0.0310047
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0308252
CKAP5 cytoskeleton associated protein 5 -0.0305227
JPT1 Jupiter microtubule associated homolog 1 -0.030354
EXOC6 exocyst complex component 6 -0.0303424
ARHGAP11B Rho GTPase activating protein 11B -0.0302486
FTH1 ferritin, heavy polypeptide 1 -0.0301873
KNTC1 kinetochore associated 1 -0.0301841
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0301752
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.030093
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.029841
POGZ pogo transposable element with ZNF domain -0.0298409
TPX2 TPX2, microtubule-associated -0.0298262
NBAS neuroblastoma amplified sequence -0.029765
SCAF11 SR-related CTD-associated factor 11 -0.0297186
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -0.0296733
SET SET nuclear proto-oncogene -0.029622
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0289997
FGA fibrinogen alpha chain -0.0287062
KIF18B kinesin family member 18B -0.028658
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0286232
NECTIN2 nectin cell adhesion molecule 2 -0.0283787
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0282402
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.0281926
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0280097
FANCI Fanconi anemia, complementation group I -0.0279952
RPL15 ribosomal protein L15 -0.0279914
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.027919
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) -0.0278411
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0277321
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0276884
TMSB10 thymosin beta 10 -0.0276843
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.0276008
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0274298
LDHA lactate dehydrogenase A -0.0273611
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0273568
TM4SF1 transmembrane 4 L six family member 1 -0.0273439
FGB fibrinogen beta chain -0.0271495
CCDC88A coiled-coil domain containing 88A -0.0271315
UBE3C ubiquitin protein ligase E3C -0.0270614
AKR1C3 aldo-keto reductase family 1, member C3 -0.0270155
LUC7L LUC7-like (S. cerevisiae) -0.0269517
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0267806
NSD2 nuclear receptor binding SET domain protein 2 -0.0266583
RPLP2 ribosomal protein, large, P2 -0.0265903
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.026532
GRAMD1B GRAM domain containing 1B -0.0264271
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0264085
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0263808
SETD5 SET domain containing 5 -0.0263607
PON2 paraoxonase 2 -0.0262966
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0261987
SAE1 SUMO1 activating enzyme subunit 1 -0.0261515
CNTNAP3B contactin associated protein-like 3B -0.0261112
ZNF609 zinc finger protein 609 -0.026032
PUM2 pumilio RNA-binding family member 2 -0.0259277
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0254912
CNKSR3 CNKSR family member 3 -0.0254711
BSG basigin (Ok blood group) -0.0253995
AKAP12 A kinase (PRKA) anchor protein 12 -0.0253652
GCLC glutamate-cysteine ligase, catalytic subunit -0.0253301
CKAP4 cytoskeleton-associated protein 4 -0.0253233
VASP vasodilator-stimulated phosphoprotein -0.0253046
HDAC8 histone deacetylase 8 -0.0252939
USP37 ubiquitin specific peptidase 37 -0.0252844
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.025252
RPS3 ribosomal protein S3 -0.0251798
KIF11 kinesin family member 11 -0.0249721
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0249511
KIFC3 kinesin family member C3 -0.0249285
ARHGAP5 Rho GTPase activating protein 5 -0.0249219
EXT1 exostosin glycosyltransferase 1 -0.0247749
PLEKHA6 pleckstrin homology domain containing, family A member 6 -0.0247461
HM13 histocompatibility (minor) 13 -0.0247438
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0247017
RPL38 ribosomal protein L38 -0.0246474
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0245366
RTN4 reticulon 4 -0.0245118
KLF13 Kruppel-like factor 13 -0.0244919
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0244892
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) -0.0244832
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0244217
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0243921
STK24 serine/threonine kinase 24 -0.0243141
TRAPPC9 trafficking protein particle complex 9 -0.0242775
KMT2A lysine (K)-specific methyltransferase 2A -0.024245
GEN1 GEN1 Holliday junction 5' flap endonuclease -0.0242211
SMIM44 small integral membrane protein 44 -0.0242205
GPATCH8 G patch domain containing 8 -0.0241916
DENND5B DENN/MADD domain containing 5B -0.0240251
THOC2 THO complex 2 -0.0240117
SNAP25 synaptosomal-associated protein, 25kDa -0.0239061
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 -0.0238589
IGFBP3 insulin-like growth factor binding protein 3 -0.0237785
KIF14 kinesin family member 14 -0.0236632
RBM39 RNA binding motif protein 39 -0.0235658
IL6ST interleukin 6 signal transducer -0.0234812
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.0234381
ANAPC5 anaphase promoting complex subunit 5 -0.0233596
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 -0.0232009
PDE8A phosphodiesterase 8A -0.0231995
NFIB nuclear factor I/B -0.0231777
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase -0.0231517
WWOX WW domain containing oxidoreductase -0.02314
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0230863
FANCA Fanconi anemia, complementation group A -0.0230465
MBTD1 mbt domain containing 1 -0.0229012
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0227543
NUP88 nucleoporin 88kDa -0.0227297
RPS6 ribosomal protein S6 -0.022698
TUBA1B tubulin, alpha 1b -0.0226723
TUBGCP5 tubulin, gamma complex associated protein 5 -0.0224986
NEO1 neogenin 1 -0.0224608
OPHN1 oligophrenin 1 -0.0224031
RPN1 ribophorin I -0.0223444
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0223387
AHI1 Abelson helper integration site 1 -0.0223246
ACACA acetyl-CoA carboxylase alpha -0.0223245
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0222904
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) -0.0222774
PRELID2 PRELI domain containing 2 -0.0222202
DTNB dystrobrevin, beta -0.0221253
CSNK2A2 casein kinase 2, alpha prime polypeptide -0.021925
ATXN2 ataxin 2 -0.021923
PFN1 profilin 1 -0.0219086
LIN52 lin-52 DREAM MuvB core complex component -0.0217351
ZSWIM7 zinc finger, SWIM-type containing 7 -0.021693
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.021607
TM4SF4 transmembrane 4 L six family member 4 -0.0216031
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.021597
SPAG9 sperm associated antigen 9 -0.0215663
PRC1 protein regulator of cytokinesis 1 -0.0215347
SHTN1 shootin 1 -0.0215273
TTC28 tetratricopeptide repeat domain 28 -0.0213549
SREBF1 sterol regulatory element binding transcription factor 1 -0.0212891
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0212832
VIM vimentin -0.0212775
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0212462
MIS18BP1 MIS18 binding protein 1 -0.0211766
BRCA1 breast cancer 1, early onset -0.0211508
RAB11FIP3 RAB11 family interacting protein 3 (class II) -0.0211427
WAC WW domain containing adaptor with coiled-coil -0.0211148
RPS11 ribosomal protein S11 -0.021104
CENPE centromere protein E, 312kDa -0.0210407
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 -0.0209907
GRAMD1A GRAM domain containing 1A -0.0209893
OLA1 Obg-like ATPase 1 -0.0209324
SETX senataxin -0.0209244
ARMH3 armadillo like helical domain containing 3 -0.0209205
HNRNPF heterogeneous nuclear ribonucleoprotein F -0.0208672
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0207667
PLAUR plasminogen activator, urokinase receptor -0.0207241
NCAPG2 non-SMC condensin II complex, subunit G2 -0.0206902
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 -0.0206833
NOSTRIN nitric oxide synthase trafficking -0.0206807
ARF4 ADP-ribosylation factor 4 -0.020669
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha -0.0206232
EFTUD2 elongation factor Tu GTP binding domain containing 2 -0.0206083
ARID1A AT rich interactive domain 1A (SWI-like) -0.0206042
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0205765
SMC6 structural maintenance of chromosomes 6 -0.0205643
POTEF POTE ankyrin domain family, member F -0.0205383
DIAPH3 diaphanous-related formin 3 -0.0204909
R3HDM1 R3H domain containing 1 -0.0204829
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0204716
PHGDH phosphoglycerate dehydrogenase -0.0204197
PRR11 proline rich 11 -0.020406
CCAR1 cell division cycle and apoptosis regulator 1 -0.0203953
SEPTIN11 septin 11 -0.0203941
MDN1 MDN1, midasin homolog (yeast) -0.0203812
SCAF8 SR-related CTD-associated factor 8 -0.020328
ANKRD17 ankyrin repeat domain 17 -0.0202308
ETF1 eukaryotic translation termination factor 1 -0.0202021
RNGTT RNA guanylyltransferase and 5'-phosphatase -0.0201288
GLG1 golgi glycoprotein 1 -0.0200083
ESYT2 extended synaptotagmin-like protein 2 -0.0199945
UBE2Z ubiquitin-conjugating enzyme E2Z -0.019986
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0199681
STRN3 striatin, calmodulin binding protein 3 -0.0199597
ATAD2 ATPase family, AAA domain containing 2 -0.0199127
RABL6 RAB, member RAS oncogene family-like 6 -0.0198693
SRFBP1 serum response factor binding protein 1 -0.0198536
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0198398
CALU calumenin -0.0197659
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0197608
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0196651
NONO non-POU domain containing, octamer-binding -0.019514
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0194965
HJURP Holliday junction recognition protein -0.0194432
SIN3A SIN3 transcription regulator family member A -0.019389
TPI1 triosephosphate isomerase 1 -0.0193884
ZFHX3 zinc finger homeobox 3 -0.0193741
SERINC5 serine incorporator 5 -0.0193713
RHOBTB1 Rho-related BTB domain containing 1 -0.0193598
PBRM1 polybromo 1 -0.019325
ASXL1 additional sex combs like transcriptional regulator 1 -0.0192667
RPS19 ribosomal protein S19 -0.01925
ATP13A3 ATPase type 13A3 -0.0192417
SLA2 Src-like-adaptor 2 -0.019228
NUP98 nucleoporin 98kDa -0.0192233
BRI3BP BRI3 binding protein -0.0192119
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.0191894
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.0191712
FAM107B family with sequence similarity 107, member B -0.0191677
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 -0.0190631
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0190604
MSH2 mutS homolog 2 -0.0190511
STRN striatin, calmodulin binding protein -0.019005
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 -0.0189656
HPCAL1 hippocalcin-like 1 -0.0189411
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0187805
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0187312
HMGA1 high mobility group AT-hook 1 -0.0187223
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0187116
ATAD5 ATPase family, AAA domain containing 5 -0.018708
RBM6 RNA binding motif protein 6 -0.0187022
CHN1 chimerin 1 -0.0186602
CEP112 centrosomal protein 112kDa -0.0186225
ARL15 ADP-ribosylation factor-like 15 -0.0185886
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0185698
NINL ninein-like -0.0185265
TICRR TOPBP1-interacting checkpoint and replication regulator -0.0184448
CLASP1 cytoplasmic linker associated protein 1 -0.0184126
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 -0.0183984
IER3 immediate early response 3 -0.0183024
TOP6BL TOP6B like initiator of meiotic double strand breaks -0.0182923
COL4A4 collagen, type IV, alpha 4 -0.0182276
LIN9 lin-9 DREAM MuvB core complex component -0.0181858
TMEM165 transmembrane protein 165 -0.0181772
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -0.018098
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 -0.0180948
NOP58 NOP58 ribonucleoprotein -0.0180837
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0180678
POU2F1 POU class 2 homeobox 1 -0.0180026
HELLS helicase, lymphoid-specific -0.0179747
OSBPL10 oxysterol binding protein-like 10 -0.0179545
KANK1 KN motif and ankyrin repeat domains 1 -0.0179431
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0179146
LETMD1 LETM1 domain containing 1 -0.0178744
POLK polymerase (DNA directed) kappa -0.0178736
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0177858
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0177783
DBF4B DBF4 zinc finger B -0.017745
CEP192 centrosomal protein 192kDa -0.0177097
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) -0.0177005
FAR1 fatty acyl CoA reductase 1 -0.0176905
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0176523
WDHD1 WD repeat and HMG-box DNA binding protein 1 -0.0176426
RIOK3 RIO kinase 3 -0.0176346
KIF13A kinesin family member 13A -0.0175679
TUBB tubulin, beta class I -0.0175252
THRAP3 thyroid hormone receptor associated protein 3 -0.0175189
MGLL monoglyceride lipase -0.0175038
CBX5 chromobox homolog 5 -0.0174606
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0174227
RBMX RNA binding motif protein, X-linked -0.017414
MISP mitotic spindle positioning -0.0174074
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.0173248
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -0.0173242
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0173006
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa -0.01727
FLVCR1 feline leukemia virus subgroup C cellular receptor 1 -0.0172585
INTS7 integrator complex subunit 7 -0.0171357
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -0.0171061
NKTR natural killer cell triggering receptor -0.017085
TNPO3 transportin 3 -0.0170652
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0170318
AKAP10 A kinase (PRKA) anchor protein 10 -0.0170029
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 -0.0169957
RETREG3 reticulophagy regulator family member 3 -0.016977
PCGF6 polycomb group ring finger 6 -0.0169589
TRIO trio Rho guanine nucleotide exchange factor -0.0169469
MAPK6 mitogen-activated protein kinase 6 -0.0169271
NF1 neurofibromin 1 -0.0169247
SHMT1 serine hydroxymethyltransferase 1 (soluble) -0.0169138
BRD4 bromodomain containing 4 -0.0168257
MORF4L1 mortality factor 4 like 1 -0.0168162
SLC38A2 solute carrier family 38, member 2 -0.0167895
CNTLN centlein, centrosomal protein -0.0167867
EIF5B eukaryotic translation initiation factor 5B -0.0167622
LOC112694756 uncharaterized LOC112694756 -0.0167341
ECT2 epithelial cell transforming 2 -0.016731
MYADM myeloid-associated differentiation marker -0.0167232
ECE1 endothelin converting enzyme 1 -0.0167188
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 -0.0167004
RAB33B RAB33B, member RAS oncogene family -0.0166859
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0166312
USP53 ubiquitin specific peptidase 53 -0.0166048
SPPL3 signal peptide peptidase like 3 -0.0165718
ILF3 interleukin enhancer binding factor 3, 90kDa -0.0165472
RBBP7 retinoblastoma binding protein 7 -0.0164546
FGG fibrinogen gamma chain -0.0164528
ATE1 arginyltransferase 1 -0.0164353
PRPF6 pre-mRNA processing factor 6 -0.0163958
ALS2 amyotrophic lateral sclerosis 2 (juvenile) -0.0163941
NUP155 nucleoporin 155kDa -0.016383
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0163608
TENT2 terminal nucleotidyltransferase 2 -0.016302
TMEM181 transmembrane protein 181 -0.0162836
PRPF3 pre-mRNA processing factor 3 -0.0162461
TOM1L1 target of myb1 (chicken)-like 1 -0.0162118
GNB5 guanine nucleotide binding protein (G protein), beta 5 -0.0162114
DPYSL2 dihydropyrimidinase-like 2 -0.0162057
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0162036
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 -0.0161635
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -0.0161211
KPNA6 karyopherin alpha 6 (importin alpha 7) -0.0160985
ANLN anillin, actin binding protein -0.0160926
GOLGA2 golgin A2 -0.0160915
COG7 component of oligomeric golgi complex 7 -0.0160868
RRP1B ribosomal RNA processing 1B -0.0160856
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0160285
RB1CC1 RB1-inducible coiled-coil 1 -0.01602
MESD mesoderm development LRP chaperone -0.0159917
ANKRD11 ankyrin repeat domain 11 -0.0159485
TAOK1 TAO kinase 1 -0.0158832
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0158816
HSPA8 heat shock 70kDa protein 8 -0.0158658
ABI2 abl-interactor 2 -0.0158607
LARP4B La ribonucleoprotein domain family, member 4B -0.0158509
HACD1 3-hydroxyacyl-CoA dehydratase 1 -0.015849
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0158336
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0158254
SENP1 SUMO1/sentrin specific peptidase 1 -0.01581
TLK2 tousled-like kinase 2 -0.0158076
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0158011
SINHCAF SIN3-HDAC complex associated factor -0.0157994
MTDH metadherin -0.0157761
USP54 ubiquitin specific peptidase 54 -0.0157748
RSF1 remodeling and spacing factor 1 -0.0157531
NUP210 nucleoporin 210kDa -0.0157378
BLM Bloom syndrome, RecQ helicase-like -0.0157112
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase -0.0156999
FAM177A1 family with sequence similarity 177, member A1 -0.0156974
TP53 tumor protein p53 -0.0156959
LRIF1 ligand dependent nuclear receptor interacting factor 1 -0.0156885
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0156589
CTCF CCCTC-binding factor (zinc finger protein) -0.0156495
SMC3 structural maintenance of chromosomes 3 -0.0156473
PDS5A PDS5 cohesin associated factor A -0.0155888
CARNMT1 carnosine N-methyltransferase 1 -0.0155755
RBBP4 retinoblastoma binding protein 4 -0.0155707
WDR62 WD repeat domain 62 -0.0155566
MYO5C myosin VC -0.0155228
RNF130 ring finger protein 130 -0.0154723
RPL8 ribosomal protein L8 -0.0154581
FOXJ3 forkhead box J3 -0.0154571
BIRC6 baculoviral IAP repeat containing 6 -0.0154568
POLR1A polymerase (RNA) I polypeptide A, 194kDa -0.0154141
RNF149 ring finger protein 149 -0.0153978
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha -0.015386
FAM20B family with sequence similarity 20, member B -0.015383
PLD3 phospholipase D family, member 3 -0.0153803
NUP107 nucleoporin 107kDa -0.0153782
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.015373
KCNT2 potassium channel, sodium activated subfamily T, member 2 -0.0153233
PDIA5 protein disulfide isomerase family A, member 5 -0.0152739
ZNRF3 zinc and ring finger 3 -0.0152587
MSH3 mutS homolog 3 -0.0152492
CEP290 centrosomal protein 290kDa -0.0152417
YY1 YY1 transcription factor -0.0152268
QRICH1 glutamine-rich 1 -0.0152104
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) -0.0151989
CCDC138 coiled-coil domain containing 138 -0.0151882
MCM10 minichromosome maintenance complex component 10 -0.0151857
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.01514
SIK2 salt-inducible kinase 2 -0.0151389
LIMCH1 LIM and calponin homology domains 1 -0.0150791
RPL27 ribosomal protein L27 -0.0150731
COPE coatomer protein complex, subunit epsilon -0.0150184
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0149956
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0149857
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0149713
TOP1 topoisomerase (DNA) I -0.0149502
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0149417
EGR1 early growth response 1 -0.0149411
RSRC1 arginine/serine-rich coiled-coil 1 -0.0149392
RNF213 ring finger protein 213 -0.0149368
KLF3 Kruppel-like factor 3 (basic) -0.0149224
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0149214
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) -0.0149194
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -0.0148656
RAP1B RAP1B, member of RAS oncogene family -0.0148637
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.014844
TMEM248 transmembrane protein 248 -0.0148235
LCOR ligand dependent nuclear receptor corepressor -0.0147916
TBX18 T-box 18 -0.0147768
ARL5B ADP-ribosylation factor-like 5B -0.0147131
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0147114
SMAD2 SMAD family member 2 -0.0146915
SURF4 surfeit 4 -0.0146787
TRIM26 tripartite motif containing 26 -0.0146783
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -0.0146618
SKIL SKI-like proto-oncogene -0.0146476
PGK1 phosphoglycerate kinase 1 -0.0146359
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0145727
TNPO1 transportin 1 -0.0145716
RNF34 ring finger protein 34, E3 ubiquitin protein ligase -0.0145599
IARS1 isoleucyl-tRNA synthetase 1 -0.0145546
MORF4L2 mortality factor 4 like 2 -0.0144948
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -0.0144889
BCLAF1 BCL2-associated transcription factor 1 -0.0144854
NOVA1 neuro-oncological ventral antigen 1 -0.0144111
BMP6 bone morphogenetic protein 6 -0.014406
CHPT1 choline phosphotransferase 1 -0.0143657
NUDC nudC nuclear distribution protein -0.0143353
DIAPH2 diaphanous-related formin 2 -0.0143258
LDLRAD3 low density lipoprotein receptor class A domain containing 3 -0.0143077
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0143057
CASP8AP2 caspase 8 associated protein 2 -0.0142936
AGTPBP1 ATP/GTP binding protein 1 -0.0142774
SF3B3 splicing factor 3b, subunit 3, 130kDa -0.014276
MRPS27 mitochondrial ribosomal protein S27 -0.0142759
TRIM28 tripartite motif containing 28 -0.0142567
VRK1 vaccinia related kinase 1 -0.0142538
RPS16 ribosomal protein S16 -0.0142426
EIF3A eukaryotic translation initiation factor 3, subunit A -0.01424
COX5A cytochrome c oxidase subunit Va -0.0142186
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0142002
SCLT1 sodium channel and clathrin linker 1 -0.0141951
ZNF331 zinc finger protein 331 -0.0141744
METTL16 methyltransferase like 16 -0.0141727
CNOT9 CCR4-NOT transcription complex subunit 9 -0.0141686
TTC39C tetratricopeptide repeat domain 39C -0.0141551
YAF2 YY1 associated factor 2 -0.014141
HDAC2 histone deacetylase 2 -0.0141342
TMEM184B transmembrane protein 184B -0.0141204
RCOR1 REST corepressor 1 -0.0141193
CCSER2 coiled-coil serine-rich protein 2 -0.0140925
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0140911
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa -0.0140736
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 -0.0140736
ETHE1 ethylmalonic encephalopathy 1 -0.014046