A549_SNS-314 Mesylate_10µM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description SNS-314 Mesylate 10µM perturbation in A549 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the A549_SNS-314 Mesylate_10µM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
KRT81 keratin 81, type II 0.183759
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.147226
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.139313
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.137042
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.124025
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.116961
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.112097
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.10851
KRT18 keratin 18, type I 0.108473
ITGB4 integrin, beta 4 0.105827
AGR2 anterior gradient 2 0.101625
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0909393
ACTN4 actinin, alpha 4 0.0908479
ASPH aspartate beta-hydroxylase 0.0861916
SYT1 synaptotagmin I 0.0847811
KRT8 keratin 8, type II 0.0796159
IGFBP4 insulin-like growth factor binding protein 4 0.0753486
PRKCA protein kinase C, alpha 0.0739588
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0719594
FLNB filamin B, beta 0.0707911
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0624252
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0623332
GLG1 golgi glycoprotein 1 0.0620527
ADGRG6 adhesion G protein-coupled receptor G6 0.0619715
BCAS3 breast carcinoma amplified sequence 3 0.0607313
KRT7 keratin 7, type II 0.0551356
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0544863
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0535819
NPAS2 neuronal PAS domain protein 2 0.0528911
THSD4 thrombospondin, type I, domain containing 4 0.0517177
RORA RAR-related orphan receptor A 0.0499247
UBL4A ubiquitin-like 4A 0.0493437
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.0486924
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0484453
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0473977
PTPRM protein tyrosine phosphatase, receptor type, M 0.0461845
LPGAT1 lysophosphatidylglycerol acyltransferase 1 0.0460187
TM7SF3 transmembrane 7 superfamily member 3 0.0452966
TRIP12 thyroid hormone receptor interactor 12 0.0452311
MORC4 MORC family CW-type zinc finger 4 0.0450632
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.0436054
COL5A2 collagen, type V, alpha 2 0.0428201
AHNAK2 AHNAK nucleoprotein 2 0.0425396
DENND5B DENN/MADD domain containing 5B 0.042517
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.042363
TMSB10 thymosin beta 10 0.0416215
MPRIP myosin phosphatase Rho interacting protein 0.0410368
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0399097
SLC38A1 solute carrier family 38, member 1 0.0389672
MAP1B microtubule-associated protein 1B 0.038689
MAML3 mastermind-like 3 (Drosophila) 0.0386777
KRT19 keratin 19, type I 0.03822
GRAMD1B GRAM domain containing 1B 0.0378594
MYOF myoferlin 0.0376893
RPL19 ribosomal protein L19 0.0364778
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0352417
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0352346
ANKRD11 ankyrin repeat domain 11 0.035019
ZFHX3 zinc finger homeobox 3 0.0348576
ALCAM activated leukocyte cell adhesion molecule 0.0337806
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0333528
ZFP36L1 ZFP36 ring finger protein-like 1 0.0332492
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0332247
PON2 paraoxonase 2 0.0330939
PHF14 PHD finger protein 14 0.0324783
METTL15 methyltransferase like 15 0.0323268
MACF1 microtubule-actin crosslinking factor 1 0.0318184
PLCE1 phospholipase C, epsilon 1 0.0315762
ITGB5 integrin, beta 5 0.0314852
POTEF POTE ankyrin domain family, member F 0.031241
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0310483
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.031046
PDIA6 protein disulfide isomerase family A, member 6 0.0304599
LRP10 low density lipoprotein receptor-related protein 10 0.0301538
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0301155
PRKD2 protein kinase D2 0.0297731
COL4A5 collagen, type IV, alpha 5 0.0295544
ACTG1 actin gamma 1 0.0287363
KIRREL3 kin of IRRE like 3 (Drosophila) 0.0284103
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0284081
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0283159
FLNA filamin A, alpha 0.0280425
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.02791
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 0.0271656
ACYP2 acylphosphatase 2, muscle type 0.0270522
CNTNAP3B contactin associated protein-like 3B 0.0269695
SH3KBP1 SH3-domain kinase binding protein 1 0.0268715
MYO1E myosin IE 0.0267217
ITGA6 integrin, alpha 6 0.0266304
PCNX2 pecanex 2 0.0266122
RPS2 ribosomal protein S2 0.0264993
TNS4 tensin 4 0.02627
TTC28 tetratricopeptide repeat domain 28 0.0260559
PDE4B phosphodiesterase 4B, cAMP-specific 0.0258535
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0254951
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0254198
NCEH1 neutral cholesterol ester hydrolase 1 0.0252074
IGFBP3 insulin-like growth factor binding protein 3 0.0250843
HIPK2 homeodomain interacting protein kinase 2 0.025009
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0249231
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.0247041
SIDT1 SID1 transmembrane family, member 1 0.0245569
RACK1 receptor for activated C kinase 1 0.0242906
PCYOX1 prenylcysteine oxidase 1 0.0240681
ERCC6L2 excision repair cross-complementation group 6-like 2 0.023998
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 0.0236207
USP8 ubiquitin specific peptidase 8 0.023428
PBX1 pre-B-cell leukemia homeobox 1 0.0233421
BSG basigin (Ok blood group) 0.0232789
RNF145 ring finger protein 145 0.0232359
ATP5F1B ATP synthase F1 subunit beta 0.023234
CAPNS1 calpain, small subunit 1 0.0232061
ECE1 endothelin converting enzyme 1 0.0231967
COL4A6 collagen, type IV, alpha 6 0.0230768
RPLP0 ribosomal protein, large, P0 0.0228293
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0228168
AARS1 alanyl-tRNA synthetase 1 0.0224728
CST3 cystatin C 0.0221959
RPL13A ribosomal protein L13a 0.0218809
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0218788
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.0216767
ARMH1 armadillo like helical domain containing 1 0.0216532
LRMDA leucine rich melanocyte differentiation associated 0.0215732
ARB2A ARB2 cotranscriptional regulator A 0.0215105
RPS5 ribosomal protein S5 0.0214516
LPP LIM domain containing preferred translocation partner in lipoma 0.0214243
ZNF652 zinc finger protein 652 0.0213327
RAD51B RAD51 paralog B 0.0211045
S100A6 S100 calcium binding protein A6 0.0210838
RPS29 ribosomal protein S29 0.0210021
PKN2 protein kinase N2 0.0209467
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0208865
PFN1 profilin 1 0.0208693
MON2 MON2 homolog (S. cerevisiae) 0.0208463
DGKG diacylglycerol kinase, gamma 90kDa 0.0207644
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0207186
WDFY3 WD repeat and FYVE domain containing 3 0.0207019
SPICE1 spindle and centriole associated protein 1 0.0206233
MED13L mediator complex subunit 13-like 0.0204519
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.0204373
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0204351
FNDC3B fibronectin type III domain containing 3B 0.0203203
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0202511
RTN4 reticulon 4 0.0198495
HRNR hornerin 0.0197679
CFAP44 cilia and flagella associated protein 44 0.0196824
DSCAM Down syndrome cell adhesion molecule 0.0196326
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.019572
SIL1 SIL1 nucleotide exchange factor 0.0195404
CLU clusterin 0.0193843
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 0.0192721
GSK3B glycogen synthase kinase 3 beta 0.0192539
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 0.0192058
RPS24 ribosomal protein S24 0.019169
ASCC1 activating signal cointegrator 1 complex subunit 1 0.0191469
DOCK5 dedicator of cytokinesis 5 0.0191342
MED13 mediator complex subunit 13 0.0191129
SUMF1 sulfatase modifying factor 1 0.0190781
CD81 CD81 molecule 0.0190388
NLK nemo-like kinase 0.0189385
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0189133
RPS8 ribosomal protein S8 0.0189124
ZBTB38 zinc finger and BTB domain containing 38 0.0188841
RIN2 Ras and Rab interactor 2 0.0188351
RPL37A ribosomal protein L37a 0.0188332
RPS4X ribosomal protein S4, X-linked 0.0188223
SH3PXD2A SH3 and PX domains 2A 0.0187968
IGSF11 immunoglobulin superfamily, member 11 0.0186678
NT5C2 5'-nucleotidase, cytosolic II 0.0185877
PLD3 phospholipase D family, member 3 0.0185279
PSAT1 phosphoserine aminotransferase 1 0.0184963
ARHGAP26 Rho GTPase activating protein 26 0.0184889
SLIT3 slit homolog 3 (Drosophila) 0.018487
EBF1 early B-cell factor 1 0.0184402
WDR72 WD repeat domain 72 0.0184381
SET SET nuclear proto-oncogene 0.0184141
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0183235
ARL4C ADP-ribosylation factor-like 4C 0.0180054
N4BP2L2 NEDD4 binding protein 2-like 2 0.0179464
RPS7 ribosomal protein S7 0.017883
FAM13A family with sequence similarity 13, member A 0.0178764
CKAP4 cytoskeleton-associated protein 4 0.0177774
HMBOX1 homeobox containing 1 0.0177677
MBD5 methyl-CpG binding domain protein 5 0.0176155
FAM107B family with sequence similarity 107, member B 0.0176075
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0175662
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0175486
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0175036
CCDC6 coiled-coil domain containing 6 0.0174174
GPHN gephyrin 0.0172873
AMOTL1 angiomotin like 1 0.0171696
ABTB3 ankyrin repeat and BTB domain containing 3 0.0171405
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 0.0170907
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0170683
ITPRID2 ITPR interacting domain containing 2 0.0170199
BCL2L1 BCL2-like 1 0.0169918
YIPF4 Yip1 domain family, member 4 0.0169762
TMEM106B transmembrane protein 106B 0.0168988
SYCP2 synaptonemal complex protein 2 0.0168541
RPS27L ribosomal protein S27-like 0.0168509
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0168502
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0167855
NRP2 neuropilin 2 0.0167728
RPL12 ribosomal protein L12 0.0167475
HMGA1 high mobility group AT-hook 1 0.0166957
RBMX RNA binding motif protein, X-linked 0.0166916
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0165904
SMYD3 SET and MYND domain containing 3 0.0165488
RPN2 ribophorin II 0.0164928
SGPP1 sphingosine-1-phosphate phosphatase 1 0.0164095
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 0.0164068
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.0163932
PCED1B PC-esterase domain containing 1B 0.0163824
TMEM230 transmembrane protein 230 0.0163817
MYO6 myosin VI 0.0163486
TMED3 transmembrane emp24 protein transport domain containing 3 0.0163021
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0162637
UBE2H ubiquitin-conjugating enzyme E2H 0.0162241
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.0161393
NEBL nebulette 0.0161223
CREB1 cAMP responsive element binding protein 1 0.0161016
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.0160787
YARS1 tyrosyl-tRNA synthetase 1 0.0160377
ZNF618 zinc finger protein 618 0.0159403
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0159154
NARS1 asparaginyl-tRNA synthetase 1 0.0159129
UNC13A unc-13 homolog A (C. elegans) 0.015756
FN1 fibronectin 1 0.0157119
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 0.0156498
NFE2L1 nuclear factor, erythroid 2-like 1 0.0156279
SMOX spermine oxidase 0.0156225
EIF3H eukaryotic translation initiation factor 3, subunit H 0.015621
RPL4 ribosomal protein L4 0.0155778
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0155576
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.0155315
HLTF helicase-like transcription factor 0.0154941
TFB1M transcription factor B1, mitochondrial 0.0154538
SNX17 sorting nexin 17 0.0154244
EGFR epidermal growth factor receptor 0.0153914
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0153623
RPL3 ribosomal protein L3 0.0153495
PYGB phosphorylase, glycogen; brain 0.0152994
PREPL prolyl endopeptidase-like 0.0152906
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) 0.015224
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.0152035
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.0151763
PRKX protein kinase, X-linked 0.0151083
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0150857
ITGAV integrin, alpha V 0.0150799
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.0150241
JAK1 Janus kinase 1 0.0149419
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0148971
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0148715
DNASE2 deoxyribonuclease II, lysosomal 0.0148018
MED29 mediator complex subunit 29 0.0147534
XPC xeroderma pigmentosum, complementation group C 0.0147424
AKR1C3 aldo-keto reductase family 1, member C3 0.0146458
SLFN5 schlafen family member 5 0.0146384
PIAS1 protein inhibitor of activated STAT, 1 0.0146349
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0146075
PRXL2A peroxiredoxin like 2A 0.0145876
BRWD3 bromodomain and WD repeat domain containing 3 0.0145633
CLINT1 clathrin interactor 1 0.0145593
ECPAS Ecm29 proteasome adaptor and scaffold 0.0144728
WWC1 WW and C2 domain containing 1 0.0144565
ANKRD30A ankyrin repeat domain 30A 0.014454
NAP1L1 nucleosome assembly protein 1-like 1 0.0144348
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 0.0144136
TUFM Tu translation elongation factor, mitochondrial 0.0144131
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.0144036
RAB14 RAB14, member RAS oncogene family 0.0143829
ETV6 ets variant 6 0.0143486
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0143149
BLTP1 bridge-like lipid transfer protein family member 1 0.0143148
KDSR 3-ketodihydrosphingosine reductase 0.0142562
H3-3B H3.3 histone B 0.0142265
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0141768
FDXR ferredoxin reductase 0.0141262
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 0.0140831
COPA coatomer protein complex, subunit alpha 0.0140574
TECPR2 tectonin beta-propeller repeat containing 2 0.0140438
RPL35 ribosomal protein L35 0.0140029
RPS15 ribosomal protein S15 0.0139019
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0138879
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0138699
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0138506
BCAR3 breast cancer anti-estrogen resistance 3 0.0138266
MAP2K5 mitogen-activated protein kinase kinase 5 0.0138119
SDC1 syndecan 1 0.0137231
RPL30 ribosomal protein L30 0.0136022
NRP1 neuropilin 1 0.0135489
TSPAN14 tetraspanin 14 0.0135425
RHOBTB1 Rho-related BTB domain containing 1 0.0135326
RPS11 ribosomal protein S11 0.0135313
YIPF5 Yip1 domain family, member 5 0.0135212
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 0.0135167
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0134889
SRPK2 SRSF protein kinase 2 0.0134855
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 0.0133914
S100A4 S100 calcium binding protein A4 0.0133883
MOB1A MOB kinase activator 1A 0.0133456
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0133182
PPP4R3A protein phosphatase 4 regulatory subunit 3A 0.013311
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa 0.0132987
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0132832
VPS25 vacuolar protein sorting 25 homolog (S. cerevisiae) 0.0132292
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.0132058
U2SURP U2 snRNP-associated SURP domain containing 0.0131411
ANAPC16 anaphase promoting complex subunit 16 0.0130848
ANXA7 annexin A7 0.0130543
PI4KB phosphatidylinositol 4-kinase, catalytic, beta 0.0130315
TIAM2 T-cell lymphoma invasion and metastasis 2 0.013019
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 0.0129689
TRAPPC9 trafficking protein particle complex 9 0.0129674
NBDY negative regulator of P-body association 0.0129608
PYCR1 pyrroline-5-carboxylate reductase 1 0.0129546
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0129333
ZC3H18 zinc finger CCCH-type containing 18 0.0128648
KIF3B kinesin family member 3B 0.0127826
CD63 CD63 molecule 0.0127825
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) 0.012768
IARS1 isoleucyl-tRNA synthetase 1 0.0127662
COG5 component of oligomeric golgi complex 5 0.0127655
PRICKLE1 prickle homolog 1 (Drosophila) 0.0127373
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 0.0127355
LAMA5 laminin, alpha 5 0.0127355
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0127232
URI1 URI1, prefoldin-like chaperone 0.0127142
RCN1 reticulocalbin 1, EF-hand calcium binding domain 0.0127
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) 0.0126959
SOCS5 suppressor of cytokine signaling 5 0.0126864
SEC63 SEC63 homolog (S. cerevisiae) 0.0126659
GPS1 G protein pathway suppressor 1 0.0126363
CCNI cyclin I 0.0126291
PRNP prion protein 0.0126153
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0126152
KAT6A K(lysine) acetyltransferase 6A 0.0126076
MCTP1 multiple C2 domains, transmembrane 1 0.0126013
SLK STE20-like kinase 0.0125823
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0125673
TP53I3 tumor protein p53 inducible protein 3 0.0125467
RPLP1 ribosomal protein, large, P1 0.0125281
TRIB3 tribbles pseudokinase 3 0.0124736
SLX4IP SLX4 interacting protein 0.0124611
CCNYL1 cyclin Y-like 1 0.0124469
TEX9 testis expressed 9 0.0124339
GNG12 guanine nucleotide binding protein (G protein), gamma 12 0.0124313
G6PC3 glucose 6 phosphatase, catalytic, 3 0.0124295
SENP6 SUMO1/sentrin specific peptidase 6 0.012315
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0123107
EVI5 ecotropic viral integration site 5 0.0122929
SYNGAP1 synaptic Ras GTPase activating protein 1 0.0122703
ATG7 autophagy related 7 0.012197
PRDX5 peroxiredoxin 5 0.0121849
WWC3 WWC family member 3 0.012183
MYO18A myosin XVIIIA 0.012176
IFT81 intraflagellar transport 81 0.0121519
TARS1 threonyl-tRNA synthetase 1 0.0121373
RPS27A ribosomal protein S27a 0.0121345
GSTP1 glutathione S-transferase pi 1 0.0121257
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.012073
CHD9 chromodomain helicase DNA binding protein 9 0.0120044
CLHC1 clathrin heavy chain linker domain containing 1 0.0120042
EHD2 EH-domain containing 2 0.0119478
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.0119467
MRRF mitochondrial ribosome recycling factor 0.0119443
GDNF glial cell derived neurotrophic factor 0.0119394
SNAP25 synaptosomal-associated protein, 25kDa 0.0119132
DNMBP dynamin binding protein 0.0119116
TRIM66 tripartite motif containing 66 0.0118856
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 0.0118348
XPR1 xenotropic and polytropic retrovirus receptor 1 0.011792
PTOV1 prostate tumor overexpressed 1 0.0117596
MMP28 matrix metallopeptidase 28 0.0117156
VEZT vezatin, adherens junctions transmembrane protein 0.0117147
LYPLA1 lysophospholipase I 0.0116841
THSD7A thrombospondin, type I, domain containing 7A 0.0116631
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.011658
HEXA hexosaminidase A (alpha polypeptide) 0.0116544
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0116256
GIPC1 GIPC PDZ domain containing family, member 1 0.0115522
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0115501
LDHB lactate dehydrogenase B 0.0115447
NUCB2 nucleobindin 2 0.0115412
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0115204
BAX BCL2-associated X protein 0.0115132
ZNF496 zinc finger protein 496 0.0114842
WNT7B wingless-type MMTV integration site family, member 7B 0.011483
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0114559
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0114113
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0114102
MTMR14 myotubularin related protein 14 0.0113775
KIAA2026 KIAA2026 0.0113557
SLC30A7 solute carrier family 30 (zinc transporter), member 7 0.0113479
SENP7 SUMO1/sentrin specific peptidase 7 0.0113195
TCERG1 transcription elongation regulator 1 0.0113139
GSN gelsolin 0.0113124
AHCTF1 AT hook containing transcription factor 1 0.0112949
FCGBP Fc fragment of IgG binding protein 0.0112501
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 0.0112458
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) 0.0112092
PTPN9 protein tyrosine phosphatase, non-receptor type 9 0.0112091
DPP9 dipeptidyl-peptidase 9 0.0111794
PUM1 pumilio RNA-binding family member 1 0.0111615
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0111524
VGLL3 vestigial-like family member 3 0.0111448
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 0.0111442
SOCS6 suppressor of cytokine signaling 6 0.0111412
NGLY1 N-glycanase 1 0.0111396
TMEM248 transmembrane protein 248 0.0111294
CLMN calmin (calponin-like, transmembrane) 0.0111137
MPZL1 myelin protein zero-like 1 0.0110717
FBXW11 F-box and WD repeat domain containing 11 0.0110595
LAMP2 lysosomal-associated membrane protein 2 0.0110455
TMBIM4 transmembrane BAX inhibitor motif containing 4 0.0110448
DMXL2 Dmx-like 2 0.0110189
ITPK1 inositol-tetrakisphosphate 1-kinase 0.0110144
PA2G4 proliferation-associated 2G4, 38kDa 0.0110049
DNHD1 dynein heavy chain domain 1 0.0109963
CCT7 chaperonin containing TCP1, subunit 7 (eta) 0.0109869
USP3 ubiquitin specific peptidase 3 0.0109865
NT5DC3 5'-nucleotidase domain containing 3 0.0109826
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.010975
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 0.010963
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0108828
JUP junction plakoglobin 0.0108815
APTX aprataxin 0.0108703
SSR1 signal sequence receptor, alpha 0.0108591
HEATR5A HEAT repeat containing 5A 0.0108458
ERCC4 excision repair cross-complementation group 4 0.0108422
CEMIP cell migration inducing protein, hyaluronan binding 0.0108415
SLC35F3 solute carrier family 35, member F3 0.0108292
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.0108121
MAP2K1 mitogen-activated protein kinase kinase 1 0.0108021
GINM1 glycoprotein integral membrane 1 0.0107936
RPL39 ribosomal protein L39 0.0107817
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0107414
EXPH5 exophilin 5 0.0107363
TBL1X transducin (beta)-like 1X-linked 0.0107353
CCDC68 coiled-coil domain containing 68 0.0107336
CCDC7 coiled-coil domain containing 7 0.0107221
ETV4 ets variant 4 0.0107055
LRP6 low density lipoprotein receptor-related protein 6 0.0107034
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 0.0106617
CDK13 cyclin-dependent kinase 13 0.010639
KIAA1217 KIAA1217 0.0106343
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0105928
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor 0.0105812
PXDN peroxidasin 0.0105576
HOXB3 homeobox B3 0.0105567
CATSPERB catsper channel auxiliary subunit beta 0.0105394
TOB2 transducer of ERBB2, 2 0.0105373
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.010525
TPRG1 tumor protein p63 regulated 1 0.0104692
FKBP14 FK506 binding protein 14, 22 kDa 0.0104683
TPD52L1 tumor protein D52-like 1 0.0104455
LDAH lipid droplet associated hydrolase 0.0104355
ZYG11B zyg-11 family member B, cell cycle regulator 0.0104059
PRSS23 protease, serine, 23 0.0104055
FLYWCH1 FLYWCH-type zinc finger 1 0.0103996
ASTN2 astrotactin 2 0.0103726
SIRT2 sirtuin 2 0.0103493
TP63 tumor protein p63 0.010348
MTMR3 myotubularin related protein 3 0.0103456
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0103451
ZFR zinc finger RNA binding protein 0.0103421
ECI1 enoyl-CoA delta isomerase 1 0.0103316
LIMCH1 LIM and calponin homology domains 1 0.0103287
CADPS2 Ca++-dependent secretion activator 2 0.0103063
SCRN1 secernin 1 0.0102815
ZNF280D zinc finger protein 280D 0.0102769
CLYBL citrate lyase beta like 0.0102649
CCPG1 cell cycle progression 1 0.0102601
GRB10 growth factor receptor-bound protein 10 0.0102523
CUEDC2 CUE domain containing 2 0.0102503
DSG2 desmoglein 2 0.0102463
RBM20 RNA binding motif protein 20 0.0102304
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 0.0102163
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0102117
DOCK4 dedicator of cytokinesis 4 0.0102079
PLCD3 phospholipase C, delta 3 0.0101893
UBA6 ubiquitin-like modifier activating enzyme 6 0.0101813
RHOC ras homolog family member C 0.0101718
TRIM33 tripartite motif containing 33 0.0101649
RBMS2 RNA binding motif, single stranded interacting protein 2 0.0101567
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 0.0101524
PLS1 plastin 1 0.0101302
PDZD8 PDZ domain containing 8 0.0101229
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0100918
SKIC3 SKI3 subunit of superkiller complex 0.0100861
ACER3 alkaline ceramidase 3 0.0100658
TOM1L2 target of myb1-like 2 (chicken) 0.0100468
CEP85L centrosomal protein 85kDa-like 0.0100384
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 0.0100245
RFLNB refilin B 0.00999928
RNF216 ring finger protein 216 0.00998921
MYO9A myosin IXA 0.00997485
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 0.00997068
NRCAM neuronal cell adhesion molecule 0.00996961
SSRP1 structure specific recognition protein 1 0.00994452

decreased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 -0.156597
FTL ferritin, light polypeptide -0.133444
PTGR1 prostaglandin reductase 1 -0.122403
CA12 carbonic anhydrase XII -0.119163
AKR1C1 aldo-keto reductase family 1, member C1 -0.0931407
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0886795
CNTN1 contactin 1 -0.088096
SQSTM1 sequestosome 1 -0.0869745
RAB10 RAB10, member RAS oncogene family -0.0840371
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0785372
MTUS1 microtubule associated tumor suppressor 1 -0.0777329
WWOX WW domain containing oxidoreductase -0.077691
PDE4D phosphodiesterase 4D, cAMP-specific -0.0767268
JMJD1C jumonji domain containing 1C -0.0728107
ZBTB20 zinc finger and BTB domain containing 20 -0.0725643
CUX1 cut-like homeobox 1 -0.0720554
GRAMD1A GRAM domain containing 1A -0.0655401
CENPF centromere protein F, 350/400kDa -0.0627917
MKI67 marker of proliferation Ki-67 -0.062636
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.0590178
MAP7 microtubule-associated protein 7 -0.0562124
PARD3 par-3 family cell polarity regulator -0.0553239
UGDH UDP-glucose 6-dehydrogenase -0.053852
AKR1C2 aldo-keto reductase family 1, member C2 -0.0522232
CYRIB CYFIP related Rac1 interactor B -0.0513979
CPLX2 complexin 2 -0.0503862
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -0.049969
EZR ezrin -0.0498103
BICC1 BicC family RNA binding protein 1 -0.0452649
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0440203
CTSD cathepsin D -0.043633
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.042599
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0425266
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0424847
ACACA acetyl-CoA carboxylase alpha -0.0422532
AGFG1 ArfGAP with FG repeats 1 -0.0407484
DAPK1 death-associated protein kinase 1 -0.0397583
BMPR1B bone morphogenetic protein receptor, type IB -0.0393415
BRCA1 breast cancer 1, early onset -0.0385732
TM4SF20 transmembrane 4 L six family member 20 -0.0382508
SFTPA2 surfactant protein A2 -0.0374416
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0372329
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.037225
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0371018
TACC2 transforming, acidic coiled-coil containing protein 2 -0.0369326
GEN1 GEN1 Holliday junction 5' flap endonuclease -0.0365581
EHBP1 EH domain binding protein 1 -0.0355117
ANKRD17 ankyrin repeat domain 17 -0.0350148
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0349708
ANXA1 annexin A1 -0.0349008
CLIP2 CAP-GLY domain containing linker protein 2 -0.0340985
PDE10A phosphodiesterase 10A -0.0339875
AOPEP aminopeptidase O (putative) -0.0337682
ZNF609 zinc finger protein 609 -0.0337211
XPO1 exportin 1 -0.0334847
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0334189
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) -0.0329762
DIAPH3 diaphanous-related formin 3 -0.0325768
STX8 syntaxin 8 -0.0324998
RBM6 RNA binding motif protein 6 -0.032454
ZNRF3 zinc and ring finger 3 -0.0324482
RASAL2 RAS protein activator like 2 -0.0324167
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0322984
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0322722
SIK3 SIK family kinase 3 -0.0322227
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0319114
GSR glutathione reductase -0.0318653
DSTN destrin (actin depolymerizing factor) -0.0317646
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0312835
CP ceruloplasmin (ferroxidase) -0.0309901
ANXA2 annexin A2 -0.030856
TPM4 tropomyosin 4 -0.030473
PCDHB16 protocadherin beta 16 -0.0302669
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0300529
FGB fibrinogen beta chain -0.0295159
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0294982
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.0291726
KTN1 kinectin 1 (kinesin receptor) -0.0290864
TNPO1 transportin 1 -0.0290392
MCU mitochondrial calcium uniporter -0.0285868
CELF1 CUGBP, Elav-like family member 1 -0.0285465
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0285451
HIP1 huntingtin interacting protein 1 -0.0283917
GCLM glutamate-cysteine ligase, modifier subunit -0.0280615
RHEB Ras homolog enriched in brain -0.0279885
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0279222
POLR1A polymerase (RNA) I polypeptide A, 194kDa -0.0278915
PTPRK protein tyrosine phosphatase, receptor type, K -0.027793
RPS16 ribosomal protein S16 -0.0277141
TPX2 TPX2, microtubule-associated -0.0276117
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0272563
RBL1 retinoblastoma-like 1 -0.0271557
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.027108
LARP4B La ribonucleoprotein domain family, member 4B -0.0270478
TMEM41B transmembrane protein 41B -0.0270185
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0269975
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0269624
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0267568
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -0.0267526
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0266293
ENO1 enolase 1, (alpha) -0.0263482
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0260395
CD44 CD44 molecule (Indian blood group) -0.0259655
TRIM37 tripartite motif containing 37 -0.0259616
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0259113
LDLR low density lipoprotein receptor -0.0258096
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 -0.0257272
AKAP13 A kinase (PRKA) anchor protein 13 -0.0257009
JPT1 Jupiter microtubule associated homolog 1 -0.0256921
MIS18BP1 MIS18 binding protein 1 -0.0256673
MYO19 myosin XIX -0.0256037
CMIP c-Maf inducing protein -0.0253702
MPHOSPH9 M-phase phosphoprotein 9 -0.0252144
PATJ PATJ crumbs cell polarity complex component -0.0250175
TMPO thymopoietin -0.0249859
PER2 period circadian clock 2 -0.0249475
ATAD2 ATPase family, AAA domain containing 2 -0.0249205
PTBP3 polypyrimidine tract binding protein 3 -0.024868
NUMB numb homolog (Drosophila) -0.0248391
RNF213 ring finger protein 213 -0.0248385
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0248338
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0246025
CHD4 chromodomain helicase DNA binding protein 4 -0.0244059
ARHGAP11B Rho GTPase activating protein 11B -0.0243522
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0242492
FAF1 Fas (TNFRSF6) associated factor 1 -0.0241835
SMIM44 small integral membrane protein 44 -0.023856
SREBF2 sterol regulatory element binding transcription factor 2 -0.0237823
DENND4C DENN/MADD domain containing 4C -0.0236817
FOSL1 FOS-like antigen 1 -0.0236776
KIF18B kinesin family member 18B -0.0235354
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit -0.0234756
PKM pyruvate kinase, muscle -0.0233887
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0233572
METTL16 methyltransferase like 16 -0.0232968
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0232879
CORO1C coronin, actin binding protein, 1C -0.0232623
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.023235
KPNB1 karyopherin (importin) beta 1 -0.0231759
LAMB1 laminin, beta 1 -0.0229927
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0229242
FANCI Fanconi anemia, complementation group I -0.0229157
TMOD3 tropomodulin 3 (ubiquitous) -0.0227445
PBX3 pre-B-cell leukemia homeobox 3 -0.0226337
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0225825
AVPI1 arginine vasopressin-induced 1 -0.0225537
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0224502
LOC112694756 uncharaterized LOC112694756 -0.0224324
EXOC6B exocyst complex component 6B -0.0224111
LRIF1 ligand dependent nuclear receptor interacting factor 1 -0.0223821
TP53 tumor protein p53 -0.0223733
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0223371
NAMPT nicotinamide phosphoribosyltransferase -0.0222878
MRTFB myocardin related transcription factor B -0.0222465
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0221508
CEP128 centrosomal protein 128kDa -0.0220849
WWTR1 WW domain containing transcription regulator 1 -0.0220134
OGA O-GlcNAcase -0.0218611
PARD3B par-3 family cell polarity regulator beta -0.0218571
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0217996
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0215695
NCAPG2 non-SMC condensin II complex, subunit G2 -0.0213459
NCOA1 nuclear receptor coactivator 1 -0.0212764
PDCD11 programmed cell death 11 -0.0212615
SHCBP1 SHC SH2-domain binding protein 1 -0.0211532
SPPL2A signal peptide peptidase like 2A -0.0210552
XRN2 5'-3' exoribonuclease 2 -0.0210192
CDC27 cell division cycle 27 -0.020839
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0208099
SOS1 son of sevenless homolog 1 (Drosophila) -0.0207751
NVL nuclear VCP-like -0.0207323
QRICH1 glutamine-rich 1 -0.0206318
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0205977
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0203348
IMMT inner membrane protein, mitochondrial -0.0203163
NSD2 nuclear receptor binding SET domain protein 2 -0.0203161
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0203082
SMAD2 SMAD family member 2 -0.0202941
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 -0.0202697
PRPF8 pre-mRNA processing factor 8 -0.0201341
FOXK2 forkhead box K2 -0.0201188
CCND1 cyclin D1 -0.0200055
IQCB1 IQ motif containing B1 -0.0199499
FLVCR1 feline leukemia virus subgroup C cellular receptor 1 -0.0199458
RIOK3 RIO kinase 3 -0.0198504
VDAC2 voltage-dependent anion channel 2 -0.0197743
KIF4A kinesin family member 4A -0.0197395
CLTC clathrin, heavy chain (Hc) -0.0196931
LMNA lamin A/C -0.0196233
PUM2 pumilio RNA-binding family member 2 -0.0195183
ZNF638 zinc finger protein 638 -0.0195121
PRKCE protein kinase C, epsilon -0.0193746
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0193199
MELK maternal embryonic leucine zipper kinase -0.0192705
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.0192443
TOPBP1 topoisomerase (DNA) II binding protein 1 -0.0192439
STIL SCL/TAL1 interrupting locus -0.0192147
CLDN2 claudin 2 -0.0191829
GMDS GDP-mannose 4,6-dehydratase -0.0191527
PHACTR2 phosphatase and actin regulator 2 -0.0191139
LITAF lipopolysaccharide-induced TNF factor -0.019058
DGKD diacylglycerol kinase, delta 130kDa -0.019042
SMG6 SMG6 nonsense mediated mRNA decay factor -0.0190181
CLASP1 cytoplasmic linker associated protein 1 -0.0190169
SYAP1 synapse associated protein 1 -0.0189926
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 -0.0188829
POLK polymerase (DNA directed) kappa -0.0188081
FANCA Fanconi anemia, complementation group A -0.0187434
FGA fibrinogen alpha chain -0.018711
TAOK3 TAO kinase 3 -0.0186993
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0186367
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.0186253
WDR62 WD repeat domain 62 -0.0185179
FTO fat mass and obesity associated -0.0184881
DENND1A DENN/MADD domain containing 1A -0.0184797
RNF43 ring finger protein 43 -0.0184636
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 -0.0184374
OLA1 Obg-like ATPase 1 -0.0184175
SHLD2 shieldin complex subunit 2 -0.0184044
DST dystonin -0.0183699
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase -0.0183648
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -0.0183603
VCL vinculin -0.0182552
UBAP2 ubiquitin associated protein 2 -0.0182244
TOP6BL TOP6B like initiator of meiotic double strand breaks -0.0182132
SESTD1 SEC14 and spectrin domains 1 -0.0181525
FAM193A family with sequence similarity 193, member A -0.0181101
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0180401
ATAD5 ATPase family, AAA domain containing 5 -0.018002
RFWD3 ring finger and WD repeat domain 3 -0.0179915
PRIM2 primase, DNA, polypeptide 2 (58kDa) -0.0179697
RTN3 reticulon 3 -0.0179565
BIRC6 baculoviral IAP repeat containing 6 -0.0179542
ETF1 eukaryotic translation termination factor 1 -0.0179285
MEGF9 multiple EGF-like-domains 9 -0.0179151
ARHGAP21 Rho GTPase activating protein 21 -0.0177723
SETBP1 SET binding protein 1 -0.0177578
TNPO3 transportin 3 -0.017735
TXN2 thioredoxin 2 -0.0177098
CYSTM1 cysteine-rich transmembrane module containing 1 -0.0176919
BLTP2 bridge-like lipid transfer protein family member 2 -0.0176831
NAP1L4 nucleosome assembly protein 1-like 4 -0.0176273
SPATS2 spermatogenesis associated, serine-rich 2 -0.0175928
PIR pirin (iron-binding nuclear protein) -0.0175899
HACD3 3-hydroxyacyl-CoA dehydratase 3 -0.0175115
DGKH diacylglycerol kinase, eta -0.0174896
CEP89 centrosomal protein 89kDa -0.0174772
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0174459
WDHD1 WD repeat and HMG-box DNA binding protein 1 -0.0174363
MPG N-methylpurine-DNA glycosylase -0.0172758
CDC42SE2 CDC42 small effector 2 -0.017246
NIPBL Nipped-B homolog (Drosophila) -0.017244
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.017207
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 -0.0171592
TEAD4 TEA domain family member 4 -0.0171539
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0171532
UNC13B unc-13 homolog B (C. elegans) -0.0170404
TBC1D14 TBC1 domain family, member 14 -0.0169938
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.016964
VCP valosin containing protein -0.0169323
MGLL monoglyceride lipase -0.0169084
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -0.0168881
SRBD1 S1 RNA binding domain 1 -0.0168696
TPR translocated promoter region, nuclear basket protein -0.016859
FBXL20 F-box and leucine-rich repeat protein 20 -0.0168493
PTPRF protein tyrosine phosphatase, receptor type, F -0.0168468
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.016815
AVEN apoptosis, caspase activation inhibitor -0.0167805
RUSC2 RUN and SH3 domain containing 2 -0.0167523
ATP13A3 ATPase type 13A3 -0.0166911
SMC4 structural maintenance of chromosomes 4 -0.0166901
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.016654
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0166476
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0165346
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0165315
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -0.0164928
NINL ninein-like -0.0164717
ZNF644 zinc finger protein 644 -0.0164669
ABHD2 abhydrolase domain containing 2 -0.0164303
PALLD palladin, cytoskeletal associated protein -0.0164218
USP9X ubiquitin specific peptidase 9, X-linked -0.0163827
BICD1 bicaudal D homolog 1 (Drosophila) -0.0163815
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) -0.0163207
PRR11 proline rich 11 -0.0163136
MAP4 microtubule-associated protein 4 -0.0163056
BMP6 bone morphogenetic protein 6 -0.0161762
FOXA2 forkhead box A2 -0.0161647
GTF2I general transcription factor IIi -0.0161485
SPAG9 sperm associated antigen 9 -0.0161219
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0160797
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein -0.0160038
TUBA1B tubulin, alpha 1b -0.0159812
PKP4 plakophilin 4 -0.0159352
TRAM1 translocation associated membrane protein 1 -0.0159006
EEF2 eukaryotic translation elongation factor 2 -0.0158698
MGST1 microsomal glutathione S-transferase 1 -0.0158176
BRI3BP BRI3 binding protein -0.0157814
GLS2 glutaminase 2 (liver, mitochondrial) -0.0157495
RBPMS RNA binding protein with multiple splicing -0.0157293
MAP2K7 mitogen-activated protein kinase kinase 7 -0.0157259
ANLN anillin, actin binding protein -0.0157257
MCM8 minichromosome maintenance complex component 8 -0.0157181
ADAM9 ADAM metallopeptidase domain 9 -0.0156938
BPTF bromodomain PHD finger transcription factor -0.0156598
SKIL SKI-like proto-oncogene -0.0156229
SERINC5 serine incorporator 5 -0.0155821
SMIM14 small integral membrane protein 14 -0.0155701
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0155655
POU2F1 POU class 2 homeobox 1 -0.0155589
ANKRD44 ankyrin repeat domain 44 -0.0155086
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0154905
ZNF367 zinc finger protein 367 -0.015358
FBXL17 F-box and leucine-rich repeat protein 17 -0.0153568
MSH2 mutS homolog 2 -0.0153354
BTBD7 BTB (POZ) domain containing 7 -0.0153299
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0153047
TIMELESS timeless circadian clock -0.0152563
DUSP5 dual specificity phosphatase 5 -0.0152144
SYNRG synergin, gamma -0.01516
HSPB1 heat shock 27kDa protein 1 -0.015142
DIAPH1 diaphanous-related formin 1 -0.0151244
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -0.0150591
ASXL2 additional sex combs like transcriptional regulator 2 -0.0150538
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 -0.0150467
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0150406
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 -0.0150288
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0150061
KNTC1 kinetochore associated 1 -0.0149127
PCBP2 poly(rC) binding protein 2 -0.0148917
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.014887
ITFG2 integrin alpha FG-GAP repeat containing 2 -0.0148858
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 -0.0148819
KNL1 kinetochore scaffold 1 -0.0148574
WDR44 WD repeat domain 44 -0.0148508
RPN1 ribophorin I -0.0148461
FAF2 Fas associated factor family member 2 -0.0148449
ECT2 epithelial cell transforming 2 -0.0148337
MYO10 myosin X -0.0148319
GSPT1 G1 to S phase transition 1 -0.0147727
PLPP1 phospholipid phosphatase 1 -0.014755
PARPBP PARP1 binding protein -0.0147288
USP36 ubiquitin specific peptidase 36 -0.0146887
KIAA0319 KIAA0319 -0.0146624
PHACTR4 phosphatase and actin regulator 4 -0.0146513
AHI1 Abelson helper integration site 1 -0.0146289
CDC25C cell division cycle 25C -0.0145659
MORF4L1 mortality factor 4 like 1 -0.0145621
KIF11 kinesin family member 11 -0.0145544
BCAS1 breast carcinoma amplified sequence 1 -0.0145519
DEK DEK proto-oncogene -0.0145464
EREG epiregulin -0.014534
EPN2 epsin 2 -0.0145021
IRS2 insulin receptor substrate 2 -0.0144972
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -0.0144753
FADS2 fatty acid desaturase 2 -0.0144495
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0144396
FGFR1 fibroblast growth factor receptor 1 -0.0144387
GPR135 G protein-coupled receptor 135 -0.0144023
PM20D1 peptidase M20 domain containing 1 -0.0143928
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 -0.0143852
KMT2E lysine (K)-specific methyltransferase 2E -0.0143838
ATAD2B ATPase family, AAA domain containing 2B -0.0143682
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -0.0143621
RBM23 RNA binding motif protein 23 -0.0143552
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.014342
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0143304
NUP160 nucleoporin 160kDa -0.0143108
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0142912
LIPH lipase, member H -0.0142742
THADA thyroid adenoma associated -0.0142474
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -0.0142453
MISP mitotic spindle positioning -0.0142446
OSBPL9 oxysterol binding protein-like 9 -0.0142167
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0141945
ENOSF1 enolase superfamily member 1 -0.0141848
RSPO3 R-spondin 3 -0.0141713
VRK2 vaccinia related kinase 2 -0.0141666
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0141278
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.0141134
DSPP dentin sialophosphoprotein -0.0141108
ADIPOR2 adiponectin receptor 2 -0.0140894
PDPR pyruvate dehydrogenase phosphatase regulatory subunit -0.0140877
PTBP2 polypyrimidine tract binding protein 2 -0.014065
UBE2Z ubiquitin-conjugating enzyme E2Z -0.0140541
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -0.0140408
RAD18 RAD18 E3 ubiquitin protein ligase -0.0140397
STIM1 stromal interaction molecule 1 -0.0139547
CEP112 centrosomal protein 112kDa -0.0139544
GPC6 glypican 6 -0.0139399
KPNA6 karyopherin alpha 6 (importin alpha 7) -0.0139172
CAMKMT calmodulin-lysine N-methyltransferase -0.0138966
ZDHHC17 zinc finger, DHHC-type containing 17 -0.0138603
IPO7 importin 7 -0.0138269
IPO9 importin 9 -0.0138181
TTC19 tetratricopeptide repeat domain 19 -0.0138032
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) -0.0137466
QSER1 glutamine and serine rich 1 -0.0137228
CLPTM1 cleft lip and palate associated transmembrane protein 1 -0.0136946
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0136913
FANCL Fanconi anemia, complementation group L -0.0136897
TBC1D17 TBC1 domain family, member 17 -0.0136738
SINHCAF SIN3-HDAC complex associated factor -0.0136244
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0136229
SETD5 SET domain containing 5 -0.0136086
CCDC57 coiled-coil domain containing 57 -0.0135908
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0135861
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0135477
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -0.0135269
FBXL18 F-box and leucine-rich repeat protein 18 -0.0135108
USP53 ubiquitin specific peptidase 53 -0.0134687
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0134241
FARSB phenylalanyl-tRNA synthetase, beta subunit -0.0133439
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit -0.0133349
PRPF3 pre-mRNA processing factor 3 -0.0133086
PSD3 pleckstrin and Sec7 domain containing 3 -0.0132686
MAU2 MAU2 sister chromatid cohesion factor -0.0132598
EPC2 enhancer of polycomb homolog 2 (Drosophila) -0.0131817
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing -0.0131719
RNF13 ring finger protein 13 -0.0131664
KDM3B lysine (K)-specific demethylase 3B -0.0131517
SMC1A structural maintenance of chromosomes 1A -0.0131431
SKA2 spindle and kinetochore associated complex subunit 2 -0.0131033
CLASP2 cytoplasmic linker associated protein 2 -0.0130985
MAP3K3 mitogen-activated protein kinase kinase kinase 3 -0.0130984
PLAUR plasminogen activator, urokinase receptor -0.0130883
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.013079
MCM4 minichromosome maintenance complex component 4 -0.0130717
BICDL1 BICD family like cargo adaptor 1 -0.0130695
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0130127
SMC6 structural maintenance of chromosomes 6 -0.0130085
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -0.0130056
WDR20 WD repeat domain 20 -0.0129902
SRRM2 serine/arginine repetitive matrix 2 -0.0129762
NEB nebulin -0.0129553
BMPR1A bone morphogenetic protein receptor, type IA -0.0129216
RBM47 RNA binding motif protein 47 -0.0128966
TPST1 tyrosylprotein sulfotransferase 1 -0.0128938
IRF3 interferon regulatory factor 3 -0.0128915
EEIG1 estrogen-induced osteoclastogenesis regulator 1 -0.0128815
PITPNB phosphatidylinositol transfer protein, beta -0.0128747
TRIO trio Rho guanine nucleotide exchange factor -0.012851
RAD21 RAD21 homolog (S. pombe) -0.0128426
VRK3 vaccinia related kinase 3 -0.0128314
DNA2 DNA replication helicase/nuclease 2 -0.0128235
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.0128161
ZSWIM5 zinc finger, SWIM-type containing 5 -0.0128053
ELMO1 engulfment and cell motility 1 -0.0127977
ELOVL5 ELOVL fatty acid elongase 5 -0.0127896
PEAK1 pseudopodium-enriched atypical kinase 1 -0.0127325
GRID1 glutamate receptor, ionotropic, delta 1 -0.0127166
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.012681
TMEM87A transmembrane protein 87A -0.0126727
CNKSR3 CNKSR family member 3 -0.0126427
MALT1 MALT1 paracaspase -0.0126028
INTS7 integrator complex subunit 7 -0.0126008
EPAS1 endothelial PAS domain protein 1 -0.0125976
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.0125902
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0125805
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.01255
PLS3 plastin 3 -0.0125338
KIF14 kinesin family member 14 -0.0125048
REL v-rel avian reticuloendotheliosis viral oncogene homolog -0.012484
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0124743
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0124727
KSR1 kinase suppressor of ras 1 -0.0124595
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0124443
DBF4B DBF4 zinc finger B -0.0124336
SLC22A23 solute carrier family 22, member 23 -0.0124152
ADAM17 ADAM metallopeptidase domain 17 -0.0124129
RPAP3 RNA polymerase II associated protein 3 -0.0123961
KIAA0232 KIAA0232 -0.0123905
WASL Wiskott-Aldrich syndrome-like -0.0123508
ZSWIM7 zinc finger, SWIM-type containing 7 -0.0123426
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) -0.0123326
BIRC5 baculoviral IAP repeat containing 5 -0.0123056
SRFBP1 serum response factor binding protein 1 -0.0122948
NCOA6 nuclear receptor coactivator 6 -0.0122852
MYH9 myosin, heavy chain 9, non-muscle -0.0122636
BCLAF1 BCL2-associated transcription factor 1 -0.0122567
SCAPER S-phase cyclin A-associated protein in the ER -0.0122026
CENPK centromere protein K -0.0121991
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0121967
CSNK1D casein kinase 1, delta -0.0121942
PRIM1 primase, DNA, polypeptide 1 (49kDa) -0.0121789
CENPE centromere protein E, 312kDa -0.0121443
MLH1 mutL homolog 1 -0.0121266
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.0121084
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0120986
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.012088
CMC2 C-x(9)-C motif containing 2 -0.0120773
UBE4A ubiquitination factor E4A -0.0120414
YTHDC1 YTH domain containing 1 -0.0120209
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0119795
RECQL RecQ helicase-like -0.0119786
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0119649
AQR aquarius intron-binding spliceosomal factor -0.011948
PRKCSH protein kinase C substrate 80K-H -0.0119345
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.0119271
FDPS farnesyl diphosphate synthase -0.011922
KIAA0930 KIAA0930 -0.0119211