A549_SNS-314 Mesylate_100nM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description SNS-314 Mesylate 100nM perturbation in A549 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the A549_SNS-314 Mesylate_100nM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.220148
RAB10 RAB10, member RAS oncogene family 0.162755
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.156977
TNS3 tensin 3 0.122624
SYT1 synaptotagmin I 0.118417
ABTB3 ankyrin repeat and BTB domain containing 3 0.111918
FTL ferritin, light polypeptide 0.108203
GLIS3 GLIS family zinc finger 3 0.100222
PCDH9 protocadherin 9 0.0902035
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0847104
PDE4D phosphodiesterase 4D, cAMP-specific 0.0738103
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0718067
MYO10 myosin X 0.071689
ANXA1 annexin A1 0.0671073
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0642984
TXNRD1 thioredoxin reductase 1 0.0635967
BCL2L1 BCL2-like 1 0.0618469
NLGN4Y neuroligin 4, Y-linked 0.0610087
IKBIP IKBKB interacting protein 0.0555046
PHF14 PHD finger protein 14 0.0542295
TKT transketolase 0.0524922
CMIP c-Maf inducing protein 0.0520655
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.0515471
GSK3B glycogen synthase kinase 3 beta 0.051374
UBE2H ubiquitin-conjugating enzyme E2H 0.0507922
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0506304
MPG N-methylpurine-DNA glycosylase 0.0467788
NCOA3 nuclear receptor coactivator 3 0.0463294
MSI2 musashi RNA-binding protein 2 0.0460131
IGSF11 immunoglobulin superfamily, member 11 0.0455219
ASTN2 astrotactin 2 0.0449247
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0447162
SEPTIN9 septin 9 0.043524
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0431864
MED13L mediator complex subunit 13-like 0.0431812
SPPL3 signal peptide peptidase like 3 0.0424092
SLC35F3 solute carrier family 35, member F3 0.0423614
ITFG1 integrin alpha FG-GAP repeat containing 1 0.0418984
THSD4 thrombospondin, type I, domain containing 4 0.0406459
BPTF bromodomain PHD finger transcription factor 0.040486
CLIP1 CAP-GLY domain containing linker protein 1 0.0404057
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.039906
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0395101
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0389209
KANSL1 KAT8 regulatory NSL complex subunit 1 0.038824
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0382758
AKR1C3 aldo-keto reductase family 1, member C3 0.0376144
AKAP13 A kinase (PRKA) anchor protein 13 0.0368626
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0358192
AKR1C2 aldo-keto reductase family 1, member C2 0.0357458
CALR calreticulin 0.0356036
STK24 serine/threonine kinase 24 0.0356036
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0352187
BCAS3 breast carcinoma amplified sequence 3 0.035053
MTPN myotrophin 0.0349143
MLEC malectin 0.034793
BICD1 bicaudal D homolog 1 (Drosophila) 0.0345754
SLTM SAFB-like, transcription modulator 0.0337078
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0333789
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0332658
VGLL4 vestigial-like family member 4 0.0330141
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0328198
PAWR PRKC, apoptosis, WT1, regulator 0.0327946
KRT8 keratin 8, type II 0.0326676
RSF1 remodeling and spacing factor 1 0.0325565
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0324478
ASXL2 additional sex combs like transcriptional regulator 2 0.0323522
ZFAND3 zinc finger, AN1-type domain 3 0.0323266
ADGRG6 adhesion G protein-coupled receptor G6 0.0320949
RPH3AL rabphilin 3A-like (without C2 domains) 0.0319825
SPATS2 spermatogenesis associated, serine-rich 2 0.0317192
IGF1R insulin-like growth factor 1 receptor 0.0316352
MYOF myoferlin 0.0315965
ABLIM1 actin binding LIM protein 1 0.031566
RPS2 ribosomal protein S2 0.0314046
PRKX protein kinase, X-linked 0.0310503
ZSWIM6 zinc finger, SWIM-type containing 6 0.0306691
CD151 CD151 molecule (Raph blood group) 0.0305748
SLC39A11 solute carrier family 39, member 11 0.0305362
GMDS GDP-mannose 4,6-dehydratase 0.0302996
KIF21A kinesin family member 21A 0.0302092
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.0299151
TBC1D5 TBC1 domain family, member 5 0.029887
TRAPPC9 trafficking protein particle complex 9 0.0298246
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0297565
PHACTR4 phosphatase and actin regulator 4 0.0291493
ARB2A ARB2 cotranscriptional regulator A 0.0288246
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.0287545
NRCAM neuronal cell adhesion molecule 0.0285851
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.02818
AOPEP aminopeptidase O (putative) 0.0280007
RFX7 regulatory factor X, 7 0.0279704
PHF20 PHD finger protein 20 0.027911
CLDN2 claudin 2 0.0277963
RBMS2 RNA binding motif, single stranded interacting protein 2 0.0277342
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0276025
VCP valosin containing protein 0.0275615
CCDC57 coiled-coil domain containing 57 0.0275468
CA12 carbonic anhydrase XII 0.0275393
DSPP dentin sialophosphoprotein 0.0275226
METTL8 methyltransferase like 8 0.0274968
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0274465
PITPNA phosphatidylinositol transfer protein, alpha 0.0274441
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0274089
ARL15 ADP-ribosylation factor-like 15 0.0274006
WDR70 WD repeat domain 70 0.0273314
MAP2K5 mitogen-activated protein kinase kinase 5 0.0273301
PROCR protein C receptor, endothelial 0.0273224
ETFA electron-transfer-flavoprotein, alpha polypeptide 0.0272672
MYO1B myosin IB 0.0271427
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0266597
GCLM glutamate-cysteine ligase, modifier subunit 0.026639
SH3RF1 SH3 domain containing ring finger 1 0.0265813
RPL12 ribosomal protein L12 0.0263901
SMYD3 SET and MYND domain containing 3 0.0260942
TGOLN2 trans-golgi network protein 2 0.0259042
AGR2 anterior gradient 2 0.0257118
CRK v-crk avian sarcoma virus CT10 oncogene homolog 0.0256131
UBN1 ubinuclein 1 0.0255965
MAN1A2 mannosidase, alpha, class 1A, member 2 0.025349
PBRM1 polybromo 1 0.0253382
ZSCAN5A zinc finger and SCAN domain containing 5A 0.0253314
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0248565
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0248517
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0248223
RBM47 RNA binding motif protein 47 0.0247267
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0245946
FAT1 FAT atypical cadherin 1 0.0243868
POLH polymerase (DNA directed), eta 0.0243351
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0242111
MGA MGA, MAX dimerization protein 0.0241308
ADAM10 ADAM metallopeptidase domain 10 0.02409
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 0.0239941
CLU clusterin 0.0239666
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0238741
SLC38A10 solute carrier family 38, member 10 0.0237043
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.0236614
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 0.0235688
AHNAK2 AHNAK nucleoprotein 2 0.0234322
CAMKMT calmodulin-lysine N-methyltransferase 0.023351
MGST1 microsomal glutathione S-transferase 1 0.0232748
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0232545
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0231923
POM121 POM121 transmembrane nucleoporin 0.0228841
ARHGAP32 Rho GTPase activating protein 32 0.0227042
NRG1 neuregulin 1 0.0226519
PLXNB2 plexin B2 0.0226386
RPL37A ribosomal protein L37a 0.0225499
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0225464
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.022456
ADD2 adducin 2 (beta) 0.0223551
PDIA4 protein disulfide isomerase family A, member 4 0.0223544
ENO1 enolase 1, (alpha) 0.0223381
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0222637
RBPMS RNA binding protein with multiple splicing 0.0222038
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.0222016
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0220479
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.0220216
BICC1 BicC family RNA binding protein 1 0.0219599
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 0.0216293
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 0.0215201
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 0.0214603
UBQLN1 ubiquilin 1 0.0214361
XPO4 exportin 4 0.0214096
YLPM1 YLP motif containing 1 0.0214002
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0213964
SULF2 sulfatase 2 0.0213817
USP33 ubiquitin specific peptidase 33 0.0213137
PLD5 phospholipase D family, member 5 0.0212759
FOXK1 forkhead box K1 0.0212693
MRTFA myocardin related transcription factor A 0.0210077
IQGAP1 IQ motif containing GTPase activating protein 1 0.0209608
KDM2A lysine (K)-specific demethylase 2A 0.0209013
TRAK1 trafficking protein, kinesin binding 1 0.0208929
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0208847
ACLY ATP citrate lyase 0.0208426
GATAD2B GATA zinc finger domain containing 2B 0.0208013
FBXO22 F-box protein 22 0.020767
SOCS5 suppressor of cytokine signaling 5 0.0207429
HDAC4 histone deacetylase 4 0.0207339
PXDN peroxidasin 0.0206852
PCED1B PC-esterase domain containing 1B 0.0206484
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 0.020587
ANXA8L1 annexin A8-like 1 0.0203565
TMEM116 transmembrane protein 116 0.020346
LGSN lengsin, lens protein with glutamine synthetase domain 0.0202693
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.0202468
CNOT6 CCR4-NOT transcription complex, subunit 6 0.0200348
C5 complement component 5 0.0200265
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0199974
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0199943
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.0198041
GPATCH2 G patch domain containing 2 0.0197682
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 0.0197437
NFE2L2 nuclear factor, erythroid 2-like 2 0.0196308
IPMK inositol polyphosphate multikinase 0.019594
KCTD1 potassium channel tetramerization domain containing 1 0.0195606
TUT7 terminal uridylyl transferase 7 0.0193498
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.01934
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0193399
ACBD6 acyl-CoA binding domain containing 6 0.0192664
MAGT1 magnesium transporter 1 0.0192607
RAD52 RAD52 homolog (S. cerevisiae) 0.01923
NOTCH3 notch 3 0.0191525
FBXL20 F-box and leucine-rich repeat protein 20 0.0191297
HPRT1 hypoxanthine phosphoribosyltransferase 1 0.0190659
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0190341
ELOVL5 ELOVL fatty acid elongase 5 0.0190174
PPP4R3B protein phosphatase 4 regulatory subunit 3B 0.0190017
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0188133
ACACA acetyl-CoA carboxylase alpha 0.0188036
CAPRIN1 cell cycle associated protein 1 0.0187496
IWS1 IWS1 homolog (S. cerevisiae) 0.0187483
NFIA nuclear factor I/A 0.0187362
ANKRD17 ankyrin repeat domain 17 0.0187308
SLC25A43 solute carrier family 25, member 43 0.0187023
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 0.018687
CNOT7 CCR4-NOT transcription complex, subunit 7 0.0186642
PDGFD platelet derived growth factor D 0.0186638
MYEOV myeloma overexpressed 0.0186028
UBASH3B ubiquitin associated and SH3 domain containing B 0.0186014
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0185676
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0185341
TCERG1 transcription elongation regulator 1 0.0184777
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0184552
SRBD1 S1 RNA binding domain 1 0.0184228
FBN2 fibrillin 2 0.0184131
UBE2N ubiquitin-conjugating enzyme E2N 0.0183952
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0182896
KDM4B lysine (K)-specific demethylase 4B 0.0181681
AVEN apoptosis, caspase activation inhibitor 0.018126
IGSF1 immunoglobulin superfamily, member 1 0.0181223
MBD5 methyl-CpG binding domain protein 5 0.0180085
PIGF phosphatidylinositol glycan anchor biosynthesis, class F 0.0179822
KHSRP KH-type splicing regulatory protein 0.0179477
MEGF9 multiple EGF-like-domains 9 0.0179398
SOS1 son of sevenless homolog 1 (Drosophila) 0.0179018
ATL3 atlastin GTPase 3 0.017834
KDM6A lysine (K)-specific demethylase 6A 0.017736
IMMT inner membrane protein, mitochondrial 0.01768
EP300 E1A binding protein p300 0.0176535
PCNX2 pecanex 2 0.017599
BSG basigin (Ok blood group) 0.0175646
SMAD3 SMAD family member 3 0.0175459
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0175332
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.0175188
GSN gelsolin 0.0174727
RNF111 ring finger protein 111 0.017439
CENPP centromere protein P 0.0173963
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0173642
RHOQ ras homolog family member Q 0.0173564
CDKL5 cyclin-dependent kinase-like 5 0.0173182
DUS2 dihydrouridine synthase 2 0.0172937
COL5A2 collagen, type V, alpha 2 0.0172609
TMEM165 transmembrane protein 165 0.0172461
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa 0.0172448
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 0.0172286
NAT8 N-acetyltransferase 8 (GCN5-related, putative) 0.017205
FOXM1 forkhead box M1 0.0171821
ZFAND5 zinc finger, AN1-type domain 5 0.0171609
NOPCHAP1 NOP protein chaperone 1 0.0171248
LIN7A lin-7 homolog A (C. elegans) 0.0171123
ACOT9 acyl-CoA thioesterase 9 0.0171094
MALT1 MALT1 paracaspase 0.0170731
UBE2O ubiquitin-conjugating enzyme E2O 0.0169972
SCFD2 sec1 family domain containing 2 0.016935
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.0168857
UIMC1 ubiquitin interaction motif containing 1 0.0168732
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 0.0168639
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 0.0168307
ZBTB20 zinc finger and BTB domain containing 20 0.0168291
LATS1 large tumor suppressor kinase 1 0.0168238
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) 0.0168045
SPRED2 sprouty-related, EVH1 domain containing 2 0.0167993
SLIT3 slit homolog 3 (Drosophila) 0.0167791
SPNS1 spinster homolog 1 (Drosophila) 0.0167693
EFCAB14 EF-hand calcium binding domain 14 0.0167187
KIAA0319 KIAA0319 0.016708
RTN3 reticulon 3 0.01665
GOLGB1 golgin B1 0.0166037
KRT18 keratin 18, type I 0.0165923
INAVA innate immunity activator 0.0165729
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 0.016564
MCFD2 multiple coagulation factor deficiency 2 0.0164901
FGFR1 fibroblast growth factor receptor 1 0.0164541
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 0.0164418
AGO3 argonaute RISC catalytic component 3 0.0162691
SOGA1 suppressor of glucose, autophagy associated 1 0.0162082
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0162065
CSNK1A1 casein kinase 1, alpha 1 0.0162
RBM25 RNA binding motif protein 25 0.0161832
SLC45A4 solute carrier family 45, member 4 0.0161439
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0160986
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.0160752
HDGFL3 HDGF like 3 0.0160644
GIPC1 GIPC PDZ domain containing family, member 1 0.0160249
EVL Enah/Vasp-like 0.0160249
LIMCH1 LIM and calponin homology domains 1 0.0159807
ZNF79 zinc finger protein 79 0.0159565
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0159332
CLIC4 chloride intracellular channel 4 0.0158977
RAB5A RAB5A, member RAS oncogene family 0.0158205
GNAS GNAS complex locus 0.0158131
ALCAM activated leukocyte cell adhesion molecule 0.0157415
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.015725
GPR135 G protein-coupled receptor 135 0.0157037
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 0.0156881
BRCC3 BRCA1/BRCA2-containing complex, subunit 3 0.0156815
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 0.0156719
RPUSD3 RNA pseudouridylate synthase domain containing 3 0.0156653
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 0.0156479
CHKA choline kinase alpha 0.0156112
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 0.015561
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 0.0155567
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0155342
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 0.0155204
DYNLT1 dynein, light chain, Tctex-type 1 0.0154876
CTNND1 catenin (cadherin-associated protein), delta 1 0.015486
STK32B serine/threonine kinase 32B 0.0154579
RPS27L ribosomal protein S27-like 0.0154466
MGME1 mitochondrial genome maintenance exonuclease 1 0.0154303
ITGB5 integrin, beta 5 0.0154296
WIPF2 WAS/WASL interacting protein family, member 2 0.0154283
RPL37 ribosomal protein L37 0.0154083
TFCP2 transcription factor CP2 0.0153862
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0153643
TRERF1 transcriptional regulating factor 1 0.0153608
TAC4 tachykinin 4 (hemokinin) 0.0153598
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0153177
TIGAR TP53 induced glycolysis regulatory phosphatase 0.0152848
RCOR1 REST corepressor 1 0.0152296
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.0152259
ZNF146 zinc finger protein 146 0.0151987
TRIML2 tripartite motif family-like 2 0.0151942
GORASP2 golgi reassembly stacking protein 2, 55kDa 0.015193
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 0.015175
ZMYND8 zinc finger, MYND-type containing 8 0.0151597
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 0.015061
TRIM16 tripartite motif containing 16 0.0150592
PUM1 pumilio RNA-binding family member 1 0.0150162
GPR39 G protein-coupled receptor 39 0.0149725
ZCCHC7 zinc finger, CCHC domain containing 7 0.0149717
TJP3 tight junction protein 3 0.014915
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0149061
NDFIP1 Nedd4 family interacting protein 1 0.0148896
SRPK2 SRSF protein kinase 2 0.0148856
KCMF1 potassium channel modulatory factor 1 0.0148453
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 0.0148448
PNPLA2 patatin-like phospholipase domain containing 2 0.0148439
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0148281
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.01482
ADGRL2 adhesion G protein-coupled receptor L2 0.0147723
CCND3 cyclin D3 0.0146912
TRIO trio Rho guanine nucleotide exchange factor 0.0146849
CPNE4 copine IV 0.0146682
ZNF18 zinc finger protein 18 0.0146489
NEMF nuclear export mediator factor 0.0146475
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 0.0146129
KIFC3 kinesin family member C3 0.0145404
LDAH lipid droplet associated hydrolase 0.0145036
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.0144934
MARCHF6 membrane associated ring-CH-type finger 6 0.0144768
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) 0.0144327
SBF2 SET binding factor 2 0.0144158
HEXB hexosaminidase B (beta polypeptide) 0.0144158
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0144143
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0143636
RPL6 ribosomal protein L6 0.0143393
GPC6 glypican 6 0.0143388
NBEAL1 neurobeachin-like 1 0.0143301
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase 0.0143201
CTTNBP2NL CTTNBP2 N-terminal like 0.0143103
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0142771
SYNGAP1 synaptic Ras GTPase activating protein 1 0.0142696
C19ORF33 chromosome 19 open reading frame 33 0.0142664
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) 0.0142645
UNC45A unc-45 homolog A (C. elegans) 0.0142594
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 0.01424
SAMD4B sterile alpha motif domain containing 4B 0.0142103
ACYP2 acylphosphatase 2, muscle type 0.014179
PRICKLE2 prickle homolog 2 (Drosophila) 0.0141701
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0141534
ZFP64 ZFP64 zinc finger protein 0.0141354
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.0141337
CAV1 caveolin 1, caveolae protein, 22kDa 0.014114
ATF7IP2 activating transcription factor 7 interacting protein 2 0.0141035
SCD5 stearoyl-CoA desaturase 5 0.0141016
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0140897
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0140695
ZFP36L1 ZFP36 ring finger protein-like 1 0.0140622
PSPH phosphoserine phosphatase 0.0140603
RPS5 ribosomal protein S5 0.0140557
RETSAT retinol saturase (all-trans-retinol 13,14-reductase) 0.0140283
PARN poly(A)-specific ribonuclease 0.0140084
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 0.0139866
TLN1 talin 1 0.0139653
CTTN cortactin 0.0139515
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0138687
MTERF1 mitochondrial transcription termination factor 1 0.0138489
KIF2C kinesin family member 2C 0.0138216
UBXN2A UBX domain protein 2A 0.0138205
EPC1 enhancer of polycomb homolog 1 (Drosophila) 0.0138187
MARK2 MAP/microtubule affinity-regulating kinase 2 0.0137889
AFTPH aftiphilin 0.0137828
SKA2 spindle and kinetochore associated complex subunit 2 0.0137618
SP100 SP100 nuclear antigen 0.0137527
GPR107 G protein-coupled receptor 107 0.0137498
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0137334
PCNA proliferating cell nuclear antigen 0.0136933
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0136756
TMEM43 transmembrane protein 43 0.0136573
ANO6 anoctamin 6 0.0136226
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 0.0135997
KANTR KDM5C adjacent non-coding transcript 0.0135918
FOCAD focadhesin 0.0135759
HFE hemochromatosis 0.0135661
CD109 CD109 molecule 0.0135604
VEGFB vascular endothelial growth factor B 0.0135389
PLBD2 phospholipase B domain containing 2 0.013524
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0135198
MAPRE2 microtubule-associated protein, RP/EB family, member 2 0.0135152
ZCCHC10 zinc finger, CCHC domain containing 10 0.0135011
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0134667
TSKU tsukushi, small leucine rich proteoglycan 0.0134432
KAT8 K(lysine) acetyltransferase 8 0.0133955
CADM2 cell adhesion molecule 2 0.0133807
NLK nemo-like kinase 0.0133797
EIF4B eukaryotic translation initiation factor 4B 0.0133461
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.0133436
PLCD3 phospholipase C, delta 3 0.0132975
NADSYN1 NAD synthetase 1 0.0132834
ERCC6L2 excision repair cross-complementation group 6-like 2 0.0132529
BMP6 bone morphogenetic protein 6 0.0132208
ANKRD33B ankyrin repeat domain 33B 0.0132171
GDE1 glycerophosphodiester phosphodiesterase 1 0.0132146
CPEB3 cytoplasmic polyadenylation element binding protein 3 0.0131994
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 0.0131548
LRP11 low density lipoprotein receptor-related protein 11 0.0131512
ARHGAP29 Rho GTPase activating protein 29 0.0131402
EPB41L4A erythrocyte membrane protein band 4.1 like 4A 0.0131136
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0131124
DNA2 DNA replication helicase/nuclease 2 0.0131101
SIL1 SIL1 nucleotide exchange factor 0.0130976
ORC4 origin recognition complex, subunit 4 0.0130843
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0130751
AP2A1 adaptor-related protein complex 2, alpha 1 subunit 0.0130509
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 0.0130275
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 0.0130231
PAPOLG poly(A) polymerase gamma 0.0130197
RASAL2 RAS protein activator like 2 0.0129716
FAM222B family with sequence similarity 222, member B 0.0129628
RRBP1 ribosome binding protein 1 0.0129619
DGCR8 DGCR8 microprocessor complex subunit 0.0129613
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 0.0129563
TMEM41B transmembrane protein 41B 0.0129438
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 0.012909
SYNJ2 synaptojanin 2 0.0128985
CARD8 caspase recruitment domain family, member 8 0.012896
RRP7A ribosomal RNA processing 7 homolog A (S. cerevisiae) 0.0128728
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0128698
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 0.0128528
RPS9 ribosomal protein S9 0.0128283
PPP1R7 protein phosphatase 1, regulatory subunit 7 0.012821
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.0128145
RPS4X ribosomal protein S4, X-linked 0.0128021
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 0.0127877
CYBA cytochrome b-245, alpha polypeptide 0.0127738
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 0.0127226
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.0127215
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0127075
ZC3HC1 zinc finger, C3HC-type containing 1 0.0127061
ITGB1BP1 integrin beta 1 binding protein 1 0.0127018
ZXDC ZXD family zinc finger C 0.0126822
ANGPT1 angiopoietin 1 0.0126654
SMC5 structural maintenance of chromosomes 5 0.0126602
RHEB Ras homolog enriched in brain 0.0126577
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0126472
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0126225
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 0.012614
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0126011
DAB2IP DAB2 interacting protein 0.0125641
TOR3A torsin family 3, member A 0.0125615
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 0.0125516
HDAC8 histone deacetylase 8 0.0125049
NIPAL3 NIPA-like domain containing 3 0.0124975
ZFAND4 zinc finger, AN1-type domain 4 0.0124969
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0124815
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0124097
PECR peroxisomal trans-2-enoyl-CoA reductase 0.0124072
LUZP1 leucine zipper protein 1 0.0123941
AGO1 argonaute RISC catalytic component 1 0.012391
SORT1 sortilin 1 0.0123884
SUFU suppressor of fused homolog (Drosophila) 0.0123669
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0123449
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 0.012342
ZNF33B zinc finger protein 33B 0.0123287
TERF2 telomeric repeat binding factor 2 0.0122981
SPATA7 spermatogenesis associated 7 0.0122951
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) 0.0122659
LCMT1 leucine carboxyl methyltransferase 1 0.0122472

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.103735
KRT81 keratin 81, type II -0.0962062
PDLIM5 PDZ and LIM domain 5 -0.0785782
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0781296
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0729597
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0654751
HIP1 huntingtin interacting protein 1 -0.0650406
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0639717
ARHGAP26 Rho GTPase activating protein 26 -0.0588163
MYO1E myosin IE -0.0569461
TPM4 tropomyosin 4 -0.0540791
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0540556
PHGDH phosphoglycerate dehydrogenase -0.0513123
FOXP1 forkhead box P1 -0.0481801
MKI67 marker of proliferation Ki-67 -0.0477796
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0468267
USP34 ubiquitin specific peptidase 34 -0.0459708
PKM pyruvate kinase, muscle -0.0448526
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0439912
PRKCSH protein kinase C substrate 80K-H -0.043957
TACC2 transforming, acidic coiled-coil containing protein 2 -0.0430417
WWTR1 WW domain containing transcription regulator 1 -0.0426145
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0425902
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 -0.0423312
METTL16 methyltransferase like 16 -0.0416437
CNTN1 contactin 1 -0.0416226
CENPF centromere protein F, 350/400kDa -0.0413355
UBL4A ubiquitin-like 4A -0.0407835
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0406671
CUX1 cut-like homeobox 1 -0.040303
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0397641
IL6ST interleukin 6 signal transducer -0.0394371
HIPK2 homeodomain interacting protein kinase 2 -0.0392019
IRS2 insulin receptor substrate 2 -0.0391367
CNTNAP3B contactin associated protein-like 3B -0.0382246
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 -0.0382216
CCDC88A coiled-coil domain containing 88A -0.0378947
MLPH melanophilin -0.0377229
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0375931
CTSD cathepsin D -0.0374457
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0371519
FILIP1 filamin A interacting protein 1 -0.0369929
WWOX WW domain containing oxidoreductase -0.0369135
ACTG1 actin gamma 1 -0.0361909
MTUS1 microtubule associated tumor suppressor 1 -0.0359556
NCOR1 nuclear receptor corepressor 1 -0.0357717
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0355919
TCF12 transcription factor 12 -0.035342
THOC2 THO complex 2 -0.0352083
EZR ezrin -0.0348142
CDC27 cell division cycle 27 -0.034801
DHDDS dehydrodolichyl diphosphate synthase -0.0343925
ADAM17 ADAM metallopeptidase domain 17 -0.0339989
TNPO1 transportin 1 -0.0339726
FCGBP Fc fragment of IgG binding protein -0.0339175
FAM107B family with sequence similarity 107, member B -0.0338929
RPS11 ribosomal protein S11 -0.0334904
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0333707
TMSB10 thymosin beta 10 -0.0331598
CLIP2 CAP-GLY domain containing linker protein 2 -0.0325543
PTK2 protein tyrosine kinase 2 -0.0325172
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0321517
PROC protein C (inactivator of coagulation factors Va and VIIIa) -0.0314933
PTPRA protein tyrosine phosphatase, receptor type, A -0.0314913
PARD3B par-3 family cell polarity regulator beta -0.0313973
PRPF8 pre-mRNA processing factor 8 -0.0313476
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0311119
CPLX2 complexin 2 -0.0309346
ATE1 arginyltransferase 1 -0.0308154
DST dystonin -0.0308014
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0307357
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.030527
ETF1 eukaryotic translation termination factor 1 -0.0304648
SKIL SKI-like proto-oncogene -0.0303423
GPATCH8 G patch domain containing 8 -0.0300502
SRSF4 serine/arginine-rich splicing factor 4 -0.0297862
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0297175
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0294469
OPHN1 oligophrenin 1 -0.0294167
CTBP2 C-terminal binding protein 2 -0.02924
CNTNAP3 contactin associated protein-like 3 -0.0291981
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0290334
KANK1 KN motif and ankyrin repeat domains 1 -0.029013
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.028996
RPS16 ribosomal protein S16 -0.0289113
ACER3 alkaline ceramidase 3 -0.0288864
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0288257
SCAF11 SR-related CTD-associated factor 11 -0.0286913
ECT2 epithelial cell transforming 2 -0.0286077
SQSTM1 sequestosome 1 -0.0285312
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0283803
FLNA filamin A, alpha -0.0279277
MED13 mediator complex subunit 13 -0.027492
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0274854
PYGB phosphorylase, glycogen; brain -0.0273472
FNDC3B fibronectin type III domain containing 3B -0.0272958
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0272286
GATAD2A GATA zinc finger domain containing 2A -0.0271618
THSD7A thrombospondin, type I, domain containing 7A -0.0271572
TGFBI transforming growth factor, beta-induced, 68kDa -0.0271549
NCOR2 nuclear receptor corepressor 2 -0.027076
CSNK2A2 casein kinase 2, alpha prime polypeptide -0.0269932
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0268912
MEF2A myocyte enhancer factor 2A -0.0268643
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -0.0268023
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0267511
RAB2A RAB2A, member RAS oncogene family -0.0265718
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0265694
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 -0.0264724
AKAP12 A kinase (PRKA) anchor protein 12 -0.0262581
SMAD2 SMAD family member 2 -0.0262492
MYO5C myosin VC -0.026234
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0262231
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.026218
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0260373
CSPP1 centrosome and spindle pole associated protein 1 -0.0259063
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.025906
PTGR1 prostaglandin reductase 1 -0.0258335
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0258131
PLAUR plasminogen activator, urokinase receptor -0.0257856
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0257067
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0256702
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0255591
RPS14 ribosomal protein S14 -0.0255386
RPLP0 ribosomal protein, large, P0 -0.0255376
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0254103
PLPP1 phospholipid phosphatase 1 -0.0254052
CHD1L chromodomain helicase DNA binding protein 1-like -0.0253166
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0251464
RSL1D1 ribosomal L1 domain containing 1 -0.0250942
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0250532
SMIM44 small integral membrane protein 44 -0.0249986
TSPAN14 tetraspanin 14 -0.0249012
AHCYL2 adenosylhomocysteinase-like 2 -0.0248
FAF2 Fas associated factor family member 2 -0.0246935
KMT2A lysine (K)-specific methyltransferase 2A -0.0246241
TSG101 tumor susceptibility 101 -0.024612
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0245717
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0245605
AVPI1 arginine vasopressin-induced 1 -0.0244901
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 -0.0244851
AHNAK AHNAK nucleoprotein -0.0244056
INVS inversin -0.0243756
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.024303
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 -0.0242628
ACBD3 acyl-CoA binding domain containing 3 -0.0242127
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0241276
ILF3 interleukin enhancer binding factor 3, 90kDa -0.024025
ZNF609 zinc finger protein 609 -0.0240186
THRB thyroid hormone receptor, beta -0.024003
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0239024
BMPR1B bone morphogenetic protein receptor, type IB -0.0239016
AGFG1 ArfGAP with FG repeats 1 -0.0237339
SLC35F5 solute carrier family 35, member F5 -0.023702
MYO19 myosin XIX -0.0236598
TLK1 tousled-like kinase 1 -0.0236301
TPT1 tumor protein, translationally-controlled 1 -0.0234156
AKAP9 A kinase (PRKA) anchor protein 9 -0.0234124
SH2D4A SH2 domain containing 4A -0.0233312
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0232678
RBL1 retinoblastoma-like 1 -0.0232312
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0232269
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0232158
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0232044
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0231714
ABHD2 abhydrolase domain containing 2 -0.0230649
PUM2 pumilio RNA-binding family member 2 -0.0229641
ARF4 ADP-ribosylation factor 4 -0.0228997
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0224797
PRR11 proline rich 11 -0.0224071
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0223174
HACD2 3-hydroxyacyl-CoA dehydratase 2 -0.0220743
TNRC6A trinucleotide repeat containing 6A -0.022067
ARMC9 armadillo repeat containing 9 -0.0219599
TLK2 tousled-like kinase 2 -0.0219541
KATNBL1 katanin p80 subunit B-like 1 -0.0219166
CRTC3 CREB regulated transcription coactivator 3 -0.021902
TANK TRAF family member-associated NFKB activator -0.0218415
NECTIN2 nectin cell adhesion molecule 2 -0.0218233
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0217987
NTN4 netrin 4 -0.0217712
FBXO17 F-box protein 17 -0.021678
HDLBP high density lipoprotein binding protein -0.0214681
PDS5A PDS5 cohesin associated factor A -0.0214607
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.0214069
LRIF1 ligand dependent nuclear receptor interacting factor 1 -0.0212296
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0210866
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0210204
RC3H1 ring finger and CCCH-type domains 1 -0.0209957
RABGAP1L RAB GTPase activating protein 1-like -0.0209077
PIGU phosphatidylinositol glycan anchor biosynthesis, class U -0.0208971
TPST1 tyrosylprotein sulfotransferase 1 -0.0208927
BLTP3A bridge-like lipid transfer protein family member 3A -0.0208443
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -0.0208418
FRMD3 FERM domain containing 3 -0.020834
CCDC91 coiled-coil domain containing 91 -0.0208249
CAPNS1 calpain, small subunit 1 -0.0208176
SPIRE1 spire-type actin nucleation factor 1 -0.0208095
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) -0.0207001
STX8 syntaxin 8 -0.0206649
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0206218
SSH1 slingshot protein phosphatase 1 -0.02061
MTDH metadherin -0.020594
GSPT1 G1 to S phase transition 1 -0.0205488
FGG fibrinogen gamma chain -0.0205386
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0205355
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.0205097
CSDE1 cold shock domain containing E1, RNA-binding -0.0204689
ITFG2 integrin alpha FG-GAP repeat containing 2 -0.020405
RNF145 ring finger protein 145 -0.0203992
RPLP1 ribosomal protein, large, P1 -0.0203988
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 -0.0203812
CEP290 centrosomal protein 290kDa -0.0203803
DUSP4 dual specificity phosphatase 4 -0.0203144
FANCC Fanconi anemia, complementation group C -0.0203091
PTPN3 protein tyrosine phosphatase, non-receptor type 3 -0.0203085
RPSA ribosomal protein SA -0.0202028
GPRIN3 GPRIN family member 3 -0.0201567
AKIRIN1 akirin 1 -0.0201175
ENOSF1 enolase superfamily member 1 -0.0200677
JMJD1C jumonji domain containing 1C -0.0200655
SFXN5 sideroflexin 5 -0.0200563
FAM177A1 family with sequence similarity 177, member A1 -0.0200525
FHIT fragile histidine triad -0.0200019
SNAP25 synaptosomal-associated protein, 25kDa -0.0199709
GON4L gon-4-like (C. elegans) -0.0199029
TUBA1B tubulin, alpha 1b -0.0198817
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0198588
GIGYF2 GRB10 interacting GYF protein 2 -0.0197371
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -0.0196597
RSL24D1 ribosomal L24 domain containing 1 -0.019652
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.0196499
BAIAP2L1 BAI1-associated protein 2-like 1 -0.01964
HINT1 histidine triad nucleotide binding protein 1 -0.019585
SESTD1 SEC14 and spectrin domains 1 -0.0195728
TBCK TBC1 domain containing kinase -0.0195537
URI1 URI1, prefoldin-like chaperone -0.0195459
EHBP1 EH domain binding protein 1 -0.0195203
FBXL17 F-box and leucine-rich repeat protein 17 -0.0194957
BMPR1A bone morphogenetic protein receptor, type IA -0.0193478
SMC4 structural maintenance of chromosomes 4 -0.0192682
AQR aquarius intron-binding spliceosomal factor -0.0192433
RHOA ras homolog family member A -0.0192244
IQGAP2 IQ motif containing GTPase activating protein 2 -0.0191923
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0191488
TUT4 terminal uridylyl transferase 4 -0.0191316
TSEN2 TSEN2 tRNA splicing endonuclease subunit -0.0190738
KLF5 Kruppel-like factor 5 (intestinal) -0.0190439
TPD52 tumor protein D52 -0.0190298
RPL27A ribosomal protein L27a -0.0189589
PRKCE protein kinase C, epsilon -0.0189242
NUP205 nucleoporin 205kDa -0.018921
IQCB1 IQ motif containing B1 -0.0189009
MGLL monoglyceride lipase -0.0188842
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) -0.0188105
ATXN2 ataxin 2 -0.0187881
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0186569
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0185991
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0185896
TPM2 tropomyosin 2 (beta) -0.0185477
ATXN7 ataxin 7 -0.0185472
SNX14 sorting nexin 14 -0.0185126
SRPK1 SRSF protein kinase 1 -0.0184907
MUSK muscle, skeletal, receptor tyrosine kinase -0.0184818
ELL2 elongation factor, RNA polymerase II, 2 -0.0184264
CBFB core-binding factor, beta subunit -0.0184065
RPL29 ribosomal protein L29 -0.018394
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0183351
SANBR SANT and BTB domain regulator of CSR -0.0183208
FOSL1 FOS-like antigen 1 -0.0183174
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0183137
USP53 ubiquitin specific peptidase 53 -0.0183126
UBAP2 ubiquitin associated protein 2 -0.0182783
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0182652
AK1 adenylate kinase 1 -0.018265
MCM8 minichromosome maintenance complex component 8 -0.0182644
H1-10 H1.10 linker histone -0.0181961
EYA4 EYA transcriptional coactivator and phosphatase 4 -0.0181841
HRNR hornerin -0.0181594
EXOC6 exocyst complex component 6 -0.0181378
TPM1 tropomyosin 1 (alpha) -0.0181346
RPL23A ribosomal protein L23a -0.0181283
FBL fibrillarin -0.0181145
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0181134
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.0180709
HMMR hyaluronan-mediated motility receptor (RHAMM) -0.0180656
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0180177
PDE8A phosphodiesterase 8A -0.017971
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0179315
KLF3 Kruppel-like factor 3 (basic) -0.0178966
ECI1 enoyl-CoA delta isomerase 1 -0.017814
TMEM245 transmembrane protein 245 -0.0177687
SGPP1 sphingosine-1-phosphate phosphatase 1 -0.0177458
RSRC1 arginine/serine-rich coiled-coil 1 -0.0177393
SMG6 SMG6 nonsense mediated mRNA decay factor -0.0177059
EXT1 exostosin glycosyltransferase 1 -0.0176879
NCKAP1 NCK-associated protein 1 -0.0176476
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -0.0176397
FANCI Fanconi anemia, complementation group I -0.0176212
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 -0.0176017
SHMT1 serine hydroxymethyltransferase 1 (soluble) -0.017595
SLF2 SMC5-SMC6 complex localization factor 2 -0.0175581
SSH2 slingshot protein phosphatase 2 -0.0175353
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0175059
PRKCA protein kinase C, alpha -0.0175041
SAMD8 sterile alpha motif domain containing 8 -0.0174987
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.0174782
ZMAT4 zinc finger, matrin-type 4 -0.0174715
MZF1 myeloid zinc finger 1 -0.0173307
LMNA lamin A/C -0.0172932
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0172832
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha -0.0172622
PREPL prolyl endopeptidase-like -0.0172517
RABL6 RAB, member RAS oncogene family-like 6 -0.0172421
RAP1GAP2 RAP1 GTPase activating protein 2 -0.017201
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0172002
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) -0.0171999
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0171986
MACF1 microtubule-actin crosslinking factor 1 -0.0171609
TAOK1 TAO kinase 1 -0.0171429
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0171146
MYO18A myosin XVIIIA -0.0171124
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like -0.017023
NHSL1 NHS-like 1 -0.0170219
DSG2 desmoglein 2 -0.0170106
TRIM37 tripartite motif containing 37 -0.0170029
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0169832
CTSB cathepsin B -0.0169803
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.016969
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.0169173
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0168791
PER2 period circadian clock 2 -0.0167885
ZSWIM7 zinc finger, SWIM-type containing 7 -0.0167355
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0167185
SERBP1 SERPINE1 mRNA binding protein 1 -0.0166783
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.0166005
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0165999
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -0.0165988
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) -0.0165921
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0165739
GLS2 glutaminase 2 (liver, mitochondrial) -0.0165703
TXN2 thioredoxin 2 -0.0165642
SIK3 SIK family kinase 3 -0.0165473
KCTD20 potassium channel tetramerization domain containing 20 -0.0165074
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.016501
ATP11C ATPase, class VI, type 11C -0.0164768
NFIB nuclear factor I/B -0.0164434
INTS7 integrator complex subunit 7 -0.0164047
TMC5 transmembrane channel-like 5 -0.0163714
RUFY1 RUN and FYVE domain containing 1 -0.0163287
RASA2 RAS p21 protein activator 2 -0.0163119
PRRC2A proline-rich coiled-coil 2A -0.0162977
LARP1 La ribonucleoprotein domain family, member 1 -0.0162709
KIF3B kinesin family member 3B -0.0162679
PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase -0.0162341
TP53 tumor protein p53 -0.0162281
PBX3 pre-B-cell leukemia homeobox 3 -0.0162211
NUDCD1 NudC domain containing 1 -0.0161833
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -0.0161377
GTF2IRD1 GTF2I repeat domain containing 1 -0.016096
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0160626
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 -0.0160587
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 -0.0160527
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -0.0160497
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.016039
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0160033
PRKD2 protein kinase D2 -0.0160021
CENPB centromere protein B, 80kDa -0.0159606
DNAAF9 dynein axonemal assembly factor 9 -0.0159565
KIF13B kinesin family member 13B -0.0159394
HNRNPF heterogeneous nuclear ribonucleoprotein F -0.0159255
LARP4B La ribonucleoprotein domain family, member 4B -0.0158991
NUP62 nucleoporin 62kDa -0.0158968
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0158883
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0158511
PLD3 phospholipase D family, member 3 -0.0158415
BRCA1 breast cancer 1, early onset -0.015838
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -0.0158323
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0158308
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0158082
NSD2 nuclear receptor binding SET domain protein 2 -0.0157797
COPS3 COP9 signalosome subunit 3 -0.0157677
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0157612
PRRC2B proline-rich coiled-coil 2B -0.0157544
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0157251
TTC28 tetratricopeptide repeat domain 28 -0.0157195
RPL10A ribosomal protein L10a -0.0157121
MAVS mitochondrial antiviral signaling protein -0.0157076
ARHGAP35 Rho GTPase activating protein 35 -0.0156873
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase -0.015684
PRPF6 pre-mRNA processing factor 6 -0.0156725
FNDC3A fibronectin type III domain containing 3A -0.0156669
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -0.0156306
ZC3H13 zinc finger CCCH-type containing 13 -0.0156248
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0155936
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase -0.0155812
CEP112 centrosomal protein 112kDa -0.0155164
LPIN2 lipin 2 -0.0154511
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0154442
ANKRD11 ankyrin repeat domain 11 -0.0154275
ZFHX3 zinc finger homeobox 3 -0.0154114
PHF21A PHD finger protein 21A -0.0153739
MROH1 maestro heat-like repeat family member 1 -0.015348
PPP6R1 protein phosphatase 6, regulatory subunit 1 -0.0153435
ZMYM2 zinc finger, MYM-type 2 -0.0153094
PRDX3 peroxiredoxin 3 -0.0153023
NCOA2 nuclear receptor coactivator 2 -0.0153015
FOXK2 forkhead box K2 -0.0152837
WDR7 WD repeat domain 7 -0.0152242
PPCDC phosphopantothenoylcysteine decarboxylase -0.0152135
OTUD4 OTU deubiquitinase 4 -0.0152085
RBM33 RNA binding motif protein 33 -0.0151992
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase -0.0151507
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0151444
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) -0.0151224
AGO2 argonaute RISC catalytic component 2 -0.0151024
FOXN3 forkhead box N3 -0.0151005
RIOK3 RIO kinase 3 -0.0150956
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0150945
NAP1L1 nucleosome assembly protein 1-like 1 -0.0150911
GRAMD1B GRAM domain containing 1B -0.0149798
MED29 mediator complex subunit 29 -0.0149704
KIF14 kinesin family member 14 -0.0149261
RBL2 retinoblastoma-like 2 -0.0149121
NR2C2 nuclear receptor subfamily 2, group C, member 2 -0.0149073
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0149054
PRPF38B pre-mRNA processing factor 38B -0.0148471
DCAF10 DDB1 and CUL4 associated factor 10 -0.0148416
SMC1A structural maintenance of chromosomes 1A -0.014782
GPS2 G protein pathway suppressor 2 -0.0147788
C11ORF58 chromosome 11 open reading frame 58 -0.0147717
PRKD3 protein kinase D3 -0.0147077
OTUD7B OTU deubiquitinase 7B -0.0147066
SERGEF secretion regulating guanine nucleotide exchange factor -0.0146962
ANXA2 annexin A2 -0.0146942
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 -0.0146937
FDPS farnesyl diphosphate synthase -0.014692
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.0146536
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) -0.0146332
NUMB numb homolog (Drosophila) -0.0146224
TMEM267 transmembrane protein 267 -0.0146026
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 -0.0145977
WDR82 WD repeat domain 82 -0.0145941
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0145834
OSBPL3 oxysterol binding protein-like 3 -0.0145804
COG5 component of oligomeric golgi complex 5 -0.0145472
CHD9 chromodomain helicase DNA binding protein 9 -0.0145427
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0145298
CCDC138 coiled-coil domain containing 138 -0.0145011
CDC25C cell division cycle 25C -0.0144918
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) -0.0144732
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0144526
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0144253
RPL13A ribosomal protein L13a -0.0143997
AAGAB alpha- and gamma-adaptin binding protein -0.014399
ENAH enabled homolog (Drosophila) -0.0143334
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0143241
CBX5 chromobox homolog 5 -0.0143074
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -0.0142654
MORF4L1 mortality factor 4 like 1 -0.0141553
ADGRA3 adhesion G protein-coupled receptor A3 -0.014145
RFWD3 ring finger and WD repeat domain 3 -0.0141369
USP37 ubiquitin specific peptidase 37 -0.0141283
NUMA1 nuclear mitotic apparatus protein 1 -0.0141239
ZNF787 zinc finger protein 787 -0.0141053
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0140684
TPCN1 two pore segment channel 1 -0.0140683
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -0.0140543
SLC22A23 solute carrier family 22, member 23 -0.0140399
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0140352
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0139788
HM13 histocompatibility (minor) 13 -0.0139684
RAD51B RAD51 paralog B -0.0139268
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0138974
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -0.0138927
APP amyloid beta (A4) precursor protein -0.0138684
PDE4B phosphodiesterase 4B, cAMP-specific -0.0138453
XPOT exportin, tRNA -0.0138381
BICDL1 BICD family like cargo adaptor 1 -0.0138337
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0138078
FTH1 ferritin, heavy polypeptide 1 -0.0137988
LDHA lactate dehydrogenase A -0.0137737
POGK pogo transposable element with KRAB domain -0.0137592
RUFY2 RUN and FYVE domain containing 2 -0.0137271
ADCY9 adenylate cyclase 9 -0.0136961
ZNF280D zinc finger protein 280D -0.0136899
RNF115 ring finger protein 115 -0.0136641
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -0.0136019
XRN2 5'-3' exoribonuclease 2 -0.0135928
METTL2B methyltransferase like 2B -0.0135774
OSGIN2 oxidative stress induced growth inhibitor family member 2 -0.0135516
KIF11 kinesin family member 11 -0.0135485
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 -0.0135457
NIPSNAP1 nipsnap homolog 1 (C. elegans) -0.0135365
ZNF592 zinc finger protein 592 -0.0135354
FAM13A family with sequence similarity 13, member A -0.0135115
NEK7 NIMA-related kinase 7 -0.0135059
MFF mitochondrial fission factor -0.0134958
ARID1B AT rich interactive domain 1B (SWI1-like) -0.013494
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0134904