A549_SNS-314 Mesylate_10nM_24h Gene Set

Dataset Sci-Plex Drug Perturbation Signatures
Category transcriptomics
Type drug perturbation
Description SNS-314 Mesylate 10nM perturbation in A549 cell line at 24h timepoint (Sci-Plex)
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Genes

1000 genes differentially expressed following the A549_SNS-314 Mesylate_10nM_24h drug perturbation from the Sci-Plex Drug Perturbation Signatures dataset.

increased expression

Symbol Name Standardized Value
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.24572
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.143095
ABTB3 ankyrin repeat and BTB domain containing 3 0.11524
PTPRM protein tyrosine phosphatase, receptor type, M 0.106198
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.104918
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.10211
FLNB filamin B, beta 0.0978045
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0962785
MYO1E myosin IE 0.0939027
MYOF myoferlin 0.085458
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0822863
AOPEP aminopeptidase O (putative) 0.0814596
ZBTB20 zinc finger and BTB domain containing 20 0.0757829
WWC1 WW and C2 domain containing 1 0.0682104
PCDH9 protocadherin 9 0.0650393
ACTN4 actinin, alpha 4 0.0636286
MPG N-methylpurine-DNA glycosylase 0.0616023
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0602181
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0602141
AKR1C2 aldo-keto reductase family 1, member C2 0.0590087
ANXA4 annexin A4 0.0586101
TNS3 tensin 3 0.0577246
UBE2H ubiquitin-conjugating enzyme E2H 0.0543497
MAP7 microtubule-associated protein 7 0.0539592
DST dystonin 0.0527653
RBM47 RNA binding motif protein 47 0.0518772
PARD3 par-3 family cell polarity regulator 0.0515354
GLIS3 GLIS family zinc finger 3 0.0514722
CA12 carbonic anhydrase XII 0.0506841
KRT7 keratin 7, type II 0.0504946
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0502312
RPLP1 ribosomal protein, large, P1 0.0499161
TGFBI transforming growth factor, beta-induced, 68kDa 0.0494885
AKR1C3 aldo-keto reductase family 1, member C3 0.0478197
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0476806
TXNRD1 thioredoxin reductase 1 0.0471782
MAML3 mastermind-like 3 (Drosophila) 0.0458146
MBD5 methyl-CpG binding domain protein 5 0.0444588
TRAM1 translocation associated membrane protein 1 0.0434472
EXOC4 exocyst complex component 4 0.0430674
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 0.0430547
ANXA2 annexin A2 0.0413733
MED13L mediator complex subunit 13-like 0.0406726
TBC1D5 TBC1 domain family, member 5 0.0403943
S100A10 S100 calcium binding protein A10 0.0403263
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0400418
FTL ferritin, light polypeptide 0.0393557
RFX7 regulatory factor X, 7 0.0387528
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 0.0379378
AHNAK2 AHNAK nucleoprotein 2 0.0378641
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0377665
KYNU kynureninase 0.0372172
ACLY ATP citrate lyase 0.0362446
ASTN2 astrotactin 2 0.0355783
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0354133
MICU1 mitochondrial calcium uptake 1 0.0353497
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.035302
RSRC1 arginine/serine-rich coiled-coil 1 0.0352129
SMAD3 SMAD family member 3 0.0349715
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0348143
ATXN7L1 ataxin 7-like 1 0.0347571
TM4SF20 transmembrane 4 L six family member 20 0.0345669
PLEC plectin 0.0342692
NCOA3 nuclear receptor coactivator 3 0.0341253
CCND3 cyclin D3 0.0341138
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0340748
LIMCH1 LIM and calponin homology domains 1 0.0330764
OSBPL9 oxysterol binding protein-like 9 0.0330247
BICC1 BicC family RNA binding protein 1 0.0324128
CUEDC1 CUE domain containing 1 0.0318107
SYT1 synaptotagmin I 0.0316883
VGLL4 vestigial-like family member 4 0.0309056
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0308308
BCL2L1 BCL2-like 1 0.0308248
DNM1 dynamin 1 0.0307393
PDE4D phosphodiesterase 4D, cAMP-specific 0.0303075
HP1BP3 heterochromatin protein 1, binding protein 3 0.0300971
CYRIB CYFIP related Rac1 interactor B 0.0299495
TRAPPC9 trafficking protein particle complex 9 0.0299461
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0296687
LRP10 low density lipoprotein receptor-related protein 10 0.0291604
PHF14 PHD finger protein 14 0.0291261
SMIM29 small integral membrane protein 29 0.0290655
KRT8 keratin 8, type II 0.0288947
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0288328
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0288094
RAB10 RAB10, member RAS oncogene family 0.0284098
MYO10 myosin X 0.0283389
LNPEP leucyl/cystinyl aminopeptidase 0.0280685
HKDC1 hexokinase domain containing 1 0.0279793
SPATS2L spermatogenesis associated, serine-rich 2-like 0.027804
AHNAK AHNAK nucleoprotein 0.0275091
RPS19 ribosomal protein S19 0.0274908
PDZD8 PDZ domain containing 8 0.0274538
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0274536
LAMB1 laminin, beta 1 0.027433
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0272097
COL5A2 collagen, type V, alpha 2 0.0271738
IGSF11 immunoglobulin superfamily, member 11 0.0269506
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0269162
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0262444
SLC35F3 solute carrier family 35, member F3 0.0261816
PFN1 profilin 1 0.0259396
RNF213 ring finger protein 213 0.0259315
PRKCA protein kinase C, alpha 0.0259138
SIL1 SIL1 nucleotide exchange factor 0.0257685
STOM stomatin 0.0256229
NIPBL Nipped-B homolog (Drosophila) 0.0255268
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0251948
PDE10A phosphodiesterase 10A 0.0250969
ZSWIM6 zinc finger, SWIM-type containing 6 0.0250118
RGS17 regulator of G-protein signaling 17 0.0248658
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.024777
ZNF207 zinc finger protein 207 0.02474
RBM20 RNA binding motif protein 20 0.0246747
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0246054
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.0245268
POLR1A polymerase (RNA) I polypeptide A, 194kDa 0.0245179
HNF1B HNF1 homeobox B 0.0245103
TP63 tumor protein p63 0.0244974
NCOA6 nuclear receptor coactivator 6 0.024383
CCND1 cyclin D1 0.0243588
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0243326
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0243246
AFF1 AF4/FMR2 family, member 1 0.0242294
SOCS6 suppressor of cytokine signaling 6 0.0242084
ZNF609 zinc finger protein 609 0.0242025
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0239389
CLU clusterin 0.0234538
ALCAM activated leukocyte cell adhesion molecule 0.0234415
ADAM9 ADAM metallopeptidase domain 9 0.0233503
SLC38A7 solute carrier family 38, member 7 0.0232021
RPS4X ribosomal protein S4, X-linked 0.023183
MAST4 microtubule associated serine/threonine kinase family member 4 0.0231654
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 0.0231135
NBEA neurobeachin 0.0231116
STRN3 striatin, calmodulin binding protein 3 0.0230451
TSPAN4 tetraspanin 4 0.0229116
TP53I3 tumor protein p53 inducible protein 3 0.0226709
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0226614
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0225541
PTK2B protein tyrosine kinase 2 beta 0.0224863
SLC39A11 solute carrier family 39, member 11 0.0224699
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.0223595
ACVR1 activin A receptor, type I 0.0223531
COG5 component of oligomeric golgi complex 5 0.0222906
DOCK5 dedicator of cytokinesis 5 0.0222173
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0221132
DIAPH1 diaphanous-related formin 1 0.022047
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0220194
FER fer (fps/fes related) tyrosine kinase 0.022008
NT5C2 5'-nucleotidase, cytosolic II 0.0219941
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.0219867
UEVLD UEV and lactate/malate dehyrogenase domains 0.0218446
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0218188
AAGAB alpha- and gamma-adaptin binding protein 0.021734
PBX1 pre-B-cell leukemia homeobox 1 0.0215322
PDGFD platelet derived growth factor D 0.0214553
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0212507
GOLPH3L golgi phosphoprotein 3-like 0.021169
GCLC glutamate-cysteine ligase, catalytic subunit 0.0211649
XPR1 xenotropic and polytropic retrovirus receptor 1 0.0210386
CHD9 chromodomain helicase DNA binding protein 9 0.0209017
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0208238
RBM41 RNA binding motif protein 41 0.0205891
RBMS2 RNA binding motif, single stranded interacting protein 2 0.0204914
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0204589
PLCD3 phospholipase C, delta 3 0.0203615
FASN fatty acid synthase 0.0203555
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0202952
BBS4 Bardet-Biedl syndrome 4 0.0202425
DSCAM Down syndrome cell adhesion molecule 0.0201892
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.0201743
HOOK3 hook microtubule-tethering protein 3 0.0201508
ACYP2 acylphosphatase 2, muscle type 0.0201114
MAP1B microtubule-associated protein 1B 0.0200856
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0200181
RBPMS RNA binding protein with multiple splicing 0.0200069
S100A6 S100 calcium binding protein A6 0.0199809
MAGT1 magnesium transporter 1 0.0199805
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.0199554
FLNA filamin A, alpha 0.019918
PIGF phosphatidylinositol glycan anchor biosynthesis, class F 0.0199024
UTRN utrophin 0.0198157
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 0.0197768
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0197749
RPL3 ribosomal protein L3 0.0197378
ARHGAP24 Rho GTPase activating protein 24 0.019621
ZCCHC10 zinc finger, CCHC domain containing 10 0.019558
DENR density-regulated protein 0.0195531
ZC3H3 zinc finger CCCH-type containing 3 0.0195442
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 0.0194687
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0193454
MDM4 MDM4, p53 regulator 0.0193229
NUP205 nucleoporin 205kDa 0.0191833
COL4A5 collagen, type IV, alpha 5 0.0190358
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0189908
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.0189752
PCYOX1 prenylcysteine oxidase 1 0.0189575
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0189459
SDC1 syndecan 1 0.0189148
ARID1A AT rich interactive domain 1A (SWI-like) 0.018889
LLGL2 lethal giant larvae homolog 2 (Drosophila) 0.0188588
RDX radixin 0.0187239
MUC13 mucin 13, cell surface associated 0.0186738
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0186564
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 0.0185901
TMEM230 transmembrane protein 230 0.0185806
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0185731
SYNGAP1 synaptic Ras GTPase activating protein 1 0.0185395
MCU mitochondrial calcium uniporter 0.0184934
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.018476
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0182776
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 0.0182744
ENO1 enolase 1, (alpha) 0.0182486
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 0.0182268
MARCHF7 membrane associated ring-CH-type finger 7 0.0181685
ANXA11 annexin A11 0.0181031
NIBAN2 niban apoptosis regulator 2 0.0180446
EI24 etoposide induced 2.4 0.0180343
SMIM14 small integral membrane protein 14 0.0180131
CARNMT1 carnosine N-methyltransferase 1 0.0180059
TUT7 terminal uridylyl transferase 7 0.0179403
MBNL2 muscleblind-like splicing regulator 2 0.0179105
GATAD2B GATA zinc finger domain containing 2B 0.0178398
JAK1 Janus kinase 1 0.0178227
ASXL2 additional sex combs like transcriptional regulator 2 0.017819
RHOT1 ras homolog family member T1 0.0177884
P3H2 prolyl 3-hydroxylase 2 0.0177881
EBF1 early B-cell factor 1 0.0177541
CXXC1 CXXC finger protein 1 0.0176906
PLCL2 phospholipase C-like 2 0.017668
RHBDD2 rhomboid domain containing 2 0.0176504
GNG12 guanine nucleotide binding protein (G protein), gamma 12 0.0176482
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 0.0174766
FAM13A family with sequence similarity 13, member A 0.0174766
TIGAR TP53 induced glycolysis regulatory phosphatase 0.0174649
FRAS1 Fraser extracellular matrix complex subunit 1 0.0173772
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0173538
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 0.0173223
WDR59 WD repeat domain 59 0.0172732
LARP4 La ribonucleoprotein domain family, member 4 0.0172558
ANXA13 annexin A13 0.0172378
CCNI cyclin I 0.0171747
SIGMAR1 sigma non-opioid intracellular receptor 1 0.0171644
CARMIL1 capping protein regulator and myosin 1 linker 1 0.0171171
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0170931
SMIM44 small integral membrane protein 44 0.0170795
CDC42SE2 CDC42 small effector 2 0.0170342
WWTR1 WW domain containing transcription regulator 1 0.0170134
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0169948
UBE4B ubiquitination factor E4B 0.0169891
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 0.0169461
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.016935
QKI QKI, KH domain containing, RNA binding 0.0169115
CDK13 cyclin-dependent kinase 13 0.0168878
TMEM106B transmembrane protein 106B 0.0168378
BCAS1 breast carcinoma amplified sequence 1 0.0167841
PHACTR4 phosphatase and actin regulator 4 0.0167631
IL18 interleukin 18 0.0167376
SSR1 signal sequence receptor, alpha 0.01672
UGDH UDP-glucose 6-dehydrogenase 0.016714
SACK1H scaffolding CK1 anchoring protein H 0.016693
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.0165978
SSH2 slingshot protein phosphatase 2 0.0165725
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.0165467
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 0.0165396
LACTB2 lactamase, beta 2 0.016537
RPL4 ribosomal protein L4 0.0164636
SOCS5 suppressor of cytokine signaling 5 0.0163501
MFSD6 major facilitator superfamily domain containing 6 0.0163327
KIAA0319 KIAA0319 0.0163181
NUP160 nucleoporin 160kDa 0.0163054
TRIR telomerase RNA component interacting RNase 0.0162919
PDLIM1 PDZ and LIM domain 1 0.0162825
NUCB1 nucleobindin 1 0.0162508
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.0162373
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0162163
KPNA6 karyopherin alpha 6 (importin alpha 7) 0.0161466
BABAM2 BRISC and BRCA1 A complex member 2 0.016134
UBE3A ubiquitin protein ligase E3A 0.0161309
ATXN10 ataxin 10 0.0161141
MYEOV myeloma overexpressed 0.0160853
CLCN3 chloride channel, voltage-sensitive 3 0.0160584
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 0.0159612
FAM149B1 family with sequence similarity 149, member B1 0.0159542
SLC39A10 solute carrier family 39 (zinc transporter), member 10 0.0159308
FBXW8 F-box and WD repeat domain containing 8 0.0159297
GOLGB1 golgin B1 0.0159268
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.0159232
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0159195
CSNK1A1 casein kinase 1, alpha 1 0.015894
DNMBP dynamin binding protein 0.0158869
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0158835
REPS1 RALBP1 associated Eps domain containing 1 0.0158684
MGST1 microsomal glutathione S-transferase 1 0.0158389
XPC xeroderma pigmentosum, complementation group C 0.0158
KRT18 keratin 18, type I 0.0156767
ATAD1 ATPase family, AAA domain containing 1 0.0156714
LCOR ligand dependent nuclear receptor corepressor 0.0156649
SENP6 SUMO1/sentrin specific peptidase 6 0.0156561
SULF2 sulfatase 2 0.0155951
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.0155763
IGFBP4 insulin-like growth factor binding protein 4 0.0155728
RPS8 ribosomal protein S8 0.0155275
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.0155148
ALPK2 alpha-kinase 2 0.0154961
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa 0.0154938
PROC protein C (inactivator of coagulation factors Va and VIIIa) 0.015482
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 0.015448
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.0154112
FBXO22 F-box protein 22 0.0153999
ZNF292 zinc finger protein 292 0.0153716
MYH9 myosin, heavy chain 9, non-muscle 0.0153384
EXOC6B exocyst complex component 6B 0.015319
DOP1A DOP1 leucine zipper like protein A 0.0153126
WNT7B wingless-type MMTV integration site family, member 7B 0.0152938
CRTC3 CREB regulated transcription coactivator 3 0.0152508
MIA2 melanoma inhibitory activity 2 0.0152334
TPCN1 two pore segment channel 1 0.0151568
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0151552
ACAD10 acyl-CoA dehydrogenase family, member 10 0.0151432
PIBF1 progesterone immunomodulatory binding factor 1 0.0151304
NSD1 nuclear receptor binding SET domain protein 1 0.0151003
DAPK1 death-associated protein kinase 1 0.0150975
ANXA1 annexin A1 0.0150937
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.0150691
PPP4R3A protein phosphatase 4 regulatory subunit 3A 0.0150602
SRSF4 serine/arginine-rich splicing factor 4 0.0150261
PNKD paroxysmal nonkinesigenic dyskinesia 0.0150042
MTA3 metastasis associated 1 family, member 3 0.0149792
IGFBP3 insulin-like growth factor binding protein 3 0.0147944
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0147906
MAP2K4 mitogen-activated protein kinase kinase 4 0.0147748
MAP2K5 mitogen-activated protein kinase kinase 5 0.0147563
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.0147483
CTPS1 CTP synthase 1 0.014702
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0146618
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0145939
PRNP prion protein 0.0145744
CDC123 cell division cycle 123 0.0145198
FDXR ferredoxin reductase 0.0144929
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 0.0144881
TMEM260 transmembrane protein 260 0.0144858
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0144763
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0144745
SFSWAP splicing factor, suppressor of white-apricot family 0.0144564
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0144355
KIAA0586 KIAA0586 0.0143906
EDEM2 ER degradation enhancer, mannosidase alpha-like 2 0.0143796
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0143572
FADS2 fatty acid desaturase 2 0.0142974
ITSN2 intersectin 2 0.0142885
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 0.0142795
SEC31A SEC31 homolog A (S. cerevisiae) 0.0142684
TMBIM4 transmembrane BAX inhibitor motif containing 4 0.0142594
PRKD1 protein kinase D1 0.0142569
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0142134
ZNF573 zinc finger protein 573 0.0141831
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 0.014164
RNF216 ring finger protein 216 0.014107
FBXW5 F-box and WD repeat domain containing 5 0.0141067
ATE1 arginyltransferase 1 0.0141047
GPATCH2 G patch domain containing 2 0.0141014
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) 0.0140999
BMAL1 basic helix-loop-helix ARNT like 1 0.0140837
ENTREP2 endosomal transmembrane epsin interactor 2 0.0140032
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.0140027
PLD3 phospholipase D family, member 3 0.013975
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0139734
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5 0.0139608
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0139394
RTF2 replication termination factor 2 0.013915
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.0139018
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 0.013856
APTX aprataxin 0.0138306
ZFP36L1 ZFP36 ring finger protein-like 1 0.0138275
MCFD2 multiple coagulation factor deficiency 2 0.0137608
GSK3B glycogen synthase kinase 3 beta 0.0137243
TACR1 tachykinin receptor 1 0.013721
RPL35A ribosomal protein L35a 0.0136903
TOP2B topoisomerase (DNA) II beta 180kDa 0.0136551
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) 0.0136329
CHUK conserved helix-loop-helix ubiquitous kinase 0.0136328
SLC38A10 solute carrier family 38, member 10 0.013545
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0135438
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 0.0135406
BRMS1L breast cancer metastasis-suppressor 1-like 0.013521
MAP2K6 mitogen-activated protein kinase kinase 6 0.0135132
FKBP15 FK506 binding protein 15, 133kDa 0.0135097
TOP6BL TOP6B like initiator of meiotic double strand breaks 0.0134718
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0134461
ASPH aspartate beta-hydroxylase 0.0134396
IL6R interleukin 6 receptor 0.0133935
TGIF1 TGFB-induced factor homeobox 1 0.0133803
FRYL FRY-like 0.0133485
ZNF407 zinc finger protein 407 0.0132936
PSPC1 paraspeckle component 1 0.0132717
UBE2Z ubiquitin-conjugating enzyme E2Z 0.0132467
N4BP1 NEDD4 binding protein 1 0.0132227
NPAS2 neuronal PAS domain protein 2 0.0132159
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0131702
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.0131585
KIRREL3 kin of IRRE like 3 (Drosophila) 0.0131494
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0131485
ARHGAP21 Rho GTPase activating protein 21 0.0131482
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 0.0131397
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 0.0131237
RORA RAR-related orphan receptor A 0.0130984
KTN1 kinectin 1 (kinesin receptor) 0.013091
FRMD5 FERM domain containing 5 0.0130893
SRGN serglycin 0.0130834
DENND4A DENN/MADD domain containing 4A 0.0130817
UBASH3B ubiquitin associated and SH3 domain containing B 0.0130786
AMIGO2 adhesion molecule with Ig-like domain 2 0.0130706
ZNF251 zinc finger protein 251 0.0130472
FASTKD1 FAST kinase domains 1 0.013034
PCNX2 pecanex 2 0.0130161
RNF170 ring finger protein 170 0.0130064
AKR1C1 aldo-keto reductase family 1, member C1 0.0130049
FAM135A family with sequence similarity 135, member A 0.0129951
FTO fat mass and obesity associated 0.0129766
RTN4RL2 reticulon 4 receptor-like 2 0.0129724
RNF145 ring finger protein 145 0.0129718
LCMT1 leucine carboxyl methyltransferase 1 0.0129436
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa 0.0129172
TIAM2 T-cell lymphoma invasion and metastasis 2 0.0129007
TXNDC15 thioredoxin domain containing 15 0.0128526
PNO1 partner of NOB1 homolog (S. cerevisiae) 0.0128512
PRICKLE2 prickle homolog 2 (Drosophila) 0.0128405
HECTD2 HECT domain containing E3 ubiquitin protein ligase 2 0.0128103
PPP1R21 protein phosphatase 1, regulatory subunit 21 0.0127966
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0127636
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0127326
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0126963
BHLHE40 basic helix-loop-helix family, member e40 0.0126687
LEPROTL1 leptin receptor overlapping transcript-like 1 0.0126615
SMG6 SMG6 nonsense mediated mRNA decay factor 0.0126406
SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33 0.0126365
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.0126359
AMBRA1 autophagy/beclin-1 regulator 1 0.0126344
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0125959
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0125928
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) 0.0125862
NAV3 neuron navigator 3 0.0125839
FMR1 fragile X mental retardation 1 0.0125715
ACO1 aconitase 1, soluble 0.0125644
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0125353
SKIC3 SKI3 subunit of superkiller complex 0.0125311
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0125149
RNFT2 ring finger protein, transmembrane 2 0.0125144
CHLSN cholesin 0.0125089
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.0125019
SESN1 sestrin 1 0.0124904
MRPS27 mitochondrial ribosomal protein S27 0.0124796
ZFAND6 zinc finger, AN1-type domain 6 0.0124748
PROSER2 proline and serine rich 2 0.0124744
NRDC nardilysin convertase 0.0124665
ANO6 anoctamin 6 0.0124563
PLCH1 phospholipase C, eta 1 0.0124544
RSPRY1 ring finger and SPRY domain containing 1 0.0124508
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 0.0124322
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) 0.0124228
ARSL arylsulfatase L 0.0124176
PDIA6 protein disulfide isomerase family A, member 6 0.0124095
BRD7 bromodomain containing 7 0.0123987
TKT transketolase 0.0123584
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.0123376
SOS2 son of sevenless homolog 2 (Drosophila) 0.0123276
TRAK1 trafficking protein, kinesin binding 1 0.0123265
DGKD diacylglycerol kinase, delta 130kDa 0.0122896
RPE ribulose-5-phosphate-3-epimerase 0.0122805
COPA coatomer protein complex, subunit alpha 0.0122597
PTPRF protein tyrosine phosphatase, receptor type, F 0.0122552
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0122424
YBX3 Y box binding protein 3 0.0122337
TET1 tet methylcytosine dioxygenase 1 0.0122185
KIDINS220 kinase D-interacting substrate, 220kDa 0.0121976
ORC4 origin recognition complex, subunit 4 0.0121571
SLC9D1 solute carrier family 9 member D1 0.0121059
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 0.0120946
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) 0.0120739
NT5DC1 5'-nucleotidase domain containing 1 0.0120566
CTSA cathepsin A 0.0120431
COMMD1 copper metabolism (Murr1) domain containing 1 0.0120263
PHB1 prohibitin 1 0.0120184
UNC93B1 unc-93 homolog B1 (C. elegans) 0.0120151
NAV2 neuron navigator 2 0.0120105
BAX BCL2-associated X protein 0.0119788
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 0.0119531
GDAP1 ganglioside induced differentiation associated protein 1 0.0119194
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0119124
NRP1 neuropilin 1 0.0118943
IFT81 intraflagellar transport 81 0.0118803
CSNK1G2 casein kinase 1, gamma 2 0.0118762
AP2A1 adaptor-related protein complex 2, alpha 1 subunit 0.0118749
TSC1 tuberous sclerosis 1 0.0118722
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0118597
OSGIN2 oxidative stress induced growth inhibitor family member 2 0.0118433
MIPOL1 mirror-image polydactyly 1 0.0118411

decreased expression

Symbol Name Standardized Value
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0990462
PTGR1 prostaglandin reductase 1 -0.0957027
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0891977
KRT81 keratin 81, type II -0.0869465
MKI67 marker of proliferation Ki-67 -0.0856162
CNTNAP3B contactin associated protein-like 3B -0.0747756
MTUS1 microtubule associated tumor suppressor 1 -0.0725335
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.067265
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0603064
BIRC6 baculoviral IAP repeat containing 6 -0.0578508
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0511758
FNDC3B fibronectin type III domain containing 3B -0.0504621
PKM pyruvate kinase, muscle -0.0499567
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0492935
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0477149
CLIP2 CAP-GLY domain containing linker protein 2 -0.0476118
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0470704
PDE8A phosphodiesterase 8A -0.0470095
HIP1 huntingtin interacting protein 1 -0.0469766
PHGDH phosphoglycerate dehydrogenase -0.0459574
KANK1 KN motif and ankyrin repeat domains 1 -0.0453685
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0449784
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0449606
GRAMD1A GRAM domain containing 1A -0.0442749
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0433586
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0432047
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) -0.0430364
EFNA5 ephrin-A5 -0.0428089
UBL4A ubiquitin-like 4A -0.0426151
LARP1 La ribonucleoprotein domain family, member 1 -0.0422016
TBL1X transducin (beta)-like 1X-linked -0.0415367
EZR ezrin -0.0413853
RPL18 ribosomal protein L18 -0.0411248
CUX1 cut-like homeobox 1 -0.0411234
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0406711
CNKSR3 CNKSR family member 3 -0.0401588
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0400181
CALD1 caldesmon 1 -0.0399723
CAPNS1 calpain, small subunit 1 -0.0398436
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0397817
METTL16 methyltransferase like 16 -0.0374645
MYO19 myosin XIX -0.037231
VDAC2 voltage-dependent anion channel 2 -0.0370723
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0369129
POLK polymerase (DNA directed) kappa -0.0368246
FCGBP Fc fragment of IgG binding protein -0.0362081
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0362037
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0361329
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0360115
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0359453
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0352914
RBM39 RNA binding motif protein 39 -0.0352872
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0351089
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase -0.0338148
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0334708
IPO9 importin 9 -0.0332522
DENND1A DENN/MADD domain containing 1A -0.0331875
NCOA2 nuclear receptor coactivator 2 -0.0331699
THOC2 THO complex 2 -0.0330789
POTEF POTE ankyrin domain family, member F -0.0330055
HIPK2 homeodomain interacting protein kinase 2 -0.0328943
RABEP1 rabaptin, RAB GTPase binding effector protein 1 -0.0328903
ZMYM2 zinc finger, MYM-type 2 -0.0325371
TPR translocated promoter region, nuclear basket protein -0.0324805
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0324461
PTMS parathymosin -0.0323365
PDS5A PDS5 cohesin associated factor A -0.0323257
TNPO1 transportin 1 -0.031964
RBM6 RNA binding motif protein 6 -0.0319569
ZCCHC7 zinc finger, CCHC domain containing 7 -0.031778
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0314122
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial -0.0313598
AGR2 anterior gradient 2 -0.0311031
WWOX WW domain containing oxidoreductase -0.0310726
GPATCH8 G patch domain containing 8 -0.031057
PUM2 pumilio RNA-binding family member 2 -0.0306262
DIS3L DIS3 like exosome 3'-5' exoribonuclease -0.030486
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0301792
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0301426
RAD51B RAD51 paralog B -0.0300878
AKAP12 A kinase (PRKA) anchor protein 12 -0.0299806
PATJ PATJ crumbs cell polarity complex component -0.0295535
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0293955
KPNB1 karyopherin (importin) beta 1 -0.0293401
CERS6 ceramide synthase 6 -0.0292657
IRS2 insulin receptor substrate 2 -0.0291014
SLC38A1 solute carrier family 38, member 1 -0.0290499
BLVRB biliverdin reductase B -0.0289703
MORF4L2 mortality factor 4 like 2 -0.0287968
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0287688
RTN4 reticulon 4 -0.0287393
TRIM33 tripartite motif containing 33 -0.028733
RBL1 retinoblastoma-like 1 -0.0286362
VCP valosin containing protein -0.0286064
SETD5 SET domain containing 5 -0.0285906
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 -0.0284679
TACC1 transforming, acidic coiled-coil containing protein 1 -0.0284227
PRPF8 pre-mRNA processing factor 8 -0.0280229
MYADM myeloid-associated differentiation marker -0.0279049
CEP128 centrosomal protein 128kDa -0.0278442
NUP98 nucleoporin 98kDa -0.0277112
TPX2 TPX2, microtubule-associated -0.0276631
TPM4 tropomyosin 4 -0.0276492
GSR glutathione reductase -0.0274533
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0273942
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -0.0272669
USP36 ubiquitin specific peptidase 36 -0.0272368
SEC11A SEC11 homolog A (S. cerevisiae) -0.0271411
ZNF652 zinc finger protein 652 -0.0268473
CKAP4 cytoskeleton-associated protein 4 -0.0268469
XPO1 exportin 1 -0.0266532
GDI2 GDP dissociation inhibitor 2 -0.0266056
NCAPG2 non-SMC condensin II complex, subunit G2 -0.0265673
PIR pirin (iron-binding nuclear protein) -0.026445
ADAM17 ADAM metallopeptidase domain 17 -0.0264092
CENPF centromere protein F, 350/400kDa -0.026296
CHD4 chromodomain helicase DNA binding protein 4 -0.0262002
PER2 period circadian clock 2 -0.0252388
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -0.0250907
SUZ12 SUZ12 polycomb repressive complex 2 subunit -0.025014
MUSK muscle, skeletal, receptor tyrosine kinase -0.024955
CMIP c-Maf inducing protein -0.0248993
KIF11 kinesin family member 11 -0.0248593
PTK2 protein tyrosine kinase 2 -0.0247888
RPH3AL rabphilin 3A-like (without C2 domains) -0.0246956
MRTFA myocardin related transcription factor A -0.0246305
USP3 ubiquitin specific peptidase 3 -0.0246059
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0244247
MCM8 minichromosome maintenance complex component 8 -0.0243632
YME1L1 YME1-like 1 ATPase -0.0243437
PHC3 polyhomeotic homolog 3 (Drosophila) -0.024291
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0242333
RPLP0 ribosomal protein, large, P0 -0.0241881
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0241766
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0241748
ZNF638 zinc finger protein 638 -0.0241398
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0241037
FHIT fragile histidine triad -0.024005
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0239979
RPL38 ribosomal protein L38 -0.0239494
UBE2K ubiquitin-conjugating enzyme E2K -0.0239321
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0239022
NAP1L1 nucleosome assembly protein 1-like 1 -0.0238511
ETF1 eukaryotic translation termination factor 1 -0.0235645
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0235523
HELLS helicase, lymphoid-specific -0.0235081
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0234777
SYAP1 synapse associated protein 1 -0.0234694
FBXO17 F-box protein 17 -0.0233969
NOSTRIN nitric oxide synthase trafficking -0.0232765
FUS FUS RNA binding protein -0.023252
RASA2 RAS p21 protein activator 2 -0.0231624
FANCI Fanconi anemia, complementation group I -0.0231618
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -0.0231001
FNBP4 formin binding protein 4 -0.0229871
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0227695
LRIF1 ligand dependent nuclear receptor interacting factor 1 -0.0226651
TMSB10 thymosin beta 10 -0.022575
BTBD1 BTB (POZ) domain containing 1 -0.0225469
ALMS1 Alstrom syndrome protein 1 -0.0225346
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) -0.0224948
CAMKMT calmodulin-lysine N-methyltransferase -0.02247
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0224641
OSBPL10 oxysterol binding protein-like 10 -0.0224261
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0223781
TTC3 tetratricopeptide repeat domain 3 -0.0222839
ATAD2 ATPase family, AAA domain containing 2 -0.0222383
PTPN3 protein tyrosine phosphatase, non-receptor type 3 -0.0222137
OPHN1 oligophrenin 1 -0.0221318
RAB1A RAB1A, member RAS oncogene family -0.0221024
ATXN3 ataxin 3 -0.0220824
SPIDR scaffolding protein involved in DNA repair -0.0220649
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0219928
POU2F1 POU class 2 homeobox 1 -0.0219909
ARHGAP26 Rho GTPase activating protein 26 -0.0219788
NCEH1 neutral cholesterol ester hydrolase 1 -0.0219119
PRC1 protein regulator of cytokinesis 1 -0.0219091
RPS17 ribosomal protein S17 -0.0218786
PUS7 pseudouridylate synthase 7 (putative) -0.0217291
LTBP1 latent transforming growth factor beta binding protein 1 -0.0216305
MTCL1 microtubule crosslinking factor 1 -0.0216269
CLSTN1 calsyntenin 1 -0.0215958
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0215601
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0213843
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0212382
SFXN5 sideroflexin 5 -0.0211856
TPD52 tumor protein D52 -0.0211148
SMC4 structural maintenance of chromosomes 4 -0.0210784
NSD2 nuclear receptor binding SET domain protein 2 -0.0210351
KLF3 Kruppel-like factor 3 (basic) -0.0209252
KARS1 lysyl-tRNA synthetase 1 -0.0209231
LRMDA leucine rich melanocyte differentiation associated -0.0208744
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0208069
KNTC1 kinetochore associated 1 -0.0207839
DPY19L1 dpy-19-like 1 (C. elegans) -0.0207513
ARHGAP35 Rho GTPase activating protein 35 -0.0207164
NEIL3 nei endonuclease VIII-like 3 (E. coli) -0.0206711
THADA thyroid adenoma associated -0.0206206
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0205442
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -0.0205397
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0205352
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -0.0205301
HJURP Holliday junction recognition protein -0.0204695
MAP3K21 mitogen-activated protein kinase kinase kinase 21 -0.0202803
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.020275
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit -0.0202568
FGA fibrinogen alpha chain -0.0202237
KIF4A kinesin family member 4A -0.0201769
CPT1A carnitine palmitoyltransferase 1A (liver) -0.0201723
SNX25 sorting nexin 25 -0.0201184
STXBP4 syntaxin binding protein 4 -0.0201167
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0201005
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0200675
ETFA electron-transfer-flavoprotein, alpha polypeptide -0.0200512
CYSTM1 cysteine-rich transmembrane module containing 1 -0.0200411
SBF2 SET binding factor 2 -0.0200143
MCM4 minichromosome maintenance complex component 4 -0.0199237
ECPAS Ecm29 proteasome adaptor and scaffold -0.0198992
RILPL1 Rab interacting lysosomal protein-like 1 -0.0198859
TRIM37 tripartite motif containing 37 -0.0198634
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide -0.0198463
LRP12 low density lipoprotein receptor-related protein 12 -0.0198167
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) -0.0197221
PCED1B PC-esterase domain containing 1B -0.0197204
UBE3C ubiquitin protein ligase E3C -0.0197043
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0196611
CD44 CD44 molecule (Indian blood group) -0.0196383
SEPTIN9 septin 9 -0.0196173
WRN Werner syndrome, RecQ helicase-like -0.0195961
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0195563
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0195434
MYH10 myosin, heavy chain 10, non-muscle -0.0194989
TESC tescalcin -0.0194814
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 -0.0194428
MELK maternal embryonic leucine zipper kinase -0.0194351
BRD4 bromodomain containing 4 -0.0194164
KIAA1958 KIAA1958 -0.0193975
KLF13 Kruppel-like factor 13 -0.0193894
CKAP5 cytoskeleton associated protein 5 -0.0193722
PRR11 proline rich 11 -0.0193407
MYO1D myosin ID -0.019334
UBA2 ubiquitin-like modifier activating enzyme 2 -0.0192933
ARHGAP12 Rho GTPase activating protein 12 -0.0192182
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0192028
FSTL4 follistatin-like 4 -0.0191706
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -0.0191674
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0191637
GPS2 G protein pathway suppressor 2 -0.0191446
QRICH1 glutamine-rich 1 -0.0189648
IARS1 isoleucyl-tRNA synthetase 1 -0.018964
PLAUR plasminogen activator, urokinase receptor -0.0189262
TXN2 thioredoxin 2 -0.0189082
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) -0.0187995
EEF2K eukaryotic elongation factor 2 kinase -0.0187828
AUTS2 autism susceptibility candidate 2 -0.0187436
CREBBP CREB binding protein -0.0187155
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -0.018622
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 -0.0185963
FN1 fibronectin 1 -0.0185754
ABI2 abl-interactor 2 -0.0185697
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0185139
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 -0.0185002
CLPTM1 cleft lip and palate associated transmembrane protein 1 -0.0184733
BRCA1 breast cancer 1, early onset -0.0184677
NAMPT nicotinamide phosphoribosyltransferase -0.018434
GNB5 guanine nucleotide binding protein (G protein), beta 5 -0.0183861
DIAPH3 diaphanous-related formin 3 -0.0183794
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -0.0183419
RPL15 ribosomal protein L15 -0.0183285
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein -0.0183236
EDN1 endothelin 1 -0.0182912
ZNF33A zinc finger protein 33A -0.0182653
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.0182316
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0182006
WDR26 WD repeat domain 26 -0.0181949
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0181376
KIF14 kinesin family member 14 -0.0179956
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0179902
FAM177A1 family with sequence similarity 177, member A1 -0.017976
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase -0.0179469
PITPNA phosphatidylinositol transfer protein, alpha -0.0178933
PBX3 pre-B-cell leukemia homeobox 3 -0.0178917
H1-10 H1.10 linker histone -0.0178889
FMN1 formin 1 -0.0177999
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0177666
RPLP2 ribosomal protein, large, P2 -0.0177453
UBTF upstream binding transcription factor, RNA polymerase I -0.0177023
TMED8 transmembrane emp24 protein transport domain containing 8 -0.01769
THRAP3 thyroid hormone receptor associated protein 3 -0.0176055
GTSE1 G-2 and S-phase expressed 1 -0.0176034
NAP1L4 nucleosome assembly protein 1-like 4 -0.0175648
FAM13B family with sequence similarity 13, member B -0.017563
GRAMD1B GRAM domain containing 1B -0.0175286
TOM1L2 target of myb1-like 2 (chicken) -0.0175158
WWP2 WW domain containing E3 ubiquitin protein ligase 2 -0.0174842
MMS22L MMS22-like, DNA repair protein -0.0174814
FOXK2 forkhead box K2 -0.0174714
AUP1 ancient ubiquitous protein 1 -0.0174606
ENSA endosulfine alpha -0.0173912
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0173683
RPL5 ribosomal protein L5 -0.0173605
TRA2A transformer 2 alpha homolog (Drosophila) -0.0173423
HACD3 3-hydroxyacyl-CoA dehydratase 3 -0.0172415
ANAPC5 anaphase promoting complex subunit 5 -0.0172114
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0172067
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0171773
KMT5B lysine methyltransferase 5B -0.0171764
TCF12 transcription factor 12 -0.0171741
STAT5B signal transducer and activator of transcription 5B -0.0171712
APP amyloid beta (A4) precursor protein -0.0171276
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0171126
BMERB1 bMERB domain containing 1 -0.0170999
NVL nuclear VCP-like -0.0170912
NR2C2 nuclear receptor subfamily 2, group C, member 2 -0.0170766
ZNRF3 zinc and ring finger 3 -0.0170235
AHI1 Abelson helper integration site 1 -0.0170179
CEP170 centrosomal protein 170kDa -0.0169392
AARS1 alanyl-tRNA synthetase 1 -0.0169273
LUC7L LUC7-like (S. cerevisiae) -0.0169181
LOC112694756 uncharaterized LOC112694756 -0.0169179
ERICH1 glutamate-rich 1 -0.0169067
ADGRE5 adhesion G protein-coupled receptor E5 -0.0168691
HACD2 3-hydroxyacyl-CoA dehydratase 2 -0.0168626
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.016862
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0168508
STRN striatin, calmodulin binding protein -0.0167826
YIPF5 Yip1 domain family, member 5 -0.0167387
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0166941
GCN1 GCN1 activator of EIF2AK4 -0.0166596
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) -0.0166518
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) -0.0166327
RFWD3 ring finger and WD repeat domain 3 -0.016609
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.016576
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0165602
CP ceruloplasmin (ferroxidase) -0.0165581
MAPK6 mitogen-activated protein kinase 6 -0.0165509
RRP1B ribosomal RNA processing 1B -0.0165371
ANTXR1 anthrax toxin receptor 1 -0.0165267
CCNY cyclin Y -0.0165215
CTCF CCCTC-binding factor (zinc finger protein) -0.0164854
ACTN1 actinin, alpha 1 -0.0164575
IGSF1 immunoglobulin superfamily, member 1 -0.0164478
LRP5 low density lipoprotein receptor-related protein 5 -0.0163299
RNPS1 RNA binding protein S1, serine-rich domain -0.0163204
HCFC1 host cell factor C1 -0.0162773
VPS35L VPS35 endosomal protein sorting factor like -0.0162703
LAMP1 lysosomal-associated membrane protein 1 -0.016269
NRF1 nuclear respiratory factor 1 -0.0162529
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0162446
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -0.0162094
UIMC1 ubiquitin interaction motif containing 1 -0.0162092
ERH enhancer of rudimentary homolog (Drosophila) -0.016194
DGKH diacylglycerol kinase, eta -0.0161913
HNRNPF heterogeneous nuclear ribonucleoprotein F -0.0161874
SHKBP1 SH3KBP1 binding protein 1 -0.0161697
MTFMT mitochondrial methionyl-tRNA formyltransferase -0.0161544
CUL5 cullin 5 -0.0161215
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.0160806
CD320 CD320 molecule -0.0160503
VEZT vezatin, adherens junctions transmembrane protein -0.0160492
AGO3 argonaute RISC catalytic component 3 -0.0160186
GMPS guanine monphosphate synthase -0.0160086
NEDD1 neural precursor cell expressed, developmentally down-regulated 1 -0.0160073
GABPB1 GA binding protein transcription factor, beta subunit 1 -0.0159855
NCOR1 nuclear receptor corepressor 1 -0.0159484
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) -0.0159355
REST RE1-silencing transcription factor -0.0159298
ECT2 epithelial cell transforming 2 -0.0159233
DLG1 discs, large homolog 1 (Drosophila) -0.0158854
CUL3 cullin 3 -0.0158776
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 -0.0158753
NTN4 netrin 4 -0.015869
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0158594
NUSAP1 nucleolar and spindle associated protein 1 -0.0158551
SPATS2 spermatogenesis associated, serine-rich 2 -0.015823
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0158198
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0157548
CDC25C cell division cycle 25C -0.0157421
KDM3B lysine (K)-specific demethylase 3B -0.0157408
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0157089
TASOR2 transcription activation suppressor family member 2 -0.0156909
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0156858
NRIP1 nuclear receptor interacting protein 1 -0.0156642
USP22 ubiquitin specific peptidase 22 -0.0156284
SGMS1 sphingomyelin synthase 1 -0.015624
MACROD2 MACRO domain containing 2 -0.0156149
RPS16 ribosomal protein S16 -0.0156126
PAQR5 progestin and adipoQ receptor family member V -0.0156036
FGB fibrinogen beta chain -0.0155798
RPN2 ribophorin II -0.0155771
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0155747
DSPP dentin sialophosphoprotein -0.0155319
LIPH lipase, member H -0.0155136
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.015468
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0154354
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0154311
TACC2 transforming, acidic coiled-coil containing protein 2 -0.0154121
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 -0.0154085
DCTN4 dynactin 4 (p62) -0.0153983
DNA2 DNA replication helicase/nuclease 2 -0.0153872
KIF13A kinesin family member 13A -0.015367
ZNF704 zinc finger protein 704 -0.0153639
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 -0.0153432
USP8 ubiquitin specific peptidase 8 -0.0152843
GOLGA4 golgin A4 -0.0152644
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0152591
HDLBP high density lipoprotein binding protein -0.0152516
FXYD5 FXYD domain containing ion transport regulator 5 -0.0152263
ANAPC1 anaphase promoting complex subunit 1 -0.015213
SYNRG synergin, gamma -0.0151653
GRK5 G protein-coupled receptor kinase 5 -0.0151564
NUP153 nucleoporin 153kDa -0.0151352
CELF1 CUGBP, Elav-like family member 1 -0.0151105
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0151093
CTSD cathepsin D -0.0150548
MCM10 minichromosome maintenance complex component 10 -0.0150512
MLPH melanophilin -0.015001
OSMR oncostatin M receptor -0.0149925
SREBF2 sterol regulatory element binding transcription factor 2 -0.0149073
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -0.0148703
RPL30 ribosomal protein L30 -0.0148661
ZNF280D zinc finger protein 280D -0.0148381
UNC5D unc-5 homolog D (C. elegans) -0.0148086
TRIM16 tripartite motif containing 16 -0.0147978
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0147949
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0147802
AKAP1 A kinase (PRKA) anchor protein 1 -0.0147115
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -0.0147097
CLIC4 chloride intracellular channel 4 -0.014692
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -0.0146906
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.0146833
IQGAP2 IQ motif containing GTPase activating protein 2 -0.0146209
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0146022
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -0.0145973
TLK1 tousled-like kinase 1 -0.0145927
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0145882
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 -0.0145841
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0144515
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -0.0144432
TM9SF4 transmembrane 9 superfamily protein member 4 -0.0144341
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -0.0143932
SLC38A2 solute carrier family 38, member 2 -0.0143802
MYO9B myosin IXB -0.0143254
AKIRIN1 akirin 1 -0.0143091
AFF4 AF4/FMR2 family, member 4 -0.0142882
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0142775
NEMF nuclear export mediator factor -0.014267
CTBP2 C-terminal binding protein 2 -0.0142425
KAT7 K(lysine) acetyltransferase 7 -0.0142123
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.014205
LRRC23 leucine rich repeat containing 23 -0.0141413
INF2 inverted formin, FH2 and WH2 domain containing -0.0141261
VASP vasodilator-stimulated phosphoprotein -0.0140757
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0140736
PDS5B PDS5 cohesin associated factor B -0.0140714
CCDC9 coiled-coil domain containing 9 -0.0140591
SCFD2 sec1 family domain containing 2 -0.0140583
PIGU phosphatidylinositol glycan anchor biosynthesis, class U -0.0140581
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) -0.0140091
CHGB chromogranin B -0.0140035
TRIM28 tripartite motif containing 28 -0.013999
LRRK2 leucine-rich repeat kinase 2 -0.0139931
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0139921
ADIPOR2 adiponectin receptor 2 -0.0139838
RTTN rotatin -0.0139754
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -0.013963
BIRC5 baculoviral IAP repeat containing 5 -0.0139509
LONP2 lon peptidase 2, peroxisomal -0.0139487
WDFY3 WD repeat and FYVE domain containing 3 -0.0139376
LSG1 large 60S subunit nuclear export GTPase 1 -0.0139197
RSL24D1 ribosomal L24 domain containing 1 -0.0139196
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0138943
RABGAP1L RAB GTPase activating protein 1-like -0.0138523
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.01385
ANKRD17 ankyrin repeat domain 17 -0.0138333
USP24 ubiquitin specific peptidase 24 -0.0138233
ENOSF1 enolase superfamily member 1 -0.0138132
ASXL1 additional sex combs like transcriptional regulator 1 -0.0138106
CHPT1 choline phosphotransferase 1 -0.0138057
COX5A cytochrome c oxidase subunit Va -0.0138044
LARP4B La ribonucleoprotein domain family, member 4B -0.013795
TMPO thymopoietin -0.0137807
SLC35B4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 -0.0137802
AEBP2 AE binding protein 2 -0.0137791
PRPF4 pre-mRNA processing factor 4 -0.0137433
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.013735
LIMS1 LIM and senescent cell antigen-like domains 1 -0.013727
CHAF1A chromatin assembly factor 1, subunit A (p150) -0.0137107
EWSR1 EWS RNA-binding protein 1 -0.0137024
DUSP16 dual specificity phosphatase 16 -0.0136946
SECISBP2 SECIS binding protein 2 -0.0136894
CST3 cystatin C -0.0136855
RRBP1 ribosome binding protein 1 -0.0136562
RCOR1 REST corepressor 1 -0.0135939
SLC31A1 solute carrier family 31 (copper transporter), member 1 -0.0135864
GK5 glycerol kinase 5 (putative) -0.0135808
RBBP4 retinoblastoma binding protein 4 -0.0135749
WDR20 WD repeat domain 20 -0.0135744
PRKCE protein kinase C, epsilon -0.0135665
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0135315