ABAT Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description 4-aminobutyrate aminotransferase|4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 18)
External Link http://www.ncbi.nlm.nih.gov/gene/18
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235 interacting proteins for ABAT from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AARS alanyl-tRNA synthetase
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1
ACAA1 acetyl-CoA acyltransferase 1
ACAD9 acyl-CoA dehydrogenase family, member 9
ACLY ATP citrate lyase
ACO2 aconitase 2, mitochondrial
ACTB actin, beta
ACTC1 actin, alpha, cardiac muscle 1
ACTN1 actinin, alpha 1
ACTN4 actinin, alpha 4
AHNAK AHNAK nucleoprotein
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA2 annexin A2
AP3D1 adaptor-related protein complex 3, delta 1 subunit
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARF1 ADP-ribosylation factor 1
ARHGAP1 Rho GTPase activating protein 1
ARMT1 acidic residue methyltransferase 1
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
BAG3 BCL2-associated athanogene 3
BZW1 basic leucine zipper and W2 domains 1
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAND1 cullin-associated and neddylation-dissociated 1
CCT7 chaperonin containing TCP1, subunit 7 (eta)
CDC73 cell division cycle 73
CDK2 cyclin-dependent kinase 2
CDK5 cyclin-dependent kinase 5
CECR5 cat eye syndrome chromosome region, candidate 5
CFL1 cofilin 1 (non-muscle)
CLIC1 chloride intracellular channel 1
CLTC clathrin, heavy chain (Hc)
CLTCL1 clathrin, heavy chain-like 1
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COPA coatomer protein complex, subunit alpha
COPG1 coatomer protein complex, subunit gamma 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CS citrate synthase
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTSD cathepsin D
CTTN cortactin
CUL3 cullin 3
DAGLB diacylglycerol lipase, beta
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DNM1L dynamin 1-like
DSP desmoplakin
DTD1 D-tyrosyl-tRNA deacylase 1
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EEF1G eukaryotic translation elongation factor 1 gamma
EEF2 eukaryotic translation elongation factor 2
EIF4A1 eukaryotic translation initiation factor 4A1
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
ENO1 enolase 1, (alpha)
ESYT1 extended synaptotagmin-like protein 1
ETFA electron-transfer-flavoprotein, alpha polypeptide
EZR ezrin
FAM213A family with sequence similarity 213, member A
FASN fatty acid synthase
FERMT2 fermitin family member 2
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FKBP1A FK506 binding protein 1A, 12kDa
FLNA filamin A, alpha
FLNB filamin B, beta
G6PD glucose-6-phosphate dehydrogenase
GANAB glucosidase, alpha; neutral AB
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GARS glycyl-tRNA synthetase
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPI glucose-6-phosphate isomerase
GSN gelsolin
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HEBP2 heme binding protein 2
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPK heterogeneous nuclear ribonucleoprotein K
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1B heat shock 70kDa protein 1B
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
HYOU1 hypoxia up-regulated 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IPO7 importin 7
IQGAP1 IQ motif containing GTPase activating protein 1
JUP junction plakoglobin
KIAA0368 KIAA0368
KPNB1 karyopherin (importin) beta 1
KRT10 keratin 10, type I
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT77 keratin 77, type II
KRT8 keratin 8, type II
KYNU kynureninase
LDHA lactate dehydrogenase A
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
MARK2 MAP/microtubule affinity-regulating kinase 2
MCM5 minichromosome maintenance complex component 5
MDH2 malate dehydrogenase 2, NAD (mitochondrial)
MED14 mediator complex subunit 14
MOGS mannosyl-oligosaccharide glucosidase
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYH10 myosin, heavy chain 10, non-muscle
MYH9 myosin, heavy chain 9, non-muscle
NACA nascent polypeptide-associated complex alpha subunit
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME2 NME/NM23 nucleoside diphosphate kinase 2
NPEPPS aminopeptidase puromycin sensitive
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUMA1 nuclear mitotic apparatus protein 1
OPA1 optic atrophy 1 (autosomal dominant)
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
OXSR1 oxidative stress responsive 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PABPC1 poly(A) binding protein, cytoplasmic 1
PCBP1 poly(rC) binding protein 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PFKL phosphofructokinase, liver
PFKP phosphofructokinase, platelet
PFN1 profilin 1
PGK1 phosphoglycerate kinase 1
PGM2 phosphoglucomutase 2
PHGDH phosphoglycerate dehydrogenase
PKLR pyruvate kinase, liver and RBC
PKM pyruvate kinase, muscle
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PPP2R2D protein phosphatase 2, regulatory subunit B, delta
PRDX1 peroxiredoxin 1
PRDX2 peroxiredoxin 2
PRDX3 peroxiredoxin 3
PRDX6 peroxiredoxin 6
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF8 pre-mRNA processing factor 8
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PUS1 pseudouridylate synthase 1
PYGB phosphorylase, glycogen; brain
RAB10 RAB10, member RAS oncogene family
RAB1A RAB1A, member RAS oncogene family
RAB7A RAB7A, member RAS oncogene family
RAN RAN, member RAS oncogene family
RAP2C RAP2C, member of RAS oncogene family
RPL18 ribosomal protein L18
RPL31 ribosomal protein L31
RPLP0 ribosomal protein, large, P0
RPS10 ribosomal protein S10
RPS11 ribosomal protein S11
RPS14 ribosomal protein S14
RPS16 ribosomal protein S16
RPS19 ribosomal protein S19
RPS2 ribosomal protein S2
RPS24 ribosomal protein S24
RPS25 ribosomal protein S25
RPS7 ribosomal protein S7
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase
RUVBL1 RuvB-like AAA ATPase 1
SARS seryl-tRNA synthetase
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEC23A Sec23 homolog A (S. cerevisiae)
SF3B1 splicing factor 3b, subunit 1, 155kDa
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIN3A SIN3 transcription regulator family member A
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SSBP1 single-stranded DNA binding protein 1, mitochondrial
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
SYNE1 spectrin repeat containing, nuclear envelope 1
TAGLN2 transgelin 2
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast)
TKT transketolase
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMX1 thioredoxin-related transmembrane protein 1
TNPO2 transportin 2
TPI1 triosephosphate isomerase 1
TPM1 tropomyosin 1 (alpha)
TRAP1 TNF receptor-associated protein 1
TRIM25 tripartite motif containing 25
TRIM28 tripartite motif containing 28
TUBA1A tubulin, alpha 1a
TUBA1B tubulin, alpha 1b
TUBA1C tubulin, alpha 1c
TUBA3C tubulin, alpha 3c
TUBB tubulin, beta class I
TUBB1 tubulin, beta 1 class VI
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TXN thioredoxin
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UGDH UDP-glucose 6-dehydrogenase
VCL vinculin
VCP valosin containing protein
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)
WDR1 WD repeat domain 1
XPO5 exportin 5
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YBX1 Y box binding protein 1
YBX3 Y box binding protein 3
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNFX1 zinc finger, NFX1-type containing 1