ABC transporters Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD). (Kyoto Encyclopedia of Genes and Genomes, hsa02010)
External Link https://www.kegg.jp/entry/hsa02010
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Genes

45 proteins participating in the ABC transporters pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
DEFB1 defensin, beta 1
SEC14L2 SEC14-like 2 (S. cerevisiae)
SEC14L3 SEC14-like 3 (S. cerevisiae)