ABC-1 Gene Set

Dataset Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles
Category genomics
Type cell line
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Genes

126 genes mutated in the ABC-1 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACLY ATP citrate lyase
ALPPL2 alkaline phosphatase, placental-like 2
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
AMER1 APC membrane recruitment protein 1
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARHGAP21 Rho GTPase activating protein 21
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ATG10 autophagy related 10
BAG1 BCL2-associated athanogene
BICD2 bicaudal D homolog 2 (Drosophila)
CABIN1 calcineurin binding protein 1
CASC5 cancer susceptibility candidate 5
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCAR2 cell cycle and apoptosis regulator 2
CCDC102A coiled-coil domain containing 102A
CCDC120 coiled-coil domain containing 120
CCNT1 cyclin T1
CCSER2 coiled-coil serine-rich protein 2
CENPB centromere protein B, 80kDa
CEP192 centrosomal protein 192kDa
CEP290 centrosomal protein 290kDa
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
COL12A1 collagen, type XII, alpha 1
CRYBG3 beta-gamma crystallin domain containing 3
DALRD3 DALR anticodon binding domain containing 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DMKN dermokine
DNAAF5 dynein, axonemal, assembly factor 5
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21
DTWD2 DTW domain containing 2
EARS2 glutamyl-tRNA synthetase 2, mitochondrial
EDRF1 erythroid differentiation regulatory factor 1
EGF epidermal growth factor
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
ELF5 E74-like factor 5 (ets domain transcription factor)
EML6 echinoderm microtubule associated protein like 6
ENOSF1 enolase superfamily member 1
EPHA2 EPH receptor A2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FANCM Fanconi anemia, complementation group M
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GSK3A glycogen synthase kinase 3 alpha
HEATR1 HEAT repeat containing 1
HES6 hes family bHLH transcription factor 6
HK2 hexokinase 2
HYOU1 hypoxia up-regulated 1
IFT172 intraflagellar transport 172
IL36RN interleukin 36 receptor antagonist
ITGB4 integrin, beta 4
KAAG1 kidney associated antigen 1
KIAA0391 KIAA0391
KRT80 keratin 80, type II
LHX4 LIM homeobox 4
LONP1 lon peptidase 1, mitochondrial
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3
LTA4H leukotriene A4 hydrolase
MAN2B1 mannosidase, alpha, class 2B, member 1
MBD3 methyl-CpG binding domain protein 3
MECR mitochondrial trans-2-enoyl-CoA reductase
MEF2D myocyte enhancer factor 2D
METTL22 methyltransferase like 22
MFSD6 major facilitator superfamily domain containing 6
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MICALL2 MICAL-like 2
MKRN2 makorin ring finger protein 2
MMS22L MMS22-like, DNA repair protein
MSH3 mutS homolog 3
MTIF2 mitochondrial translational initiation factor 2
MUC20 mucin 20, cell surface associated
MYH14 myosin, heavy chain 14, non-muscle
NHSL1 NHS-like 1
NLK nemo-like kinase
NOL10 nucleolar protein 10
NSD1 nuclear receptor binding SET domain protein 1
NT5DC2 5'-nucleotidase domain containing 2
NUCB1 nucleobindin 1
ORC1 origin recognition complex, subunit 1
PASK PAS domain containing serine/threonine kinase
PCYOX1 prenylcysteine oxidase 1
PFKL phosphofructokinase, liver
PNISR PNN-interacting serine/arginine-rich protein
POLE polymerase (DNA directed), epsilon, catalytic subunit
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PPP6R1 protein phosphatase 6, regulatory subunit 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTPN14 protein tyrosine phosphatase, non-receptor type 14
RAB4B RAB4B, member RAS oncogene family
RAB8B RAB8B, member RAS oncogene family
RC3H1 ring finger and CCCH-type domains 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RNF43 ring finger protein 43
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPF1 ribosome production factor 1 homolog (S. cerevisiae)
RSL1D1 ribosomal L1 domain containing 1
RUNX1 runt-related transcription factor 1
SEPT9 septin 9
SETD9 SET domain containing 9
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLK STE20-like kinase
SMAD7 SMAD family member 7
SRD5A3 steroid 5 alpha-reductase 3
SUGP2 SURP and G patch domain containing 2
SYDE2 synapse defective 1, Rho GTPase, homolog 2 (C. elegans)
TCF25 transcription factor 25 (basic helix-loop-helix)
TERF2IP telomeric repeat binding factor 2, interacting protein
THADA thyroid adenoma associated
TMEM248 transmembrane protein 248
TMEM59 transmembrane protein 59
TP53 tumor protein p53
TRADD TNFRSF1A-associated via death domain
UTRN utrophin
VASN vasorin
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
VPS9D1 VPS9 domain containing 1
YEATS2 YEATS domain containing 2
YLPM1 YLP motif containing 1
ZNF227 zinc finger protein 227
ZNF235 zinc finger protein 235
ZNF615 zinc finger protein 615
ZNF638 zinc finger protein 638
ZNF710 zinc finger protein 710
ZNF76 zinc finger protein 76