ABCC8 Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description ATP-binding cassette, sub-family C (CFTR/MRP), member 8|The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013] (NCBI Entrez Gene Database, 6833)
External Link http://www.ncbi.nlm.nih.gov/gene/6833
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Genes

135 interacting proteins for hub protein ABCC8 from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACTL6A actin-like 6A
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
AQP9 aquaporin 9
ARFIP2 ADP-ribosylation factor interacting protein 2
ATM ATM serine/threonine kinase
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
AZF1 azoospermia factor 1
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CCL14 chemokine (C-C motif) ligand 14
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD1A CD1a molecule
CD3EAP CD3e molecule, epsilon associated protein
CD40LG CD40 ligand
CDC14A cell division cycle 14A
CDC45 cell division cycle 45
CDK9 cyclin-dependent kinase 9
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHD1 chromodomain helicase DNA binding protein 1
CLEC14A C-type lectin domain family 14, member A
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COQ4 coenzyme Q4
CPA1 carboxypeptidase A1 (pancreatic)
CPA2 carboxypeptidase A2 (pancreatic)
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
DMAP1 DNA methyltransferase 1 associated protein 1
DOT1L DOT1-like histone H3K79 methyltransferase
EAF1 ELL associated factor 1
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
ENG endoglin
EPC1 enhancer of polycomb homolog 1 (Drosophila)
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
EXOSC7 exosome component 7
FHL1 four and a half LIM domains 1
FOXO1 forkhead box O1
FPR2 formyl peptide receptor 2
FPR3 formyl peptide receptor 3
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GID4 GID complex subunit 4
HAT1 histone acetyltransferase 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
ICE2 interactor of little elongation complex ELL subunit 2
INO80 INO80 complex subunit
IPO5 importin 5
ITC1 hypertrichosis universalis congenita, Ambras type
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KAT2A K(lysine) acetyltransferase 2A
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KIAA0020 KIAA0020
KRI1 KRI1 homolog (S. cerevisiae)
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MDN1 MDN1, midasin homolog (yeast)
MORF4L1 mortality factor 4 like 1
MUS81 MUS81 structure-specific endonuclease subunit
NABP1 nucleic acid binding protein 1
NET1 neuroepithelial cell transforming 1
NOM1 nucleolar protein with MIF4G domain 1
ORC1 origin recognition complex, subunit 1
ORC2 origin recognition complex, subunit 2
ORC4 origin recognition complex, subunit 4
ORC6 origin recognition complex, subunit 6
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
PEX19 peroxisomal biogenesis factor 19
PFKM phosphofructokinase, muscle
PHB2 prohibitin 2
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PSD2 pleckstrin and Sec7 domain containing 2
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RFX1 regulatory factor X, 1 (influences HLA class II expression)
RNF20 ring finger protein 20, E3 ubiquitin protein ligase
RNF4 ring finger protein 4
RPA2 replication protein A2, 32kDa
RPL10 ribosomal protein L10
RPL18A ribosomal protein L18a
RPL30 ribosomal protein L30
RPL38 ribosomal protein L38
RPL5 ribosomal protein L5
RPL7A ribosomal protein L7a
RPL7AP7 ribosomal protein L7a pseudogene 7
RPLP0 ribosomal protein, large, P0
RPS3 ribosomal protein S3
RPS5 ribosomal protein S5
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
RYBP RING1 and YY1 binding protein
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SETD1A SET domain containing 1A
SETD2 SET domain containing 2
SIN3A SIN3 transcription regulator family member A
SIRT2 sirtuin 2
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMC3 structural maintenance of chromosomes 3
SMC6 structural maintenance of chromosomes 6
SPC24 SPC24, NDC80 kinetochore complex component
SPPL3 signal peptide peptidase like 3
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SRCAP Snf2-related CREBBP activator protein
SRF serum response factor (c-fos serum response element-binding transcription factor)
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
SYS1 Sys1 golgi trafficking protein
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
TCP1 t-complex 1
TGFBI transforming growth factor, beta-induced, 68kDa
THA1P threonine aldolase 1, pseudogene
TRAF3IP2 TRAF3 interacting protein 2
TRAPPC1 trafficking protein particle complex 1
TRIM21 tripartite motif containing 21
TROVE2 TROVE domain family, member 2
TRRAP transformation/transcription domain-associated protein
TSEN15 TSEN15 tRNA splicing endonuclease subunit
USO1 USO1 vesicle transport factor
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
VTA1 vesicle (multivesicular body) trafficking 1
WDR18 WD repeat domain 18
WDR46 WD repeat domain 46
ZNF410 zinc finger protein 410