ABCG2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)|The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] (NCBI Entrez Gene Database, 9429)
External Link http://www.ncbi.nlm.nih.gov/gene/9429
Similar Terms
Downloads & Tools

Genes

40 interacting proteins for ABCG2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALPP alkaline phosphatase, placental
CPM carboxypeptidase M
DSG2 desmoglein 2
FLOT1 flotillin 1
FLOT2 flotillin 2
FOLR1 folate receptor 1 (adult)
FYN FYN proto-oncogene, Src family tyrosine kinase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNAS GNAS complex locus
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GPRC5A G protein-coupled receptor, class C, group 5, member A
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPCL1 heterogeneous nuclear ribonucleoprotein C-like 1
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
LGALS1 lectin, galactoside-binding, soluble, 1
LYN LYN proto-oncogene, Src family tyrosine kinase
LYPD3 LY6/PLAUR domain containing 3
MISP mitotic spindle positioning
NEXN nexilin (F actin binding protein)
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PKM pyruvate kinase, muscle
PPP1R12A protein phosphatase 1, regulatory subunit 12A
RBMX RNA binding motif protein, X-linked
RPL17 ribosomal protein L17
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RTN4RL2 reticulon 4 receptor-like 2
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1
STOM stomatin
SVIL supervillin
TMOD3 tropomodulin 3 (ubiquitous)
TRIM69 tripartite motif containing 69
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBC ubiquitin C