ABL1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description ABL proto-oncogene 1, non-receptor tyrosine kinase|This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014] (NCBI Entrez Gene Database, 25)
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Genes

350 genes differentially expressed following the ABL1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GPR26 G protein-coupled receptor 26 3.35281
TCERG1L transcription elongation regulator 1-like 3.35281
LRRC32 leucine rich repeat containing 32 3.35281
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 3.35281
ITGB7 integrin, beta 7 3.35281
GOLGA6A golgin A6 family, member A 3.35281
LY6H lymphocyte antigen 6 complex, locus H 3.35281
SP100 SP100 nuclear antigen 3.35281
CCDC121 coiled-coil domain containing 121 3.35281
TRAF3IP3 TRAF3 interacting protein 3 3.35281
POU5F2 POU domain class 5, transcription factor 2 3.35281
PADI6 peptidyl arginine deiminase, type VI 3.35281
GLUD2 glutamate dehydrogenase 2 3.35281
FMR1NB fragile X mental retardation 1 neighbor 3.35281
PRM1 protamine 1 3.35281
TUBA3D tubulin, alpha 3d 3.35281
GOLGA8N golgin A8 family, member N 3.35281
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 3.35281
ARHGAP20 Rho GTPase activating protein 20 3.35281
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 3.3512
OR8A1 olfactory receptor, family 8, subfamily A, member 1 3.3512
OR2A25 olfactory receptor, family 2, subfamily A, member 25 3.3512
OR52A5 olfactory receptor, family 52, subfamily A, member 5 3.3512
ZNF208 zinc finger protein 208 3.3512
MAGEB10 melanoma antigen family B10 3.3512
FPR2 formyl peptide receptor 2 3.3512
IGFL2 IGF-like family member 2 3.3512
SLC22A10 solute carrier family 22, member 10 3.3512
WEE2 WEE1 homolog 2 (S. pombe) 3.3512
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.3512
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 3.3512
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 3.3512
ZNF492 zinc finger protein 492 3.3512
TRIM10 tripartite motif containing 10 3.3512
MAGEA2 melanoma antigen family A2 3.3512
SLC9C2 solute carrier family 9, member C2 (putative) 3.3512
ADAMTSL5 ADAMTS-like 5 3.3512
MGARP mitochondria-localized glutamic acid-rich protein 3.3512
UMODL1 uromodulin-like 1 3.3512
CPB1 carboxypeptidase B1 (tissue) 3.3512
F2 coagulation factor II (thrombin) 3.3512
DPPA3 developmental pluripotency associated 3 3.3512
CRYGA crystallin, gamma A 3.3512
ATOH1 atonal homolog 1 (Drosophila) 3.3512
SP7 Sp7 transcription factor 3.3512
AIRE autoimmune regulator 3.3512
PCDHB1 protocadherin beta 1 3.3512
TM4SF1 transmembrane 4 L six family member 1 3.3512
SLC25A45 solute carrier family 25, member 45 3.3512
SKOR1 SKI family transcriptional corepressor 1 3.3512
PTH2 parathyroid hormone 2 3.3512
SCNN1G sodium channel, non voltage gated 1 gamma subunit 3.3512
ATP1B4 ATPase, Na+/K+ transporting, beta 4 polypeptide 3.3512
GYPB glycophorin B (MNS blood group) 3.3512
C19ORF67 chromosome 19 open reading frame 67 3.3512
MYO1A myosin IA 3.3512
LIPC lipase, hepatic 3.3512
SAXO5 stabilizer of axonemal microtubules 5 3.3512
CD300LF CD300 molecule-like family member f 3.3512
CCER2 coiled-coil glutamate-rich protein 2 3.3512
ALX4 ALX homeobox 4 3.3512
ADGRG3 adhesion G protein-coupled receptor G3 3.3512
PKD2L1 polycystic kidney disease 2-like 1 3.3512
GPR37L1 G protein-coupled receptor 37 like 1 3.3512
GCSAM germinal center-associated, signaling and motility 3.3512
IMPG1 interphotoreceptor matrix proteoglycan 1 3.3512
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 3.3512
OPRM1 opioid receptor, mu 1 3.3512
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.3512
LY6S-AS1 LY6S antisense RNA 1 3.3512
NOTCH2NLB notch 2 N-terminal like B 3.3512
OOSP4B oocyte secreted protein family member 4B 3.3512
MINDY4B MINDY family member 4B 3.3512
GASK1B golgi associated kinase 1B 3.3512
CPHXL2 cytoplasmic polyadenylated homeobox like 2 3.3512
H3-5 H3.5 histone 3.3512
H2BC1 H2B clustered histone 1 3.3512
MCHR1 melanin-concentrating hormone receptor 1 3.3512
CSAG1 chondrosarcoma associated gene 1 3.3512
NDP Norrie disease (pseudoglioma) 3.3512
CCDC42 coiled-coil domain containing 42 3.3512
MSX1 msh homeobox 1 3.3512
C10ORF67 chromosome 10 open reading frame 67 3.3512
NR1I3 nuclear receptor subfamily 1, group I, member 3 3.3512
ANXA13 annexin A13 3.3512
CKM creatine kinase, muscle 3.3512
WNT11 wingless-type MMTV integration site family, member 11 3.3512
PTGDR2 prostaglandin D2 receptor 2 3.3512
ARL5C ADP-ribosylation factor-like 5C 3.3512
PCDHA8 protocadherin alpha 8 3.3512
FAM90A11 family with sequence similarity 90 member A11 3.3512
PRRT4 proline-rich transmembrane protein 4 3.3512
PRG3 proteoglycan 3 3.3512
COX8C cytochrome c oxidase subunit VIIIC 3.3512
MSH3 mutS homolog 3 3.3512
OOSP1 oocyte secreted protein 1, pseudogene 3.3512
IL1RN interleukin 1 receptor antagonist 3.3512
RGS21 regulator of G-protein signaling 21 3.3512
PGLYRP2 peptidoglycan recognition protein 2 3.3512
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 3.3512
CREB3L3 cAMP responsive element binding protein 3-like 3 3.3512
PCDHA2 protocadherin alpha 2 3.3512
TMC3 transmembrane channel-like 3 3.3512
FNDC9 fibronectin type III domain containing 9 3.3512
LHX9 LIM homeobox 9 3.3512
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 3.3512
CGB7 chorionic gonadotropin, beta polypeptide 7 3.3512
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 3.3512
TSPAN32 tetraspanin 32 3.3512
SPEF1 sperm flagellar 1 3.3512
PCDHGA2 protocadherin gamma subfamily A, 2 3.3512
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 3.3512
ANKRD33 ankyrin repeat domain 33 3.3512
CLEC18C C-type lectin domain family 18, member C 3.3512
PLGLB2 plasminogen-like B2 3.3512
IL19 interleukin 19 3.3512
CFAP126 cilia and flagella associated protein 126 3.3512
PAGE4 P antigen family, member 4 (prostate associated) 3.3512
GPR50 G protein-coupled receptor 50 3.3512
ALAS2 5'-aminolevulinate synthase 2 3.3512
MYF6 myogenic factor 6 (herculin) 3.3512
PLCD4 phospholipase C, delta 4 3.3512
EFCAB3 EF-hand calcium binding domain 3 3.3512
KLHL1 kelch-like family member 1 3.3512
HGFAC HGF activator 3.3512
ETNPPL ethanolamine-phosphate phospho-lyase 3.3512
TAS2R50 taste receptor, type 2, member 50 3.3512
PHOSPHO1 phosphatase, orphan 1 3.3512
TRIM50 tripartite motif containing 50 3.3512
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10 3.3512
TMEM150B transmembrane protein 150B 3.3512
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 3.3512
HELT helt bHLH transcription factor 3.3512
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 3.3512
SLC51B solute carrier family 51, beta subunit 3.3512
FSHR follicle stimulating hormone receptor 3.3512
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 3.3512
RNASE6 ribonuclease, RNase A family, k6 3.3512
NT5C1B 5'-nucleotidase, cytosolic IB 3.3512
FGF7 fibroblast growth factor 7 3.3512
FGB fibrinogen beta chain 3.3512
PDCD1LG2 programmed cell death 1 ligand 2 3.3512
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 3.3512
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 3.3512
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 3.3512
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 3.3512
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 3.3512
SYNGR4 synaptogyrin 4 3.3512
GRM6 glutamate receptor, metabotropic 6 3.3512
CFHR4 complement factor H-related 4 3.3512
GSC2 goosecoid homeobox 2 3.3512
FKBP1C FK506 binding protein 1C 3.3512
PF4V1 platelet factor 4 variant 1 3.3512
NKPD1 NTPase, KAP family P-loop domain containing 1 3.3512
OR51I2 olfactory receptor, family 51, subfamily I, member 2 3.3512
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 3.3512
RAB7B RAB7B, member RAS oncogene family 3.3512
COL6A5 collagen, type VI, alpha 5 3.3512
OXER1 oxoeicosanoid (OXE) receptor 1 3.3512
MPC1L mitochondrial pyruvate carrier 1-like 3.3512
ASCL5 achaete-scute family bHLH transcription factor 5 3.3512
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 3.3512
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 3.3512
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 3.24404
GPX8 glutathione peroxidase 8 (putative) 3.17571
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 3.02106
CCNI2 cyclin I family, member 2 2.9417
METTL14 methyltransferase like 14 2.84623
ROR2 receptor tyrosine kinase-like orphan receptor 2 2.82959
MAGOHB mago-nashi homolog B (Drosophila) 2.64482
SHPK sedoheptulokinase 2.64156
UBAP2 ubiquitin associated protein 2 2.61433
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 2.58299
DEPDC1 DEP domain containing 1 2.50953
KRI1 KRI1 homolog (S. cerevisiae) 2.45798
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 2.44809
MORC3 MORC family CW-type zinc finger 3 2.43725
FGD2 FYVE, RhoGEF and PH domain containing 2 2.42222
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 2.41171
IPO4 importin 4 2.37185
SRPK1 SRSF protein kinase 1 2.35786
PHACTR4 phosphatase and actin regulator 4 2.35021
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 2.34108
SH3GL3 SH3-domain GRB2-like 3 2.33484
POGZ pogo transposable element with ZNF domain 2.31875
ECI1 enoyl-CoA delta isomerase 1 2.30409
COG3 component of oligomeric golgi complex 3 2.29042
CNIH2 cornichon family AMPA receptor auxiliary protein 2 2.27979
PCDH11X protocadherin 11 X-linked 2.27979
EEF1AKMT1 EEF1A lysine methyltransferase 1 2.27979
ZNF71 zinc finger protein 71 2.26244
MYO1D myosin ID 2.25824
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 2.25568
SDR42E2 short chain dehydrogenase/reductase family 42E, member 2 2.25568
PRDM16 PR domain containing 16 2.25568
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 2.25568
FERMT3 fermitin family member 3 2.25568
SCG3 secretogranin III 2.25568
HPCAL4 hippocalcin like 4 2.25568
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 2.25568
ZBED5 zinc finger, BED-type containing 5 2.25568
PPP2R5D protein phosphatase 2, regulatory subunit B', delta 2.25269
MTRF1L mitochondrial translational release factor 1-like 2.24783
PNKP polynucleotide kinase 3'-phosphatase 2.24172
SFSWAP splicing factor, suppressor of white-apricot family 2.24041
NEU3 sialidase 3 (membrane sialidase) 2.20649
PDZRN3 PDZ domain containing ring finger 3 2.20649
ZNF35 zinc finger protein 35 2.20649
TBC1D25 TBC1 domain family, member 25 2.20033
CPQ carboxypeptidase Q 2.20033
ACBD6 acyl-CoA binding domain containing 6 2.19357
BRD1 bromodomain containing 1 2.18727
PCDHGA6 protocadherin gamma subfamily A, 6 2.17502
TSPYL5 TSPY-like 5 2.16879
REXO1 REX1, RNA exonuclease 1 homolog (S. cerevisiae) 2.16821
MRFAP1 Morf4 family associated protein 1 2.14528
INO80D INO80 complex subunit D 2.14177
ZNF771 zinc finger protein 771 2.12896
ZBTB6 zinc finger and BTB domain containing 6 2.12669
TSPAN3 tetraspanin 3 2.12578
PDE4B phosphodiesterase 4B, cAMP-specific 2.12552
SURF4 surfeit 4 2.12181
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.10819
RBM46 RNA binding motif protein 46 2.08904
UBTD2 ubiquitin domain containing 2 2.07875
BRIP1 BRCA1 interacting protein C-terminal helicase 1 2.07361
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 2.06238
MAF1 MAF1 homolog (S. cerevisiae) 2.06212
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 2.06212
GRTP1 growth hormone regulated TBC protein 1 2.054
LDLRAP1 low density lipoprotein receptor adaptor protein 1 2.05194
RBL1 retinoblastoma-like 1 2.04344
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 2.04305
KATNBL1 katanin p80 subunit B-like 1 2.03976
FAM107B family with sequence similarity 107, member B 2.03509
SLMAP sarcolemma associated protein 2.02324

decreased expression

Symbol Name Standardized Value
ARHGEF33 Rho guanine nucleotide exchange factor (GEF) 33 -3.35281
SLA2 Src-like-adaptor 2 -3.35281
LTB4R leukotriene B4 receptor -3.35281
ADGRD1 adhesion G protein-coupled receptor D1 -3.35281
SUSD2 sushi domain containing 2 -3.35281
TMEM191C transmembrane protein 191C -3.3512
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -3.3512
RUFY4 RUN and FYVE domain containing 4 -3.3512
AQP4 aquaporin 4 -3.3512
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) -3.3512
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 -3.3512
GFAP glial fibrillary acidic protein -3.3512
SCGN secretagogin, EF-hand calcium binding protein -3.3512
SLC25A52 solute carrier family 25, member 52 -3.3512
ARHGAP36 Rho GTPase activating protein 36 -3.3512
WFDC1 WAP four-disulfide core domain 1 -3.3512
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 -3.3512
ANGPTL8 angiopoietin like 8 -3.3512
LOC390937 Ets2 repressor factor-like -3.3512
PCDH8 protocadherin 8 -3.3512
EFCAB12 EF-hand calcium binding domain 12 -3.3512
MOGAT3 monoacylglycerol O-acyltransferase 3 -3.3512
TMEM225B transmembrane protein 225B -3.3512
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) -3.3512
SCRG1 stimulator of chondrogenesis 1 -3.3512
ASB14 ankyrin repeat and SOCS box containing 14 -3.3512
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 -3.3512
KISS1R KISS1 receptor -3.3512
KLHL31 kelch-like family member 31 -3.3512
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 -3.2831
ZNF285 zinc finger protein 285 -3.2831
MAST3 microtubule associated serine/threonine kinase 3 -3.20788
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 -3.10722
CEP55 centrosomal protein 55kDa -2.91529
BEX5 brain expressed, X-linked 5 -2.87528
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -2.81984
VEGFC vascular endothelial growth factor C -2.79091
PRR19 proline rich 19 -2.78261
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 -2.78261
LAT linker for activation of T cells -2.75356
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase -2.69899
KDM5B lysine (K)-specific demethylase 5B -2.66182
KDM6A lysine (K)-specific demethylase 6A -2.61433
USP19 ubiquitin specific peptidase 19 -2.61273
TRHDE thyrotropin-releasing hormone degrading enzyme -2.57931
HDHD2 haloacid dehalogenase-like hydrolase domain containing 2 -2.55782
GPATCH4 G patch domain containing 4 -2.54305
AFAP1L2 actin filament associated protein 1-like 2 -2.54011
RAMP3 receptor (G protein-coupled) activity modifying protein 3 -2.53976
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 -2.48496
IRF2BP1 interferon regulatory factor 2 binding protein 1 -2.47359
FNDC4 fibronectin type III domain containing 4 -2.47359
C22ORF23 chromosome 22 open reading frame 23 -2.43975
MYCBPAP MYCBP associated protein -2.41171
AP1S2 adaptor-related protein complex 1, sigma 2 subunit -2.41037
TULP1 tubby like protein 1 -2.40642
NFE2L1 nuclear factor, erythroid 2-like 1 -2.40427
RUMY2 RUMY family member 2 -2.38974
WDR59 WD repeat domain 59 -2.3805
C1R complement component 1, r subcomponent -2.36114
TRIM22 tripartite motif containing 22 -2.35841
LEMD2 LEM domain containing 2 -2.34691
ALKBH7 alkB, alkylation repair homolog 7 (E. coli) -2.33284
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa -2.32203
HAP1 huntingtin-associated protein 1 -2.31875
CACNB3 calcium channel, voltage-dependent, beta 3 subunit -2.31875
CLPSL1 colipase-like 1 -2.31875
TRABD TraB domain containing -2.31875
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -2.31875
KIAA2012 KIAA2012 -2.31875
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) -2.31875
KLKB1 kallikrein B, plasma (Fletcher factor) 1 -2.31597
PSORS1C2 psoriasis susceptibility 1 candidate 2 -2.3145
SPATA32 spermatogenesis associated 32 -2.3145
CCK cholecystokinin -2.3145
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa -2.30409
SELENOO selenoprotein O -2.27838
BRME1 break repair meiotic recombinase recruitment factor 1 -2.2631
ALAD aminolevulinate dehydratase -2.25568
LDLR low density lipoprotein receptor -2.24172
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 -2.23849
FSCN3 fascin actin-bundling protein 3, testicular -2.22752
RPL7 ribosomal protein L7 -2.22394
YY1 YY1 transcription factor -2.21855
RPH3AL rabphilin 3A-like (without C2 domains) -2.2167
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -2.21395
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 -2.20649
NNAT neuronatin -2.20649
SLC16A11 solute carrier family 16, member 11 -2.20649
VSTM2L V-set and transmembrane domain containing 2 like -2.20649
PTGES2 prostaglandin E synthase 2 -2.19357
SF3B5 splicing factor 3b, subunit 5, 10kDa -2.18727
TWF1 twinfilin actin binding protein 1 -2.1856
ENDOV endonuclease V -2.16966
PYGL phosphorylase, glycogen, liver -2.16666
CEP290 centrosomal protein 290kDa -2.16121
ZNF2 zinc finger protein 2 -2.15412
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 -2.14831
LONP1 lon peptidase 1, mitochondrial -2.14492
CDK12 cyclin-dependent kinase 12 -2.12669
MPHOSPH9 M-phase phosphoprotein 9 -2.12669
DOHH deoxyhypusine hydroxylase/monooxygenase -2.12616
RGPD8 RANBP2-like and GRIP domain containing 8 -2.11463
GHRL ghrelin/obestatin prepropeptide -2.11463
PRC1 protein regulator of cytokinesis 1 -2.10047
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 -2.10047
ELP1 elongator acetyltransferase complex subunit 1 -2.07875
SLC9D1 solute carrier family 9 member D1 -2.07361
KIAA1143 KIAA1143 -2.06861
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 -2.0566
CREB3L4 cAMP responsive element binding protein 3-like 4 -2.04344
GAR1 GAR1 ribonucleoprotein -2.04305
RALBP1 ralA binding protein 1 -2.03976
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -2.01377