ABL1 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description ABL proto-oncogene 1, non-receptor tyrosine kinase|This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014] (NCBI Entrez Gene Database, 25)
External Link http://www.ncbi.nlm.nih.gov/gene/25
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Genes

88 substrates of the kinase ABL1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ABI1 abl-interactor 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ANXA1 annexin A1
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APP amyloid beta (A4) precursor protein
ATR ATR serine/threonine kinase
BCR breakpoint cluster region
BMPR1A bone morphogenetic protein receptor, type IA
BTK Bruton agammaglobulinemia tyrosine kinase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD19 CD19 molecule
CDC73 cell division cycle 73
CDK5 cyclin-dependent kinase 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDV3 CDV3 homolog (mouse)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
EGFR epidermal growth factor receptor
EMD emerin
ENAH enabled homolog (Drosophila)
ERCC6 excision repair cross-complementation group 6
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GPX1 glutathione peroxidase 1
GRB2 growth factor receptor-bound protein 2
JAK2 Janus kinase 2
JUN jun proto-oncogene
KAT5 K(lysine) acetyltransferase 5
LASP1 LIM and SH3 protein 1
LGALS3 lectin, galactoside-binding, soluble, 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MET MET proto-oncogene, receptor tyrosine kinase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLK myosin light chain kinase
MYOD1 myogenic differentiation 1
NCK1 NCK adaptor protein 1
NCOA3 nuclear receptor coactivator 3
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUMA1 nuclear mitotic apparatus protein 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PLCG1 phospholipase C, gamma 1
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2
PLSCR1 phospholipid scramblase 1
PRKCD protein kinase C, delta
PRKD1 protein kinase D1
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAD51 RAD51 recombinase
RAD52 RAD52 homolog (S. cerevisiae)
RAD9A RAD9 homolog A (S. pombe)
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
RB1 retinoblastoma 1
RIN1 Ras and Rab interactor 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SORBS1 sorbin and SH3 domain containing 1
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SRCIN1 SRC kinase signaling inhibitor 1
STK3 serine/threonine kinase 3
STK4 serine/threonine kinase 4
STX17 syntaxin 17
TBX21 T-box 21
TOP1 topoisomerase (DNA) I
TP63 tumor protein p63
TP73 tumor protein p73
VAV1 vav 1 guanine nucleotide exchange factor
WAS Wiskott-Aldrich syndrome
WASF2 WAS protein family, member 2
WWTR1 WW domain containing transcription regulator 1
YAP1 Yes-associated protein 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa