ABT-199 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/49846579
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Genes

199 proteins with high or low expression in ABT-199 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
ALAS1 5'-aminolevulinate synthase 1 2.11
MDM1 Mdm1 nuclear protein homolog (mouse) 1.23
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 1.21
CCDC112 coiled-coil domain containing 112 1.2
DCHS1 dachsous cadherin-related 1 0.98
MCL1 myeloid cell leukemia 1 0.85
PRELID3B PRELI domain containing 3B 0.81
CAV2 caveolin 2 0.77
MSH5 mutS homolog 5 0.76
CFAP58 cilia and flagella associated protein 58 0.68
B2M beta-2-microglobulin 0.67
TMEM64 transmembrane protein 64 0.64
TFAP2E transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) 0.63
CYBA cytochrome b-245, alpha polypeptide 0.56
MFAP3 microfibrillar-associated protein 3 0.56
PES1 pescadillo ribosomal biogenesis factor 1 0.53
MIEF1 mitochondrial elongation factor 1 0.53
PPP2R2D protein phosphatase 2, regulatory subunit B, delta 0.5
NEB nebulin 0.5
PXDN peroxidasin 0.49
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 0.49
GSTZ1 glutathione S-transferase zeta 1 0.49
SH3YL1 SH3 and SYLF domain containing 1 0.48
SLC39A3 solute carrier family 39 (zinc transporter), member 3 0.47
DUSP5 dual specificity phosphatase 5 0.45
MCOLN2 mucolipin 2 0.45
ALPK3 alpha-kinase 3 0.44
RNF41 ring finger protein 41, E3 ubiquitin protein ligase 0.44
POLR1A polymerase (RNA) I polypeptide A, 194kDa 0.42
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.42
DISP2 dispatched homolog 2 (Drosophila) 0.42
PAQR7 progestin and adipoQ receptor family member VII 0.41
ARL4A ADP-ribosylation factor-like 4A 0.41
ZNRD1 zinc ribbon domain containing 1 0.4
TDRD6 tudor domain containing 6 0.39
DEAF1 DEAF1 transcription factor 0.39
PRELID1 PRELI domain containing 1 0.39
BCL2L1 BCL2-like 1 0.38
TMEM135 transmembrane protein 135 0.38
ZGRF1 zinc finger, GRF-type containing 1 0.38
JMJD8 jumonji domain containing 8 0.38
PBLD phenazine biosynthesis-like protein domain containing 0.37
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 0.37
ATG101 autophagy related 101 0.37
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.37
FKTN fukutin 0.37
HFE hemochromatosis 0.36
PRDM15 PR domain containing 15 0.36
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.36
ABHD4 abhydrolase domain containing 4 0.35
ZNF581 zinc finger protein 581 0.34
SLC38A9 solute carrier family 38, member 9 0.34
ZNF304 zinc finger protein 304 0.33
COMTD1 catechol-O-methyltransferase domain containing 1 0.33
DCAKD dephospho-CoA kinase domain containing 0.33
TYSND1 trypsin domain containing 1 0.33
PML promyelocytic leukemia 0.33
TPGS2 tubulin polyglutamylase complex subunit 2 0.33
MFAP3L microfibrillar-associated protein 3-like 0.32
CDC37 cell division cycle 37 0.32
ABRACL ABRA C-terminal like 0.32
STXBP6 syntaxin binding protein 6 (amisyn) 0.32
ATN1 atrophin 1 0.32
TRIM15 tripartite motif containing 15 0.31
PHETA1 PH domain containing endocytic trafficking adaptor 1 0.31
DEPDC1B DEP domain containing 1B 0.31
CEP44 centrosomal protein 44kDa 0.31
TMEM102 transmembrane protein 102 0.31
TMEM184C transmembrane protein 184C 0.31
TRIM7 tripartite motif containing 7 0.31
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.3
ZNF34 zinc finger protein 34 0.3
ADIPOR1 adiponectin receptor 1 0.3
TFR2 transferrin receptor 2 0.3
NEK2 NIMA-related kinase 2 0.3
KLK6 kallikrein-related peptidase 6 0.29
EHF ets homologous factor 0.29
DUSP22 dual specificity phosphatase 22 0.29
DDN dendrin 0.29
ZCCHC10 zinc finger, CCHC domain containing 10 0.29
POLR1B polymerase (RNA) I polypeptide B, 128kDa 0.29
AKNA AT-hook transcription factor 0.29
ST5 suppression of tumorigenicity 5 0.29
SYT17 synaptotagmin XVII 0.28
RPS26 ribosomal protein S26 0.28
NABP2 nucleic acid binding protein 2 0.28
ZNF431 zinc finger protein 431 0.28
CBY1 chibby homolog 1 (Drosophila) 0.28
TMEM128 transmembrane protein 128 0.28
SHLD2 shieldin complex subunit 2 0.27
RETREG1 reticulophagy regulator 1 0.27
HINFP histone H4 transcription factor 0.27
PDGFC platelet derived growth factor C 0.27
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 0.27
KIF1B kinesin family member 1B 0.27
POLH polymerase (DNA directed), eta 0.27
RGN regucalcin 0.27
CASKIN1 CASK interacting protein 1 0.27
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 0.27

low expression

Symbol Name Standardized Value
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 -2.26
ZG16B zymogen granule protein 16B -1.27
C7 complement component 7 -1.13
TMC4 transmembrane channel-like 4 -1.01
BAD BCL2-associated agonist of cell death -0.92
FADS1 fatty acid desaturase 1 -0.83
CYCS cytochrome c, somatic -0.73
HAL histidine ammonia-lyase -0.73
SLC4A11 solute carrier family 4, sodium borate transporter, member 11 -0.7
NEU3 sialidase 3 (membrane sialidase) -0.67
ARSK arylsulfatase family, member K -0.62
ERBB3 erb-b2 receptor tyrosine kinase 3 -0.61
PIP4P2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 -0.61
ABHD17C abhydrolase domain containing 17C -0.6
STEAP1 six transmembrane epithelial antigen of the prostate 1 -0.57
KIZ kizuna centrosomal protein -0.56
WSB2 WD repeat and SOCS box containing 2 -0.56
AMPD1 adenosine monophosphate deaminase 1 -0.55
ZFPM1 zinc finger protein, FOG family member 1 -0.55
AMACR alpha-methylacyl-CoA racemase -0.54
AZGP1 alpha-2-glycoprotein 1, zinc-binding -0.52
FAM117A family with sequence similarity 117, member A -0.51
CIB1 calcium and integrin binding 1 (calmyrin) -0.51
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.5
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 -0.5
SEPTIN7 septin 7 -0.48
GFOD1 glucose-fructose oxidoreductase domain containing 1 -0.48
CYB561 cytochrome b561 -0.47
MOSPD3 motile sperm domain containing 3 -0.47
FTL ferritin, light polypeptide -0.47
CYB5A cytochrome b5 type A (microsomal) -0.47
GGACT gamma-glutamylamine cyclotransferase -0.46
FBXL2 F-box and leucine-rich repeat protein 2 -0.46
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) -0.46
ALG12 ALG12, alpha-1,6-mannosyltransferase -0.46
TVP23C trans-golgi network vesicle protein 23 homolog C (S. cerevisiae) -0.45
CYBRD1 cytochrome b reductase 1 -0.44
CYB5D2 cytochrome b5 domain containing 2 -0.44
METTL22 methyltransferase like 22 -0.43
CDC42SE2 CDC42 small effector 2 -0.43
FN1 fibronectin 1 -0.42
GHITM growth hormone inducible transmembrane protein -0.41
CUX1 cut-like homeobox 1 -0.41
SCG2 secretogranin II -0.41
LSM11 LSM11, U7 small nuclear RNA associated -0.4
IL6ST interleukin 6 signal transducer -0.39
REEP3 receptor accessory protein 3 -0.38
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.38
ZNF814 zinc finger protein 814 -0.38
MFSD5 major facilitator superfamily domain containing 5 -0.38
ABHD17B abhydrolase domain containing 17B -0.37
SLX4 SLX4 structure-specific endonuclease subunit -0.37
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 -0.37
DPYSL2 dihydropyrimidinase-like 2 -0.37
PEX26 peroxisomal biogenesis factor 26 -0.37
TMSB10 thymosin beta 10 -0.36
NECTIN3 nectin cell adhesion molecule 3 -0.36
CHCHD2P9 coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 -0.36
LRP10 low density lipoprotein receptor-related protein 10 -0.36
KLF4 Kruppel-like factor 4 (gut) -0.36
ZNF316 zinc finger protein 316 -0.36
LIMCH1 LIM and calponin homology domains 1 -0.35
MYH13 myosin, heavy chain 13, skeletal muscle -0.35
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 -0.35
ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit -0.35
TREX1 three prime repair exonuclease 1 -0.35
R3HDM4 R3H domain containing 4 -0.35
SARAF store-operated calcium entry-associated regulatory factor -0.34
CLGN calmegin -0.34
RUFY3 RUN and FYVE domain containing 3 -0.34
ANKS6 ankyrin repeat and sterile alpha motif domain containing 6 -0.34
PLEKHA6 pleckstrin homology domain containing, family A member 6 -0.34
MTFR2 mitochondrial fission regulator 2 -0.34
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 -0.34
FADS3 fatty acid desaturase 3 -0.33
TOR3A torsin family 3, member A -0.33
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 -0.33
IFITM3 interferon induced transmembrane protein 3 -0.33
CASP9 caspase 9, apoptosis-related cysteine peptidase -0.33
ENDOG endonuclease G -0.33
FAR1 fatty acyl CoA reductase 1 -0.32
CTSV cathepsin V -0.32
DUOX1 dual oxidase 1 -0.32
PTMA prothymosin, alpha -0.32
NRM nurim (nuclear envelope membrane protein) -0.31
SELENOI selenoprotein I -0.31
GON7 GON7 subunit of KEOPS complex -0.31
RGS19 regulator of G-protein signaling 19 -0.31
HMOX1 heme oxygenase 1 -0.3
E4F1 E4F transcription factor 1 -0.3
SELENOM selenoprotein M -0.3
SNRPF small nuclear ribonucleoprotein polypeptide F -0.3
FBXW2 F-box and WD repeat domain containing 2 -0.3
FRMPD3 FERM and PDZ domain containing 3 -0.3
TMC6 transmembrane channel-like 6 -0.3
ANKRD10 ankyrin repeat domain 10 -0.3
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.3
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 -0.3
NTSR1 neurotensin receptor 1 (high affinity) -0.3
MAGEA6 melanoma antigen family A6 -0.29