ABT-737 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/11228183
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Genes

198 proteins with high or low expression in ABT-737 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
CREB3L2 cAMP responsive element binding protein 3-like 2 1.23
SPC24 SPC24, NDC80 kinetochore complex component 0.9
CCN3 cellular communication network factor 3 0.77
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) 0.71
SEC24D SEC24 family member D 0.67
NUCB2 nucleobindin 2 0.62
FICD FIC domain containing 0.61
BOLA1 bolA family member 1 0.59
RPGR retinitis pigmentosa GTPase regulator 0.57
CDC26 cell division cycle 26 0.56
E2F8 E2F transcription factor 8 0.55
SOX4 SRY (sex determining region Y)-box 4 0.54
CHPF chondroitin polymerizing factor 0.54
CDC25B cell division cycle 25B 0.53
ERH enhancer of rudimentary homolog (Drosophila) 0.5
TMEM39A transmembrane protein 39A 0.5
ATF6B activating transcription factor 6 beta 0.49
DUOX1 dual oxidase 1 0.48
EXO1 exonuclease 1 0.47
MED29 mediator complex subunit 29 0.47
CRCP CGRP receptor component 0.47
MXRA7 matrix-remodelling associated 7 0.46
PRELID1 PRELI domain containing 1 0.45
KMT2E lysine (K)-specific methyltransferase 2E 0.45
PMF1 polyamine-modulated factor 1 0.45
KMT5C lysine methyltransferase 5C 0.45
C9ORF40 chromosome 9 open reading frame 40 0.45
DIAPH3 diaphanous-related formin 3 0.44
CADPS Ca++-dependent secretion activator 0.44
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.43
CIB1 calcium and integrin binding 1 (calmyrin) 0.42
RRM2 ribonucleotide reductase M2 0.42
NEIL3 nei endonuclease VIII-like 3 (E. coli) 0.42
JAG1 jagged 1 0.42
GLRX glutaredoxin (thioltransferase) 0.41
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 0.41
RPP25 ribonuclease P/MRP 25kDa subunit 0.4
HNF4A hepatocyte nuclear factor 4, alpha 0.4
KATNBL1 katanin p80 subunit B-like 1 0.4
JPT1 Jupiter microtubule associated homolog 1 0.4
C12ORF57 chromosome 12 open reading frame 57 0.4
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.39
TOX2 TOX high mobility group box family member 2 0.39
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) 0.39
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.39
MPZL2 myelin protein zero-like 2 0.39
DGCR2 DiGeorge syndrome critical region gene 2 0.38
PXDN peroxidasin 0.38
HID1 HID1 domain containing 0.38
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa 0.37
GREB1 growth regulation by estrogen in breast cancer 1 0.36
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.36
COX5A cytochrome c oxidase subunit Va 0.36
DNAH9 dynein, axonemal, heavy chain 9 0.36
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.35
TMEM260 transmembrane protein 260 0.35
USP53 ubiquitin specific peptidase 53 0.35
CCNF cyclin F 0.35
RAD51AP1 RAD51 associated protein 1 0.35
EXT2 exostosin glycosyltransferase 2 0.35
ZCCHC24 zinc finger, CCHC domain containing 24 0.34
ZNF544 zinc finger protein 544 0.34
RPL26 ribosomal protein L26 0.34
MAPKBP1 mitogen-activated protein kinase binding protein 1 0.34
ZNF286B zinc finger protein 286B 0.34
RPLP1 ribosomal protein, large, P1 0.33
H3C1 H3 clustered histone 1 0.33
SYTL3 synaptotagmin-like 3 0.33
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) 0.33
DPY30 dpy-30 homolog (C. elegans) 0.33
FBXO5 F-box protein 5 0.33
FUBP1 far upstream element (FUSE) binding protein 1 0.33
PABPC1 poly(A) binding protein, cytoplasmic 1 0.32
SPC25 SPC25, NDC80 kinetochore complex component 0.32
SHANK3 SH3 and multiple ankyrin repeat domains 3 0.32
UNC80 unc-80 homolog (C. elegans) 0.32
NIN ninein (GSK3B interacting protein) 0.32
USP1 ubiquitin specific peptidase 1 0.32
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 0.32
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.32
HYPK huntingtin interacting protein K 0.32
MANF mesencephalic astrocyte-derived neurotrophic factor 0.32
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.32
FAM3C family with sequence similarity 3, member C 0.32
PDIA4 protein disulfide isomerase family A, member 4 0.32
LOXL2 lysyl oxidase-like 2 0.32
SLC38A10 solute carrier family 38, member 10 0.32
STK17B serine/threonine kinase 17b 0.32
NENF neudesin neurotrophic factor 0.32
PGM3 phosphoglucomutase 3 0.31
E2F2 E2F transcription factor 2 0.31
MCL1 myeloid cell leukemia 1 0.31
PCLAF PCNA clamp associated factor 0.31
SPINT2 serine peptidase inhibitor, Kunitz type, 2 0.31
GMPPA GDP-mannose pyrophosphorylase A 0.31
FKBP14 FK506 binding protein 14, 22 kDa 0.31
AKT1S1 AKT1 substrate 1 (proline-rich) 0.31
MUTYH mutY homolog 0.31
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.31

low expression

Symbol Name Standardized Value
FAM241B family with sequence similarity 241 member B -2.43
KMT2B lysine (K)-specific methyltransferase 2B -2.32
KSR2 kinase suppressor of ras 2 -2.28
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12 -2.09
BAD BCL2-associated agonist of cell death -2.01
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 -1.84
KMT2C lysine (K)-specific methyltransferase 2C -1.79
CEP112 centrosomal protein 112kDa -1.16
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -1.13
GVINP1 GTPase, very large interferon inducible pseudogene 1 -1.12
DHRS1 dehydrogenase/reductase (SDR family) member 1 -0.98
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.97
RARG retinoic acid receptor, gamma -0.93
ZNF175 zinc finger protein 175 -0.92
PIP prolactin-induced protein -0.91
SARAF store-operated calcium entry-associated regulatory factor -0.89
WSB2 WD repeat and SOCS box containing 2 -0.8
VGF VGF nerve growth factor inducible -0.76
DIPK1B divergent protein kinase domain 1B -0.75
NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.74
COL11A1 collagen, type XI, alpha 1 -0.73
BCAM basal cell adhesion molecule (Lutheran blood group) -0.73
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.72
TP53 tumor protein p53 -0.72
GOSR2 golgi SNAP receptor complex member 2 -0.7
PLIN2 perilipin 2 -0.69
HEATR5A HEAT repeat containing 5A -0.67
SMIM19 small integral membrane protein 19 -0.64
ATP5IF1 ATP synthase inhibitory factor subunit 1 -0.6
RNF7 ring finger protein 7 -0.55
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2 -0.54
IER2 immediate early response 2 -0.54
TCTEX1D2 Tctex1 domain containing 2 -0.53
HIKESHI heat shock protein nuclear import factor hikeshi -0.53
ZNF282 zinc finger protein 282 -0.5
HSPA8 heat shock 70kDa protein 8 -0.5
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.49
CYB5D2 cytochrome b5 domain containing 2 -0.49
C1ORF43 chromosome 1 open reading frame 43 -0.48
FGFR1 fibroblast growth factor receptor 1 -0.48
FTL ferritin, light polypeptide -0.47
BTBD11 BTB (POZ) domain containing 11 -0.46
CLCN2 chloride channel, voltage-sensitive 2 -0.45
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G -0.45
TMEM64 transmembrane protein 64 -0.45
MFSD6 major facilitator superfamily domain containing 6 -0.44
RNF115 ring finger protein 115 -0.44
ERCC6 excision repair cross-complementation group 6 -0.42
CREG1 cellular repressor of E1A-stimulated genes 1 -0.42
CLSTN3 calsyntenin 3 -0.42
DEDD death effector domain containing -0.4
FGFR4 fibroblast growth factor receptor 4 -0.4
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D -0.4
NPHP4 nephronophthisis 4 -0.39
RCAN3 RCAN family member 3 -0.39
PLSCR3 phospholipid scramblase 3 -0.39
WDSUB1 WD repeat, sterile alpha motif and U-box domain containing 1 -0.39
FGD1 FYVE, RhoGEF and PH domain containing 1 -0.38
SESN1 sestrin 1 -0.38
FGFBP1 fibroblast growth factor binding protein 1 -0.38
HBA1 hemoglobin, alpha 1 -0.38
TMEM63B transmembrane protein 63B -0.38
TRIM9 tripartite motif containing 9 -0.38
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.37
CCDC73 coiled-coil domain containing 73 -0.37
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.37
LYSMD1 LysM, putative peptidoglycan-binding, domain containing 1 -0.36
TENT5A terminal nucleotidyltransferase 5A -0.36
STIM2 stromal interaction molecule 2 -0.36
EGFL7 EGF-like-domain, multiple 7 -0.36
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.36
TP53I3 tumor protein p53 inducible protein 3 -0.35
ZC3H12C zinc finger CCCH-type containing 12C -0.35
CCND1 cyclin D1 -0.35
PRG4 proteoglycan 4 -0.34
ADCY7 adenylate cyclase 7 -0.34
MCTP2 multiple C2 domains, transmembrane 2 -0.34
PHLDA3 pleckstrin homology-like domain, family A, member 3 -0.34
BHLHE40 basic helix-loop-helix family, member e40 -0.34
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.34
TSSC4 tumor suppressing subtransferable candidate 4 -0.33
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.33
UBTD1 ubiquitin domain containing 1 -0.33
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.33
CRTC3 CREB regulated transcription coactivator 3 -0.33
IREB2 iron-responsive element binding protein 2 -0.32
TMEM208 transmembrane protein 208 -0.32
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 -0.32
HMOX1 heme oxygenase 1 -0.32
MEGF8 multiple EGF-like-domains 8 -0.32
CCDC84 coiled-coil domain containing 84 -0.32
SLC39A4 solute carrier family 39 (zinc transporter), member 4 -0.32
RBM42 RNA binding motif protein 42 -0.32
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.32
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.32
ZNF776 zinc finger protein 776 -0.32
TMEM165 transmembrane protein 165 -0.32
MISO1 mitochondrial inner membrane subdomain organizer 1 -0.31
FN1 fibronectin 1 -0.31