| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/9797568 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in AC-7954 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PMFBP1 | polyamine modulated factor 1 binding protein 1 | 0.64 |
| TULP4 | tubby like protein 4 | 0.56 |
| TXNDC16 | thioredoxin domain containing 16 | 0.51 |
| KANK3 | KN motif and ankyrin repeat domains 3 | 0.45 |
| WDR19 | WD repeat domain 19 | 0.42 |
| DNAH6 | dynein, axonemal, heavy chain 6 | 0.36 |
| CALU | calumenin | 0.35 |
| MYH16 | myosin, heavy chain 16 pseudogene | 0.34 |
| DTD2 | D-tyrosyl-tRNA deacylase 2 (putative) | 0.34 |
| FAM185A | family with sequence similarity 185, member A | 0.34 |
| KCNAB2 | potassium channel, voltage gated subfamily A regulatory beta subunit 2 | 0.34 |
| RGPD2 | RANBP2-like and GRIP domain containing 2 | 0.33 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.33 |
| MT1F | metallothionein 1F | 0.33 |
| LIX1L | Lix1 homolog (chicken) like | 0.32 |
| PLEKHG2 | pleckstrin homology domain containing, family G (with RhoGef domain) member 2 | 0.32 |
| GJC1 | gap junction protein, gamma 1, 45kDa | 0.32 |
| CLGN | calmegin | 0.31 |
| DOCK10 | dedicator of cytokinesis 10 | 0.31 |
| VSIR | V-set immunoregulatory receptor | 0.31 |
| CFAP58 | cilia and flagella associated protein 58 | 0.31 |
| TM7SF3 | transmembrane 7 superfamily member 3 | 0.31 |
| EID2 | EP300 interacting inhibitor of differentiation 2 | 0.3 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.3 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | 0.3 |
| ZNRF2 | zinc and ring finger 2, E3 ubiquitin protein ligase | 0.29 |
| ZNF700 | zinc finger protein 700 | 0.28 |
| CCND3 | cyclin D3 | 0.28 |
| CD63 | CD63 molecule | 0.28 |
| GSE1 | Gse1 coiled-coil protein | 0.27 |
| TESK1 | testis-specific kinase 1 | 0.27 |
| FDXACB1 | ferredoxin-fold anticodon binding domain containing 1 | 0.27 |
| SPPL3 | signal peptide peptidase like 3 | 0.27 |
| KCTD12 | potassium channel tetramerization domain containing 12 | 0.27 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.27 |
| ZDHHC3 | zinc finger, DHHC-type containing 3 | 0.26 |
| CAPRIN2 | caprin family member 2 | 0.26 |
| MSL3 | male-specific lethal 3 homolog (Drosophila) | 0.26 |
| PRIMPOL | primase and polymerase (DNA-directed) | 0.25 |
| RNF13 | ring finger protein 13 | 0.25 |
| AUNIP | aurora kinase A and ninein interacting protein | 0.25 |
| TTC7A | tetratricopeptide repeat domain 7A | 0.25 |
| IL27RA | interleukin 27 receptor, alpha | 0.24 |
| FMNL1 | formin-like 1 | 0.24 |
| CCDC73 | coiled-coil domain containing 73 | 0.24 |
| TOX2 | TOX high mobility group box family member 2 | 0.24 |
| STK19 | serine/threonine kinase 19 | 0.24 |
| PALM3 | paralemmin 3 | 0.24 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | 0.23 |
| GNAZ | guanine nucleotide binding protein (G protein), alpha z polypeptide | 0.23 |
| TRIM62 | tripartite motif containing 62 | 0.23 |
| THAP11 | THAP domain containing 11 | 0.23 |
| GPBP1L1 | GC-rich promoter binding protein 1-like 1 | 0.23 |
| RPL36A | ribosomal protein L36a | 0.22 |
| ACD | adrenocortical dysplasia homolog (mouse) | 0.22 |
| MYBPC1 | myosin binding protein C, slow type | 0.22 |
| SLC45A1 | solute carrier family 45, member 1 | 0.22 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | 0.22 |
| POLE4 | polymerase (DNA-directed), epsilon 4, accessory subunit | 0.22 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.22 |
| RTN4RL2 | reticulon 4 receptor-like 2 | 0.21 |
| GEMIN7 | gem (nuclear organelle) associated protein 7 | 0.21 |
| ADAP2 | ArfGAP with dual PH domains 2 | 0.21 |
| LAMA2 | laminin, alpha 2 | 0.21 |
| ZNF280B | zinc finger protein 280B | 0.21 |
| TMEM185B | transmembrane protein 185B | 0.21 |
| SIAH1 | siah E3 ubiquitin protein ligase 1 | 0.21 |
| BMP1 | bone morphogenetic protein 1 | 0.21 |
| ZBTB43 | zinc finger and BTB domain containing 43 | 0.21 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.21 |
| MTERF2 | mitochondrial transcription termination factor 2 | 0.21 |
| SLC35A4 | solute carrier family 35, member A4 | 0.2 |
| ZNF273 | zinc finger protein 273 | 0.2 |
| RPS27A | ribosomal protein S27a | 0.2 |
| CCDC138 | coiled-coil domain containing 138 | 0.2 |
| EPOP | elongin BC and polycomb repressive complex 2 associated protein | 0.2 |
| SET | SET nuclear proto-oncogene | 0.2 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.2 |
| SRF | serum response factor (c-fos serum response element-binding transcription factor) | 0.2 |
| ALG8 | ALG8, alpha-1,3-glucosyltransferase | 0.2 |
| DISP2 | dispatched homolog 2 (Drosophila) | 0.19 |
| POLK | polymerase (DNA directed) kappa | 0.19 |
| OGFRL1 | opioid growth factor receptor-like 1 | 0.19 |
| CEP76 | centrosomal protein 76kDa | 0.19 |
| AKNA | AT-hook transcription factor | 0.19 |
| ADAT2 | adenosine deaminase, tRNA-specific 2 | 0.19 |
| TXN2 | thioredoxin 2 | 0.19 |
| UTP14C | UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) | 0.19 |
| PIGA | phosphatidylinositol glycan anchor biosynthesis, class A | 0.19 |
| DAPK1 | death-associated protein kinase 1 | 0.19 |
| MSX2 | msh homeobox 2 | 0.19 |
| SUMO2 | small ubiquitin-like modifier 2 | 0.19 |
| CRIP2 | cysteine-rich protein 2 | 0.19 |
| TBCK | TBC1 domain containing kinase | 0.19 |
| MYH15 | myosin, heavy chain 15 | 0.19 |
| PLEKHH1 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 | 0.19 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | 0.18 |
| EPDR1 | ependymin related 1 | 0.18 |
| ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 | 0.18 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CPLANE1 | ciliogenesis and planar polarity effector complex subunit 1 | -1.54 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -1.02 |
| MEGF9 | multiple EGF-like-domains 9 | -0.95 |
| PHF1 | PHD finger protein 1 | -0.92 |
| ADPRH | ADP-ribosylarginine hydrolase | -0.77 |
| THAP9 | THAP domain containing 9 | -0.66 |
| HMBOX1 | homeobox containing 1 | -0.66 |
| SLC25A20 | solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 | -0.64 |
| SH3RF2 | SH3 domain containing ring finger 2 | -0.63 |
| ABCB4 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | -0.62 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.61 |
| NOCT | nocturnin | -0.59 |
| PRF1 | perforin 1 (pore forming protein) | -0.59 |
| ZFP62 | ZFP62 zinc finger protein | -0.58 |
| YPEL5 | yippee-like 5 (Drosophila) | -0.57 |
| ICOSLG | inducible T-cell co-stimulator ligand | -0.55 |
| MISO1 | mitochondrial inner membrane subdomain organizer 1 | -0.53 |
| SLC15A4 | solute carrier family 15 (oligopeptide transporter), member 4 | -0.53 |
| CENPK | centromere protein K | -0.51 |
| SNED1 | sushi, nidogen and EGF-like domains 1 | -0.49 |
| STARD3 | StAR-related lipid transfer (START) domain containing 3 | -0.48 |
| PPP1R2B | PPP1R2 family member B | -0.47 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.47 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.46 |
| CYP4V2 | cytochrome P450, family 4, subfamily V, polypeptide 2 | -0.46 |
| OTX1 | orthodenticle homeobox 1 | -0.46 |
| ZNF227 | zinc finger protein 227 | -0.45 |
| BOD1 | biorientation of chromosomes in cell division 1 | -0.45 |
| MYH13 | myosin, heavy chain 13, skeletal muscle | -0.43 |
| ZFPM1 | zinc finger protein, FOG family member 1 | -0.42 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.42 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | -0.42 |
| PRSS12 | protease, serine, 12 (neurotrypsin, motopsin) | -0.42 |
| F2R | coagulation factor II (thrombin) receptor | -0.41 |
| ENTR1 | endosome associated trafficking regulator 1 | -0.41 |
| GPN3 | GPN-loop GTPase 3 | -0.41 |
| PROS1 | protein S (alpha) | -0.41 |
| CLTA | clathrin, light chain A | -0.4 |
| MEST | mesoderm specific transcript | -0.39 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.39 |
| ZNF7 | zinc finger protein 7 | -0.39 |
| RTL6 | retrotransposon Gag like 6 | -0.39 |
| WWOX | WW domain containing oxidoreductase | -0.38 |
| TMEM39B | transmembrane protein 39B | -0.38 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | -0.38 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | -0.37 |
| SMIM26 | small integral membrane protein 26 | -0.37 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.37 |
| TANGO2 | transport and golgi organization 2 homolog (Drosophila) | -0.36 |
| ALOXE3 | arachidonate lipoxygenase 3 | -0.36 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | -0.36 |
| VPS26B | vacuolar protein sorting 26 homolog B (S. pombe) | -0.36 |
| HSPA12B | heat shock 70kD protein 12B | -0.36 |
| YAE1 | YAE1 maturation factor of ABCE1 | -0.35 |
| BLOC1S3 | biogenesis of lysosomal organelles complex-1, subunit 3 | -0.35 |
| RPP30 | ribonuclease P/MRP 30kDa subunit | -0.35 |
| BSDC1 | BSD domain containing 1 | -0.35 |
| TRAPPC10 | trafficking protein particle complex 10 | -0.34 |
| C2ORF42 | chromosome 2 open reading frame 42 | -0.34 |
| VPS28 | vacuolar protein sorting 28 homolog (S. cerevisiae) | -0.34 |
| SYVN1 | synovial apoptosis inhibitor 1, synoviolin | -0.33 |
| BORCS6 | BLOC-1 related complex subunit 6 | -0.33 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.33 |
| UBQLN1 | ubiquilin 1 | -0.33 |
| MON1A | MON1 secretory trafficking family member A | -0.32 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.32 |
| LAMA5 | laminin, alpha 5 | -0.32 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.32 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.32 |
| SIRT3 | sirtuin 3 | -0.32 |
| NAT9 | N-acetyltransferase 9 (GCN5-related, putative) | -0.32 |
| SLC29A1 | solute carrier family 29 (equilibrative nucleoside transporter), member 1 | -0.32 |
| ZNF669 | zinc finger protein 669 | -0.32 |
| ZNF511 | zinc finger protein 511 | -0.31 |
| FASTKD1 | FAST kinase domains 1 | -0.31 |
| TPP1 | tripeptidyl peptidase I | -0.31 |
| CCN3 | cellular communication network factor 3 | -0.31 |
| ZNF692 | zinc finger protein 692 | -0.31 |
| BCO2 | beta-carotene oxygenase 2 | -0.31 |
| TESC | tescalcin | -0.31 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.31 |
| BLOC1S4 | biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino | -0.31 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | -0.31 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | -0.3 |
| PTMA | prothymosin, alpha | -0.3 |
| TPM1 | tropomyosin 1 (alpha) | -0.3 |
| ETV5 | ets variant 5 | -0.3 |
| GDPGP1 | GDP-D-glucose phosphorylase 1 | -0.29 |
| MESD | mesoderm development LRP chaperone | -0.29 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.29 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.29 |
| NDRG1 | N-myc downstream regulated 1 | -0.29 |
| NAAA | N-acylethanolamine acid amidase | -0.29 |
| ZNF808 | zinc finger protein 808 | -0.29 |
| SPHK2 | sphingosine kinase 2 | -0.29 |
| FKRP | fukutin related protein | -0.29 |
| ELMOD2 | ELMO/CED-12 domain containing 2 | -0.29 |
| KLHL23 | kelch-like family member 23 | -0.29 |
| CMTM4 | CKLF-like MARVEL transmembrane domain containing 4 | -0.28 |
| CDX2 | caudal type homeobox 2 | -0.28 |
