| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5353376 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in ACA relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KLHL23 | kelch-like family member 23 | 1.66 |
| PLEKHH2 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 | 1.17 |
| GATA2 | GATA binding protein 2 | 0.7 |
| PLCB4 | phospholipase C, beta 4 | 0.69 |
| MLX | MLX, MAX dimerization protein | 0.67 |
| LMOD1 | leiomodin 1 (smooth muscle) | 0.54 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.48 |
| TBC1D31 | TBC1 domain family, member 31 | 0.47 |
| BCDIN3D | BCDIN3 domain containing | 0.47 |
| TRAF3IP2 | TRAF3 interacting protein 2 | 0.42 |
| TRMO | tRNA methyltransferase O | 0.42 |
| EIF3C | eukaryotic translation initiation factor 3, subunit C | 0.39 |
| ZNF888 | zinc finger protein 888 | 0.39 |
| PCGF3 | polycomb group ring finger 3 | 0.38 |
| ATM | ATM serine/threonine kinase | 0.38 |
| COL17A1 | collagen, type XVII, alpha 1 | 0.37 |
| COA5 | cytochrome c oxidase assembly factor 5 | 0.37 |
| FAR1 | fatty acyl CoA reductase 1 | 0.36 |
| TTC30B | tetratricopeptide repeat domain 30B | 0.36 |
| ARL16 | ADP-ribosylation factor-like 16 | 0.36 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | 0.36 |
| CFD | complement factor D (adipsin) | 0.35 |
| SCARA3 | scavenger receptor class A, member 3 | 0.35 |
| DEPDC1 | DEP domain containing 1 | 0.35 |
| DNMT3B | DNA (cytosine-5-)-methyltransferase 3 beta | 0.35 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 0.34 |
| CDC25A | cell division cycle 25A | 0.34 |
| TOB1 | transducer of ERBB2, 1 | 0.34 |
| SETD5 | SET domain containing 5 | 0.33 |
| TOX2 | TOX high mobility group box family member 2 | 0.33 |
| TSLIG1 | tRNA splicing ligase complex subunit 1 | 0.32 |
| C2CD3 | C2 calcium-dependent domain containing 3 | 0.32 |
| EHF | ets homologous factor | 0.32 |
| ZNF749 | zinc finger protein 749 | 0.32 |
| NOP16 | NOP16 nucleolar protein | 0.32 |
| NEU3 | sialidase 3 (membrane sialidase) | 0.32 |
| PLEKHA6 | pleckstrin homology domain containing, family A member 6 | 0.32 |
| ZDHHC9 | zinc finger, DHHC-type containing 9 | 0.32 |
| ERG28 | ergosterol biosynthesis 28 homolog | 0.31 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.31 |
| UPRT | uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) | 0.31 |
| CPA4 | carboxypeptidase A4 | 0.31 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.31 |
| CCDC102A | coiled-coil domain containing 102A | 0.31 |
| KIF26A | kinesin family member 26A | 0.31 |
| CST6 | cystatin E/M | 0.31 |
| TMEM189 | transmembrane protein 189 | 0.3 |
| MGA | MGA, MAX dimerization protein | 0.3 |
| DONSON | downstream neighbor of SON | 0.3 |
| TATDN2 | TatD DNase domain containing 2 | 0.3 |
| WNT10B | wingless-type MMTV integration site family, member 10B | 0.29 |
| PAQR7 | progestin and adipoQ receptor family member VII | 0.29 |
| TTC39B | tetratricopeptide repeat domain 39B | 0.29 |
| DIPK1B | divergent protein kinase domain 1B | 0.29 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | 0.29 |
| TTC7A | tetratricopeptide repeat domain 7A | 0.29 |
| CCDC85B | coiled-coil domain containing 85B | 0.29 |
| KCTD17 | potassium channel tetramerization domain containing 17 | 0.29 |
| GLB1L2 | galactosidase, beta 1-like 2 | 0.29 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.28 |
| MRC2 | mannose receptor, C type 2 | 0.28 |
| PJA1 | praja ring finger 1, E3 ubiquitin protein ligase | 0.28 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.28 |
| ADM | adrenomedullin | 0.28 |
| DYRK2 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 | 0.28 |
| ZNF267 | zinc finger protein 267 | 0.28 |
| ZMYND19 | zinc finger, MYND-type containing 19 | 0.27 |
| TGDS | TDP-glucose 4,6-dehydratase | 0.27 |
| RAD54L | RAD54-like (S. cerevisiae) | 0.27 |
| PLPP6 | phospholipid phosphatase 6 | 0.26 |
| RTN4R | reticulon 4 receptor | 0.26 |
| RUBCN | rubicon autophagy regulator | 0.26 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.26 |
| SGK3 | serum/glucocorticoid regulated kinase family, member 3 | 0.26 |
| RUNX2 | runt-related transcription factor 2 | 0.26 |
| NSUN3 | NOP2/Sun domain family, member 3 | 0.26 |
| HHEX | hematopoietically expressed homeobox | 0.26 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.26 |
| ZNF367 | zinc finger protein 367 | 0.25 |
| KLF4 | Kruppel-like factor 4 (gut) | 0.25 |
| FOXRED2 | FAD-dependent oxidoreductase domain containing 2 | 0.25 |
| DPP8 | dipeptidyl-peptidase 8 | 0.25 |
| TP73 | tumor protein p73 | 0.25 |
| CDON | cell adhesion associated, oncogene regulated | 0.25 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.25 |
| LMO4 | LIM domain only 4 | 0.25 |
| LRFN3 | leucine rich repeat and fibronectin type III domain containing 3 | 0.25 |
| NOCT | nocturnin | 0.24 |
| FAM102A | family with sequence similarity 102, member A | 0.24 |
| NDE1 | nudE neurodevelopment protein 1 | 0.24 |
| OGG1 | 8-oxoguanine DNA glycosylase | 0.24 |
| DUSP5 | dual specificity phosphatase 5 | 0.24 |
| CCDC18 | coiled-coil domain containing 18 | 0.24 |
| DNLZ | DNL-type zinc finger | 0.24 |
| PRMT2IP | PRMT2 interacting protein | 0.24 |
| RGPD2 | RANBP2-like and GRIP domain containing 2 | 0.24 |
| ROR1 | receptor tyrosine kinase-like orphan receptor 1 | 0.24 |
| ARL14EPL | ADP-ribosylation factor-like 14 effector protein-like | 0.24 |
| AGFG2 | ArfGAP with FG repeats 2 | 0.23 |
| C2ORF42 | chromosome 2 open reading frame 42 | 0.23 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ATG4D | autophagy related 4D, cysteine peptidase | -1.01 |
| SPTBN5 | spectrin, beta, non-erythrocytic 5 | -0.93 |
| PIP | prolactin-induced protein | -0.83 |
| ANKRD10 | ankyrin repeat domain 10 | -0.67 |
| LAMC3 | laminin, gamma 3 | -0.65 |
| NRBP2 | nuclear receptor binding protein 2 | -0.59 |
| CAVIN2 | caveolae associated protein 2 | -0.59 |
| B4GALT3 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 | -0.52 |
| AGA | aspartylglucosaminidase | -0.5 |
| IL10RB | interleukin 10 receptor, beta | -0.49 |
| CD99 | CD99 molecule | -0.48 |
| JMJD8 | jumonji domain containing 8 | -0.45 |
| GPANK1 | G patch domain and ankyrin repeats 1 | -0.43 |
| ITFG2 | integrin alpha FG-GAP repeat containing 2 | -0.42 |
| FUT1 | fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) | -0.41 |
| ADIRF | adipogenesis regulatory factor | -0.41 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | -0.4 |
| ONECUT2 | one cut homeobox 2 | -0.39 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | -0.39 |
| APOLTP | apolipoprotein lipid transfer particle homolog | -0.39 |
| TMEM222 | transmembrane protein 222 | -0.38 |
| KSR1 | kinase suppressor of ras 1 | -0.37 |
| MCFD2 | multiple coagulation factor deficiency 2 | -0.37 |
| CELSR2 | cadherin, EGF LAG seven-pass G-type receptor 2 | -0.36 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.35 |
| TSPAN3 | tetraspanin 3 | -0.35 |
| TTC9 | tetratricopeptide repeat domain 9 | -0.35 |
| CCN3 | cellular communication network factor 3 | -0.35 |
| ARSD | arylsulfatase D | -0.34 |
| DTD2 | D-tyrosyl-tRNA deacylase 2 (putative) | -0.34 |
| NEIL1 | nei endonuclease VIII-like 1 (E. coli) | -0.34 |
| FBXO17 | F-box protein 17 | -0.33 |
| RAC3 | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) | -0.33 |
| PCMTD2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | -0.32 |
| IER3IP1 | immediate early response 3 interacting protein 1 | -0.32 |
| TMEM129 | transmembrane protein 129, E3 ubiquitin protein ligase | -0.32 |
| GPRASP2 | G protein-coupled receptor associated sorting protein 2 | -0.32 |
| ABCC10 | ATP-binding cassette, sub-family C (CFTR/MRP), member 10 | -0.32 |
| DALRD3 | DALR anticodon binding domain containing 3 | -0.32 |
| FRMD6 | FERM domain containing 6 | -0.31 |
| PHF1 | PHD finger protein 1 | -0.31 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -0.31 |
| RNF130 | ring finger protein 130 | -0.31 |
| GGT1 | gamma-glutamyltransferase 1 | -0.31 |
| NALCN | sodium leak channel, non selective | -0.3 |
| H1-0 | H1.0 linker histone | -0.3 |
| ARL6IP6 | ADP-ribosylation factor-like 6 interacting protein 6 | -0.3 |
| MPZL2 | myelin protein zero-like 2 | -0.3 |
| ENDOV | endonuclease V | -0.29 |
| PKHD1 | polycystic kidney and hepatic disease 1 (autosomal recessive) | -0.29 |
| SGSM3 | small G protein signaling modulator 3 | -0.29 |
| GNPTG | N-acetylglucosamine-1-phosphate transferase, gamma subunit | -0.29 |
| ZNF646 | zinc finger protein 646 | -0.29 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | -0.29 |
| ZDHHC23 | zinc finger, DHHC-type containing 23 | -0.28 |
| USP53 | ubiquitin specific peptidase 53 | -0.28 |
| STARD10 | StAR-related lipid transfer (START) domain containing 10 | -0.28 |
| RNF17 | ring finger protein 17 | -0.28 |
| METTL26 | methyltransferase like 26 | -0.28 |
| PRSS12 | protease, serine, 12 (neurotrypsin, motopsin) | -0.28 |
| CCDC57 | coiled-coil domain containing 57 | -0.28 |
| SYK | spleen tyrosine kinase | -0.27 |
| SLC25A44 | solute carrier family 25, member 44 | -0.27 |
| GLRX | glutaredoxin (thioltransferase) | -0.27 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.27 |
| COPRS | coordinator of PRMT5, differentiation stimulator | -0.27 |
| HSH2D | hematopoietic SH2 domain containing | -0.27 |
| RPP25 | ribonuclease P/MRP 25kDa subunit | -0.27 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | -0.27 |
| VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) | -0.27 |
| TIGD5 | tigger transposable element derived 5 | -0.27 |
| PTGES | prostaglandin E synthase | -0.26 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.26 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.26 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -0.26 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.26 |
| CD63 | CD63 molecule | -0.26 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.26 |
| PDE5A | phosphodiesterase 5A, cGMP-specific | -0.25 |
| HAL | histidine ammonia-lyase | -0.25 |
| ATG4A | autophagy related 4A, cysteine peptidase | -0.25 |
| TMC4 | transmembrane channel-like 4 | -0.25 |
| ZNF777 | zinc finger protein 777 | -0.25 |
| ATG14 | autophagy related 14 | -0.25 |
| FHL1 | four and a half LIM domains 1 | -0.25 |
| NPDC1 | neural proliferation, differentiation and control, 1 | -0.25 |
| PER2 | period circadian clock 2 | -0.25 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.25 |
| PLA2G12A | phospholipase A2, group XIIA | -0.24 |
| TRIM2 | tripartite motif containing 2 | -0.24 |
| SYTL1 | synaptotagmin-like 1 | -0.24 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | -0.24 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.24 |
| ZBTB44 | zinc finger and BTB domain containing 44 | -0.24 |
| IL6ST | interleukin 6 signal transducer | -0.24 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.24 |
| ETV6 | ets variant 6 | -0.24 |
| GTF3A | general transcription factor IIIA | -0.24 |
| MKS1 | Meckel syndrome, type 1 | -0.24 |
