ACE Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description angiotensin I converting enzyme|This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010] (NCBI Entrez Gene Database, 1636)
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Genes

345 genes differentially expressed following the ACE gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SACK1A scaffolding CK1 anchoring protein A 3.18399
HES4 hes family bHLH transcription factor 4 3.18399
PNMA5 paraneoplastic Ma antigen family member 5 3.18399
AZGP1 alpha-2-glycoprotein 1, zinc-binding 3.18399
AFM afamin 3.18399
SLC25A41 solute carrier family 25, member 41 3.18399
NME5 NME/NM23 family member 5 3.18399
CSTL1 cystatin-like 1 3.18399
TUBB8 tubulin, beta 8 class VIII 3.18399
OPRL1 opiate receptor-like 1 3.18399
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 3.18399
SLC35G6 solute carrier family 35, member G6 3.18399
PCDHB7 protocadherin beta 7 3.18399
SLC26A9 solute carrier family 26 (anion exchanger), member 9 3.18399
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 3.18399
ENTHD1 ENTH domain containing 1 3.18399
CD1C CD1c molecule 3.18399
IL22RA1 interleukin 22 receptor, alpha 1 3.18399
PLIN1 perilipin 1 3.18399
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 3.18399
DNASE1L2 deoxyribonuclease I-like 2 3.18399
GLUD2 glutamate dehydrogenase 2 3.18399
PBOV1 prostate and breast cancer overexpressed 1 3.18399
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 3.18399
GLRA3 glycine receptor, alpha 3 3.18399
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 3.18399
PCDHGA11 protocadherin gamma subfamily A, 11 3.18399
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 3.18399
HRC histidine rich calcium binding protein 3.18399
EBI3 Epstein-Barr virus induced 3 3.18399
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 3.18399
RHOJ ras homolog family member J 3.18399
SPINT4 serine peptidase inhibitor, Kunitz type 4 3.18399
ICAM5 intercellular adhesion molecule 5, telencephalin 3.18399
RXRG retinoid X receptor, gamma 3.18399
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 3.18399
HMX3 H6 family homeobox 3 3.18399
MAGED4 melanoma antigen family D4 3.18399
TMEM89 transmembrane protein 89 3.18399
RIMBP3C RIMS binding protein 3C 3.18399
MUC22 mucin 22 3.18399
HBB hemoglobin, beta 3.18399
CRYGB crystallin, gamma B 3.18399
WNT3A wingless-type MMTV integration site family, member 3A 3.18399
ATOH1 atonal homolog 1 (Drosophila) 3.18399
BMP5 bone morphogenetic protein 5 3.18399
ASCL5 achaete-scute family bHLH transcription factor 5 3.18399
UCN urocortin 3.18399
LOC114841035 uncharacterized LOC114841035 3.18399
STX17 syntaxin 17 3.18399
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.18399
ACSL5 acyl-CoA synthetase long-chain family member 5 3.18399
SRPK3 SRSF protein kinase 3 3.18399
TSPAN8 tetraspanin 8 3.18399
SOAT2 sterol O-acyltransferase 2 3.18399
GPR83 G protein-coupled receptor 83 3.18399
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 3.18399
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 3.18399
OR2T8 olfactory receptor, family 2, subfamily T, member 8 3.18399
DUSP8 dual specificity phosphatase 8 3.18399
TRPC7 transient receptor potential cation channel, subfamily C, member 7 3.18399
ZC3H11C zinc finger CCCH-type containing 11C 3.18399
LY6S lymphocyte antigen 6 family member S 3.18399
EZHIP EZH inhibitory protein 3.18399
TMEM275 transmembrane protein 275 3.18399
SQOR sulfide quinone oxidoreductase 3.18399
NECTIN4 nectin cell adhesion molecule 4 3.18399
UNC93A unc-93 homolog A (C. elegans) 3.18399
AANAT aralkylamine N-acetyltransferase 3.18399
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 3.18399
PGA5 pepsinogen 5, group I (pepsinogen A) 3.18399
RBM46 RNA binding motif protein 46 3.18399
S100B S100 calcium binding protein B 3.18399
ZNF582 zinc finger protein 582 3.18399
NDRG1 N-myc downstream regulated 1 3.18399
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 3.18399
HLF hepatic leukemia factor 3.18399
HRH1 histamine receptor H1 3.18399
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 3.18399
CD6 CD6 molecule 3.18399
LY86 lymphocyte antigen 86 3.18399
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 3.18399
KLHL35 kelch-like family member 35 3.18399
HBA2 hemoglobin, alpha 2 3.18399
CPED1 cadherin-like and PC-esterase domain containing 1 3.18399
ZAN zonadhesin (gene/pseudogene) 3.18399
THPO thrombopoietin 3.18399
PANX3 pannexin 3 3.18399
SNX21 sorting nexin family member 21 3.18399
DEFB1 defensin, beta 1 3.18399
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 3.18399
RHOXF2 Rhox homeobox family, member 2 3.18399
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 3.18399
CD300LG CD300 molecule-like family member g 3.18399
PARP3 poly (ADP-ribose) polymerase family, member 3 3.18399
CHRDL2 chordin-like 2 3.18399
SUPT20HL1 suppressor of Ty 20 homolog (S. cerevisiae)-like 1 3.18399
GOLGA6A golgin A6 family, member A 3.18399
ADAM7 ADAM metallopeptidase domain 7 3.18399
C10ORF71 chromosome 10 open reading frame 71 3.18399
F2RL3 coagulation factor II (thrombin) receptor-like 3 3.18399
NIPAL4 NIPA-like domain containing 4 3.18399
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 3.18399
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 3.18399
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 3.18399
ERICH6B glutamate-rich 6B 3.18399
CAMK2B calcium/calmodulin-dependent protein kinase II beta 3.18399
LCN9 lipocalin 9 3.18399
LCT lactase 3.18399
ZNF541 zinc finger protein 541 3.18399
CLDN34 claudin 34 3.18399
KLHL6 kelch-like family member 6 3.18399
RETNLB resistin like beta 3.18399
ANKRD63 ankyrin repeat domain 63 3.18399
CDHR5 cadherin-related family member 5 3.18399
HGH1 HGH1 homolog (S. cerevisiae) 3.18399
C2CD4D C2 calcium-dependent domain containing 4D 3.18399
PCDHGA3 protocadherin gamma subfamily A, 3 3.18399
IGIP IgA-inducing protein 3.18399
LMAN1L lectin, mannose-binding, 1 like 3.18399
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 3.18399
C22ORF31 chromosome 22 open reading frame 31 3.18399
SYT5 synaptotagmin V 3.18399
GOLGA8H golgin A8 family, member H 3.18399
RAD9B RAD9 homolog B (S. pombe) 3.18399
CFB complement factor B 3.18399
RIBC1 RIB43A domain with coiled-coils 1 3.18399
CD27 CD27 molecule 3.18399
LYZ lysozyme 3.18399
VWA7 von Willebrand factor A domain containing 7 3.18399
DHH desert hedgehog 3.18399
C8ORF89 chromosome 8 open reading frame 89 3.18399
KLK12 kallikrein-related peptidase 12 3.18399
UTS2R urotensin 2 receptor 3.18399
UTS2B urotensin 2B 3.18399
ZGLP1 zinc finger, GATA-like protein 1 3.18399
NT5DC4 5'-nucleotidase domain containing 4 3.18399
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 3.18399
BRDT bromodomain, testis-specific 3.18399
ZPLD1 zona pellucida-like domain containing 1 3.18399
ZNF471 zinc finger protein 471 3.18399
PMP2 peripheral myelin protein 2 3.18399
ACSM1 acyl-CoA synthetase medium-chain family member 1 3.18399
PRR15L proline rich 15-like 3.18399
CHRM1 cholinergic receptor, muscarinic 1 3.18399
GBX1 gastrulation brain homeobox 1 3.18399
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 3.18399
GP1BB glycoprotein Ib (platelet), beta polypeptide 3.18399
RTN4RL1 reticulon 4 receptor-like 1 3.18399
PCDHGB1 protocadherin gamma subfamily B, 1 3.18399
DUOXA1 dual oxidase maturation factor 1 3.18399
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 3.18399
TGM4 transglutaminase 4 3.18399
FNDC9 fibronectin type III domain containing 9 3.18399
THEM5 thioesterase superfamily member 5 3.18399
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 3.18399
APOL5 apolipoprotein L, 5 3.18399
ARMC7 armadillo repeat containing 7 3.15548
ZNF524 zinc finger protein 524 3.087
BEST1 bestrophin 1 3.087
RPS17 ribosomal protein S17 3.01634
MARS1 methionyl-tRNA synthetase 1 2.92785
CGRRF1 cell growth regulator with ring finger domain 1 2.91583
DENND2D DENN/MADD domain containing 2D 2.91583
CHD9NB CHD9 neighbor 2.84719
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.61941
TRIB3 tribbles pseudokinase 3 2.61803
MAF1 MAF1 homolog (S. cerevisiae) 2.59976
RPS8 ribosomal protein S8 2.58572
MCTS1 malignant T cell amplified sequence 1 2.5517
HK1 hexokinase 1 2.51238
UIMC1 ubiquitin interaction motif containing 1 2.50291
DMPK dystrophia myotonica-protein kinase 2.49631
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 2.48043
RTL8C retrotransposon Gag like 8C 2.47313
GIP gastric inhibitory polypeptide 2.46087
SLC25A30 solute carrier family 25, member 30 2.43195
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta 2.40429
LRRN3 leucine rich repeat neuronal 3 2.36809
EFCAB12 EF-hand calcium binding domain 12 2.36032
STAP1 signal transducing adaptor family member 1 2.36032
CDRT4 CMT1A duplicated region transcript 4 2.34372
CBX6 chromobox homolog 6 2.31999
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 2.31199
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 2.31199
CNIH2 cornichon family AMPA receptor auxiliary protein 2 2.31199
PEX6 peroxisomal biogenesis factor 6 2.3014
PFDN5 prefoldin subunit 5 2.29737
KLHL18 kelch-like family member 18 2.29102
RPS9 ribosomal protein S9 2.24958
ZNF534 zinc finger protein 534 2.24782
NOS2 nitric oxide synthase 2, inducible 2.24782
PLEKHN1 pleckstrin homology domain containing, family N member 1 2.24782
TIGD6 tigger transposable element derived 6 2.24782
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.24782
GPHA2 glycoprotein hormone alpha 2 2.24782
RPL18A ribosomal protein L18a 2.23277
TACC1 transforming, acidic coiled-coil containing protein 1 2.21956
TMEM39A transmembrane protein 39A 2.21767
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 2.19953
SLC25A40 solute carrier family 25, member 40 2.19685
MAP7D1 MAP7 domain containing 1 2.19336
ZSCAN29 zinc finger and SCAN domain containing 29 2.18881
CFAP69 cilia and flagella associated protein 69 2.17067
NUP85 nucleoporin 85kDa 2.17067
MOCS2 molybdenum cofactor synthesis 2 2.17067
MSANTD7 Myb/SANT DNA binding domain containing 7 2.17067
YPEL3 yippee-like 3 (Drosophila) 2.17067
TELO2 telomere maintenance 2 2.16952
RPS5 ribosomal protein S5 2.1585
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 2.15607
DENND3 DENN/MADD domain containing 3 2.14631
RPL37 ribosomal protein L37 2.13809
SOCS6 suppressor of cytokine signaling 6 2.12828
DUSP14 dual specificity phosphatase 14 2.12817
SOGA1 suppressor of glucose, autophagy associated 1 2.12169
RANBP17 RAN binding protein 17 2.1049
MRPS34 mitochondrial ribosomal protein S34 2.10378
B2M beta-2-microglobulin 2.0999
SUSD5 sushi domain containing 5 2.09286
SDK1 sidekick cell adhesion molecule 1 2.08809
PBRM1 polybromo 1 2.08237
TSPAN31 tetraspanin 31 2.08237
EYA3 EYA transcriptional coactivator and phosphatase 3 2.08237
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 2.07167
MAP3K20 mitogen-activated protein kinase kinase kinase 20 2.05853
TUBGCP6 tubulin, gamma complex associated protein 6 2.05122
BANF1 barrier to autointegration factor 1 2.04457
CLTA clathrin, light chain A 2.04457
GCHFR GTP cyclohydrolase I feedback regulator 2.04457
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 2.04017
PCSK7 proprotein convertase subtilisin/kexin type 7 2.04017
SHMT1 serine hydroxymethyltransferase 1 (soluble) 2.02846
ATG5 autophagy related 5 2.02786
HMGN4 high mobility group nucleosomal binding domain 4 2.01839
RBM22 RNA binding motif protein 22 2.01397
TUBA4A tubulin, alpha 4a 2.01397
TMEM237 transmembrane protein 237 2.01065
TK1 thymidine kinase 1, soluble 2.00978

decreased expression

Symbol Name Standardized Value
GINS4 GINS complex subunit 4 (Sld5 homolog) -3.18399
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 -3.18399
FAM43A family with sequence similarity 43, member A -3.18399
RHOU ras homolog family member U -3.18399
TGFB2 transforming growth factor, beta 2 -3.18399
NOP16 NOP16 nucleolar protein -3.18399
MSR1 macrophage scavenger receptor 1 -3.18399
CNBD1 cyclic nucleotide binding domain containing 1 -3.18399
INHBE inhibin, beta E -3.18399
CRYGS crystallin, gamma S -3.18399
C20ORF203 chromosome 20 open reading frame 203 -3.18399
NCSTN nicastrin -2.95215
TLE6 transducin-like enhancer of split 6 -2.91583
GRHL3 grainyhead-like 3 (Drosophila) -2.91583
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -2.91583
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -2.91583
SPINK1 serine peptidase inhibitor, Kazal type 1 -2.91583
VSX1 visual system homeobox 1 -2.91583
NFAM1 NFAT activating protein with ITAM motif 1 -2.91583
FCRL5 Fc receptor-like 5 -2.91583
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) -2.91583
ZNF324B zinc finger protein 324B -2.91583
SHD Src homology 2 domain containing transforming protein D -2.91583
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 -2.91583
BMX BMX non-receptor tyrosine kinase -2.91583
MCHR1 melanin-concentrating hormone receptor 1 -2.91583
HAL histidine ammonia-lyase -2.91583
RBM44 RNA binding motif protein 44 -2.91583
KLK14 kallikrein-related peptidase 14 -2.91583
MYOT myotilin -2.91583
DRD4 dopamine receptor D4 -2.91583
FAM209A family with sequence similarity 209, member A -2.91583
FSTL3 follistatin-like 3 (secreted glycoprotein) -2.91583
AKR1D1 aldo-keto reductase family 1, member D1 -2.91583
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 -2.91583
PIH1D2 PIH1 domain containing 2 -2.91583
TUBA8 tubulin, alpha 8 -2.91583
CLC Charcot-Leyden crystal galectin -2.91583
PHOX2A paired-like homeobox 2a -2.91583
SAPCD1 suppressor APC domain containing 1 -2.91583
ZNF182 zinc finger protein 182 -2.90044
VENTX VENT homeobox -2.75511
TMEM50B transmembrane protein 50B -2.73992
ZNF550 zinc finger protein 550 -2.6992
TRAFD1 TRAF-type zinc finger domain containing 1 -2.68509
C2ORF92 chromosome 2 open reading frame 92 -2.6825
TXNRD2 thioredoxin reductase 2 -2.66592
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -2.60586
ATAD3C ATPase family, AAA domain containing 3C -2.52328
GPHRB golgi pH regulator B -2.5175
IFFO1 intermediate filament family orphan 1 -2.51238
IGF1 insulin-like growth factor 1 (somatomedin C) -2.51238
ZNF487 zinc finger protein 487 -2.50313
CREB1 cAMP responsive element binding protein 1 -2.49224
VIL1 villin 1 -2.48206
MKX mohawk homeobox -2.43195
ZNF713 zinc finger protein 713 -2.43082
CKAP4 cytoskeleton-associated protein 4 -2.42086
PPP1R17 protein phosphatase 1, regulatory subunit 17 -2.41404
GMIP GEM interacting protein -2.4041
ANGPTL1 angiopoietin-like 1 -2.4041
KIF16B kinesin family member 16B -2.34372
TMF1 TATA element modulatory factor 1 -2.32788
SARM1 sterile alpha and TIR motif containing 1 -2.31646
ZFAT zinc finger and AT hook domain containing -2.31199
TMTC4 transmembrane and tetratricopeptide repeat containing 4 -2.31199
TMEM168 transmembrane protein 168 -2.28715
SEC61G Sec61 gamma subunit -2.27953
TXNRD3 thioredoxin reductase 3 -2.27643
C1S complement component 1, s subcomponent -2.24782
PPP1R9B protein phosphatase 1, regulatory subunit 9B -2.24782
GRIK3 glutamate receptor, ionotropic, kainate 3 -2.21867
MED10 mediator complex subunit 10 -2.2167
SPRY2 sprouty homolog 2 (Drosophila) -2.20546
DMC1 DNA meiotic recombinase 1 -2.20362
BICDL1 BICD family like cargo adaptor 1 -2.18301
ZNF221 zinc finger protein 221 -2.18301
CEP70 centrosomal protein 70kDa -2.17256
KALRN kalirin, RhoGEF kinase -2.17067
FHIP2B FHF complex subunit HOOK interacting protein 2B -2.17067
RTKN rhotekin -2.17067
COA5 cytochrome c oxidase assembly factor 5 -2.17067
CCNL2 cyclin L2 -2.15704
SMOC2 SPARC related modular calcium binding 2 -2.15691
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) -2.15463
NCAN neurocan -2.14429
NME8 NME/NM23 family member 8 -2.14429
OLFM3 olfactomedin 3 -2.14429
MOGAT1 monoacylglycerol O-acyltransferase 1 -2.1394
SYAP1 synapse associated protein 1 -2.13375
TGDS TDP-glucose 4,6-dehydratase -2.11923
VPS33B vacuolar protein sorting 33 homolog B (yeast) -2.08809
OCLN occludin -2.07931
HDHD2 haloacid dehalogenase-like hydrolase domain containing 2 -2.07409
INSIG2 insulin induced gene 2 -2.07409
BTN3A2 butyrophilin, subfamily 3, member A2 -2.07167
C6ORF120 chromosome 6 open reading frame 120 -2.06147
ATP7A ATPase, Cu++ transporting, alpha polypeptide -2.06058
ATG4C autophagy related 4C, cysteine peptidase -2.05675
GZF1 GDNF-inducible zinc finger protein 1 -2.05289
KIRREL1 kirre like nephrin family adhesion molecule 1 -2.04457
ZGPAT zinc finger, CCCH-type with G patch domain -2.04017
TMEM150A transmembrane protein 150A -2.04017
ZNF552 zinc finger protein 552 -2.01764
RANGRF RAN guanine nucleotide release factor -2.01764
ABI2 abl-interactor 2 -2.01223