| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | actinin, alpha 4|Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 81) |
| External Link | https://ncbi.nlm.nih.gov/gene/81 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the ACTN4 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| S100P | S100 calcium binding protein P | 0.0188905 |
| ANXA3 | annexin A3 | 0.0161605 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.0160082 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0140126 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0138653 |
| AREG | amphiregulin | 0.0134599 |
| FABP4 | fatty acid binding protein 4, adipocyte | 0.0133977 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0124342 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.0122764 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.0116443 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.0115491 |
| RBM34 | RNA binding motif protein 34 | 0.0113153 |
| TAGLN | transgelin | 0.0112282 |
| CCN2 | cellular communication network factor 2 | 0.0111735 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 0.0107037 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0106935 |
| RGCC | regulator of cell cycle | 0.010388 |
| C1QB | complement component 1, q subcomponent, B chain | 0.0103747 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0103293 |
| NNMT | nicotinamide N-methyltransferase | 0.00999782 |
| CRYAB | crystallin, alpha B | 0.00995103 |
| ANXA1 | annexin A1 | 0.00993237 |
| MT1X | metallothionein 1X | 0.00991012 |
| IL32 | interleukin 32 | 0.00984335 |
| TNNC1 | troponin C type 1 (slow) | 0.00978935 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.00970242 |
| STC2 | stanniocalcin 2 | 0.0094028 |
| INHBA | inhibin, beta A | 0.00935488 |
| ABLIM1 | actin binding LIM protein 1 | 0.00933484 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.00932898 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | 0.00923663 |
| MAP7 | microtubule-associated protein 7 | 0.00913789 |
| KLF10 | Kruppel-like factor 10 | 0.00908689 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 | 0.00908062 |
| MMP3 | matrix metallopeptidase 3 | 0.00901072 |
| LXN | latexin | 0.00896279 |
| SIK1 | salt-inducible kinase 1 | 0.00877422 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | 0.00871127 |
| CCNA2 | cyclin A2 | 0.00861106 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | 0.00843745 |
| BMP2 | bone morphogenetic protein 2 | 0.00841802 |
| POSTN | periostin, osteoblast specific factor | 0.00837634 |
| KRT14 | keratin 14, type I | 0.00835065 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.00827701 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.00825252 |
| JAK1 | Janus kinase 1 | 0.00819536 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.00818238 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | 0.00816709 |
| HBEGF | heparin-binding EGF-like growth factor | 0.00816025 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 0.00812251 |
| MYO1C | myosin IC | 0.00802033 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.007962 |
| PLK2 | polo-like kinase 2 | 0.00793065 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.00791209 |
| S100A11 | S100 calcium binding protein A11 | 0.00789937 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.00785979 |
| MPO | myeloperoxidase | 0.00783139 |
| PTHLH | parathyroid hormone-like hormone | 0.00782661 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.00779868 |
| SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | 0.00777756 |
| NRCAM | neuronal cell adhesion molecule | 0.00776965 |
| MYO1B | myosin IB | 0.00776961 |
| MXRA7 | matrix-remodelling associated 7 | 0.00776625 |
| BIK | BCL2-interacting killer (apoptosis-inducing) | 0.00772658 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.00768485 |
| HTATIP2 | HIV-1 Tat interactive protein 2, 30kDa | 0.00761849 |
| CLIC5 | chloride intracellular channel 5 | 0.00760733 |
| GRK5 | G protein-coupled receptor kinase 5 | 0.00760269 |
| TTN | titin | 0.00759437 |
| RTN2 | reticulon 2 | 0.00757199 |
| EGR1 | early growth response 1 | 0.00754398 |
| AURKB | aurora kinase B | 0.0075132 |
| LAMC2 | laminin, gamma 2 | 0.00749552 |
| KRT7 | keratin 7, type II | 0.00748213 |
| VWF | von Willebrand factor | 0.00746515 |
| PLSCR1 | phospholipid scramblase 1 | 0.00738687 |
| CFD | complement factor D (adipsin) | 0.00736662 |
| PALLD | palladin, cytoskeletal associated protein | 0.00730288 |
| ELANE | elastase, neutrophil expressed | 0.00724429 |
| MT1HL1 | metallothionein 1H-like 1 | 0.00723892 |
| SPRR3 | small proline-rich protein 3 | 0.0072277 |
| KBTBD11 | kelch repeat and BTB (POZ) domain containing 11 | 0.00721534 |
| KLK10 | kallikrein-related peptidase 10 | 0.00719071 |
| PLAU | plasminogen activator, urokinase | 0.00716709 |
| CDV3 | CDV3 homolog (mouse) | 0.00714435 |
| ACTA1 | actin, alpha 1, skeletal muscle | 0.00713375 |
| SNAPC1 | small nuclear RNA activating complex, polypeptide 1, 43kDa | 0.00712924 |
| UPP1 | uridine phosphorylase 1 | 0.00710282 |
| STXBP2 | syntaxin binding protein 2 | 0.00709966 |
| SLC18A1 | solute carrier family 18 (vesicular monoamine transporter), member 1 | 0.00708754 |
| TPM4 | tropomyosin 4 | 0.00703919 |
| EGR2 | early growth response 2 | 0.00703734 |
| KLF6 | Kruppel-like factor 6 | 0.00703584 |
| CHEK1 | checkpoint kinase 1 | 0.00703157 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | 0.00696257 |
| ZNF706 | zinc finger protein 706 | 0.00692687 |
| SLC31A2 | solute carrier family 31 (copper transporter), member 2 | 0.00691313 |
| MT2A | metallothionein 2A | 0.00684862 |
| KRT19 | keratin 19, type I | 0.00684425 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.00683261 |
| CTSZ | cathepsin Z | 0.00678953 |
| PFDN4 | prefoldin subunit 4 | 0.00677965 |
| RGS4 | regulator of G-protein signaling 4 | 0.00677515 |
| CKM | creatine kinase, muscle | 0.00676995 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | 0.00673805 |
| KLHL41 | kelch-like family member 41 | 0.00670512 |
| SIRPA | signal-regulatory protein alpha | 0.00669646 |
| ATF3 | activating transcription factor 3 | 0.00668775 |
| MMP10 | matrix metallopeptidase 10 | 0.00667621 |
| LY96 | lymphocyte antigen 96 | 0.00667119 |
| MMP1 | matrix metallopeptidase 1 | 0.00664935 |
| SDCBP | syndecan binding protein (syntenin) | 0.00664666 |
| TMEM100 | transmembrane protein 100 | 0.00661585 |
| HOMER1 | homer scaffolding protein 1 | 0.00654424 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.00654323 |
| SMC1A | structural maintenance of chromosomes 1A | 0.00653956 |
| KRT18 | keratin 18, type I | 0.00652918 |
| SS18 | synovial sarcoma translocation, chromosome 18 | 0.00652492 |
| FABP7 | fatty acid binding protein 7, brain | 0.00652342 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.00650706 |
| RHOF | ras homolog family member F (in filopodia) | 0.0064884 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.00647429 |
| MCL1 | myeloid cell leukemia 1 | 0.00644865 |
| GOLGA8A | golgin A8 family, member A | 0.00644602 |
| CAV2 | caveolin 2 | 0.00643308 |
| SH3YL1 | SH3 and SYLF domain containing 1 | 0.00640649 |
| MID1IP1 | MID1 interacting protein 1 | 0.00639762 |
| LRRN3 | leucine rich repeat neuronal 3 | 0.0063594 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0063516 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.00633914 |
| OSBPL1A | oxysterol binding protein-like 1A | 0.00633835 |
| MYL2 | myosin, light chain 2, regulatory, cardiac, slow | 0.00631755 |
| TSPO | translocator protein (18kDa) | 0.00631088 |
| TAX1BP3 | Tax1 (human T-cell leukemia virus type I) binding protein 3 | 0.00629831 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | 0.00628212 |
| PITX3 | paired-like homeodomain 3 | 0.00625725 |
| MYBPC1 | myosin binding protein C, slow type | 0.00625193 |
| MT1H | metallothionein 1H | 0.00624997 |
| IRX5 | iroquois homeobox 5 | 0.00624692 |
| ELF1 | E74-like factor 1 (ets domain transcription factor) | 0.00624043 |
| RHOBTB1 | Rho-related BTB domain containing 1 | 0.00621061 |
| IL6 | interleukin 6 | 0.0061962 |
| TPM2 | tropomyosin 2 (beta) | 0.00618074 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | 0.00617648 |
| IER5 | immediate early response 5 | 0.0061632 |
| GALC | galactosylceramidase | 0.00615822 |
| MEX3C | mex-3 RNA binding family member C | 0.00615066 |
| GATA6 | GATA binding protein 6 | 0.00614319 |
| BGN | biglycan | 0.00613147 |
| MT1F | metallothionein 1F | 0.00611411 |
| MS4A3 | membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) | 0.00611122 |
| RRAGD | Ras-related GTP binding D | 0.00608658 |
| PROM1 | prominin 1 | 0.00607483 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | 0.00606588 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.00605892 |
| CALB1 | calbindin 1, 28kDa | 0.00605756 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.00605707 |
| TNNT1 | troponin T type 1 (skeletal, slow) | 0.00605315 |
| FAM107A | family with sequence similarity 107, member A | 0.00604705 |
| KRT23 | keratin 23, type I | 0.00604298 |
| CLC | Charcot-Leyden crystal galectin | 0.00604072 |
| C1QA | complement component 1, q subcomponent, A chain | 0.0060371 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | 0.00600904 |
| ZBTB16 | zinc finger and BTB domain containing 16 | 0.00599958 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.00599077 |
| PCTP | phosphatidylcholine transfer protein | 0.00599067 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.00599006 |
| CXCL6 | chemokine (C-X-C motif) ligand 6 | 0.00596662 |
| WWC1 | WW and C2 domain containing 1 | 0.00592468 |
| MFAP3L | microfibrillar-associated protein 3-like | 0.00592359 |
| FBXO11 | F-box protein 11 | 0.00592306 |
| MGLL | monoglyceride lipase | 0.00589624 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 0.00589586 |
| SELE | selectin E | 0.00589507 |
| FADD | Fas (TNFRSF6)-associated via death domain | 0.00588156 |
| HECA | headcase homolog (Drosophila) | 0.00588006 |
| SLC25A32 | solute carrier family 25 (mitochondrial folate carrier), member 32 | 0.00586622 |
| TRIB3 | tribbles pseudokinase 3 | 0.00585757 |
| CEBPG | CCAAT/enhancer binding protein (C/EBP), gamma | 0.00585514 |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta | 0.00584829 |
| PLAUR | plasminogen activator, urokinase receptor | 0.00584487 |
| NDFIP1 | Nedd4 family interacting protein 1 | 0.00584007 |
| MT1M | metallothionein 1M | 0.00583089 |
| EREG | epiregulin | 0.00582102 |
| FBLN5 | fibulin 5 | 0.00580994 |
| PTGER4 | prostaglandin E receptor 4 (subtype EP4) | 0.00578054 |
| NEBL | nebulette | 0.00577943 |
| ATP6V1C1 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 | 0.00576383 |
| ZC3H12A | zinc finger CCCH-type containing 12A | 0.00575985 |
| CLEC11A | C-type lectin domain family 11, member A | 0.00575063 |
| TNNI1 | troponin I type 1 (skeletal, slow) | 0.00574891 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | 0.00574725 |
| CDH5 | cadherin 5, type 2 (vascular endothelium) | 0.0057329 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.00572334 |
| TGFA | transforming growth factor, alpha | 0.0057173 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.00570904 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | 0.00570665 |
| TPM3 | tropomyosin 3 | 0.00570376 |
| IL33R | interleukin 33 receptor | 0.00570109 |
| TMEM204 | transmembrane protein 204 | 0.0056978 |
| GRAMD2B | GRAM domain containing 2B | 0.00566172 |
| MYL1 | myosin, light chain 1, alkali; skeletal, fast | 0.00565537 |
| SGPP1 | sphingosine-1-phosphate phosphatase 1 | 0.0056374 |
| MYH2 | myosin, heavy chain 2, skeletal muscle, adult | 0.00563451 |
| SLC38A1 | solute carrier family 38, member 1 | 0.00562512 |
| REEP5 | receptor accessory protein 5 | 0.00561677 |
| CLCN4 | chloride channel, voltage-sensitive 4 | 0.00559686 |
| PDE4DIP | phosphodiesterase 4D interacting protein | 0.00556003 |
| AZIN1 | antizyme inhibitor 1 | 0.00555427 |
| DSG3 | desmoglein 3 | 0.00553641 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 0.00553243 |
| TFRC | transferrin receptor | 0.00552132 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.00552028 |
| STATH | statherin | 0.00551911 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | 0.00551558 |
| NBN | nibrin | 0.00549387 |
| S100A10 | S100 calcium binding protein A10 | 0.00548842 |
| GPR137B | G protein-coupled receptor 137B | 0.00548538 |
| MYOZ2 | myozenin 2 | 0.00548321 |
| TRIM29 | tripartite motif containing 29 | 0.00547117 |
| COX6C | cytochrome c oxidase subunit VIc | 0.00546496 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.00546413 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.00545844 |
| ATP6V1G1 | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 | 0.00545644 |
| AMOTL2 | angiomotin like 2 | 0.00545072 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.00544703 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.00544607 |
| PPP1R16B | protein phosphatase 1, regulatory subunit 16B | 0.00543538 |
| POU4F1 | POU class 4 homeobox 1 | 0.00543435 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0054321 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.00542923 |
| TRIM22 | tripartite motif containing 22 | 0.0054275 |
| ZBED2 | zinc finger, BED-type containing 2 | 0.00542479 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.00542149 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.00541826 |
| IFNGR1 | interferon gamma receptor 1 | 0.00541575 |
| KLF4 | Kruppel-like factor 4 (gut) | 0.00541473 |
| MFAP5 | microfibrillar associated protein 5 | 0.0054092 |
| SULF1 | sulfatase 1 | 0.00539612 |
| MSLN | mesothelin | 0.00539523 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | 0.00538407 |
| AZU1 | azurocidin 1 | 0.0053824 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.00537794 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 0.00536961 |
| DACT1 | dishevelled-binding antagonist of beta-catenin 1 | 0.00536396 |
| MYB | v-myb avian myeloblastosis viral oncogene homolog | 0.00536114 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.00535941 |
| SMPX | small muscle protein, X-linked | 0.00535618 |
| LAMA3 | laminin, alpha 3 | 0.00535153 |
| GALNT6 | polypeptide N-acetylgalactosaminyltransferase 6 | 0.00532981 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.0152407 |
| NVL | nuclear VCP-like | -0.0138842 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.0124451 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | -0.0120195 |
| CNPY3 | canopy FGF signaling regulator 3 | -0.0103305 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.010321 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 | -0.00979607 |
| SEPP1 | selenoprotein P, plasma, 1 | -0.00975711 |
| COLEC12 | collectin sub-family member 12 | -0.00969275 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.00955317 |
| TPSAB1 | tryptase alpha/beta 1 | -0.009534 |
| TM7SF2 | transmembrane 7 superfamily member 2 | -0.00923061 |
| ACP3 | acid phosphatase 3 | -0.00909055 |
| CTSH | cathepsin H | -0.0090821 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.00888638 |
| TMSB15A | thymosin beta 15a | -0.00872368 |
| METTL7A | methyltransferase like 7A | -0.00864259 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.00836501 |
| TNC | tenascin C | -0.00825351 |
| FASN | fatty acid synthase | -0.00820605 |
| PCP4 | Purkinje cell protein 4 | -0.00819874 |
| BCHE | butyrylcholinesterase | -0.00809406 |
| SELENBP1 | selenium binding protein 1 | -0.00804287 |
| SFTPA2 | surfactant protein A2 | -0.00801605 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.00798414 |
| TOX3 | TOX high mobility group box family member 3 | -0.00781269 |
| CP | ceruloplasmin (ferroxidase) | -0.00776184 |
| HOMER2 | homer scaffolding protein 2 | -0.00770666 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0076166 |
| DCT | dopachrome tautomerase | -0.00758201 |
| IPO13 | importin 13 | -0.00742297 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.00737295 |
| LSP1 | lymphocyte-specific protein 1 | -0.00733714 |
| SDC2 | syndecan 2 | -0.00729704 |
| ELOVL5 | ELOVL fatty acid elongase 5 | -0.00726315 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.00722526 |
| TGFBR3 | transforming growth factor, beta receptor III | -0.00721618 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.00714523 |
| XPO7 | exportin 7 | -0.00712506 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.00699522 |
| COL4A5 | collagen, type IV, alpha 5 | -0.00699333 |
| ECI2 | enoyl-CoA delta isomerase 2 | -0.00687575 |
| EPHX2 | epoxide hydrolase 2, cytoplasmic | -0.00677581 |
| SH3BGRL | SH3 domain binding glutamate-rich protein like | -0.00672245 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -0.00671129 |
| LMO3 | LIM domain only 3 (rhombotin-like 2) | -0.00670324 |
| DCXR | dicarbonyl/L-xylulose reductase | -0.00668615 |
| ITGA7 | integrin, alpha 7 | -0.00667063 |
| SFTPC | surfactant protein C | -0.00666216 |
| GANAB | glucosidase, alpha; neutral AB | -0.00666111 |
| RAPSN | receptor-associated protein of the synapse | -0.00656926 |
| RTN1 | reticulon 1 | -0.00656202 |
| SCD5 | stearoyl-CoA desaturase 5 | -0.00655998 |
| ARFIP1 | ADP-ribosylation factor interacting protein 1 | -0.0065076 |
| LAMA4 | laminin, alpha 4 | -0.00649265 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.00648814 |
| CCR2 | chemokine (C-C motif) receptor 2 | -0.00648495 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.0064589 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.00643997 |
| COL18A1 | collagen, type XVIII, alpha 1 | -0.00643519 |
| OGFOD3 | 2-oxoglutarate and iron-dependent oxygenase domain containing 3 | -0.00640721 |
| CYB5A | cytochrome b5 type A (microsomal) | -0.00639421 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.00639325 |
| GLO1 | glyoxalase I | -0.00634988 |
| ADCY1 | adenylate cyclase 1 (brain) | -0.00632747 |
| FAM13A | family with sequence similarity 13, member A | -0.00630999 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | -0.00629999 |
| PDZRN3 | PDZ domain containing ring finger 3 | -0.00627925 |
| FGL2 | fibrinogen-like 2 | -0.00626407 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | -0.00625514 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.00624317 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | -0.00623313 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | -0.00619075 |
| LEF1 | lymphoid enhancer-binding factor 1 | -0.00616354 |
| TWIST1 | twist family bHLH transcription factor 1 | -0.00606748 |
| HLA-DOB | major histocompatibility complex, class II, DO beta | -0.00606126 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | -0.00605788 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | -0.00604269 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | -0.00601913 |
| EPHB2 | EPH receptor B2 | -0.00601547 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | -0.00600512 |
| JCHAIN | joining chain of multimeric IgA and IgM | -0.00600224 |
| FLOT1 | flotillin 1 | -0.00599202 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | -0.00597239 |
| NANOG | Nanog homeobox | -0.00595089 |
| CHST2 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 | -0.00594647 |
| LSR | lipolysis stimulated lipoprotein receptor | -0.00590412 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | -0.00589355 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.00589164 |
| FCGR2B | Fc fragment of IgG, low affinity IIb, receptor (CD32) | -0.00588535 |
| PPL | periplakin | -0.00586892 |
| CHN1 | chimerin 1 | -0.00585821 |
| FBXO28 | F-box protein 28 | -0.00581651 |
| NUDT11 | nudix (nucleoside diphosphate linked moiety X)-type motif 11 | -0.00581174 |
| MLPH | melanophilin | -0.00575684 |
| SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 | -0.00574486 |
| NARF | nuclear prelamin A recognition factor | -0.00574287 |
| PTCH1 | patched 1 | -0.0057325 |
| AMT | aminomethyltransferase | -0.00572595 |
| KLHDC3 | kelch domain containing 3 | -0.00572472 |
| GATA2 | GATA binding protein 2 | -0.00570818 |
| SERPIND1 | serpin peptidase inhibitor, clade D (heparin cofactor), member 1 | -0.00570465 |
| CRLF1 | cytokine receptor-like factor 1 | -0.00570393 |
| CFI | complement factor I | -0.0056942 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -0.00568535 |
| FGFR3 | fibroblast growth factor receptor 3 | -0.00568324 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.00568198 |
| CPM | carboxypeptidase M | -0.0056645 |
| C4BPA | complement component 4 binding protein, alpha | -0.00566334 |
| SFTPB | surfactant protein B | -0.00565207 |
| KRT2 | keratin 2, type II | -0.00564496 |
| AOC3 | amine oxidase, copper containing 3 | -0.00562551 |
| CCL19 | chemokine (C-C motif) ligand 19 | -0.00562219 |
| COBLL1 | cordon-bleu WH2 repeat protein-like 1 | -0.00562212 |
| GLYR1 | glyoxylate reductase 1 homolog (Arabidopsis) | -0.00561767 |
| RXRA | retinoid X receptor, alpha | -0.00558352 |
| ACOX2 | acyl-CoA oxidase 2, branched chain | -0.00555884 |
| DPM3 | dolichyl-phosphate mannosyltransferase polypeptide 3 | -0.00554762 |
| ABHD17A | abhydrolase domain containing 17A | -0.0055363 |
| VKORC1 | vitamin K epoxide reductase complex, subunit 1 | -0.00550001 |
| MYCL | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog | -0.00549852 |
| TOP1 | topoisomerase (DNA) I | -0.00548558 |
| APMAP | adipocyte plasma membrane associated protein | -0.00548507 |
| EXPH5 | exophilin 5 | -0.00548329 |
| MEA1 | male-enhanced antigen 1 | -0.00547497 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.00546691 |
| HMG20B | high mobility group 20B | -0.00545845 |
| PTMS | parathymosin | -0.00545107 |
| PMEL | premelanosome protein | -0.00545105 |
| PGRMC2 | progesterone receptor membrane component 2 | -0.00544672 |
| ACSM3 | acyl-CoA synthetase medium-chain family member 3 | -0.00544066 |
| RCAN2 | regulator of calcineurin 2 | -0.00543892 |
| MMUT | methylmalonyl-CoA mutase | -0.00542501 |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | -0.00542423 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | -0.0054184 |
| MEIS2 | Meis homeobox 2 | -0.00541479 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.00541237 |
| CHKB | choline kinase beta | -0.00541189 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | -0.00540473 |
| CST3 | cystatin C | -0.00538331 |
| CD300A | CD300a molecule | -0.00538068 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | -0.00537589 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.00537042 |
| UBL3 | ubiquitin-like 3 | -0.00536562 |
| SPINK5 | serine peptidase inhibitor, Kazal type 5 | -0.00535908 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | -0.0053567 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.00534919 |
| C1ORF115 | chromosome 1 open reading frame 115 | -0.00533968 |
| MAOA | monoamine oxidase A | -0.00532773 |
| DPP4 | dipeptidyl-peptidase 4 | -0.00532705 |
| PER3 | period circadian clock 3 | -0.00532659 |
| MOXD1 | monooxygenase, DBH-like 1 | -0.00532627 |
| C2 | complement component 2 | -0.00530974 |
| CD1C | CD1c molecule | -0.00530497 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | -0.00528944 |
| GUCY1A3 | guanylate cyclase 1, soluble, alpha 3 | -0.00528437 |
| CREBL2 | cAMP responsive element binding protein-like 2 | -0.00527761 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.00527085 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.00522792 |
| EDRF1 | erythroid differentiation regulatory factor 1 | -0.00522217 |
| CAMK1 | calcium/calmodulin-dependent protein kinase I | -0.00521709 |
| AGPAT1 | 1-acylglycerol-3-phosphate O-acyltransferase 1 | -0.00521101 |
| FGR | FGR proto-oncogene, Src family tyrosine kinase | -0.00520091 |
| LY86 | lymphocyte antigen 86 | -0.00517094 |
| EPAS1 | endothelial PAS domain protein 1 | -0.00516742 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.00516639 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | -0.00516367 |
| AHSG | alpha-2-HS-glycoprotein | -0.00516213 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | -0.00515045 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | -0.00513998 |
| BCL7C | B-cell CLL/lymphoma 7C | -0.00513087 |
| TMC5 | transmembrane channel-like 5 | -0.00512889 |
| SLC2A4RG | SLC2A4 regulator | -0.00512848 |
| PRAME | preferentially expressed antigen in melanoma | -0.00511752 |
| SLC29A1 | solute carrier family 29 (equilibrative nucleoside transporter), member 1 | -0.00511262 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.00510756 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.00510395 |
| RNF5 | ring finger protein 5, E3 ubiquitin protein ligase | -0.00510126 |
| ESR1 | estrogen receptor 1 | -0.00509576 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | -0.00509109 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.00508816 |
| PYGB | phosphorylase, glycogen; brain | -0.00506524 |
| CES1 | carboxylesterase 1 | -0.00506358 |
| NRN1 | neuritin 1 | -0.00506283 |
| CSAD | cysteine sulfinic acid decarboxylase | -0.00505583 |
| CD86 | CD86 molecule | -0.00504613 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0050461 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.00504488 |
| WFDC2 | WAP four-disulfide core domain 2 | -0.00503384 |
| ERGIC2 | ERGIC and golgi 2 | -0.00501538 |
| KANK2 | KN motif and ankyrin repeat domains 2 | -0.00500657 |
| HABP2 | hyaluronan binding protein 2 | -0.00500359 |
| PFKL | phosphofructokinase, liver | -0.00500351 |
| HOXA10 | homeobox A10 | -0.00499789 |
| CLGN | calmegin | -0.00498892 |
| FCER1A | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | -0.00498665 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.00498221 |
| OAZ2 | ornithine decarboxylase antizyme 2 | -0.00496784 |
| SC5D | sterol-C5-desaturase | -0.0049635 |
| TRIB2 | tribbles pseudokinase 2 | -0.00495856 |
| CRYM | crystallin, mu | -0.00495849 |
| CNTNAP2 | contactin associated protein-like 2 | -0.00492719 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.00492368 |
| PCBP2 | poly(rC) binding protein 2 | -0.00492255 |
| PRR11 | proline rich 11 | -0.00492148 |
| COL1A2 | collagen, type I, alpha 2 | -0.00491833 |
| GNMT | glycine N-methyltransferase | -0.00491613 |
| EIF3L | eukaryotic translation initiation factor 3, subunit L | -0.00490164 |
| IRF8 | interferon regulatory factor 8 | -0.0049004 |
| HSD17B4 | hydroxysteroid (17-beta) dehydrogenase 4 | -0.00489972 |
| RAB40B | RAB40B, member RAS oncogene family | -0.00488672 |
| PON3 | paraoxonase 3 | -0.00488029 |
| GNAO1 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O | -0.00487887 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0048746 |
| CPVL | carboxypeptidase, vitellogenic-like | -0.00486384 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.00486079 |
| GMPR | guanosine monophosphate reductase | -0.0048556 |
| H2AX | H2A.X variant histone | -0.00485184 |
| ECI1 | enoyl-CoA delta isomerase 1 | -0.00484093 |
| OTUB1 | OTU deubiquitinase, ubiquitin aldehyde binding 1 | -0.00483788 |
| SDF4 | stromal cell derived factor 4 | -0.00483152 |
| DHFR | dihydrofolate reductase | -0.00482851 |
| DMBT1 | deleted in malignant brain tumors 1 | -0.00482685 |
| ICMT | isoprenylcysteine carboxyl methyltransferase | -0.00481699 |
| EMP3 | epithelial membrane protein 3 | -0.00481635 |
| WLS | wntless Wnt ligand secretion mediator | -0.00481333 |
| MAGT1 | magnesium transporter 1 | -0.00481009 |
| DDOST | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) | -0.004802 |
| IL2RB | interleukin 2 receptor, beta | -0.00480146 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.00479576 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | -0.00479575 |
| OVGP1 | oviductal glycoprotein 1, 120kDa | -0.00479371 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | -0.00479335 |
| KDM5A | lysine (K)-specific demethylase 5A | -0.00479 |
| HLA-DMB | major histocompatibility complex, class II, DM beta | -0.00478113 |
| KCNN2 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 | -0.00477781 |
| RMND5B | required for meiotic nuclear division 5 homolog B (S. cerevisiae) | -0.00477566 |
| FOLH1B | folate hydrolase 1B | -0.00475963 |
| SHROOM2 | shroom family member 2 | -0.00475428 |
| MECOM | MDS1 and EVI1 complex locus | -0.00475388 |
| GLDC | glycine dehydrogenase (decarboxylating) | -0.00475022 |
| KCNMB1 | potassium channel subfamily M regulatory beta subunit 1 | -0.00475021 |
| EML3 | echinoderm microtubule associated protein like 3 | -0.00474885 |
| ZNF76 | zinc finger protein 76 | -0.00474865 |
| PLA2G7 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | -0.00474835 |
| SLC16A7 | solute carrier family 16 (monocarboxylate transporter), member 7 | -0.00474533 |
| PDK1 | pyruvate dehydrogenase kinase, isozyme 1 | -0.00474474 |
| CDKN2C | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | -0.00474279 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.00473851 |
