ADAMTS13 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description ADAM metallopeptidase with thrombospondin type 1 motif, 13|This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 11093)
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Genes

315 genes differentially expressed following the ADAMTS13 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
OR2A5 olfactory receptor, family 2, subfamily A, member 5 3.74245
PLN phospholamban 3.74245
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 3.74245
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 3.74245
KCNRG potassium channel regulator 3.74245
TPBGL trophoblast glycoprotein-like 3.74245
S100A1 S100 calcium binding protein A1 3.74245
MAB21L2 mab-21-like 2 (C. elegans) 3.74245
PTPRC protein tyrosine phosphatase, receptor type, C 3.74245
PRR18 proline rich 18 3.74245
TPTE transmembrane phosphatase with tensin homology 3.74245
DNASE2B deoxyribonuclease II beta 3.74245
CTAGE9 CTAGE family, member 9 3.74245
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 3.74245
BSND barttin CLCNK-type chloride channel accessory beta subunit 3.74245
CRX cone-rod homeobox 3.74245
ADCY4 adenylate cyclase 4 3.74245
PCDHB4 protocadherin beta 4 3.74245
GOLGA8H golgin A8 family, member H 3.74245
LOC114841035 uncharacterized LOC114841035 3.74245
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 3.74245
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 3.74245
TG thyroglobulin 3.74245
HORMAD2 HORMA domain containing 2 3.61723
HORMAD1 HORMA domain containing 1 3.61723
SIX6 SIX homeobox 6 3.61723
CD3D CD3d molecule, delta (CD3-TCR complex) 3.61723
LURAP1L leucine rich adaptor protein 1-like 3.61723
HES3 hes family bHLH transcription factor 3 3.61723
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.61723
NAPSA napsin A aspartic peptidase 3.61723
UCN2 urocortin 2 3.61723
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 3.61723
OR1D2 olfactory receptor, family 1, subfamily D, member 2 3.61723
CCNB3 cyclin B3 3.61723
RLN1 relaxin 1 3.61723
CEP295NL CEP295 N-terminal like 3.61723
S100A5 S100 calcium binding protein A5 3.61723
RFPL2 ret finger protein-like 2 3.61723
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 3.61723
EN1 engrailed homeobox 1 3.61723
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 3.61723
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 3.61723
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 3.61723
NFAM1 NFAT activating protein with ITAM motif 1 3.61723
STAP1 signal transducing adaptor family member 1 3.61723
TYRP1 tyrosinase-related protein 1 3.61723
MBD3L3 methyl-CpG binding domain protein 3-like 3 3.61723
IL5RA interleukin 5 receptor, alpha 3.61723
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 3.61723
FABP9 fatty acid binding protein 9, testis 3.61723
USH1G Usher syndrome 1G (autosomal recessive) 3.61723
PKD2L1 polycystic kidney disease 2-like 1 3.61723
OR2T8 olfactory receptor, family 2, subfamily T, member 8 3.61723
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 3.61723
HTRA4 HtrA serine peptidase 4 3.61723
SCEL sciellin 3.61723
GPX5 glutathione peroxidase 5 3.61723
ZNF728 zinc finger protein 728 3.61723
CCDC9B coiled-coil domain containing 9B 3.61723
CFAP65 cilia and flagella associated protein 65 3.61723
CALHM5 calcium homeostasis modulator family member 5 3.61723
CPHXL cytoplasmic polyadenylated homeobox like 3.61723
CLEC20A C-type lectin domain containing 20A 3.61723
LY6L lymphocyte antigen 6 family member L 3.61723
MINDY4B MINDY family member 4B 3.61723
GREP1 glycine rich extracellular protein 1 3.61723
FAM246C family with sequence similarity 246 member C (gene/pseudogene) 3.61723
OR6F1 olfactory receptor, family 6, subfamily F, member 1 3.61723
DOK7 docking protein 7 3.61723
FPR1 formyl peptide receptor 1 3.61723
FPR2 formyl peptide receptor 2 3.61723
ATP13A5 ATPase type 13A5 3.61723
CD300LD CD300 molecule-like family member d 3.61723
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 3.61723
TRIM60 tripartite motif containing 60 3.61723
CHRD chordin 3.61723
ZSWIM2 zinc finger, SWIM-type containing 2 3.61723
PIWIL1 piwi-like RNA-mediated gene silencing 1 3.61723
CCR3 chemokine (C-C motif) receptor 3 3.61723
BARX2 BARX homeobox 2 3.61723
GTSF1 gametocyte specific factor 1 3.61723
BLNK B-cell linker 3.61723
OPN5 opsin 5 3.61723
DLK1 delta-like 1 homolog (Drosophila) 3.61723
GATA4 GATA binding protein 4 3.61723
WASL-DT WASL divergent transcript 3.61723
CALB2 calbindin 2 3.61723
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 3.61723
ENDOU endonuclease, polyU-specific 3.61723
PCDHGB5 protocadherin gamma subfamily B, 5 3.61723
PYHIN1 pyrin and HIN domain family, member 1 3.61723
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 3.61723
CIDEA cell death-inducing DFFA-like effector a 3.61723
LMOD2 leiomodin 2 (cardiac) 3.61723
AGR3 anterior gradient 3 3.61723
ALOX15B arachidonate 15-lipoxygenase, type B 3.61723
TECRL trans-2,3-enoyl-CoA reductase-like 3.61723
CHIT1 chitinase 1 (chitotriosidase) 3.61723
AOC3 amine oxidase, copper containing 3 3.61723
TH tyrosine hydroxylase 3.61723
KCNK7 potassium channel, two pore domain subfamily K, member 7 3.61723
SOWAHA sosondowah ankyrin repeat domain family member A 3.61723
CYP8B1 cytochrome P450, family 8, subfamily B, polypeptide 1 3.61723
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 3.61723
TRIM50 tripartite motif containing 50 3.61723
LCN1 lipocalin 1 3.61723
CCDC27 coiled-coil domain containing 27 3.61723
THTPA thiamine triphosphatase 3.61723
UBQLN3 ubiquilin 3 3.61723
PCDHGA3 protocadherin gamma subfamily A, 3 3.61723
PCDHGA2 protocadherin gamma subfamily A, 2 3.61723
EFCAB3 EF-hand calcium binding domain 3 3.61723
ITGA8 integrin, alpha 8 3.61723
FAM177B family with sequence similarity 177, member B 3.61723
CT55 cancer/testis antigen 55 3.61723
HAMP hepcidin antimicrobial peptide 3.61723
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 3.61723
SLC7A4 solute carrier family 7, member 4 3.61723
IL17B interleukin 17B 3.61723
C18ORF63 chromosome 18 open reading frame 63 3.61723
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 3.61723
LYZL4 lysozyme-like 4 3.61723
PENK proenkephalin 3.61723
NPY2R neuropeptide Y receptor Y2 3.61723
ERVV-1 endogenous retrovirus group V, member 1 3.61723
C5ORF46 chromosome 5 open reading frame 46 3.61723
IL37 interleukin 37 3.61723
CHRDL2 chordin-like 2 3.61723
CLCNKA chloride channel, voltage-sensitive Ka 3.61723
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 3.61723
CAPSL calcyphosine-like 3.61723
LY6G6C lymphocyte antigen 6 complex, locus G6C 3.61723
CIB4 calcium and integrin binding family member 4 3.61723
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 3.61723
NR5A1 nuclear receptor subfamily 5, group A, member 1 3.61723
SLC36A3 solute carrier family 36, member 3 3.61723
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 3.61723
SLITRK1 SLIT and NTRK-like family, member 1 3.61723
APOD apolipoprotein D 3.61723
PRAP1 proline-rich acidic protein 1 3.61723
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 3.61723
PRRT4 proline-rich transmembrane protein 4 3.56905
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa 3.48759
MIS12 MIS12 kinetochore complex component 3.42148
S100G S100 calcium binding protein G 3.36097
SPTB spectrin, beta, erythrocytic 3.15842
SCN10A sodium channel, voltage gated, type X alpha subunit 3.02702
ZNF709 zinc finger protein 709 3.00041
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 2.96417
CA7 carbonic anhydrase VII 2.94268
LAMP1 lysosomal-associated membrane protein 1 2.88787
VGLL3 vestigial-like family member 3 2.87563
DAAM2 dishevelled associated activator of morphogenesis 2 2.80913
AP1M2 adaptor-related protein complex 1, mu 2 subunit 2.74543
USP21 ubiquitin specific peptidase 21 2.71876
PARL presenilin associated, rhomboid-like 2.64564
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.64456
SHOX short stature homeobox 2.64456
CFAP54 cilia and flagella associated 54 2.64456
ADGRG1 adhesion G protein-coupled receptor G1 2.64456
TMEM229B transmembrane protein 229B 2.64456
IL21R interleukin 21 receptor 2.64456
PRDM6 PR domain containing 6 2.64456
OR4D1 olfactory receptor, family 4, subfamily D, member 1 2.64456
ZNF383 zinc finger protein 383 2.62346
SOCS2 suppressor of cytokine signaling 2 2.61135
CHD4 chromodomain helicase DNA binding protein 4 2.58556
PROM1 prominin 1 2.51067
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) 2.509
DNASE1L1 deoxyribonuclease I-like 1 2.48239
NUDT8 nudix (nucleoside diphosphate linked moiety X)-type motif 8 2.40586
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.39585
ADGRF3 adhesion G protein-coupled receptor F3 2.35845
THBD thrombomodulin 2.34175
DPRX divergent-paired related homeobox 2.32324
ZMYND12 zinc finger, MYND-type containing 12 2.32324
ADAM23 ADAM metallopeptidase domain 23 2.31467
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.31467
CREB3 cAMP responsive element binding protein 3 2.28099
TBC1D7-LOC100130357 TBC1D7-LOC100130357 readthrough 2.27156
ZNF687 zinc finger protein 687 2.25832
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 2.2407
POMP proteasome maturation protein 2.2407
AFAP1 actin filament associated protein 1 2.2407
C3ORF38 chromosome 3 open reading frame 38 2.20365
SGK3 serum/glucocorticoid regulated kinase family, member 3 2.19485
TMOD1 tropomodulin 1 2.1794
PLCB4 phospholipase C, beta 4 2.1794
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 2.17838
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 2.17474
POLE polymerase (DNA directed), epsilon, catalytic subunit 2.17282
ZNF630 zinc finger protein 630 2.15656
ZBTB40 zinc finger and BTB domain containing 40 2.1539
FBLIM1 filamin binding LIM protein 1 2.15219
UBXN8 UBX domain protein 8 2.14632
NRG4 neuregulin 4 2.12839
ARHGAP35 Rho GTPase activating protein 35 2.1122
ARL4C ADP-ribosylation factor-like 4C 2.10322
LAMA5 laminin, alpha 5 2.10322
MPZL1 myelin protein zero-like 1 2.10103
PRDX3 peroxiredoxin 3 2.09772
CLDN7 claudin 7 2.05488
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 2.04639
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 2.04125
MARS1 methionyl-tRNA synthetase 1 2.03475
RUBCN rubicon autophagy regulator 2.03398
ORAI2 ORAI calcium release-activated calcium modulator 2 2.03124
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 2.01792
CDKN3 cyclin-dependent kinase inhibitor 3 2.00422

decreased expression

Symbol Name Standardized Value
CSF1 colony stimulating factor 1 (macrophage) -3.74245
DRC3 dynein regulatory complex subunit 3 -3.74245
ANKRD65 ankyrin repeat domain 65 -3.74245
ZEB1 zinc finger E-box binding homeobox 1 -3.74245
CDK20 cyclin-dependent kinase 20 -3.6791
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) -3.6791
CD68 CD68 molecule -3.6791
AQP5 aquaporin 5 -3.61723
STAB1 stabilin 1 -3.56905
MMP20 matrix metallopeptidase 20 -3.56905
HLF hepatic leukemia factor -3.56905
SNX31 sorting nexin 31 -3.56905
BOLL boule-like RNA-binding protein -3.56905
GYS2 glycogen synthase 2 (liver) -3.56905
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 -3.56905
ARSI arylsulfatase family, member I -3.56905
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) -3.56905
FAM90A1 family with sequence similarity 90, member A1 -3.56905
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 -3.56905
CCL2 chemokine (C-C motif) ligand 2 -3.56905
IFITM10 interferon induced transmembrane protein 10 -3.56905
FRMPD2 FERM and PDZ domain containing 2 -3.56905
KYNU kynureninase -3.56905
FADS6 fatty acid desaturase 6 -3.56905
PLET1 placenta expressed transcript 1 -3.56905
SLC38A8 solute carrier family 38, member 8 -3.56905
GPR150 G protein-coupled receptor 150 -3.56905
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 -3.56905
DUSP9 dual specificity phosphatase 9 -3.56905
CLUL1 clusterin-like 1 (retinal) -3.56905
PTH1R parathyroid hormone 1 receptor -3.56905
GBX2 gastrulation brain homeobox 2 -3.56905
HAP1 huntingtin-associated protein 1 -3.56905
HPR haptoglobin-related protein -3.56905
COL19A1 collagen, type XIX, alpha 1 -3.56905
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 -3.56905
HSPB6 heat shock protein, alpha-crystallin-related, B6 -3.56905
FLI1 Fli-1 proto-oncogene, ETS transcription factor -3.56905
SLC22A31 solute carrier family 22, member 31 -3.4627
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 -3.3644
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) -3.1506
CCNY cyclin Y -3.1506
GNL1 guanine nucleotide binding protein-like 1 -3.07686
FRMD6 FERM domain containing 6 -3.05777
FLT3LG fms-related tyrosine kinase 3 ligand -3.05232
ATP8B4 ATPase, class I, type 8B, member 4 -3.05232
XPC xeroderma pigmentosum, complementation group C -2.97202
DENND1C DENN/MADD domain containing 1C -2.90316
CDH9 cadherin 9, type 2 (T1-cadherin) -2.75353
NIPSNAP3B nipsnap homolog 3B (C. elegans) -2.7372
UNC119B unc-119 homolog B (C. elegans) -2.72795
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -2.70678
GMPR guanosine monophosphate reductase -2.65428
RAB6A RAB6A, member RAS oncogene family -2.62021
HSDL1 hydroxysteroid dehydrogenase like 1 -2.60826
GFOD2 glucose-fructose oxidoreductase domain containing 2 -2.56119
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 -2.48239
TUNAR TCL1 upstream neural differentiation-associated RNA -2.48239
ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 -2.46452
WRAP73 WD repeat containing, antisense to TP73 -2.44292
IFI6 interferon, alpha-inducible protein 6 -2.42496
DNAH10 dynein, axonemal, heavy chain 10 -2.42496
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 -2.42496
CFAP52 cilia and flagella associated protein 52 -2.42496
DNAAF3 dynein, axonemal, assembly factor 3 -2.42496
KLHL22 kelch-like family member 22 -2.38835
USH1C Usher syndrome 1C (autosomal recessive, severe) -2.37401
ZNF749 zinc finger protein 749 -2.36701
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 -2.34366
LIN37 lin-37 DREAM MuvB core complex component -2.33512
PRADC1 protease-associated domain containing 1 -2.32767
TUBGCP3 tubulin, gamma complex associated protein 3 -2.31587
C1ORF122 chromosome 1 open reading frame 122 -2.2726
CAND2 cullin-associated and neddylation-dissociated 2 (putative) -2.27135
CTBP1 C-terminal binding protein 1 -2.27135
METTL5 methyltransferase like 5 -2.26883
CHPF chondroitin polymerizing factor -2.24211
PARVA parvin, alpha -2.20835
GP6 glycoprotein VI (platelet) -2.20777
TUBB2B tubulin, beta 2B class IIb -2.20306
SP140 SP140 nuclear body protein -2.19485
CATSPERD catsper channel auxiliary subunit delta -2.19485
OTX1 orthodenticle homeobox 1 -2.19485
PARP10 poly (ADP-ribose) polymerase family, member 10 -2.19485
CFAP126 cilia and flagella associated protein 126 -2.19159
NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit -2.18304
CTNNA3 catenin (cadherin-associated protein), alpha 3 -2.17282
LAMB2 laminin, beta 2 (laminin S) -2.16367
AZU1 azurocidin 1 -2.16367
SAXO4 stabilizer of axonemal microtubules 4 -2.16367
MCTP1 multiple C2 domains, transmembrane 1 -2.16124
DCXR dicarbonyl/L-xylulose reductase -2.10343
TMEM223 transmembrane protein 223 -2.10322
MANEAL mannosidase, endo-alpha-like -2.10322
OFD1 oral-facial-digital syndrome 1 -2.10322
AARD alanine and arginine rich domain containing protein -2.10045
SRSF12 serine/arginine-rich splicing factor 12 -2.09772
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -2.0976
XDH xanthine dehydrogenase -2.0831
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -2.08169
AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 -2.06044
COBL cordon-bleu WH2 repeat protein -2.05814
ESD esterase D -2.05252
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein -2.02781
EFCAB6 EF-hand calcium binding domain 6 -2.01669