ADO Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description 2-aminoethanethiol (cysteamine) dioxygenase|Human thiol dioxygenases include cysteine dioxygenase (CDO; MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO; EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine (Dominy et al., 2007 [PubMed 17581819]).[supplied by OMIM, Mar 2008] (NCBI Entrez Gene Database, 84890)
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Genes

288 genes differentially expressed following the ADO gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FAM81B family with sequence similarity 81, member B 2.50603
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.50603
TTL tubulin tyrosine ligase 2.50603
ARHGAP36 Rho GTPase activating protein 36 2.50603
ASB12 ankyrin repeat and SOCS box containing 12 2.50603
ASB10 ankyrin repeat and SOCS box containing 10 2.50603
SSTR5 somatostatin receptor 5 2.50603
SFXN3 sideroflexin 3 2.50603
MYOM2 myomesin 2 2.50603
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.50603
GJB5 gap junction protein, beta 5, 31.1kDa 2.50603
CELF3 CUGBP, Elav-like family member 3 2.50603
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.50603
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 2.50603
CX3CL1 chemokine (C-X3-C motif) ligand 1 2.50603
CD163 CD163 molecule 2.50603
CELA3B chymotrypsin-like elastase family, member 3B 2.50603
SSTR1 somatostatin receptor 1 2.50603
CCL5 chemokine (C-C motif) ligand 5 2.50603
TCAF2 TRPM8 channel-associated factor 2 2.50603
ADGB androglobin 2.50603
MUC22 mucin 22 2.50603
PTK6 protein tyrosine kinase 6 2.50603
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 2.50603
OR2B11 olfactory receptor, family 2, subfamily B, member 11 2.50603
SPAG6 sperm associated antigen 6 2.50603
STAP1 signal transducing adaptor family member 1 2.50603
BOLA2 bolA family member 2 2.50603
FAM161B family with sequence similarity 161, member B 2.50603
MISP mitotic spindle positioning 2.50603
TMEM121 transmembrane protein 121 2.50603
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.50603
GCKR glucokinase (hexokinase 4) regulator 2.50603
TPSD1 tryptase delta 1 2.50603
DEFB124 defensin, beta 124 2.50603
MS4A14 membrane-spanning 4-domains, subfamily A, member 14 2.50603
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.50603
SMIM5 small integral membrane protein 5 2.50603
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.50603
IGFL4 IGF-like family member 4 2.50603
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.50603
ZNF208 zinc finger protein 208 2.50603
FAM220A family with sequence similarity 220, member A 2.50603
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.50603
SMLR1 small leucine-rich protein 1 2.50603
C20ORF202 chromosome 20 open reading frame 202 2.50603
LY6K lymphocyte antigen 6 complex, locus K 2.50603
KHDC1L KH homology domain containing 1-like 2.50603
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 2.50603
DYNAP dynactin associated protein 2.50603
PKD2L1 polycystic kidney disease 2-like 1 2.50603
RD3 retinal degeneration 3 2.50603
RTL9 retrotransposon Gag like 9 2.50603
VEGFD vascular endothelial growth factor D 2.50603
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.50603
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.50603
PROP1 PROP paired-like homeobox 1 2.50603
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 2.50603
RCVRN recoverin 2.50603
HTRA4 HtrA serine peptidase 4 2.50603
LTF lactotransferrin 2.50603
TINAG tubulointerstitial nephritis antigen 2.50603
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.50603
PCDHA2 protocadherin alpha 2 2.50603
IL12RB1 interleukin 12 receptor, beta 1 2.50603
ZNF99 zinc finger protein 99 2.50603
MEP1A meprin A, alpha (PABA peptide hydrolase) 2.50603
TSSK4 testis-specific serine kinase 4 2.50603
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.50603
FBXL8 F-box and leucine-rich repeat protein 8 2.50603
DSG1 desmoglein 1 2.50603
AXDND1 axonemal dynein light chain domain containing 1 2.50603
ACE2 angiotensin I converting enzyme 2 2.50603
GDF7 growth differentiation factor 7 2.50603
PTCHD3 patched domain containing 3 2.50603
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 2.50603
PRR4 proline rich 4 (lacrimal) 2.50603
LSP1 lymphocyte-specific protein 1 2.50603
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.50603
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.50603
H2BW2 H2B.W histone 2 2.50603
HRG histidine-rich glycoprotein 2.50603
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.50603
TNR tenascin R 2.50603
EDN3 endothelin 3 2.50603
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.50603
MRLN myoregulin 2.50603
CTSF cathepsin F 2.50603
MKRN3 makorin ring finger protein 3 2.50603
FNDC8 fibronectin type III domain containing 8 2.50603
PALMD palmdelphin 2.50603
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 2.50603
PHGR1 proline/histidine/glycine-rich 1 2.50603
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 2.50603
ERVV-1 endogenous retrovirus group V, member 1 2.50603
GPR150 G protein-coupled receptor 150 2.50603
TOPAZ1 testis and ovary specific PAZ domain containing 1 2.50603
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 2.50603
BTNL2 butyrophilin-like 2 2.50603
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.50603
PLA1A phospholipase A1 member A 2.50603
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 2.50603
ISL1 ISL LIM homeobox 1 2.50603
VWA7 von Willebrand factor A domain containing 7 2.50603
C8G complement component 8, gamma polypeptide 2.50603
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 2.50603
SPEF1 sperm flagellar 1 2.50603
EPHA3 EPH receptor A3 2.50603
FCRL4 Fc receptor-like 4 2.50603
BPIFB1 BPI fold containing family B, member 1 2.50603
SPHKAP SPHK1 interactor, AKAP domain containing 2.50603
SCML4 sex comb on midleg-like 4 (Drosophila) 2.50603
CDH17 cadherin 17, LI cadherin (liver-intestine) 2.50603
AGR2 anterior gradient 2 2.50603
TBC1D21 TBC1 domain family, member 21 2.50603
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 2.50603
ADRA1B adrenoceptor alpha 1B 2.50603
TAS2R46 taste receptor, type 2, member 46 2.50603
GPR17 G protein-coupled receptor 17 2.50603
NEUROD2 neuronal differentiation 2 2.50603
NEUROD1 neuronal differentiation 1 2.50603
SYT5 synaptotagmin V 2.50603
HEPN1 hepatocellular carcinoma, down-regulated 1 2.50603
IRX4 iroquois homeobox 4 2.50603
PSD2 pleckstrin and Sec7 domain containing 2 2.50603
WFDC11 WAP four-disulfide core domain 11 2.50603
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 2.50603
ARHGAP20 Rho GTPase activating protein 20 2.50603
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.50603
TWIST1 twist family bHLH transcription factor 1 2.50603
CD80 CD80 molecule 2.50603
POTEJ POTE ankyrin domain family, member J 2.50603
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.50603
GPR146 G protein-coupled receptor 146 2.50603
NCR3 natural cytotoxicity triggering receptor 3 2.50603
LST1 leukocyte specific transcript 1 2.50603
GPRC6A G protein-coupled receptor, class C, group 6, member A 2.50603
ETV3L ets variant 3-like 2.50603
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 2.50603
NKAP NFKB activating protein 2.50422
DIPK2A divergent protein kinase domain 2A 2.49979
CLCN1 chloride channel, voltage-sensitive 1 2.43956
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.43956
BAIAP3 BAI1-associated protein 3 2.43956
LRIF1 ligand dependent nuclear receptor interacting factor 1 2.43271
MLH1 mutL homolog 1 2.43271
PJVK pejvakin 2.42043
HAUS1 HAUS augmin-like complex, subunit 1 2.37177
APOL6 apolipoprotein L, 6 2.35449
RNF130 ring finger protein 130 2.35449
CD200 CD200 molecule 2.35449
SOX10 SRY (sex determining region Y)-box 10 2.34368
THEM4 thioesterase superfamily member 4 2.33876
PACS1 phosphofurin acidic cluster sorting protein 1 2.33876
MRPL24 mitochondrial ribosomal protein L24 2.31966
ROR1 receptor tyrosine kinase-like orphan receptor 1 2.31966
HDLBP high density lipoprotein binding protein 2.31752
TNPO3 transportin 3 2.31752
UBE2Q2 ubiquitin-conjugating enzyme E2Q family member 2 2.31039
IGIP IgA-inducing protein 2.30095
PCDH19 protocadherin 19 2.2853
TM2D1 TM2 domain containing 1 2.28134
MTM1 myotubularin 1 2.28134
GUCA1A guanylate cyclase activator 1A (retina) 2.27694
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2.26836
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase 2.26046
ANKRD17 ankyrin repeat domain 17 2.25442
MRS2 MRS2 magnesium transporter 2.25123
ZNF518A zinc finger protein 518A 2.22563
ZNF232 zinc finger protein 232 2.21068
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 2.21068
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.21048
ZNF84 zinc finger protein 84 2.20781
MAP2K7 mitogen-activated protein kinase kinase 7 2.20175
CCDC141 coiled-coil domain containing 141 2.16974
STXBP1 syntaxin binding protein 1 2.16974
KHDC1 KH homology domain containing 1 2.16933
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 2.15697
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 2.14413
USP16 ubiquitin specific peptidase 16 2.13019
MTFR2 mitochondrial fission regulator 2 2.12865
UCK1 uridine-cytidine kinase 1 2.1264
STX12 syntaxin 12 2.12044
TEAD2 TEA domain family member 2 2.12044
ZGPAT zinc finger, CCCH-type with G patch domain 2.12044
SATB1 SATB homeobox 1 2.11079
GALT galactose-1-phosphate uridylyltransferase 2.11068
NLRC5 NLR family, CARD domain containing 5 2.09376
BEND3 BEN domain containing 3 2.09007
SAMD14 sterile alpha motif domain containing 14 2.08978
H3C4 H3 clustered histone 4 2.03651
KIAA0513 KIAA0513 2.03651
ZNF83 zinc finger protein 83 2.02696
DPY19L3 dpy-19-like 3 (C. elegans) 2.02299
CKAP2L cytoskeleton associated protein 2-like 2.02299

decreased expression

Symbol Name Standardized Value
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 -2.50603
KIAA1586 KIAA1586 -2.50603
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -2.50603
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.50603
TRIT1 tRNA isopentenyltransferase 1 -2.50603
SNAP47 synaptosomal-associated protein, 47kDa -2.50603
BZW1 basic leucine zipper and W2 domains 1 -2.50603
RELT RELT tumor necrosis factor receptor -2.50603
C2CD2L C2CD2-like -2.50603
SAPCD1 suppressor APC domain containing 1 -2.50603
LINC02798 long intergenic non-protein coding RNA 2798 -2.50603
TMEM236 transmembrane protein 236 -2.4564
ACAD8 acyl-CoA dehydrogenase family, member 8 -2.42621
CACTIN cactin, spliceosome C complex subunit -2.42372
PCDHA9 protocadherin alpha 9 -2.37177
SH2D3C SH2 domain containing 3C -2.35582
GFAP glial fibrillary acidic protein -2.35449
FAM216B family with sequence similarity 216, member B -2.35449
OLIG1 oligodendrocyte transcription factor 1 -2.35449
CRIP1 cysteine-rich protein 1 (intestinal) -2.35449
KIAA2012 KIAA2012 -2.35449
RLN1 relaxin 1 -2.35449
SPMIP9 sperm microtubule inner protein 9 -2.35449
ADAMTSL2 ADAMTS-like 2 -2.35449
RPS21-DT RPS21 divergent transcript -2.35449
HES5 hes family bHLH transcription factor 5 -2.35449
MUC6 mucin 6, oligomeric mucus/gel-forming -2.35449
SMIM45 small integral membrane protein 45 -2.35449
SMIM35 small integral membrane protein 35 -2.35449
DUSP9 dual specificity phosphatase 9 -2.35449
C9ORF43 chromosome 9 open reading frame 43 -2.35449
FOXN4 forkhead box N4 -2.35449
IMPG2 interphotoreceptor matrix proteoglycan 2 -2.35449
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 -2.35449
TACR2 tachykinin receptor 2 -2.35449
PCDHA3 protocadherin alpha 3 -2.35449
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha -2.35449
MYL7 myosin, light chain 7, regulatory -2.35449
GAD1 glutamate decarboxylase 1 (brain, 67kDa) -2.35449
TPI1 triosephosphate isomerase 1 -2.35449
FCRLB Fc receptor-like B -2.35449
CPZ carboxypeptidase Z -2.35449
ZFP92 ZFP92 zinc finger protein -2.35449
AMER2 APC membrane recruitment protein 2 -2.35449
DKK2 dickkopf WNT signaling pathway inhibitor 2 -2.35449
DES desmin -2.35449
CAMK1G calcium/calmodulin-dependent protein kinase IG -2.35449
MZB1 marginal zone B and B1 cell-specific protein -2.35449
IRGM immunity-related GTPase family, M -2.35449
RFX1 regulatory factor X, 1 (influences HLA class II expression) -2.35449
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 -2.35449
BCAP29 B-cell receptor-associated protein 29 -2.32629
PGAP6 post-GPI attachment to proteins 6 -2.31752
LHX8 LIM homeobox 8 -2.30095
ZNF446 zinc finger protein 446 -2.23077
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 -2.23077
GFY golgi-associated, olfactory signaling regulator -2.23077
SNX7 sorting nexin 7 -2.23077
CARMIL3 capping protein regulator and myosin 1 linker 3 -2.21068
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 -2.21068
MEIOB meiosis specific with OB domains -2.21068
ACVR1C activin A receptor, type IC -2.20535
NME1 NME/NM23 nucleoside diphosphate kinase 1 -2.19618
EME1 essential meiotic structure-specific endonuclease 1 -2.19618
ZNF892 zinc finger protein 892 -2.19011
CSRP2 cysteine and glycine-rich protein 2 -2.18053
DBNL drebrin-like -2.17807
FAM199X family with sequence similarity 199, X-linked -2.17686
CDK2 cyclin-dependent kinase 2 -2.1548
POU5F1 POU class 5 homeobox 1 -2.1548
CISD2 CDGSH iron sulfur domain 2 -2.13173
DEUP1 deuterosome assembly protein 1 -2.12865
TTC4 tetratricopeptide repeat domain 4 -2.12865
PRIMA1 proline rich membrane anchor 1 -2.12865
MARK2 MAP/microtubule affinity-regulating kinase 2 -2.12865
ESPN espin -2.10294
F2R coagulation factor II (thrombin) receptor -2.10069
RPRM reprimo, TP53 dependent G2 arrest mediator candidate -2.09376
MAT1A methionine adenosyltransferase I, alpha -2.08899
CNTN5 contactin 5 -2.08899
MMP19 matrix metallopeptidase 19 -2.08899
ZNF608 zinc finger protein 608 -2.08539
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 -2.07471
FREM2 FRAS1 related extracellular matrix protein 2 -2.04682
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 -2.03794
MTDH metadherin -2.03794
LDB3 LIM domain binding 3 -2.02299
FRZB frizzled-related protein -2.02299
LHX1 LIM homeobox 1 -2.02299
ZNF540 zinc finger protein 540 -2.02299
FNTB farnesyltransferase, CAAX box, beta -2.02299
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -2.02045
JAK1 Janus kinase 1 -2.00081