ADRB2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description adrenoceptor beta 2, surface|This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 154)
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Genes

359 genes differentially expressed following the ADRB2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
OR52E5 olfactory receptor, family 52, subfamily E, member 5 3.63127
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 3.63127
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 3.63127
ZNF556 zinc finger protein 556 3.63127
TDRD1 tudor domain containing 1 3.63127
RDH8 retinol dehydrogenase 8 (all-trans) 3.63127
RGPD3 RANBP2-like and GRIP domain containing 3 3.63127
RLN1 relaxin 1 3.63127
PROC protein C (inactivator of coagulation factors Va and VIIIa) 3.63127
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1 3.63127
HBZ hemoglobin, zeta 3.63127
UBE2U ubiquitin-conjugating enzyme E2U (putative) 3.63127
MYPN myopalladin 3.63127
DSG3 desmoglein 3 3.63127
MYL10 myosin, light chain 10, regulatory 3.63127
TBR1 T-box, brain, 1 3.63127
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 3.63127
SLC30A2 solute carrier family 30 (zinc transporter), member 2 3.63127
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 3.63127
C19ORF67 chromosome 19 open reading frame 67 3.63127
GPR26 G protein-coupled receptor 26 3.63127
FLI1 Fli-1 proto-oncogene, ETS transcription factor 3.63127
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 3.63127
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 3.63127
AVP arginine vasopressin 3.63127
BMP3 bone morphogenetic protein 3 3.63127
DSPP dentin sialophosphoprotein 3.63127
HIGD1C HIG1 hypoxia inducible domain family, member 1C 3.63127
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 3.63127
VPREB3 pre-B lymphocyte 3 3.63127
PASD1 PAS domain containing 1 3.63127
YIPF2 Yip1 domain family, member 2 3.63127
NLRP6 NLR family, pyrin domain containing 6 3.63127
IL17D interleukin 17D 3.63127
OR51I2 olfactory receptor, family 51, subfamily I, member 2 3.63127
NKPD1 NTPase, KAP family P-loop domain containing 1 3.63127
OR5A1 olfactory receptor, family 5, subfamily A, member 1 3.63127
GPR35 G protein-coupled receptor 35 3.63127
BMP5 bone morphogenetic protein 5 3.63127
C20ORF202 chromosome 20 open reading frame 202 3.63127
ACER1 alkaline ceramidase 1 3.63127
MGAT4D MGAT4 family, member D 3.63127
SPAG8 sperm associated antigen 8 3.63127
TRPC7 transient receptor potential cation channel, subfamily C, member 7 3.63127
EPHB3 EPH receptor B3 3.63127
ERAP2 endoplasmic reticulum aminopeptidase 2 3.63127
FGF4 fibroblast growth factor 4 3.63127
BTBD19 BTB (POZ) domain containing 19 3.63127
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 3.63127
GLIPR1L2 GLI pathogenesis-related 1 like 2 3.63127
ARL5C ADP-ribosylation factor-like 5C 3.63127
PTPRH protein tyrosine phosphatase, receptor type, H 3.63127
MTNR1B melatonin receptor 1B 3.63127
SLC35D3 solute carrier family 35, member D3 3.63127
CAPN11 calpain 11 3.63127
ZNF436 zinc finger protein 436 3.63127
OR2A7 olfactory receptor, family 2, subfamily A, member 7 3.63127
OR2A1 olfactory receptor, family 2, subfamily A, member 1 3.63127
PVRIG poliovirus receptor related immunoglobulin domain containing 3.63127
FPR1 formyl peptide receptor 1 3.63127
MAGEB3 melanoma antigen family B3 3.63127
IRF5 interferon regulatory factor 5 3.63127
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 3.63127
PIWIL1 piwi-like RNA-mediated gene silencing 1 3.63127
CFAP45 cilia and flagella associated protein 45 3.63127
BHLHA9 basic helix-loop-helix family, member a9 3.63127
ZNF575 zinc finger protein 575 3.63127
RGS22 regulator of G-protein signaling 22 3.63127
TMCO2 transmembrane and coiled-coil domains 2 3.63127
MAL mal, T-cell differentiation protein 3.63127
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 3.63127
ERVFRD-1 endogenous retrovirus group FRD, member 1 3.63127
PRB1 proline-rich protein BstNI subfamily 1 3.63127
SYCP2 synaptonemal complex protein 2 3.63127
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 3.63127
BSND barttin CLCNK-type chloride channel accessory beta subunit 3.63127
CELF6 CUGBP, Elav-like family member 6 3.63127
SPINK6 serine peptidase inhibitor, Kazal type 6 3.63127
PRICKLE4 prickle homolog 4 (Drosophila) 3.63127
CABP4 calcium binding protein 4 3.63127
GLUD2 glutamate dehydrogenase 2 3.63127
MBLAC1 metallo-beta-lactamase domain containing 1 3.63127
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like 3.63127
NRAP nebulin-related anchoring protein 3.63127
OSTN osteocrin 3.63127
GNLY granulysin 3.63127
IGFL3 IGF-like family member 3 3.63127
PLEK pleckstrin 3.63127
LRRD1 leucine-rich repeats and death domain containing 1 3.63127
NPAP1 nuclear pore associated protein 1 3.63127
PLB1 phospholipase B1 3.63127
USP26 ubiquitin specific peptidase 26 3.63127
SLC26A1 solute carrier family 26 (anion exchanger), member 1 3.63127
TRH thyrotropin-releasing hormone 3.63127
SIGLECL1 SIGLEC family like 1 3.63127
CTRC chymotrypsin C (caldecrin) 3.63127
PGA5 pepsinogen 5, group I (pepsinogen A) 3.63127
ZNF560 zinc finger protein 560 3.63127
NOG noggin 3.63127
FAM177B family with sequence similarity 177, member B 3.63127
PKDREJ polycystin (PKD) family receptor for egg jelly 3.63127
NPBWR1 neuropeptides B/W receptor 1 3.63127
LHFPL7 LHFPL tetraspan subfamily member 7 3.63127
TRIM55 tripartite motif containing 55 3.63127
FYB2 FYN binding protein 2 3.63127
PCDHGA3 protocadherin gamma subfamily A, 3 3.63127
WNT7B wingless-type MMTV integration site family, member 7B 3.63127
MS4A7 membrane-spanning 4-domains, subfamily A, member 7 3.63127
PDZRN4 PDZ domain containing ring finger 4 3.63127
WFDC1 WAP four-disulfide core domain 1 3.63127
CAMK2B calcium/calmodulin-dependent protein kinase II beta 3.63127
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 3.63127
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 3.63127
C18ORF63 chromosome 18 open reading frame 63 3.63127
LCNL1 lipocalin-like 1 3.63127
LCT lactase 3.63127
ZNF541 zinc finger protein 541 3.63127
UBQLNL ubiquilin-like 3.63127
ADGRA1 adhesion G protein-coupled receptor A1 3.63127
BTNL9 butyrophilin-like 9 3.63127
CRYBB3 crystallin, beta B3 3.63127
CFAP206 cilia and flagella associated protein 206 3.63127
KLK11 kallikrein-related peptidase 11 3.63127
FBXO40 F-box protein 40 3.63127
CSDC2 cold shock domain containing C2, RNA binding 3.63127
MOS v-mos Moloney murine sarcoma viral oncogene homolog 3.63127
LY6G6D lymphocyte antigen 6 complex, locus G6D 3.63127
EFCAB12 EF-hand calcium binding domain 12 3.63127
MSMP microseminoprotein, prostate associated 3.63127
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 3.63127
PCDHAC2 protocadherin alpha subfamily C, 2 3.63127
ADAM18 ADAM metallopeptidase domain 18 3.63127
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 3.63127
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 3.63127
IDI2 isopentenyl-diphosphate delta isomerase 2 3.63127
OR5B2 olfactory receptor, family 5, subfamily B, member 2 3.63127
CA5A carbonic anhydrase VA, mitochondrial 3.63127
DKK4 dickkopf WNT signaling pathway inhibitor 4 3.63127
ZFP92 ZFP92 zinc finger protein 3.63127
UTS2B urotensin 2B 3.63127
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.63127
PRR35 proline rich 35 3.63127
MDFIC2 MyoD family inhibitor domain containing 2 3.63127
TPPP3 tubulin polymerization-promoting protein family member 3 3.63127
SCNN1B sodium channel, non voltage gated 1 beta subunit 3.63127
LOC122526780 uncharacterized LOC122526780 3.63127
PRSS38 protease, serine, 38 3.63127
MYF5 myogenic factor 5 3.63127
ANXA8 annexin A8 3.63127
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 3.63127
GH1 growth hormone 1 3.63127
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 3.63127
MAEL maelstrom spermatogenic transposon silencer 3.63127
ADIRF adipogenesis regulatory factor 3.63127
YIPF7 Yip1 domain family, member 7 3.63127
RHAG Rh-associated glycoprotein 3.63127
ZMYND10 zinc finger, MYND-type containing 10 3.63127
APOL5 apolipoprotein L, 5 3.63127
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 3.63127
TRPM8 transient receptor potential cation channel, subfamily M, member 8 3.63127
ADAM20 ADAM metallopeptidase domain 20 3.63127
ADRA1B adrenoceptor alpha 1B 3.63127
C10ORF90 chromosome 10 open reading frame 90 3.63127
MAGEA12 melanoma antigen family A12 3.63127
GRAPL GRB2-related adaptor protein-like 3.63127
SLC51B solute carrier family 51, beta subunit 3.63127
PTCRA pre T-cell antigen receptor alpha 3.63127
RGR retinal G protein coupled receptor 3.63127
RORC RAR-related orphan receptor C 3.63127
NPPA natriuretic peptide A 3.63127
ANGPTL8 angiopoietin like 8 3.63127
NACA2 nascent polypeptide-associated complex alpha subunit 2 3.63127
TIGIT T cell immunoreceptor with Ig and ITIM domains 3.63127
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 3.63127
EPOP elongin BC and polycomb repressive complex 2 associated protein 3.63127
MRLN myoregulin 3.63127
TMEM156 transmembrane protein 156 3.63127
OTOF otoferlin 3.63127
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 3.63127
GAL3ST2 galactose-3-O-sulfotransferase 2 3.63127
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 3.63127
CCL25 chemokine (C-C motif) ligand 25 3.63127
EXD1 exonuclease 3'-5' domain containing 1 3.57102
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A 3.57102
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 3.57102
PDE4DIP phosphodiesterase 4D interacting protein 3.38283
SAR1A secretion associated, Ras related GTPase 1A 3.0849
AGAP6 ArfGAP with GTPase domain, ankyrin repeat and PH domain 6 3.06237
SCRG1 stimulator of chondrogenesis 1 3.00746
TMEM160 transmembrane protein 160 2.93551
PTDSS2 phosphatidylserine synthase 2 2.90651
DVL2 dishevelled segment polarity protein 2 2.88515
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 2.88349
AP5M1 adaptor-related protein complex 5, mu 1 subunit 2.86827
UROS uroporphyrinogen III synthase 2.85476
DOCK10 dedicator of cytokinesis 10 2.84941
DPY19L2 dpy-19-like 2 (C. elegans) 2.74796
KLHL20 kelch-like family member 20 2.70049
POLN polymerase (DNA directed) nu 2.69138
NAT10 N-acetyltransferase 10 (GCN5-related) 2.63664
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 2.56986
POMC proopiomelanocortin 2.56724
PGBD4 piggyBac transposable element derived 4 2.56724
CSPG4 chondroitin sulfate proteoglycan 4 2.56724
SDR42E2 short chain dehydrogenase/reductase family 42E, member 2 2.56724
CRHR1 corticotropin releasing hormone receptor 1 2.56724
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 2.56724
GPR87 G protein-coupled receptor 87 2.56724
PRODH proline dehydrogenase (oxidase) 1 2.56724
NSD1 nuclear receptor binding SET domain protein 1 2.5393
CPTP ceramide-1-phosphate transfer protein 2.53701
ZNF792 zinc finger protein 792 2.53701
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.48025
GJB3 gap junction protein, beta 3, 31kDa 2.48025
ZDHHC4 zinc finger, DHHC-type containing 4 2.47824
PRPF6 pre-mRNA processing factor 6 2.46984
RBM44 RNA binding motif protein 44 2.4658
QSOX2 quiescin Q6 sulfhydryl oxidase 2 2.45223
CCNP cyclin P 2.43054
ZNF341 zinc finger protein 341 2.42986
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 2.42301
EP400 E1A binding protein p400 2.41238
SNTG1 syntrophin, gamma 1 2.35932
GALNT17 polypeptide N-acetylgalactosaminyltransferase 17 2.35337
GEN1 GEN1 Holliday junction 5' flap endonuclease 2.33473
MYO10 myosin X 2.33399
SULF1 sulfatase 1 2.31941
TONSL tonsoku-like, DNA repair protein 2.3185
RPS20 ribosomal protein S20 2.27745
SCN5A sodium channel, voltage gated, type V alpha subunit 2.26671
SLC66A1 solute carrier family 66 member 1 2.26671
ARL2 ADP-ribosylation factor-like 2 2.266
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 2.26219
P3H2 prolyl 3-hydroxylase 2 2.26059
HIBADH 3-hydroxyisobutyrate dehydrogenase 2.25583
WDR91 WD repeat domain 91 2.24111
NOA1 nitric oxide associated 1 2.23187
FAM8A1 family with sequence similarity 8, member A1 2.2112
ADCK2 aarF domain containing kinase 2 2.17883
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 2.13584
METTL21A methyltransferase like 21A 2.10243
COL16A1 collagen, type XVI, alpha 1 2.0908
PI15 peptidase inhibitor 15 2.0908
C1ORF56 chromosome 1 open reading frame 56 2.08775
DRC10 dynein regulatory complex subunit 10 2.08064
PIANP PILR alpha associated neural protein 2.06732
C3 complement component 3 2.06073
ANKLE1 ankyrin repeat and LEM domain containing 1 2.04838
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 2.04838
ERCC1 excision repair cross-complementation group 1 2.04838
ARRDC4 arrestin domain containing 4 2.02662
STXBP2 syntaxin binding protein 2 2.0156

decreased expression

Symbol Name Standardized Value
SV2C synaptic vesicle glycoprotein 2C -3.63127
EOLA2 endothelium and lymphocyte associated ASCH domain 2 -3.63127
SIM1 single-minded family bHLH transcription factor 1 -3.63127
OLFML1 olfactomedin-like 1 -3.63127
WDR43 WD repeat domain 43 -3.63127
PSD4 pleckstrin and Sec7 domain containing 4 -3.63127
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 -3.63127
HAO2 hydroxyacid oxidase 2 (long chain) -3.63127
DYDC1 DPY30 domain containing 1 -3.63127
CCER2 coiled-coil glutamate-rich protein 2 -3.63127
GGN gametogenetin -3.63127
IGFBP7 insulin-like growth factor binding protein 7 -3.63127
PKD1L1 polycystic kidney disease 1 like 1 -3.63127
OR14A16 olfactory receptor, family 14, subfamily A, member 16 -3.63127
TUBB2B tubulin, beta 2B class IIb -3.63127
VCX3B variable charge, X-linked 3B -3.63127
PRDM1 PR domain containing 1, with ZNF domain -3.63127
ITGA11 integrin, alpha 11 -3.63127
MTMR11 myotubularin related protein 11 -3.63127
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -3.63127
ELF4 E74-like factor 4 (ets domain transcription factor) -3.63127
SERF1A small EDRK-rich factor 1A (telomeric) -3.63127
CCDC71 coiled-coil domain containing 71 -3.63127
THRSP thyroid hormone responsive -3.63127
NLRP10 NLR family, pyrin domain containing 10 -3.63127
GPD1L glycerol-3-phosphate dehydrogenase 1-like -3.63127
RIPPLY2 ripply transcriptional repressor 2 -3.63127
CRYGN crystallin, gamma N -3.63127
SPACDR sperm acrosome developmental regulator -3.63127
TMEM31 transmembrane protein 31 -3.63127
KLHDC8A kelch domain containing 8A -3.63127
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 -3.63127
CARMIL3 capping protein regulator and myosin 1 linker 3 -3.63127
RBM20 RNA binding motif protein 20 -3.63127
DSCAM Down syndrome cell adhesion molecule -3.5215
GLIPR1 GLI pathogenesis-related 1 -3.5215
ACTG1 actin gamma 1 -3.49884
STRAP serine/threonine kinase receptor associated protein -3.35201
ARHGAP10 Rho GTPase activating protein 10 -3.29629
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.2928
STRADB STE20-related kinase adaptor beta -3.26336
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 -3.11943
ZNF253 zinc finger protein 253 -3.00105
ZBTB7C zinc finger and BTB domain containing 7C -2.99806
AHNAK2 AHNAK nucleoprotein 2 -2.99806
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -2.92039
LYRM4 LYR motif containing 4 -2.90651
TEC tec protein tyrosine kinase -2.88349
SCFD1 sec1 family domain containing 1 -2.84756
NHSL3 NHS like 3 -2.73565
WARS1 tryptophanyl-tRNA synthetase 1 -2.69249
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -2.67363
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -2.67081
ZNF213 zinc finger protein 213 -2.65358
EBP emopamil binding protein (sterol isomerase) -2.63551
DYNC2I2 dynein 2 intermediate chain 2 -2.56986
ACVR2B activin A receptor, type IIB -2.56986
BMP2 bone morphogenetic protein 2 -2.52067
PTCD3 pentatricopeptide repeat domain 3 -2.49091
OR56A1 olfactory receptor, family 56, subfamily A, member 1 -2.47824
H2BC12 H2B clustered histone 12 -2.47824
PTGDS prostaglandin D2 synthase 21kDa (brain) -2.47824
TSC1 tuberous sclerosis 1 -2.45343
ZNF653 zinc finger protein 653 -2.45223
ZNF165 zinc finger protein 165 -2.42986
ZSWIM7 zinc finger, SWIM-type containing 7 -2.42146
EIF1B eukaryotic translation initiation factor 1B -2.41867
CORO6 coronin 6 -2.40206
MRNIP MRN complex interacting protein -2.40096
LYRM1 LYR motif containing 1 -2.38489
KREMEN2 kringle containing transmembrane protein 2 -2.38489
HRH3 histamine receptor H3 -2.38489
ECEL1 endothelin converting enzyme-like 1 -2.38489
TIPIN TIMELESS interacting protein -2.38445
BAIAP3 BAI1-associated protein 3 -2.38346
LPAR2 lysophosphatidic acid receptor 2 -2.37687
C1QTNF3 C1q and tumor necrosis factor related protein 3 -2.36289
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase -2.31935
SLC71A2 solute carrier family 71 member 2 -2.3124
CCM2 cerebral cavernous malformation 2 -2.29233
AKIRIN1 akirin 1 -2.26129
IGSF10 immunoglobulin superfamily, member 10 -2.26102
ADAM11 ADAM metallopeptidase domain 11 -2.26102
CDK3 cyclin-dependent kinase 3 -2.26102
GEMIN4 gem (nuclear organelle) associated protein 4 -2.25751
TERF2IP telomeric repeat binding factor 2, interacting protein -2.25583
CCDC174 coiled-coil domain containing 174 -2.25566
RLIG1 RNA 5'-phosphate and 3'-OH ligase 1 -2.24681
BASP1 brain abundant, membrane attached signal protein 1 -2.23187
H2AX H2A.X variant histone -2.22881
FAM227B family with sequence similarity 227, member B -2.22806
ASPHD1 aspartate beta-hydroxylase domain containing 1 -2.22549
MED20 mediator complex subunit 20 -2.20084
NBN nibrin -2.19487
TTLL1 tubulin tyrosine ligase-like family member 1 -2.1924
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 -2.15835
NODAL nodal growth differentiation factor -2.14264
TTC21A tetratricopeptide repeat domain 21A -2.14264
ZNF20 zinc finger protein 20 -2.13946
ST14 suppression of tumorigenicity 14 (colon carcinoma) -2.13037
AADAT aminoadipate aminotransferase -2.12455
MALT1 MALT1 paracaspase -2.10526
NBPF3 neuroblastoma breakpoint family, member 3 -2.09438
IVNS1ABP influenza virus NS1A binding protein -2.0908
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) -2.06259
SDC3 syndecan 3 -2.04772
PARPBP PARP1 binding protein -2.0156