ADSL Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description adenylosuccinate lyase|Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 158)
External Link http://www.ncbi.nlm.nih.gov/gene/158
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Genes

103 interacting proteins for ADSL from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AKAP7 A kinase (PRKA) anchor protein 7
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ALDH9A1 aldehyde dehydrogenase 9 family, member A1
ALDOA aldolase A, fructose-bisphosphate
AMBRA1 autophagy/beclin-1 regulator 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
API5 apoptosis inhibitor 5
ASNS asparagine synthetase (glutamine-hydrolyzing)
BTF3L4 basic transcription factor 3-like 4
CALCOCO2 calcium binding and coiled-coil domain 2
CALML3 calmodulin-like 3
CAND1 cullin-associated and neddylation-dissociated 1
CBR1 carbonyl reductase 1
CKB creatine kinase, brain
COPA coatomer protein complex, subunit alpha
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CTSC cathepsin C
DCAF11 DDB1 and CUL4 associated factor 11
DCAF17 DDB1 and CUL4 associated factor 17
DCAF5 DDB1 and CUL4 associated factor 5
DCP1A decapping mRNA 1A
DCP1B decapping mRNA 1B
DDA1 DET1 and DDB1 associated 1
DDB1 damage-specific DNA binding protein 1, 127kDa
DDB2 damage-specific DNA binding protein 2, 48kDa
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DRG2 developmentally regulated GTP binding protein 2
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial
EDC3 enhancer of mRNA decapping 3
EHD4 EH-domain containing 4
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF4E2 eukaryotic translation initiation factor 4E family member 2
ESD esterase D
ETFA electron-transfer-flavoprotein, alpha polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FARSB phenylalanyl-tRNA synthetase, beta subunit
FKBP4 FK506 binding protein 4, 59kDa
GMPS guanine monphosphate synthase
GTF2I general transcription factor IIi
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
KRT31 keratin 31, type I
KRT33B keratin 33B, type I
KRT34 keratin 34, type I
KRT81 keratin 81, type II
KRT85 keratin 85, type II
LAP3 leucine aminopeptidase 3
LARS leucyl-tRNA synthetase
LGALS7B lectin, galactoside-binding, soluble, 7B
LRRC15 leucine rich repeat containing 15
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTA4H leukotriene A4 hydrolase
MCM2 minichromosome maintenance complex component 2
MEPCE methylphosphate capping enzyme
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYH4 myosin, heavy chain 4, skeletal muscle
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit
NAMPT nicotinamide phosphoribosyltransferase
NANS N-acetylneuraminic acid synthase
NOV nephroblastoma overexpressed
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)
NRBF2 nuclear receptor binding factor 2
NT5C2 5'-nucleotidase, cytosolic II
OXSR1 oxidative stress responsive 1
PA2G4 proliferation-associated 2G4, 38kDa
PAIP1 poly(A) binding protein interacting protein 1
PDE12 phosphodiesterase 12
PGAM2 phosphoglycerate mutase 2 (muscle)
PGK1 phosphoglycerate kinase 1
PLIN3 perilipin 3
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRPF3 pre-mRNA processing factor 3
PRPF31 pre-mRNA processing factor 31
PRPF4 pre-mRNA processing factor 4
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
RAD23B RAD23 homolog B (S. cerevisiae)
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RNF40 ring finger protein 40, E3 ubiquitin protein ligase
SAE1 SUMO1 activating enzyme subunit 1
SELENBP1 selenium binding protein 1
SEPT9 septin 9
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SRM spermidine synthase
SUMO1 small ubiquitin-like modifier 1
TARS threonyl-tRNA synthetase
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
TWF1 twinfilin actin binding protein 1
TYMS thymidylate synthetase
UBC ubiquitin C
UBQLN2 ubiquilin 2
USP15 ubiquitin specific peptidase 15
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
VPRBP Vpr (HIV-1) binding protein
VSIG8 V-set and immunoglobulin domain containing 8
WARS tryptophanyl-tRNA synthetase
WDR4 WD repeat domain 4
WDTC1 WD and tetratricopeptide repeats 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble