AG-013608-5909 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the AG-013608-5909 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADRBK2 adrenergic, beta, receptor kinase 2
AGO4 argonaute RISC catalytic component 4
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
BGN biglycan
C1ORF116 chromosome 1 open reading frame 116
C1QL1 complement component 1, q subcomponent-like 1
CA5B carbonic anhydrase VB, mitochondrial
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CALD1 caldesmon 1
CASP4 caspase 4, apoptosis-related cysteine peptidase
CD70 CD70 molecule
COPE coatomer protein complex, subunit epsilon
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8
DDIT4 DNA-damage-inducible transcript 4
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DGCR8 DGCR8 microprocessor complex subunit
DRICH1 aspartate-rich 1
EGR1 early growth response 1
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
ERN2 endoplasmic reticulum to nucleus signaling 2
ESR1 estrogen receptor 1
FAM134B family with sequence similarity 134, member B
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GRIK2 glutamate receptor, ionotropic, kainate 2
H2AFJ H2A histone family, member J
ICOSLG inducible T-cell co-stimulator ligand
IFT140 intraflagellar transport 140
IGHMBP2 immunoglobulin mu binding protein 2
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL36G interleukin 36, gamma
INHBA inhibin, beta A
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
LOC729164 hCG1732469
LRRK1 leucine-rich repeat kinase 1
MAPT microtubule-associated protein tau
MEF2D myocyte enhancer factor 2D
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MUC3A mucin 3A, cell surface associated
MYF5 myogenic factor 5
NF2 neurofibromin 2 (merlin)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NLRP3 NLR family, pyrin domain containing 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRDE2 NRDE-2, necessary for RNA interference, domain containing
NUPR1 nuclear protein, transcriptional regulator, 1
OGFR opioid growth factor receptor
OXCT2 3-oxoacid CoA transferase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE4B phosphodiesterase 4B, cAMP-specific
PEX16 peroxisomal biogenesis factor 16
PLA1A phospholipase A1 member A
PLA2G1B phospholipase A2, group IB (pancreas)
PLCH1 phospholipase C, eta 1
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PODNL1 podocan-like 1
PRELP proline/arginine-rich end leucine-rich repeat protein
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
REG1A regenerating islet-derived 1 alpha
RGS12 regulator of G-protein signaling 12
RGS5 regulator of G-protein signaling 5
RNF122 ring finger protein 122
RNF126P1 ring finger protein 126 pseudogene 1
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPL7 ribosomal protein L7
RUFY3 RUN and FYVE domain containing 3
SAYSD1 SAYSVFN motif domain containing 1
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SLC48A1 solute carrier family 48 (heme transporter), member 1
SMIM14 small integral membrane protein 14
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SPON1 spondin 1, extracellular matrix protein
SPTBN1 spectrin, beta, non-erythrocytic 1
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
STAT2 signal transducer and activator of transcription 2, 113kDa
STC2 stanniocalcin 2
TAPBPL TAP binding protein-like
TJP3 tight junction protein 3
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNPO3 transportin 3
TNXB tenascin XB
TPP1 tripeptidyl peptidase I
TRAIP TRAF interacting protein
TRIB3 tribbles pseudokinase 3
TTLL1 tubulin tyrosine ligase-like family member 1
VAC14 Vac14 homolog (S. cerevisiae)
VASH1 vasohibin 1
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)
ZBTB7A zinc finger and BTB domain containing 7A
ZHX3 zinc fingers and homeoboxes 3
ZNF214 zinc finger protein 214
ZNF407 zinc finger protein 407

decreased expression

Symbol Name
AADAC arylacetamide deacetylase
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADAM15 ADAM metallopeptidase domain 15
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BRS3 bombesin-like receptor 3
C4ORF19 chromosome 4 open reading frame 19
CCP110 centriolar coiled coil protein 110kDa
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDK18 cyclin-dependent kinase 18
CDT1 chromatin licensing and DNA replication factor 1
CHML choroideremia-like (Rab escort protein 2)
CHRDL1 chordin-like 1
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CLDND1 claudin domain containing 1
COBL cordon-bleu WH2 repeat protein
CPNE7 copine VII
CPOX coproporphyrinogen oxidase
CTGF connective tissue growth factor
DCLRE1A DNA cross-link repair 1A
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DIO3 deiodinase, iodothyronine, type III
ELSPBP1 epididymal sperm binding protein 1
EML4 echinoderm microtubule associated protein like 4
EXTL2 exostosin-like glycosyltransferase 2
FAM46C family with sequence similarity 46, member C
FBXL7 F-box and leucine-rich repeat protein 7
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FKBP5 FK506 binding protein 5
FLJ11710 uncharacterized protein FLJ11710
GEMIN8 gem (nuclear organelle) associated protein 8
GJC1 gap junction protein, gamma 1, 45kDa
GPR176 G protein-coupled receptor 176
GPR85 G protein-coupled receptor 85
GRAMD3 GRAM domain containing 3
GRB7 growth factor receptor-bound protein 7
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BN histone cluster 1, H2bn
HIST1H4E histone cluster 1, H4e
HOXA6 homeobox A6
HOXD11 homeobox D11
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
ICAM5 intercellular adhesion molecule 5, telencephalin
IL6 interleukin 6
INCENP inner centromere protein antigens 135/155kDa
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCTD14 potassium channel tetramerization domain containing 14
KDM8 lysine (K)-specific demethylase 8
KLF3 Kruppel-like factor 3 (basic)
LMNB1 lamin B1
LONRF3 LON peptidase N-terminal domain and ring finger 3
MAK male germ cell-associated kinase
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MIS12 MIS12 kinetochore complex component
MOXD1 monooxygenase, DBH-like 1
MRAS muscle RAS oncogene homolog
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL44 mitochondrial ribosomal protein L44
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
NCALD neurocalcin delta
NTF3 neurotrophin 3
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OSBP2 oxysterol binding protein 2
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDZK1 PDZ domain containing 1
PENK proenkephalin
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PXMP4 peroxisomal membrane protein 4, 24kDa
RAB36 RAB36, member RAS oncogene family
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
SCD5 stearoyl-CoA desaturase 5
SCEL sciellin
SCG2 secretogranin II
SCML1 sex comb on midleg-like 1 (Drosophila)
SCML2 sex comb on midleg-like 2 (Drosophila)
SCRT1 scratch family zinc finger 1
SCUBE3 signal peptide, CUB domain, EGF-like 3
SEMG2 semenogelin II
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SGPP1 sphingosine-1-phosphate phosphatase 1
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TMCC2 transmembrane and coiled-coil domain family 2
TMEM230 transmembrane protein 230
TMEM74B transmembrane protein 74B
TRIM25 tripartite motif containing 25
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
WNT10B wingless-type MMTV integration site family, member 10B
ZBTB6 zinc finger and BTB domain containing 6
ZNF516 zinc finger protein 516
ZNF770 zinc finger protein 770