AG-013608-5944 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the AG-013608-5944 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
AAMDC adipogenesis associated, Mth938 domain containing
ALCAM activated leukocyte cell adhesion molecule
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ALK anaplastic lymphoma receptor tyrosine kinase
ALPK1 alpha-kinase 1
ARL4C ADP-ribosylation factor-like 4C
BAIAP3 BAI1-associated protein 3
BMP10 bone morphogenetic protein 10
BTN2A2 butyrophilin, subfamily 2, member A2
C14ORF79 chromosome 14 open reading frame 79
CARD9 caspase recruitment domain family, member 9
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFLAR CASP8 and FADD-like apoptosis regulator
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLCN6 chloride channel, voltage-sensitive 6
CLCN7 chloride channel, voltage-sensitive 7
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CNPY4 canopy FGF signaling regulator 4
CRELD1 cysteine-rich with EGF-like domains 1
CTIF CBP80/20-dependent translation initiation factor
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNM3 dynamin 3
EGFR epidermal growth factor receptor
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
EPOR erythropoietin receptor
ETNK2 ethanolamine kinase 2
EVA1B eva-1 homolog B (C. elegans)
FAM155A family with sequence similarity 155, member A
FAM46C family with sequence similarity 46, member C
FCMR Fc fragment of IgM receptor
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
GAS7 growth arrest-specific 7
GLP1R glucagon-like peptide 1 receptor
GP5 glycoprotein V (platelet)
GPR161 G protein-coupled receptor 161
GRTP1 growth hormone regulated TBC protein 1
GSTA3 glutathione S-transferase alpha 3
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDS iduronate 2-sulfatase
ING1 inhibitor of growth family, member 1
ITM2C integral membrane protein 2C
KIAA0125 KIAA0125
LAMP1 lysosomal-associated membrane protein 1
LHX1 LIM homeobox 1
LIN7B lin-7 homolog B (C. elegans)
LMO2 LIM domain only 2 (rhombotin-like 1)
LTBP4 latent transforming growth factor beta binding protein 4
MAN1A2 mannosidase, alpha, class 1A, member 2
MAPT microtubule-associated protein tau
MARK4 MAP/microtubule affinity-regulating kinase 4
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MTSS1L metastasis suppressor 1-like
MVB12B multivesicular body subunit 12B
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYO1E myosin IE
NCAPH2 non-SMC condensin II complex, subunit H2
NEK11 NIMA-related kinase 11
NFYA nuclear transcription factor Y, alpha
NNAT neuronatin
NPPB natriuretic peptide B
NR2E3 nuclear receptor subfamily 2, group E, member 3
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2
ORAI2 ORAI calcium release-activated calcium modulator 2
PHF20 PHD finger protein 20
PTBP3 polypyrimidine tract binding protein 3
PYHIN1 pyrin and HIN domain family, member 1
RAB33A RAB33A, member RAS oncogene family
REPS1 RALBP1 associated Eps domain containing 1
RIN1 Ras and Rab interactor 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
SAYSD1 SAYSVFN motif domain containing 1
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD1 SMAD family member 1
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SSTR5 somatostatin receptor 5
STAB2 stabilin 2
STK4 serine/threonine kinase 4
STX1A syntaxin 1A (brain)
TAZ tafazzin
TBX19 T-box 19
TH tyrosine hydroxylase
TM2D1 TM2 domain containing 1
TMEM121 transmembrane protein 121
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TPMT thiopurine S-methyltransferase
TRIM5 tripartite motif containing 5
VAC14 Vac14 homolog (S. cerevisiae)
VAMP5 vesicle-associated membrane protein 5
VPS9D1 VPS9 domain containing 1
WDTC1 WD and tetratricopeptide repeats 1
ZNF137P zinc finger protein 137, pseudogene
ZNF227 zinc finger protein 227
ZNF235 zinc finger protein 235

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ANKRD40 ankyrin repeat domain 40
ANKRD7 ankyrin repeat domain 7
ARHGAP4 Rho GTPase activating protein 4
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATG10 autophagy related 10
AUTS2 autism susceptibility candidate 2
C2ORF27A chromosome 2 open reading frame 27A
C3ORF18 chromosome 3 open reading frame 18
CCDC186 coiled-coil domain containing 186
CD1A CD1a molecule
CDCP1 CUB domain containing protein 1
CDH18 cadherin 18, type 2
CDON cell adhesion associated, oncogene regulated
CEND1 cell cycle exit and neuronal differentiation 1
CHST10 carbohydrate sulfotransferase 10
CLGN calmegin
CLSTN3 calsyntenin 3
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DPF1 D4, zinc and double PHD fingers family 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ERN2 endoplasmic reticulum to nucleus signaling 2
ETV6 ets variant 6
F13A1 coagulation factor XIII, A1 polypeptide
FAM124B family with sequence similarity 124B
FAM76A family with sequence similarity 76, member A
FAM86C1 family with sequence similarity 86, member C1
FGF16 fibroblast growth factor 16
FOXN2 forkhead box N2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GCKR glucokinase (hexokinase 4) regulator
GEMIN7 gem (nuclear organelle) associated protein 7
GIPC2 GIPC PDZ domain containing family, member 2
GPR27 G protein-coupled receptor 27
HCRTR2 hypocretin (orexin) receptor 2
HHLA3 HERV-H LTR-associating 3
HIST1H2AJ histone cluster 1, H2aj
HOXA4 homeobox A4
HSPB6 heat shock protein, alpha-crystallin-related, B6
IL12RB1 interleukin 12 receptor, beta 1
INCENP inner centromere protein antigens 135/155kDa
INHA inhibin, alpha
IRF8 interferon regulatory factor 8
JAM3 junctional adhesion molecule 3
LGALS4 lectin, galactoside-binding, soluble, 4
LOC257152 uncharacterized LOC257152
LONRF3 LON peptidase N-terminal domain and ring finger 3
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAL mal, T-cell differentiation protein
MCC mutated in colorectal cancers
MED31 mediator complex subunit 31
MYO15A myosin XVA
NAG18 NAG18 mRNA
NAT6 N-acetyltransferase 6 (GCN5-related)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NIPAL2 NIPA-like domain containing 2
NT5DC3 5'-nucleotidase domain containing 3
OLFML2B olfactomedin-like 2B
PADI1 peptidyl arginine deiminase, type I
PGBD5 piggyBac transposable element derived 5
PLCH2 phospholipase C, eta 2
POM121L2 POM121 transmembrane nucleoporin-like 2
POU3F2 POU class 3 homeobox 2
PQLC2 PQ loop repeat containing 2
PRDM16 PR domain containing 16
PRF1 perforin 1 (pore forming protein)
PRR4 proline rich 4 (lacrimal)
PRSS53 protease, serine, 53
PTPRH protein tyrosine phosphatase, receptor type, H
QPCT glutaminyl-peptide cyclotransferase
RASL11B RAS-like, family 11, member B
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGB Ras-related GTP binding B
SALL1 spalt-like transcription factor 1
SCG5 secretogranin V
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SIX3 SIX homeobox 3
SKAP1 src kinase associated phosphoprotein 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
STIM1 stromal interaction molecule 1
STRN striatin, calmodulin binding protein
SULT4A1 sulfotransferase family 4A, member 1
TARP TCR gamma alternate reading frame protein
TIGD6 tigger transposable element derived 6
TMCC2 transmembrane and coiled-coil domain family 2
TPSG1 tryptase gamma 1
TRIM25 tripartite motif containing 25
TRIM36 tripartite motif containing 36
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TUBA3D tubulin, alpha 3d
WDR62 WD repeat domain 62
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBTB6 zinc finger and BTB domain containing 6
ZIC3 Zic family member 3