AG-013608-5949 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the AG-013608-5949 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCK2 aarF domain containing kinase 2
ADRBK1 adrenergic, beta, receptor kinase 1
ARHGAP26 Rho GTPase activating protein 26
ARHGAP33 Rho GTPase activating protein 33
ARTN artemin
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP9A ATPase, class II, type 9A
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
B9D1 B9 protein domain 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CBS cystathionine-beta-synthase
CEP68 centrosomal protein 68kDa
CGREF1 cell growth regulator with EF-hand domain 1
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DCTN1 dynactin 1
DRP2 dystrophin related protein 2
ECM1 extracellular matrix protein 1
ERAP1 endoplasmic reticulum aminopeptidase 1
EXTL3 exostosin-like glycosyltransferase 3
FYB FYN binding protein
GABARAPL1 GABA(A) receptor-associated protein like 1
GBP2 guanylate binding protein 2, interferon-inducible
GLI2 GLI family zinc finger 2
H2AFJ H2A histone family, member J
HAUS5 HAUS augmin-like complex, subunit 5
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIP1 huntingtin interacting protein 1
HIST1H2BI histone cluster 1, H2bi
HPS4 Hermansky-Pudlak syndrome 4
HSF2BP heat shock transcription factor 2 binding protein
IFT27 intraflagellar transport 27
IGHMBP2 immunoglobulin mu binding protein 2
KRIT1 KRIT1, ankyrin repeat containing
LINC00260 long intergenic non-protein coding RNA 260
LRP1 low density lipoprotein receptor-related protein 1
MARS methionyl-tRNA synthetase
MB myoglobin
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MITF microphthalmia-associated transcription factor
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MRPL44 mitochondrial ribosomal protein L44
MRPS11 mitochondrial ribosomal protein S11
MSX2 msh homeobox 2
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYOZ3 myozenin 3
MYRF myelin regulatory factor
NAGLU N-acetylglucosaminidase, alpha
NF2 neurofibromin 2 (merlin)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOL10 nucleolar protein 10
NPR2 natriuretic peptide receptor 2
NUPR1 nuclear protein, transcriptional regulator, 1
OASL 2'-5'-oligoadenylate synthetase-like
OAZ3 ornithine decarboxylase antizyme 3
PDGFA platelet-derived growth factor alpha polypeptide
PFDN4 prefoldin subunit 4
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RFPL3 ret finger protein-like 3
RNF122 ring finger protein 122
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
RREB1 ras responsive element binding protein 1
S100A13 S100 calcium binding protein A13
SCAPER S-phase cyclin A-associated protein in the ER
SCN9A sodium channel, voltage gated, type IX alpha subunit
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SENP6 SUMO1/sentrin specific peptidase 6
SFTPB surfactant protein B
SIDT2 SID1 transmembrane family, member 2
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SMG6 SMG6 nonsense mediated mRNA decay factor
SPINK1 serine peptidase inhibitor, Kazal type 1
SRD5A3 steroid 5 alpha-reductase 3
STAG3 stromal antigen 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STYK1 serine/threonine/tyrosine kinase 1
SYNDIG1 synapse differentiation inducing 1
TAOK1 TAO kinase 1
TET3 tet methylcytosine dioxygenase 3
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THBD thrombomodulin
TMEM231 transmembrane protein 231
TMOD1 tropomodulin 1
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TRADD TNFRSF1A-associated via death domain
TRPM4 transient receptor potential cation channel, subfamily M, member 4
UBR2 ubiquitin protein ligase E3 component n-recognin 2
WIPI2 WD repeat domain, phosphoinositide interacting 2
YEATS4 YEATS domain containing 4
ZBTB20 zinc finger and BTB domain containing 20
ZNF224 zinc finger protein 224
ZNF440 zinc finger protein 440
ZNF529 zinc finger protein 529
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ADRA1B adrenoceptor alpha 1B
AFAP1 actin filament associated protein 1
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ARHGAP10 Rho GTPase activating protein 10
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARSB arylsulfatase B
BTF3P12 basic transcription factor 3 pseudogene 12
C11ORF63 chromosome 11 open reading frame 63
C1ORF21 chromosome 1 open reading frame 21
CD101 CD101 molecule
CDK18 cyclin-dependent kinase 18
CDK3 cyclin-dependent kinase 3
CENPO centromere protein O
CFHR2 complement factor H-related 2
CHGA chromogranin A
CHIA chitinase, acidic
CREB5 cAMP responsive element binding protein 5
CTGF connective tissue growth factor
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DEPDC5 DEP domain containing 5
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
ERCC2 excision repair cross-complementation group 2
FOXN2 forkhead box N2
GADD45G growth arrest and DNA-damage-inducible, gamma
GATA4 GATA binding protein 4
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
HIST2H2AA3 histone cluster 2, H2aa3
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXC8 homeobox C8
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IFNA14 interferon, alpha 14
IL24 interleukin 24
IL36R interleukin 36 receptor
INF2 inverted formin, FH2 and WH2 domain containing
INHBB inhibin, beta B
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
LHX6 LIM homeobox 6
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAGEA6 melanoma antigen family A6
MEF2D myocyte enhancer factor 2D
MEGF8 multiple EGF-like-domains 8
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MT1HL1 metallothionein 1H-like 1
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
MXRA8 matrix-remodelling associated 8
NFS1 NFS1 cysteine desulfurase
NOL12 nucleolar protein 12
NRN1 neuritin 1
NSUN6 NOP2/Sun domain family, member 6
P2RY13 purinergic receptor P2Y, G-protein coupled, 13
PACS1 phosphofurin acidic cluster sorting protein 1
PHEX phosphate regulating endopeptidase homolog, X-linked
PLAG1 pleiomorphic adenoma gene 1
PMFBP1 polyamine modulated factor 1 binding protein 1
POU5F1B POU class 5 homeobox 1B
PPCS phosphopantothenoylcysteine synthetase
PRDM1 PR domain containing 1, with ZNF domain
PROM1 prominin 1
PRSS53 protease, serine, 53
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
QPCTL glutaminyl-peptide cyclotransferase-like
RALY RALY heterogeneous nuclear ribonucleoprotein
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
RNF126P1 ring finger protein 126 pseudogene 1
RUSC2 RUN and SH3 domain containing 2
SCIN scinderin
SECISBP2 SECIS binding protein 2
SENP7 SUMO1/sentrin specific peptidase 7
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC46A3 solute carrier family 46, member 3
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SMAD5-AS1 SMAD5 antisense RNA 1
SNRPN small nuclear ribonucleoprotein polypeptide N
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STARD3 StAR-related lipid transfer (START) domain containing 3
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TBXAS1 thromboxane A synthase 1 (platelet)
TIMP4 TIMP metallopeptidase inhibitor 4
TMEM53 transmembrane protein 53
TMEM74B transmembrane protein 74B
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNS2 tensin 2
TRIM25 tripartite motif containing 25
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TUBA3C tubulin, alpha 3c
UBL4A ubiquitin-like 4A
WDR25 WD repeat domain 25
WDR33 WD repeat domain 33
ZNF140 zinc finger protein 140
ZNF141 zinc finger protein 141
ZNF385D zinc finger protein 385D
ZNF484 zinc finger protein 484
ZNF721 zinc finger protein 721