| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/71299339 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in AGI-6780 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLIN2 | perilipin 2 | 1.14 |
| CYBA | cytochrome b-245, alpha polypeptide | 1.03 |
| SREBF1 | sterol regulatory element binding transcription factor 1 | 1.01 |
| NIBAN1 | niban apoptosis regulator 1 | 0.91 |
| ANKRD46 | ankyrin repeat domain 46 | 0.88 |
| NRP1 | neuropilin 1 | 0.8 |
| MT1E | metallothionein 1E | 0.75 |
| MT1F | metallothionein 1F | 0.75 |
| UPP1 | uridine phosphorylase 1 | 0.74 |
| ABHD5 | abhydrolase domain containing 5 | 0.71 |
| CLTA | clathrin, light chain A | 0.69 |
| PEX19 | peroxisomal biogenesis factor 19 | 0.67 |
| MT2A | metallothionein 2A | 0.65 |
| HGH1 | HGH1 homolog (S. cerevisiae) | 0.65 |
| TIGD5 | tigger transposable element derived 5 | 0.63 |
| CHPF | chondroitin polymerizing factor | 0.63 |
| TBC1D31 | TBC1 domain family, member 31 | 0.62 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | 0.61 |
| MXRA7 | matrix-remodelling associated 7 | 0.6 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | 0.6 |
| KLHL29 | kelch-like family member 29 | 0.57 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | 0.57 |
| SLC25A38 | solute carrier family 25, member 38 | 0.55 |
| CDK18 | cyclin-dependent kinase 18 | 0.55 |
| SLFN5 | schlafen family member 5 | 0.55 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 0.53 |
| MT1X | metallothionein 1X | 0.53 |
| RPE | ribulose-5-phosphate-3-epimerase | 0.52 |
| MAGEF1 | melanoma antigen family F1 | 0.51 |
| MT1L | metallothionein 1L (gene/pseudogene) | 0.49 |
| GDF15 | growth differentiation factor 15 | 0.48 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.46 |
| TRIB3 | tribbles pseudokinase 3 | 0.45 |
| RHOQ | ras homolog family member Q | 0.45 |
| GGACT | gamma-glutamylamine cyclotransferase | 0.44 |
| ORMDL1 | ORMDL sphingolipid biosynthesis regulator 1 | 0.43 |
| BSDC1 | BSD domain containing 1 | 0.43 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.42 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.42 |
| PAQR4 | progestin and adipoQ receptor family member IV | 0.41 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.41 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.41 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.41 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | 0.41 |
| IL17RB | interleukin 17 receptor B | 0.4 |
| TRABD | TraB domain containing | 0.4 |
| DIABLO | diablo, IAP-binding mitochondrial protein | 0.4 |
| MAN2C1 | mannosidase, alpha, class 2C, member 1 | 0.4 |
| TMEM159 | transmembrane protein 159 | 0.4 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.4 |
| TPM1 | tropomyosin 1 (alpha) | 0.39 |
| GCSH | glycine cleavage system protein H (aminomethyl carrier) | 0.39 |
| HEBP2 | heme binding protein 2 | 0.39 |
| PRELID3B | PRELI domain containing 3B | 0.38 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 0.38 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 0.38 |
| FAM171A2 | family with sequence similarity 171, member A2 | 0.37 |
| PNPLA2 | patatin-like phospholipase domain containing 2 | 0.37 |
| FANCC | Fanconi anemia, complementation group C | 0.37 |
| PIGW | phosphatidylinositol glycan anchor biosynthesis, class W | 0.36 |
| ANAPC16 | anaphase promoting complex subunit 16 | 0.34 |
| COA3 | cytochrome c oxidase assembly factor 3 | 0.34 |
| GLT8D2 | glycosyltransferase 8 domain containing 2 | 0.34 |
| PYGB | phosphorylase, glycogen; brain | 0.34 |
| C6ORF89 | chromosome 6 open reading frame 89 | 0.34 |
| NFYB | nuclear transcription factor Y, beta | 0.34 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 0.33 |
| METTL26 | methyltransferase like 26 | 0.33 |
| GPT2 | glutamic pyruvate transaminase (alanine aminotransferase) 2 | 0.33 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | 0.33 |
| MID1IP1 | MID1 interacting protein 1 | 0.33 |
| PHGDH | phosphoglycerate dehydrogenase | 0.32 |
| SPTBN5 | spectrin, beta, non-erythrocytic 5 | 0.32 |
| PYGM | phosphorylase, glycogen, muscle | 0.32 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.32 |
| PRAF2 | PRA1 domain family, member 2 | 0.32 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.32 |
| CDCA7 | cell division cycle associated 7 | 0.32 |
| HSP90AB3P | heat shock protein 90kDa alpha (cytosolic), class B member 3, pseudogene | 0.32 |
| ATG10 | autophagy related 10 | 0.32 |
| KIAA0556 | KIAA0556 | 0.32 |
| VRK2 | vaccinia related kinase 2 | 0.32 |
| HSBP1 | heat shock factor binding protein 1 | 0.32 |
| KLK7 | kallikrein-related peptidase 7 | 0.31 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | 0.31 |
| FIG4 | FIG4 phosphoinositide 5-phosphatase | 0.31 |
| PGBD2 | piggyBac transposable element derived 2 | 0.31 |
| ZNF888 | zinc finger protein 888 | 0.31 |
| ABRACL | ABRA C-terminal like | 0.31 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | 0.31 |
| MEST | mesoderm specific transcript | 0.31 |
| NENF | neudesin neurotrophic factor | 0.31 |
| TMEM68 | transmembrane protein 68 | 0.31 |
| PMF1 | polyamine-modulated factor 1 | 0.3 |
| NECTIN1 | nectin cell adhesion molecule 1 | 0.3 |
| MFAP3L | microfibrillar-associated protein 3-like | 0.3 |
| HNF4A | hepatocyte nuclear factor 4, alpha | 0.3 |
| NUCB1 | nucleobindin 1 | 0.3 |
| ABHD3 | abhydrolase domain containing 3 | 0.3 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SAYSD1 | SAYSVFN motif domain containing 1 | -1.1 |
| PIP | prolactin-induced protein | -0.99 |
| DYRK2 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 | -0.78 |
| FN1 | fibronectin 1 | -0.65 |
| CCDC77 | coiled-coil domain containing 77 | -0.62 |
| METTL22 | methyltransferase like 22 | -0.59 |
| ALPK1 | alpha-kinase 1 | -0.58 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | -0.56 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | -0.56 |
| PSMC1 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | -0.55 |
| ANGPTL4 | angiopoietin-like 4 | -0.54 |
| IFT22 | intraflagellar transport 22 | -0.51 |
| ENDOG | endonuclease G | -0.5 |
| TSPAN14 | tetraspanin 14 | -0.5 |
| C1ORF43 | chromosome 1 open reading frame 43 | -0.5 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.49 |
| ZNF268 | zinc finger protein 268 | -0.48 |
| RWDD2A | RWD domain containing 2A | -0.47 |
| SGSH | N-sulfoglucosamine sulfohydrolase | -0.47 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.47 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.46 |
| KIAA0825 | KIAA0825 | -0.46 |
| ADCY10 | adenylate cyclase 10 (soluble) | -0.46 |
| RILPL2 | Rab interacting lysosomal protein-like 2 | -0.46 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.45 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | -0.44 |
| ALOXE3 | arachidonate lipoxygenase 3 | -0.44 |
| RCAN3 | RCAN family member 3 | -0.44 |
| SERF2 | small EDRK-rich factor 2 | -0.44 |
| PDE4A | phosphodiesterase 4A, cAMP-specific | -0.43 |
| MSMO1 | methylsterol monooxygenase 1 | -0.42 |
| TTN | titin | -0.41 |
| TP73 | tumor protein p73 | -0.41 |
| DIXDC1 | DIX domain containing 1 | -0.41 |
| TM7SF2 | transmembrane 7 superfamily member 2 | -0.4 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.4 |
| KCNK5 | potassium channel, two pore domain subfamily K, member 5 | -0.39 |
| CCDC170 | coiled-coil domain containing 170 | -0.39 |
| SNX16 | sorting nexin 16 | -0.39 |
| TRAM2 | translocation associated membrane protein 2 | -0.39 |
| EVA1C | eva-1 homolog C (C. elegans) | -0.38 |
| HEMK1 | HemK methyltransferase family member 1 | -0.37 |
| ARSK | arylsulfatase family, member K | -0.37 |
| SLC30A3 | solute carrier family 30 (zinc transporter), member 3 | -0.37 |
| ZNF440 | zinc finger protein 440 | -0.36 |
| NARF | nuclear prelamin A recognition factor | -0.36 |
| ZNF740 | zinc finger protein 740 | -0.36 |
| BDNF | brain-derived neurotrophic factor | -0.36 |
| CCN3 | cellular communication network factor 3 | -0.36 |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | -0.36 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.36 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.35 |
| ZBTB8A | zinc finger and BTB domain containing 8A | -0.35 |
| ZNF799 | zinc finger protein 799 | -0.35 |
| ACVR2A | activin A receptor, type IIA | -0.35 |
| PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | -0.35 |
| PRR36 | proline rich 36 | -0.35 |
| TICAM1 | toll-like receptor adaptor molecule 1 | -0.34 |
| TYSND1 | trypsin domain containing 1 | -0.34 |
| SQLE | squalene epoxidase | -0.34 |
| RNF145 | ring finger protein 145 | -0.34 |
| SPCS1 | signal peptidase complex subunit 1 homolog (S. cerevisiae) | -0.34 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.34 |
| PMS1 | PMS1 postmeiotic segregation increased 1 (S. cerevisiae) | -0.34 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.34 |
| MCOLN1 | mucolipin 1 | -0.34 |
| ONECUT2 | one cut homeobox 2 | -0.33 |
| TRAIP | TRAF interacting protein | -0.33 |
| TYMS | thymidylate synthetase | -0.33 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.33 |
| TSPAN6 | tetraspanin 6 | -0.32 |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 | -0.32 |
| AXIN2 | axin 2 | -0.32 |
| NECTIN3 | nectin cell adhesion molecule 3 | -0.32 |
| WASF3 | WAS protein family, member 3 | -0.32 |
| COA5 | cytochrome c oxidase assembly factor 5 | -0.32 |
| ZNF100 | zinc finger protein 100 | -0.32 |
| PRMT6 | protein arginine methyltransferase 6 | -0.31 |
| ZIC5 | Zic family member 5 | -0.31 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | -0.31 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.3 |
| ZNF124 | zinc finger protein 124 | -0.3 |
| ALS2CL | ALS2 C-terminal like | -0.3 |
| PDGFC | platelet derived growth factor C | -0.3 |
| PACSIN1 | protein kinase C and casein kinase substrate in neurons 1 | -0.3 |
| TTC19 | tetratricopeptide repeat domain 19 | -0.3 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | -0.3 |
| PRR11 | proline rich 11 | -0.3 |
| KLHL2 | kelch-like family member 2 | -0.3 |
| CCNF | cyclin F | -0.29 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.29 |
| TRIB1 | tribbles pseudokinase 1 | -0.29 |
| TGFB1 | transforming growth factor, beta 1 | -0.29 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.29 |
| FSIP2 | fibrous sheath interacting protein 2 | -0.29 |
| RAB43 | RAB43, member RAS oncogene family | -0.29 |
| METTL7A | methyltransferase like 7A | -0.28 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.28 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | -0.28 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.28 |
