AGT Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description angiotensinogen (serpin peptidase inhibitor, clade A, member 8)|The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 183)
External Link http://www.ncbi.nlm.nih.gov/gene/183
Similar Terms
Downloads & Tools

Genes

57 interacting proteins for AGT from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ADRBK1 adrenergic, beta, receptor kinase 1
ADRBK2 adrenergic, beta, receptor kinase 2
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
ANPEP alanyl (membrane) aminopeptidase
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
CASR calcium-sensing receptor
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CMA1 chymase 1, mast cell
CPA3 carboxypeptidase A3 (mast cell)
CPB1 carboxypeptidase B1 (tissue)
CPB2 carboxypeptidase B2 (plasma)
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
CTSD cathepsin D
CTSG cathepsin G
CTSZ cathepsin Z
DNPEP aspartyl aminopeptidase
ECE1 endothelin converting enzyme 1
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EWSR1 EWS RNA-binding protein 1
GRB2 growth factor receptor-bound protein 2
GRK5 G protein-coupled receptor kinase 5
GRK6 G protein-coupled receptor kinase 6
GSDMB gasdermin B
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
HNF1A HNF1 homeobox A
HNF4A hepatocyte nuclear factor 4, alpha
ITSN2 intersectin 2
JUP junction plakoglobin
KNG1 kininogen 1
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MEP1A meprin A, alpha (PABA peptide hydrolase)
MME membrane metallo-endopeptidase
ONECUT1 one cut homeobox 1
PRCP prolylcarboxypeptidase (angiotensinase C)
PREP prolyl endopeptidase
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
REN renin
RHOA ras homolog family member A
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
TP53 tumor protein p53