AHR Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description aryl hydrocarbon receptor|This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 196)
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Genes

325 genes differentially expressed following the AHR gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CFHR3 complement factor H-related 3 3.8502
OR52A5 olfactory receptor, family 52, subfamily A, member 5 3.8502
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 3.8502
MGAM2 maltase-glucoamylase 2 (putative) 3.8502
PDYN prodynorphin 3.8502
GLYAT glycine-N-acyltransferase 3.8502
IL5RA interleukin 5 receptor, alpha 3.8502
TREX1 three prime repair exonuclease 1 3.8502
GPR20 G protein-coupled receptor 20 3.8502
ADAMTSL5 ADAMTS-like 5 3.8502
IGFL3 IGF-like family member 3 3.8502
IGFL2 IGF-like family member 2 3.8502
ZNF285 zinc finger protein 285 3.8502
SOX1 SRY (sex determining region Y)-box 1 3.8502
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma 3.8502
CARD18 caspase recruitment domain family, member 18 3.8502
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 3.8502
SCG2 secretogranin II 3.8502
GPR52 G protein-coupled receptor 52 3.8502
SLC26A4 solute carrier family 26 (anion exchanger), member 4 3.8502
XAF1 XIAP associated factor 1 3.8502
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 3.8502
OR1L8 olfactory receptor, family 1, subfamily L, member 8 3.8502
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 3.8502
MYL2 myosin, light chain 2, regulatory, cardiac, slow 3.8502
NMUR1 neuromedin U receptor 1 3.8502
SLC10A5 solute carrier family 10, member 5 3.8502
FGF7 fibroblast growth factor 7 3.8502
PRSS21 protease, serine, 21 (testisin) 3.8502
GPR78 G protein-coupled receptor 78 3.8502
TWIST1 twist family bHLH transcription factor 1 3.8502
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 3.8502
TSHZ1 teashirt zinc finger homeobox 1 3.8502
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) 3.8502
TMEM71 transmembrane protein 71 3.8502
LCN12 lipocalin 12 3.8502
LCN10 lipocalin 10 3.8502
PAEP progestagen-associated endometrial protein 3.8502
RLN3 relaxin 3 3.8502
F2 coagulation factor II (thrombin) 3.8502
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 3.8502
MISP mitotic spindle positioning 3.8502
PRICKLE4 prickle homolog 4 (Drosophila) 3.8502
MMRN1 multimerin 1 3.8502
SBK3 SH3 domain binding kinase family, member 3 3.8502
LOC128125822 uncharacterized LOC128125822 3.8502
ARX aristaless related homeobox 3.8502
YIPF7 Yip1 domain family, member 7 3.8502
AVPR1A arginine vasopressin receptor 1A 3.8502
LTB4R2 leukotriene B4 receptor 2 3.8502
SPI1 Spi-1 proto-oncogene 3.8502
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase 3.8502
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 3.8502
TBC1D3B TBC1 domain family, member 3B 3.8502
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 3.8502
SEPTIN14 septin 14 3.8502
TMEM275 transmembrane protein 275 3.8502
GNG5B G protein subunit gamma 5B 3.8502
MYMK myomaker, myoblast fusion factor 3.8502
CFAP276 cilia and flagella associated protein 276 3.8502
TEX55 testis expressed 55 3.8502
CFAP97D1 CFAP97 domain containing 1 3.8502
PLPP4 phospholipid phosphatase 4 3.8502
RTL9 retrotransposon Gag like 9 3.8502
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 3.8502
PMIS2 PMIS2 transmembrane protein 3.8502
ADRB1 adrenoceptor beta 1 3.8502
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 3.8502
TBX5 T-box 5 3.8502
DMBX1 diencephalon/mesencephalon homeobox 1 3.8502
UROC1 urocanate hydratase 1 3.8502
NR1I3 nuclear receptor subfamily 1, group I, member 3 3.8502
SLC22A25 solute carrier family 22, member 25 3.8502
OR51B5 olfactory receptor, family 51, subfamily B, member 5 3.8502
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 3.8502
CIMIP7 ciliary microtubule inner protein 7 3.8502
C4ORF17 chromosome 4 open reading frame 17 3.8502
PRR18 proline rich 18 3.8502
FOXI2 forkhead box I2 3.8502
ASB4 ankyrin repeat and SOCS box containing 4 3.8502
FOXC1 forkhead box C1 3.8502
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 3.8502
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 3.8502
COX8C cytochrome c oxidase subunit VIIIC 3.8502
HAL histidine ammonia-lyase 3.8502
VCX3A variable charge, X-linked 3A 3.8502
CCR7 chemokine (C-C motif) receptor 7 3.8502
CCR3 chemokine (C-C motif) receptor 3 3.8502
RHOXF2 Rhox homeobox family, member 2 3.8502
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 3.8502
LYPD5 LY6/PLAUR domain containing 5 3.8502
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 3.8502
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 3.8502
ANKRD65 ankyrin repeat domain 65 3.8502
SYT5 synaptotagmin V 3.8502
TMEM255A transmembrane protein 255A 3.8502
DQX1 DEAQ box RNA-dependent ATPase 1 3.8502
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 3.8502
LCNL1 lipocalin-like 1 3.8502
OR56A3 olfactory receptor, family 56, subfamily A, member 3 3.8502
FNDC9 fibronectin type III domain containing 9 3.8502
NPPA natriuretic peptide A 3.8502
MORC1 MORC family CW-type zinc finger 1 3.8502
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 3.8502
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 3.8502
RGS8 regulator of G-protein signaling 8 3.8502
HOXD1 homeobox D1 3.8502
OR9I1 olfactory receptor, family 9, subfamily I, member 1 3.8502
ZNF750 zinc finger protein 750 3.8502
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 3.8502
C20ORF144 chromosome 20 open reading frame 144 3.8502
C8ORF89 chromosome 8 open reading frame 89 3.8502
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 3.8502
PRTN3 proteinase 3 3.8502
GPR62 G protein-coupled receptor 62 3.8502
DSC1 desmocollin 1 3.8502
MUC17 mucin 17, cell surface associated 3.8502
CGB2 chorionic gonadotropin, beta polypeptide 2 3.8502
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 3.8502
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 3.8502
IL36R interleukin 36 receptor 3.8502
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 3.8502
SPATA3 spermatogenesis associated 3 3.8502
RORC RAR-related orphan receptor C 3.8502
SLITRK1 SLIT and NTRK-like family, member 1 3.8502
TEX35 testis expressed 35 3.8502
BTG4 B-cell translocation gene 4 3.8502
DEFB125 defensin, beta 125 3.8502
LRRC74A leucine rich repeat containing 74A 3.8502
GCM1 glial cells missing homolog 1 (Drosophila) 3.8502
VMO1 vitelline membrane outer layer 1 homolog (chicken) 3.8502
RHAG Rh-associated glycoprotein 3.8502
CCDC170 coiled-coil domain containing 170 3.8502
ZBED6 zinc finger, BED-type containing 6 3.8502
CLEC1A C-type lectin domain family 1, member A 3.8502
GSDMC gasdermin C 3.8502
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 3.8502
LST1 leukocyte specific transcript 1 3.8502
PPP1R3A protein phosphatase 1, regulatory subunit 3A 3.8502
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 3.8502
USP17L1 ubiquitin specific peptidase 17-like family member 1 3.8502
GPR179 G protein-coupled receptor 179 3.8502
OR8K3 olfactory receptor, family 8, subfamily K, member 3 (gene/pseudogene) 3.8502
MAEL maelstrom spermatogenic transposon silencer 3.8502
GJC2 gap junction protein, gamma 2, 47kDa 3.8502
POU3F2 POU class 3 homeobox 2 3.8502
C9ORF57 chromosome 9 open reading frame 57 3.8502
SP100 SP100 nuclear antigen 3.8502
EPO erythropoietin 3.8502
OR1F1 olfactory receptor, family 1, subfamily F, member 1 3.83332
HPD 4-hydroxyphenylpyruvate dioxygenase 3.83332
WSCD2 WSC domain containing 2 3.83332
MTTP microsomal triglyceride transfer protein 3.83332
ELOVL5 ELOVL fatty acid elongase 5 3.45115
DENND2D DENN/MADD domain containing 2D 3.43425
DRD4 dopamine receptor D4 3.39789
CCT8 chaperonin containing TCP1, subunit 8 (theta) 3.3704
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa 2.94151
LRIF1 ligand dependent nuclear receptor interacting factor 1 2.94151
MAP3K4-AS1 MAP3K4 antisense RNA 1 2.83898
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 2.83898
TP53INP2 tumor protein p53 inducible nuclear protein 2 2.83898
DGAT2 diacylglycerol O-acyltransferase 2 2.83898
RXRA retinoid X receptor, alpha 2.75693
JUN jun proto-oncogene 2.748
NUP54 nucleoporin 54kDa 2.74513
NCOA3 nuclear receptor coactivator 3 2.71381
AGAP4 ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 2.70917
PTPRG protein tyrosine phosphatase, receptor type, G 2.5366
NLGN1 neuroligin 1 2.50945
LAPTM4A lysosomal protein transmembrane 4 alpha 2.4656
TBC1D15 TBC1 domain family, member 15 2.42155
CEP57L1 centrosomal protein 57kDa-like 1 2.40279
P3H2 prolyl 3-hydroxylase 2 2.38481
BCL2L1 BCL2-like 1 2.38353
IRF4 interferon regulatory factor 4 2.3411
MAGEA4 melanoma antigen family A4 2.3411
ZNF540 zinc finger protein 540 2.3411
TBCD tubulin folding cofactor D 2.33206
EMP1 epithelial membrane protein 1 2.33206
APOD apolipoprotein D 2.3041
CTSS cathepsin S 2.3041
SIRAL2 SIR2 antiphage like 2 2.27459
DDHD1 DDHD domain containing 1 2.25324
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2.25171
PGF placental growth factor 2.25137
NCAM1 neural cell adhesion molecule 1 2.22512
SRI sorcin 2.22512
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 2.21637
RAB33A RAB33A, member RAS oncogene family 2.1817
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.17072
ACSF3 acyl-CoA synthetase family member 3 2.1684
ZFAND3 zinc finger, AN1-type domain 3 2.16715
SNRK SNF related kinase 2.16715
DSC2 desmocollin 2 2.14597
SNX19 sorting nexin 19 2.14597
TRMT6 tRNA methyltransferase 6 2.13608
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 2.12242
ZNF283 zinc finger protein 283 2.10176
PGM2L1 phosphoglucomutase 2-like 1 2.08717
TMEM134 transmembrane protein 134 2.08541
UBR4 ubiquitin protein ligase E3 component n-recognin 4 2.08541
ZBED1 zinc finger, BED-type containing 1 2.08541
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 2.08444
SLC35B1 solute carrier family 35, member B1 2.07252
RUBCNL rubicon like autophagy enhancer 2.05594
MED22 mediator complex subunit 22 2.02331
H4C8 H4 clustered histone 8 2.01961
FANCL Fanconi anemia, complementation group L 2.01961
SEC23IP SEC23 interacting protein 2.01169
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 2.00622

decreased expression

Symbol Name Standardized Value
SLC26A11 solute carrier family 26 (anion exchanger), member 11 -3.8502
OVOL1 ovo-like zinc finger 1 -3.8502
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 -3.8502
LRRC66 leucine rich repeat containing 66 -3.8502
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 -3.8502
FST follistatin -3.8502
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 -3.8502
DUSP10 dual specificity phosphatase 10 -3.8502
TBX15 T-box 15 -3.83332
ARHGAP15 Rho GTPase activating protein 15 -3.83332
TMEM132E transmembrane protein 132E -3.83332
HNF1B HNF1 homeobox B -3.83332
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 -3.83332
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 -3.83332
WBP2NL WBP2 N-terminal like -3.83332
ZPLD1 zona pellucida-like domain containing 1 -3.83332
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 -3.83332
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 -3.83332
GLIS2 GLIS family zinc finger 2 -3.83332
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled -3.83332
GALR3 galanin receptor 3 -3.83332
MUC1 mucin 1, cell surface associated -3.83332
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) -3.83332
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) -3.83332
F2RL2 coagulation factor II (thrombin) receptor-like 2 -3.83332
UBE2L5 ubiquitin conjugating enzyme E2 L5 -3.83332
TERB1 telomere repeat binding bouquet formation protein 1 -3.83332
CSTL1 cystatin-like 1 -3.83332
BAHCC1 BAH domain and coiled-coil containing 1 -3.83332
MYEOV myeloma overexpressed -3.83332
SPHKAP SPHK1 interactor, AKAP domain containing -3.83332
CXCR4 chemokine (C-X-C motif) receptor 4 -3.83332
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 -3.83332
NDP Norrie disease (pseudoglioma) -3.83332
GATA4 GATA binding protein 4 -3.83332
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled -3.74876
C1QTNF12 C1q and TNF related 12 -3.74876
TTC29 tetratricopeptide repeat domain 29 -3.74876
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 -3.47786
AQP3 aquaporin 3 (Gill blood group) -3.23179
SPARCL1 SPARC-like 1 (hevin) -3.23179
BIRC5 baculoviral IAP repeat containing 5 -3.22161
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -3.13002
RFX4 regulatory factor X, 4 (influences HLA class II expression) -2.90786
ATXN1 ataxin 1 -2.84199
PPIA peptidylprolyl isomerase A (cyclophilin A) -2.83389
IFNAR2 interferon (alpha, beta and omega) receptor 2 -2.81733
PTK7 protein tyrosine kinase 7 (inactive) -2.76854
PGM2 phosphoglucomutase 2 -2.76346
RPS27A ribosomal protein S27a -2.7365
OAF OAF homolog (Drosophila) -2.68462
ZNF706 zinc finger protein 706 -2.68462
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) -2.68462
CLIC5 chloride intracellular channel 5 -2.68462
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -2.57353
RTF2 replication termination factor 2 -2.56258
PDIK1L PDLIM1 interacting kinase 1 like -2.56258
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -2.52318
TSPAN6 tetraspanin 6 -2.51568
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase -2.49313
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 -2.42155
CALCB calcitonin-related polypeptide beta -2.3856
STAB1 stabilin 1 -2.38533
SNAP91 synaptosomal-associated protein, 91kDa -2.38533
CYB5R3 cytochrome b5 reductase 3 -2.38481
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -2.37056
PSEN2 presenilin 2 -2.36936
SLC39A13 solute carrier family 39 (zinc transporter), member 13 -2.35461
MCL1 myeloid cell leukemia 1 -2.32007
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.31609
AGMO alkylglycerol monooxygenase -2.31481
CLCN5 chloride channel, voltage-sensitive 5 -2.31481
OLFM1 olfactomedin 1 -2.30197
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 -2.29704
GMPPB GDP-mannose pyrophosphorylase B -2.28532
RPS21-DT RPS21 divergent transcript -2.28507
CHML choroideremia-like (Rab escort protein 2) -2.27459
RANGAP1 Ran GTPase activating protein 1 -2.26258
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 -2.25799
IL32 interleukin 32 -2.25799
ATG101 autophagy related 101 -2.25281
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -2.25281
SH3YL1 SH3 and SYLF domain containing 1 -2.25235
SKIC8 SKI8 subunit of superkiller complex -2.25137
BAX BCL2-associated X protein -2.22512
SPRYD4 SPRY domain containing 4 -2.17933
ZNF561 zinc finger protein 561 -2.16715
NYNRIN NYN domain and retroviral integrase containing -2.15365
SLC26A8 solute carrier family 26 (anion exchanger), member 8 -2.14597
LRRC61 leucine rich repeat containing 61 -2.14597
FKBP6 FK506 binding protein 6, 36kDa -2.14597
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) -2.14597
OSBPL7 oxysterol binding protein-like 7 -2.14597
NGFR nerve growth factor receptor -2.14597
GJD3 gap junction protein, delta 3, 31.9kDa -2.14597
RBP2 retinol binding protein 2, cellular -2.14597
CRYGS crystallin, gamma S -2.14597
DLG3 discs, large homolog 3 (Drosophila) -2.13612
ZNF449 zinc finger protein 449 -2.13612
TMEM208 transmembrane protein 208 -2.12536
MPV17L MPV17 mitochondrial membrane protein-like -2.11325
USP6 ubiquitin specific peptidase 6 -2.10927
FAM81A family with sequence similarity 81, member A -2.10927
KLHL14 kelch-like family member 14 -2.08471
ARPP19 cAMP-regulated phosphoprotein, 19kDa -2.08417
PTPDC1 protein tyrosine phosphatase domain containing 1 -2.07964
ETV1 ets variant 1 -2.07933
TRPM3 transient receptor potential cation channel, subfamily M, member 3 -2.07252
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa -2.07252
AHR aryl hydrocarbon receptor -2.06404
BST2 bone marrow stromal cell antigen 2 -2.01419
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) -2.01271
LOC124902694 uncharacterized LOC124902694 -2.00724
CKAP5 cytoskeleton associated protein 5 -2.0009