AIM2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description absent in melanoma 2|AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9447)
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Genes

345 genes differentially expressed following the AIM2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SPHKAP SPHK1 interactor, AKAP domain containing 2.99072
ANXA10 annexin A10 2.99072
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) 2.99072
FAM209B family with sequence similarity 209, member B 2.99072
CXCL14 chemokine (C-X-C motif) ligand 14 2.99072
ILDR2 immunoglobulin-like domain containing receptor 2 2.99072
DSG1 desmoglein 1 2.99072
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.99072
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.99072
C19ORF67 chromosome 19 open reading frame 67 2.99072
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 2.99072
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 2.99072
THEM6 thioesterase superfamily member 6 2.99072
TM4SF20 transmembrane 4 L six family member 20 2.99072
NPAP1 nuclear pore associated protein 1 2.99072
BBS9 Bardet-Biedl syndrome 9 2.99072
ERVV-2 endogenous retrovirus group V, member 2 2.99072
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.99072
ISL2 ISL LIM homeobox 2 2.99072
LYPD5 LY6/PLAUR domain containing 5 2.99072
CSF3R colony stimulating factor 3 receptor (granulocyte) 2.99072
OIT3 oncoprotein induced transcript 3 2.99072
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.97073
PLVAP plasmalemma vesicle associated protein 2.97073
BSX brain-specific homeobox 2.97073
HABP2 hyaluronan binding protein 2 2.97073
COL20A1 collagen, type XX, alpha 1 2.97073
CD274 CD274 molecule 2.97073
SEC23B Sec23 homolog B (S. cerevisiae) 2.97073
DNASE1L2 deoxyribonuclease I-like 2 2.97073
TEX13B testis expressed 13B 2.97073
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.97073
SPINK4 serine peptidase inhibitor, Kazal type 4 2.97073
SELPLG selectin P ligand 2.97073
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.97073
FAM180A family with sequence similarity 180, member A 2.97073
CASP4 caspase 4, apoptosis-related cysteine peptidase 2.97073
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.97073
GMNC geminin coiled-coil domain containing 2.97073
EDDM3A epididymal protein 3A 2.97073
S100A3 S100 calcium binding protein A3 2.97073
WNT8B wingless-type MMTV integration site family, member 8B 2.97073
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) 2.97073
TBATA thymus, brain and testes associated 2.97073
PODNL1 podocan-like 1 2.97073
CRYAA crystallin, alpha A 2.97073
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.97073
TMEM217 transmembrane protein 217 2.97073
DNAAF6 dynein axonemal assembly factor 6 2.97073
OR1L8 olfactory receptor, family 1, subfamily L, member 8 2.97073
SKOR2 SKI family transcriptional corepressor 2 2.97073
ZNF560 zinc finger protein 560 2.97073
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.97073
AVP arginine vasopressin 2.97073
PAX8 paired box 8 2.97073
GDNF glial cell derived neurotrophic factor 2.97073
ARSF arylsulfatase F 2.97073
FAM221B family with sequence similarity 221, member B 2.97073
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.97073
PTGER4 prostaglandin E receptor 4 (subtype EP4) 2.97073
TPPP tubulin polymerization promoting protein 2.97073
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.97073
LOC124906892 uncharacterized LOC124906892 2.97073
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 2.97073
PCDHGA9 protocadherin gamma subfamily A, 9 2.97073
MCHR1 melanin-concentrating hormone receptor 1 2.97073
AVPR1A arginine vasopressin receptor 1A 2.97073
OPRM1 opioid receptor, mu 1 2.97073
LTB4R2 leukotriene B4 receptor 2 2.97073
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) 2.97073
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 2.97073
TMPRSS7 transmembrane protease, serine 7 2.97073
SQOR sulfide quinone oxidoreductase 2.97073
CCDC198 coiled-coil domain containing 198 2.97073
AJM1 apical junction component 1 homolog 2.97073
CATSPERT catsper channel auxiliary subunit tau 2.97073
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.97073
SPMIP10 sperm microtubule inner protein 10 2.97073
CIROZ ciliated left-right organizer protein containing ZP-N domains 2.97073
DRC5 dynein regulatory complex subunit 5 2.97073
EPCIP exosomal polycystin 1 interacting protein 2.97073
LITAFD LITAF domain containing 2.97073
GREP1 glycine rich extracellular protein 1 2.97073
ARMH2 armadillo like helical domain containing 2 2.97073
GC group-specific component (vitamin D binding protein) 2.97073
WNT16 wingless-type MMTV integration site family, member 16 2.97073
SMTNL1 smoothelin-like 1 2.97073
ZNF575 zinc finger protein 575 2.97073
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 2.97073
ZSWIM2 zinc finger, SWIM-type containing 2 2.97073
WNT11 wingless-type MMTV integration site family, member 11 2.97073
CCR6 chemokine (C-C motif) receptor 6 2.97073
IRF5 interferon regulatory factor 5 2.97073
PCDHA2 protocadherin alpha 2 2.97073
ACOT4 acyl-CoA thioesterase 4 2.97073
IZUMO1 izumo sperm-egg fusion 1 2.97073
SH3TC2 SH3 domain and tetratricopeptide repeats 2 2.97073
SLAMF1 signaling lymphocytic activation molecule family member 1 2.97073
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.97073
GATA2 GATA binding protein 2 2.97073
ROPN1 rhophilin associated tail protein 1 2.97073
SAMD15 sterile alpha motif domain containing 15 2.97073
C7 complement component 7 2.97073
CNTFR ciliary neurotrophic factor receptor 2.97073
SBSN suprabasin 2.97073
S100B S100 calcium binding protein B 2.97073
CCR7 chemokine (C-C motif) receptor 7 2.97073
EXOC3L4 exocyst complex component 3-like 4 2.97073
PRB1 proline-rich protein BstNI subfamily 1 2.97073
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 2.97073
THTPA thiamine triphosphatase 2.97073
AQP7 aquaporin 7 2.97073
CTAGE4 CTAGE family, member 4 2.97073
BPIFB2 BPI fold containing family B, member 2 2.97073
TBC1D10C TBC1 domain family, member 10C 2.97073
PRM1 protamine 1 2.97073
CALHM1 calcium homeostasis modulator 1 2.97073
SPINK9 serine peptidase inhibitor, Kazal type 9 2.97073
NIPAL4 NIPA-like domain containing 4 2.97073
APLNR apelin receptor 2.97073
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 2.97073
SHOX short stature homeobox 2.97073
FIGLA folliculogenesis specific basic helix-loop-helix 2.97073
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.97073
FCN1 ficolin (collagen/fibrinogen domain containing) 1 2.97073
KRT15 keratin 15, type I 2.97073
HP haptoglobin 2.97073
ALAS2 5'-aminolevulinate synthase 2 2.97073
KCNK4 potassium channel, two pore domain subfamily K, member 4 2.97073
ZSCAN4 zinc finger and SCAN domain containing 4 2.97073
C22ORF42 chromosome 22 open reading frame 42 2.97073
NUPR1 nuclear protein, transcriptional regulator, 1 2.97073
MAGED4B melanoma antigen family D4B 2.97073
OR4D1 olfactory receptor, family 4, subfamily D, member 1 2.97073
SLC38A3 solute carrier family 38, member 3 2.97073
RGS8 regulator of G-protein signaling 8 2.97073
RGS4 regulator of G-protein signaling 4 2.97073
TRIM7 tripartite motif containing 7 2.97073
FAM151A family with sequence similarity 151, member A 2.97073
MB myoglobin 2.97073
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 2.97073
NLRP14 NLR family, pyrin domain containing 14 2.97073
TF transferrin 2.97073
COX7B2 cytochrome c oxidase subunit VIIb2 2.97073
DHH desert hedgehog 2.97073
ARHGAP20 Rho GTPase activating protein 20 2.97073
CATIP ciliogenesis associated TTC17 interacting protein 2.97073
EGR3 early growth response 3 2.97073
ZFP92 ZFP92 zinc finger protein 2.97073
C20ORF144 chromosome 20 open reading frame 144 2.97073
KLK4 kallikrein-related peptidase 4 2.97073
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.97073
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 2.97073
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 2.97073
A1CF APOBEC1 complementation factor 2.97073
KRTAP5-2 keratin associated protein 5-2 2.97073
NPS neuropeptide S 2.97073
BTBD19 BTB (POZ) domain containing 19 2.97073
TGM3 transglutaminase 3 2.97073
CHRDL2 chordin-like 2 2.97073
GHRH growth hormone releasing hormone 2.97073
ZPLD1 zona pellucida-like domain containing 1 2.97073
SNAI2 snail family zinc finger 2 2.97073
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.97073
PPP1R3G protein phosphatase 1, regulatory subunit 3G 2.97073
NPR3 natriuretic peptide receptor 3 2.97073
TRAF3IP3 TRAF3 interacting protein 3 2.97073
TFCP2L1 transcription factor CP2-like 1 2.97073
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.97073
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.97073
PEX11B peroxisomal biogenesis factor 11 beta 2.97073
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 2.97073
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.97073
NPC1L1 NPC1-like 1 2.97073
PATE2 prostate and testis expressed 2 2.97073
LRRC74A leucine rich repeat containing 74A 2.97073
CLCNKA chloride channel, voltage-sensitive Ka 2.97073
GCM1 glial cells missing homolog 1 (Drosophila) 2.97073
SLC51B solute carrier family 51, beta subunit 2.97073
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 2.97073
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 2.95995
GJA4 gap junction protein, alpha 4, 37kDa 2.91182
FNDC7 fibronectin type III domain containing 7 2.91182
CALHM2 calcium homeostasis modulator 2 2.85237
LIMS2 LIM and senescent cell antigen-like domains 2 2.85237
PROX1 prospero homeobox 1 2.85237
KANK4 KN motif and ankyrin repeat domains 4 2.85237
RAB27B RAB27B, member RAS oncogene family 2.85237
PPP1R3D protein phosphatase 1, regulatory subunit 3D 2.85237
TMEM8B transmembrane protein 8B 2.77669
GDF15 growth differentiation factor 15 2.77669
TUBG2 tubulin, gamma 2 2.74609
METTL13 methyltransferase like 13 2.72884
KBTBD3 kelch repeat and BTB (POZ) domain containing 3 2.71521
TMEM35B transmembrane protein 35B 2.7038
FAM171A2 family with sequence similarity 171, member A2 2.60773
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 2.57409
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 2.48981
IL20RA interleukin 20 receptor, alpha 2.48958
CDC25C cell division cycle 25C 2.47254
TOR1AIP1 torsin A interacting protein 1 2.45141
P2RY12 purinergic receptor P2Y, G-protein coupled, 12 2.44531
SCN5A sodium channel, voltage gated, type V alpha subunit 2.44531
ASB18 ankyrin repeat and SOCS box containing 18 2.39771
PCDH12 protocadherin 12 2.39771
NCBP1 nuclear cap binding protein subunit 1, 80kDa 2.39771
RCE1 Ras converting CAAX endopeptidase 1 2.37929
GOLGA6L4 golgin A6 family-like 4 2.37483
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 2.36503
MTF2 metal response element binding transcription factor 2 2.35417
SYT10 synaptotagmin X 2.33056
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 2.32388
TUBB6 tubulin, beta 6 class V 2.25993
GYPC glycophorin C (Gerbich blood group) 2.25127
SEPTIN10 septin 10 2.23994
LINS1 lines homolog 1 2.19738
MRPL13 mitochondrial ribosomal protein L13 2.18298
ODAD4 outer dynein arm docking complex subunit 4 2.16955
MARVELD2 MARVEL domain containing 2 2.15971
SNCB synuclein, beta 2.15357
EPDR1 ependymin related 1 2.12637
ATXN1L ataxin 1-like 2.12009
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3 2.11482
IL20RB interleukin 20 receptor beta 2.11316
DLAT dihydrolipoamide S-acetyltransferase 2.1093
ZNF148 zinc finger protein 148 2.06064
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 2.03452
PMM1 phosphomannomutase 1 2.01705
NRG3 neuregulin 3 2.01705
PTPN2 protein tyrosine phosphatase, non-receptor type 2 2.00974

decreased expression

Symbol Name Standardized Value
BCL6B B-cell CLL/lymphoma 6, member B -2.99072
NACAD NAC alpha domain containing -2.99072
LOC122539214 Zinc finger protein LOC122539214 -2.99072
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 -2.99072
IL23A interleukin 23, alpha subunit p19 -2.99072
TMEM81 transmembrane protein 81 -2.99072
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 -2.99072
ADGRD2 adhesion G protein-coupled receptor D2 -2.99072
MOCS1 molybdenum cofactor synthesis 1 -2.97073
PANO1 proapoptotic nucleolar protein 1 -2.97073
PCDHGA12 protocadherin gamma subfamily A, 12 -2.97073
PCDHA5 protocadherin alpha 5 -2.97073
GRM6 glutamate receptor, metabotropic 6 -2.97073
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma -2.97073
MEP1B meprin A, beta -2.97073
ASB9 ankyrin repeat and SOCS box containing 9 -2.97073
NBPF8 neuroblastoma breakpoint family, member 8 -2.97073
DNAAF1 dynein, axonemal, assembly factor 1 -2.97073
FAM3D family with sequence similarity 3, member D -2.97073
RAD17 RAD17 homolog (S. pombe) -2.97073
GPR83 G protein-coupled receptor 83 -2.97073
CAPS calcyphosine -2.97073
ACOT12 acyl-CoA thioesterase 12 -2.97073
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 -2.97073
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 -2.97073
CKM creatine kinase, muscle -2.97073
CCDC92 coiled-coil domain containing 92 -2.97073
ARHGAP15 Rho GTPase activating protein 15 -2.97073
C11ORF87 chromosome 11 open reading frame 87 -2.97073
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -2.97073
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -2.97073
ADGRE3 adhesion G protein-coupled receptor E3 -2.97073
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 -2.97073
ZFYVE27 zinc finger, FYVE domain containing 27 -2.97073
RPL3L ribosomal protein L3-like -2.97073
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -2.97073
SVOP SV2 related protein homolog (rat) -2.97073
CDC5L cell division cycle 5-like -2.97073
BTNL9 butyrophilin-like 9 -2.97073
BCO1 beta-carotene oxygenase 1 -2.97073
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 -2.97073
JAML junction adhesion molecule like -2.97073
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 -2.97073
H4C12 H4 clustered histone 12 -2.97073
CELF3 CUGBP, Elav-like family member 3 -2.97073
ARG1 arginase 1 -2.97073
GPRC6A G protein-coupled receptor, class C, group 6, member A -2.97073
FNDC1 fibronectin type III domain containing 1 -2.97073
UBXN10 UBX domain protein 10 -2.97073
MAJIN membrane anchored junction protein -2.97073
CHCT1 CHD1 helical C-terminal domain containing 1 -2.97073
PARL presenilin associated, rhomboid-like -2.91367
A4GALT alpha 1,4-galactosyltransferase -2.88984
MDH2 malate dehydrogenase 2, NAD (mitochondrial) -2.8563
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -2.81693
GUCD1 guanylyl cyclase domain containing 1 -2.79146
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 -2.79025
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 -2.68337
ANPEP alanyl (membrane) aminopeptidase -2.67518
ALOX12 arachidonate 12-lipoxygenase -2.6701
ZXDB zinc finger, X-linked, duplicated B -2.64015
C15ORF40 chromosome 15 open reading frame 40 -2.64015
LCA5L Leber congenital amaurosis 5-like -2.64015
SMIM20 small integral membrane protein 20 -2.61698
TOR1B torsin family 1, member B (torsin B) -2.5883
FAM227B family with sequence similarity 227, member B -2.4963
GK glycerol kinase -2.45565
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 -2.44531
PLAAT5 phospholipase A and acyltransferase 5 -2.40069
PRH1 proline-rich protein HaeIII subfamily 1 -2.371
CCDC71 coiled-coil domain containing 71 -2.35539
RNF207 ring finger protein 207 -2.32192
AUTS2 autism susceptibility candidate 2 -2.26951
MAU2 MAU2 sister chromatid cohesion factor -2.26616
TP73 tumor protein p73 -2.25121
IFI35 interferon-induced protein 35 -2.24285
HLA-DMA major histocompatibility complex, class II, DM alpha -2.24285
MOB3C MOB kinase activator 3C -2.24285
IP6K1 inositol hexakisphosphate kinase 1 -2.24285
YJEFN3 YjeF N-terminal domain containing 3 -2.23811
TEX11 testis expressed 11 -2.21307
IQCC IQ motif containing C -2.21307
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -2.18968
TCEANC transcription elongation factor A (SII) N-terminal and central domain containing -2.18761
RNH1 ribonuclease/angiogenin inhibitor 1 -2.18761
ZFP37 ZFP37 zinc finger protein -2.18487
RILPL1 Rab interacting lysosomal protein-like 1 -2.18182
TMLHE trimethyllysine hydroxylase, epsilon -2.15942
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -2.15738
LYRM4 LYR motif containing 4 -2.15655
SFXN1 sideroflexin 1 -2.15357
N4BP2 NEDD4 binding protein 2 -2.1478
OGN osteoglycin -2.14673
FUZ fuzzy planar cell polarity protein -2.138
CTPS1 CTP synthase 1 -2.13775
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) -2.12637
PBX3 pre-B-cell leukemia homeobox 3 -2.12637
RAB39A RAB39A, member RAS oncogene family -2.1261
ZNF689 zinc finger protein 689 -2.11482
DACT3 dishevelled-binding antagonist of beta-catenin 3 -2.11316
CENPF centromere protein F, 350/400kDa -2.11283
LYSET lysosomal enzyme trafficking factor -2.1093
RNF214 ring finger protein 214 -2.1093
TUG1 taurine up-regulated 1 (non-protein coding) -2.10654
CNBD1 cyclic nucleotide binding domain containing 1 -2.09899
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 -2.09618
ZNF577 zinc finger protein 577 -2.07861
STK38L serine/threonine kinase 38 like -2.07559
FAM234A family with sequence similarity 234 member A -2.06087
KRIT1 KRIT1, ankyrin repeat containing -2.04792
PRMT3 protein arginine methyltransferase 3 -2.04792
NAGS N-acetylglutamate synthase -2.041
SEC16A SEC16 homolog A (S. cerevisiae) -2.03337
B3GAT3 beta-1,3-glucuronyltransferase 3 -2.0316
CNGA4 cyclic nucleotide gated channel alpha 4 -2.0316