AIRE Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description autoimmune regulator|This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012] (NCBI Entrez Gene Database, 326)
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Genes

264 genes differentially expressed following the AIRE gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CCDC152 coiled-coil domain containing 152 2.8302
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 2.8302
EPHA10 EPH receptor A10 2.8302
SLC25A45 solute carrier family 25, member 45 2.8302
DUSP8 dual specificity phosphatase 8 2.8302
ADTRP androgen-dependent TFPI-regulating protein 2.8302
MAMLD1 mastermind-like domain containing 1 2.8302
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 2.8302
HNF1A HNF1 homeobox A 2.8302
IL16 interleukin 16 2.8302
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 2.8302
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.8302
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.8302
PCDHGA11 protocadherin gamma subfamily A, 11 2.8302
CLUL1 clusterin-like 1 (retinal) 2.8302
LRRC8C-DT LRRC8C divergent transcript 2.8302
DRC7 dynein regulatory complex subunit 7 2.8302
GREP1 glycine rich extracellular protein 1 2.8302
DNAAF8 dynein axonemal assembly factor 8 2.8302
OXT oxytocin/neurophysin I prepropeptide 2.8302
OR6C70 olfactory receptor, family 6, subfamily C, member 70 2.82072
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.82072
MYBPHL myosin binding protein H-like 2.82072
NDRG1 N-myc downstream regulated 1 2.82072
ABI3BP ABI family, member 3 (NESH) binding protein 2.82072
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.82072
ZNF99 zinc finger protein 99 2.82072
RAB44 RAB44, member RAS oncogene family 2.82072
DAO D-amino-acid oxidase 2.82072
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.82072
OLAH oleoyl-ACP hydrolase 2.82072
LIX1 Lix1 homolog (chicken) 2.82072
DNAJC5B DnaJ (Hsp40) homolog, subfamily C, member 5 beta 2.82072
TNRC6B trinucleotide repeat containing 6B 2.82072
NCF1 neutrophil cytosolic factor 1 2.82072
FFAR4 free fatty acid receptor 4 2.82072
CCL3 chemokine (C-C motif) ligand 3 2.82072
PLCH2 phospholipase C, eta 2 2.82072
ASB10 ankyrin repeat and SOCS box containing 10 2.82072
VSTM2A V-set and transmembrane domain containing 2A 2.82072
GMFG glia maturation factor, gamma 2.82072
OSR2 odd-skipped related transciption factor 2 2.82072
LCN12 lipocalin 12 2.82072
TXNDC2 thioredoxin domain containing 2 (spermatozoa) 2.82072
AZGP1 alpha-2-glycoprotein 1, zinc-binding 2.82072
GNRH2 gonadotropin-releasing hormone 2 2.82072
PKP1 plakophilin 1 2.82072
RAX retina and anterior neural fold homeobox 2.82072
AKR1C2 aldo-keto reductase family 1, member C2 2.82072
TMEM176B transmembrane protein 176B 2.82072
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.82072
CLDN2 claudin 2 2.82072
ZNF575 zinc finger protein 575 2.82072
SRGN serglycin 2.82072
DNAAF1 dynein, axonemal, assembly factor 1 2.82072
ACKR5 atypical chemokine receptor 5 2.82072
ZNF229 zinc finger protein 229 2.82072
ALX4 ALX homeobox 4 2.82072
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 2.82072
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 2.82072
DEFB108B defensin, beta 108B 2.82072
SEPTIN14 septin 14 2.82072
NECTIN4 nectin cell adhesion molecule 4 2.82072
STING1 stimulator of interferon response cGAMP interactor 1 2.82072
SPATA31H1 SPATA31 subfamily H member 1 2.82072
CALHM5 calcium homeostasis modulator family member 5 2.82072
CCDC190 coiled-coil domain containing 190 2.82072
H1-8 H1.8 linker histone 2.82072
IHO1 interactor of HORMAD1 1 2.82072
LOC124904411 uncharacterized LOC124904411 2.82072
C9ORF43 chromosome 9 open reading frame 43 2.82072
C20ORF202 chromosome 20 open reading frame 202 2.82072
SLC45A2 solute carrier family 45, member 2 2.82072
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.82072
CREB3L3 cAMP responsive element binding protein 3-like 3 2.82072
MYOT myotilin 2.82072
SPDYC speedy/RINGO cell cycle regulator family member C 2.82072
CELA2A chymotrypsin-like elastase family, member 2A 2.82072
SBSN suprabasin 2.82072
STARD6 StAR-related lipid transfer (START) domain containing 6 2.82072
FGFBP1 fibroblast growth factor binding protein 1 2.82072
ARMC12 armadillo repeat containing 12 2.82072
CNGA4 cyclic nucleotide gated channel alpha 4 2.82072
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) 2.82072
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.82072
SRPK3 SRSF protein kinase 3 2.82072
BDKRB1 bradykinin receptor B1 2.82072
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 2.82072
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.82072
CIMAP1D CIMAP1 family member D 2.82072
CFB complement factor B 2.82072
MEFV Mediterranean fever 2.82072
CPA2 carboxypeptidase A2 (pancreatic) 2.82072
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.82072
SMIM23 small integral membrane protein 23 2.82072
CLRN2 clarin 2 2.82072
KLHL6 kelch-like family member 6 2.82072
CSTA cystatin A (stefin A) 2.82072
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.82072
RNF112 ring finger protein 112 2.82072
ZNF132 zinc finger protein 132 2.82072
BPIFB1 BPI fold containing family B, member 1 2.82072
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 2.82072
PCDHGB4 protocadherin gamma subfamily B, 4 2.82072
CALML6 calmodulin-like 6 2.82072
ACSM4 acyl-CoA synthetase medium-chain family member 4 2.82072
ABHD1 abhydrolase domain containing 1 2.82072
C9ORF50 chromosome 9 open reading frame 50 2.82072
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 2.82072
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.82072
OR52K1 olfactory receptor, family 52, subfamily K, member 1 2.82072
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.82072
ETV3L ets variant 3-like 2.82072
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 2.82072
PLA2G2F phospholipase A2, group IIF 2.82072
POU4F3 POU class 4 homeobox 3 2.82072
RASA4 RAS p21 protein activator 4 2.82072
PHGR1 proline/histidine/glycine-rich 1 2.82072
MYADML2 myeloid-associated differentiation marker-like 2 2.82072
SLC38A3 solute carrier family 38, member 3 2.82072
OR4D5 olfactory receptor, family 4, subfamily D, member 5 2.82072
CTSF cathepsin F 2.82072
FBXL22 F-box and leucine-rich repeat protein 22 2.82072
PLA1A phospholipase A1 member A 2.82072
THBD thrombomodulin 2.82072
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.82072
VWA1 von Willebrand factor A domain containing 1 2.82072
TAT tyrosine aminotransferase 2.82072
PLGLB2 plasminogen-like B2 2.82072
STK31 serine/threonine kinase 31 2.82072
GPRC5D G protein-coupled receptor, class C, group 5, member D 2.82072
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.82072
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 2.82072
CHRDL2 chordin-like 2 2.82072
ASCL1 achaete-scute family bHLH transcription factor 1 2.82072
ICAM2 intercellular adhesion molecule 2 2.82072
R3HDML R3H domain containing-like 2.82072
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.82072
TCEAL4 transcription elongation factor A (SII)-like 4 2.82072
EBI3 Epstein-Barr virus induced 3 2.82072
BOLA2 bolA family member 2 2.82072
STAP1 signal transducing adaptor family member 1 2.82072
CSNK2A3 casein kinase 2, alpha 3 polypeptide 2.82072
TAS2R10 taste receptor, type 2, member 10 2.82072
GNRHR gonadotropin-releasing hormone receptor 2.82072
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 2.82072
CD22 CD22 molecule 2.82072
IL10RA interleukin 10 receptor, alpha 2.82072
XCR1 chemokine (C motif) receptor 1 2.82072
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.82072
ZPLD1 zona pellucida-like domain containing 1 2.82072
APOL6 apolipoprotein L, 6 2.82072
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 2.82072
CLPSL1 colipase-like 1 2.82072
IFITM10 interferon induced transmembrane protein 10 2.82072
SETSIP SET-like protein 2.82072
H4C4 H4 clustered histone 4 2.81879
ZNF580 zinc finger protein 580 2.80607
MARK3 MAP/microtubule affinity-regulating kinase 3 2.79053
OLFM2 olfactomedin 2 2.65562
TSPYL1 TSPY-like 1 2.65562
COPA coatomer protein complex, subunit alpha 2.58594
GPR143 G protein-coupled receptor 143 2.5835
CCDC74A coiled-coil domain containing 74A 2.57345
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 2.55669
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 2.5418
DACH2 dachshund family transcription factor 2 2.54017
LRRC47 leucine rich repeat containing 47 2.54017
TEX10 testis expressed 10 2.50659
LIAS lipoic acid synthetase 2.50096
LCT lactase 2.48468
INSYN2B inhibitory synaptic factor family member 2B 2.45252
LCN15 lipocalin 15 2.45252
GNA14 guanine nucleotide binding protein (G protein), alpha 14 2.45149
RBMX RNA binding motif protein, X-linked 2.43307
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 2.43307
MRPL30 mitochondrial ribosomal protein L30 2.35898
EPHX4 epoxide hydrolase 4 2.33441
BLMH bleomycin hydrolase 2.32523
MORN2 MORN repeat containing 2 2.31398
ZFP1 ZFP1 zinc finger protein 2.30248
EMP2 epithelial membrane protein 2 2.23356
DCP1B decapping mRNA 1B 2.19142
SPP1 secreted phosphoprotein 1 2.17871
TAFA2 TAFA chemokine like family member 2 2.15931
KIF5A kinesin family member 5A 2.08932
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 2.06715
YIPF2 Yip1 domain family, member 2 2.05422
PRR36 proline rich 36 2.03564
RHCE Rh blood group, CcEe antigens 2.01269
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2.00775

decreased expression

Symbol Name Standardized Value
SLC22A31 solute carrier family 22, member 31 -2.8302
ZNF223 zinc finger protein 223 -2.8302
SYPL2 synaptophysin-like 2 -2.82072
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 -2.82072
CLP1 cleavage and polyadenylation factor I subunit 1 -2.82072
NOP16 NOP16 nucleolar protein -2.82072
RPRM reprimo, TP53 dependent G2 arrest mediator candidate -2.82072
PLXDC1 plexin domain containing 1 -2.82072
KCNK17 potassium channel, two pore domain subfamily K, member 17 -2.82072
KIF19 kinesin family member 19 -2.82072
ZNF668 zinc finger protein 668 -2.82072
BTBD18 BTB (POZ) domain containing 18 -2.82072
BOLA2B bolA family member 2B -2.82072
SHISA6 shisa family member 6 -2.81576
OCIAD1 OCIA domain containing 1 -2.6873
GSKIP GSK3B interacting protein -2.65954
EFCAB9 EF-hand calcium binding domain 9 -2.65562
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough -2.65562
LMNTD2 lamin tail domain containing 2 -2.65562
AMN amnion associated transmembrane protein -2.65562
CX3CL1 chemokine (C-X3-C motif) ligand 1 -2.65562
ICAM5 intercellular adhesion molecule 5, telencephalin -2.65562
C2ORF72 chromosome 2 open reading frame 72 -2.65562
TAFA1 TAFA chemokine like family member 1 -2.65562
EIF4E1B eukaryotic translation initiation factor 4E family member 1B -2.65562
TTLL2 tubulin tyrosine ligase-like family member 2 -2.65562
SMKR1 small lysine-rich protein 1 -2.65562
GREM2 gremlin 2, DAN family BMP antagonist -2.65562
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 -2.65562
AKAP14 A kinase (PRKA) anchor protein 14 -2.65562
XKRX XK, Kell blood group complex subunit-related, X-linked -2.65562
CD48 CD48 molecule -2.65562
GGACT gamma-glutamylamine cyclotransferase -2.65562
SACK1A scaffolding CK1 anchoring protein A -2.65562
TRPM2 transient receptor potential cation channel, subfamily M, member 2 -2.65562
PTPN7 protein tyrosine phosphatase, non-receptor type 7 -2.65562
SLA2 Src-like-adaptor 2 -2.65562
SECISBP2 SECIS binding protein 2 -2.56824
SEC14L4 SEC14-like 4 (S. cerevisiae) -2.49607
HGF hepatocyte growth factor (hepapoietin A; scatter factor) -2.48468
ETNPPL ethanolamine-phosphate phospho-lyase -2.48468
ANXA9 annexin A9 -2.48468
UQCC5 ubiquinol-cytochrome c reductase complex assembly factor 5 -2.45034
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) -2.45034
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 -2.42833
COMT catechol-O-methyltransferase -2.41863
MT2A metallothionein 2A -2.35898
KLHL8 kelch-like family member 8 -2.35898
TCTA T-cell leukemia translocation altered -2.33744
SPDYE12 speedy/RINGO cell cycle regulator family member E12 -2.32354
PRR14 proline rich 14 -2.31422
SF1 splicing factor 1 -2.3121
NEXN nexilin (F actin binding protein) -2.28086
DYNLL2 dynein, light chain, LC8-type 2 -2.26041
LYG2 lysozyme G-like 2 -2.24183
MAP2K2 mitogen-activated protein kinase kinase 2 -2.24183
POU5F1B POU class 5 homeobox 1B -2.24183
SOX21 SRY (sex determining region Y)-box 21 -2.24183
PRX periaxin -2.23275
FXYD7 FXYD domain containing ion transport regulator 7 -2.19479
VWA5B1 von Willebrand factor A domain containing 5B1 -2.17205
POMK protein-O-mannose kinase -2.16796
MYLK4 myosin light chain kinase family, member 4 -2.09128
DUSP9 dual specificity phosphatase 9 -2.09128
C2CD4D C2 calcium-dependent domain containing 4D -2.09128
VIPR1 vasoactive intestinal peptide receptor 1 -2.08843
SENP7 SUMO1/sentrin specific peptidase 7 -2.05422
TMEM276 transmembrane protein 276 -2.0381
WDR82 WD repeat domain 82 -2.03796
MTNR1A melatonin receptor 1A -2.03261
ZNF605 zinc finger protein 605 -2.01269
PLLP plasmolipin -2.00741
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 -2.00741