AIRE Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description autoimmune regulator|This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012] (NCBI Entrez Gene Database, 326)
External Link http://www.ncbi.nlm.nih.gov/gene/326
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Genes

78 interacting proteins for AIRE from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide
CCDC87 coiled-coil domain containing 87
CHD6 chromodomain helicase DNA binding protein 6
CREBBP CREB binding protein
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DAXX death-domain associated protein
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
EFTUD2 elongation factor Tu GTP binding domain containing 2
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3
FAT1 FAT atypical cadherin 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GEMIN5 gem (nuclear organelle) associated protein 5
GIGYF2 GRB10 interacting GYF protein 2
GRB2 growth factor receptor-bound protein 2
H2AFX H2A histone family, member X
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HIST1H2AC histone cluster 1, H2ac
HIST1H2BB histone cluster 1, H2bb
HIST1H2BO histone cluster 1, H2bo
HIST1H3B histone cluster 1, H3b
HIST2H2BE histone cluster 2, H2be
HIST3H3 histone cluster 3, H3
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1B heat shock 70kDa protein 1B
HSPA1L heat shock 70kDa protein 1-like
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
IPO7 importin 7
KPNB1 karyopherin (importin) beta 1
LMNB1 lamin B1
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MYBBP1A MYB binding protein (P160) 1a
NASP nuclear autoantigenic sperm protein (histone-binding)
NCK1 NCK adaptor protein 1
NOP56 NOP56 ribonucleoprotein
NUP93 nucleoporin 93kDa
PABPC1 poly(A) binding protein, cytoplasmic 1
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCG1 phospholipase C, gamma 1
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RAD21 RAD21 homolog (S. pombe)
RANBP2 RAN binding protein 2
RANBP9 RAN binding protein 9
RAVER1 ribonucleoprotein, PTB-binding 1
RUVBL2 RuvB-like AAA ATPase 2
SMC1A structural maintenance of chromosomes 1A
SMC3 structural maintenance of chromosomes 3
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRRM2 serine/arginine repetitive matrix 2
SRSF1 serine/arginine-rich splicing factor 1
SRSF2 serine/arginine-rich splicing factor 2
SRSF3 serine/arginine-rich splicing factor 3
SSRP1 structure specific recognition protein 1
TMPRSS13 transmembrane protease, serine 13
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM28 tripartite motif containing 28
TUBA1C tubulin, alpha 1c
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
UBAC1 UBA domain containing 1
UBB ubiquitin B
XPO1 exportin 1
XPOT exportin, tRNA
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)