AK2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description adenylate kinase 2|Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010] (NCBI Entrez Gene Database, 204)
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Genes

350 genes differentially expressed following the AK2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ATP13A5 ATPase type 13A5 2.956
NXPH3 neurexophilin 3 2.956
TRIM15 tripartite motif containing 15 2.956
TEX13B testis expressed 13B 2.956
ZEB2 zinc finger E-box binding homeobox 2 2.956
DNASE1L2 deoxyribonuclease I-like 2 2.956
CD160 CD160 molecule 2.956
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 2.956
BTLA B and T lymphocyte associated 2.956
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 2.956
HORMAD1 HORMA domain containing 1 2.956
RUNDC3A RUN domain containing 3A 2.956
EGFL8 EGF-like-domain, multiple 8 2.956
CELF3 CUGBP, Elav-like family member 3 2.956
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.956
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.956
CD300E CD300e molecule 2.956
UCK1 uridine-cytidine kinase 1 2.956
COL19A1 collagen, type XIX, alpha 1 2.956
NDRG1 N-myc downstream regulated 1 2.956
TMPRSS11A transmembrane protease, serine 11A 2.956
HLF hepatic leukemia factor 2.956
ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7 2.956
INHBA inhibin, beta A 2.956
VCX2 variable charge, X-linked 2 2.956
SACK1A scaffolding CK1 anchoring protein A 2.956
OSGIN1 oxidative stress induced growth inhibitor 1 2.956
OR10A2 olfactory receptor, family 10, subfamily A, member 2 2.956
RGL3 ral guanine nucleotide dissociation stimulator-like 3 2.956
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.956
ACVRL1 activin A receptor type II-like 1 2.956
DPPA3 developmental pluripotency associated 3 2.956
DLL4 delta-like 4 (Drosophila) 2.956
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.956
CRYGA crystallin, gamma A 2.956
CRYGN crystallin, gamma N 2.956
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 2.956
LGALS2 lectin, galactoside-binding, soluble, 2 2.956
MRC1 mannose receptor, C type 1 2.956
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 2.956
NRROS negative regulator of reactive oxygen species 2.956
GFI1 growth factor independent 1 transcription repressor 2.956
PTAFR platelet-activating factor receptor 2.956
HBA1 hemoglobin, alpha 1 2.956
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.956
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 2.956
MSC musculin 2.956
GYPE glycophorin E (MNS blood group) 2.956
C19ORF67 chromosome 19 open reading frame 67 2.956
GPR26 G protein-coupled receptor 26 2.956
MYOM3 myomesin 3 2.956
GIMAP2 GTPase, IMAP family member 2 2.956
TCAF2 TRPM8 channel-associated factor 2 2.956
ATG4A autophagy related 4A, cysteine peptidase 2.956
LOC124900192 uncharacterized LOC124900192 2.956
CCDC9B coiled-coil domain containing 9B 2.956
VSIR V-set immunoregulatory receptor 2.956
SPATS1 spermatogenesis associated, serine-rich 1 2.956
ALDOB aldolase B, fructose-bisphosphate 2.956
AVPR1A arginine vasopressin receptor 1A 2.956
AVPR1B arginine vasopressin receptor 1B 2.956
CAPN6 calpain 6 2.956
PLN phospholamban 2.956
SPRR2F small proline-rich protein 2F 2.956
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.956
PAPOLB poly(A) polymerase beta (testis specific) 2.956
DERPC DERPC proline and glycine rich nuclear protein 2.956
EPOP elongin BC and polycomb repressive complex 2 associated protein 2.956
CATSPERZ catsper channel auxiliary subunit zeta 2.956
LINC02268 long intergenic non-protein coding RNA 2268 2.956
LRRC8C-DT LRRC8C divergent transcript 2.956
PRRT1B proline rich transmembrane protein 1B 2.956
H2BK1 H2B.K variant histone 1 2.956
LOC124902436 talanin 2.956
SMIM45 small integral membrane protein 45 2.956
RHEX regulator of hemoglobinization and erythroid cell expansion 2.956
H3C14 H3 clustered histone 14 2.956
CFAP276 cilia and flagella associated protein 276 2.956
H2BW2 H2B.W histone 2 2.956
H1-8 H1.8 linker histone 2.956
FCMR Fc fragment of IgM receptor 2.956
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 2.956
SH3TC2 SH3 domain and tetratricopeptide repeats 2 2.956
DMBX1 diencephalon/mesencephalon homeobox 1 2.956
SCRT2 scratch family zinc finger 2 2.956
SIM2 single-minded family bHLH transcription factor 2 2.956
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.956
MEOX1 mesenchyme homeobox 1 2.956
ANXA13 annexin A13 2.956
IRF8 interferon regulatory factor 8 2.956
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.956
GGT5 gamma-glutamyltransferase 5 2.956
NKX2-5 NK2 homeobox 5 2.956
C1QTNF2 C1q and tumor necrosis factor related protein 2 2.956
GSC goosecoid homeobox 2.956
VCX3A variable charge, X-linked 3A 2.956
MAGIX MAGI family member, X-linked 2.956
KHDC1L KH homology domain containing 1-like 2.956
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 2.956
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like 2.956
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 2.956
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 2.956
MROH5 maestro heat-like repeat family member 5 2.956
HNF1A HNF1 homeobox A 2.956
TMEM119 transmembrane protein 119 2.956
NPIPB8 nuclear pore complex interacting protein family, member B8 2.956
FAM131C family with sequence similarity 131, member C 2.956
FOXD1 forkhead box D1 2.956
CTSF cathepsin F 2.956
MAPK11 mitogen-activated protein kinase 11 2.956
IL12B interleukin 12B 2.956
FGR FGR proto-oncogene, Src family tyrosine kinase 2.956
ANKRD62 ankyrin repeat domain 62 2.956
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.956
SPATA9 spermatogenesis associated 9 2.956
CFAP47 cilia and flagella associated protein 47 2.956
ONECUT3 one cut homeobox 3 2.956
TPPP3 tubulin polymerization-promoting protein family member 3 2.956
DCAF8L2 DDB1 and CUL4 associated factor 8-like 2 2.956
CARNS1 carnosine synthase 1 2.956
CRHBP corticotropin releasing hormone binding protein 2.956
SYNGR4 synaptogyrin 4 2.956
OR11G2 olfactory receptor, family 11, subfamily G, member 2 2.956
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.956
CHRM1 cholinergic receptor, muscarinic 1 2.956
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 2.956
POTEF POTE ankyrin domain family, member F 2.956
POTEI POTE ankyrin domain family, member I 2.956
C17ORF107 chromosome 17 open reading frame 107 2.956
PCDHGB5 protocadherin gamma subfamily B, 5 2.956
CDH10 cadherin 10, type 2 (T2-cadherin) 2.956
KLHL6 kelch-like family member 6 2.956
DRD1 dopamine receptor D1 2.956
AQP8 aquaporin 8 2.956
KLHL40 kelch-like family member 40 2.956
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 2.956
SPINK9 serine peptidase inhibitor, Kazal type 9 2.956
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.956
DRD3 dopamine receptor D3 2.956
ZBP1 Z-DNA binding protein 1 2.956
LCT lactase 2.956
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.956
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 2.956
FNDC8 fibronectin type III domain containing 8 2.956
CCDC185 coiled-coil domain containing 185 2.956
ZNF132 zinc finger protein 132 2.956
MRLN myoregulin 2.956
TTLL10 tubulin tyrosine ligase-like family member 10 2.956
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 2.956
IRGM immunity-related GTPase family, M 2.956
PODN podocan 2.956
SPAG6 sperm associated antigen 6 2.956
CLCF1 cardiotrophin-like cytokine factor 1 2.956
GCGR glucagon receptor 2.956
OR5A1 olfactory receptor, family 5, subfamily A, member 1 2.956
HIGD1C HIG1 hypoxia inducible domain family, member 1C 2.956
MEIG1 meiosis/spermiogenesis associated 1 2.956
RBP4 retinol binding protein 4, plasma 2.956
SFTA2 surfactant associated 2 2.956
TEX26 testis expressed 26 2.956
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.956
HMX3 H6 family homeobox 3 2.956
LDHC lactate dehydrogenase C 2.956
ART1 ADP-ribosyltransferase 1 2.956
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.956
KCNU1 potassium channel, subfamily U, member 1 2.956
HIC1 hypermethylated in cancer 1 2.956
HES2 hes family bHLH transcription factor 2 2.956
CFAP54 cilia and flagella associated 54 2.956
CXORF58 chromosome X open reading frame 58 2.956
LAMB3 laminin, beta 3 2.956
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 2.956
ORM1 orosomucoid 1 2.956
OR51I2 olfactory receptor, family 51, subfamily I, member 2 2.956
CSDC2 cold shock domain containing C2, RNA binding 2.956
MMP13 matrix metallopeptidase 13 2.956
ANGPTL3 angiopoietin-like 3 2.956
OR10G3 olfactory receptor, family 10, subfamily G, member 3 2.956
PTPN9 protein tyrosine phosphatase, non-receptor type 9 2.956
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 2.956
CD34 CD34 molecule 2.956
GAS2L2 growth arrest-specific 2 like 2 2.956
PSD2 pleckstrin and Sec7 domain containing 2 2.956
VPREB3 pre-B lymphocyte 3 2.956
TYR tyrosinase 2.956
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 2.88489
OPN1SW opsin 1 (cone pigments), short-wave-sensitive 2.81955
H4C2 H4 clustered histone 2 2.81955
SHD Src homology 2 domain containing transforming protein D 2.81955
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) 2.81955
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 2.67302
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 2.62438
COL6A5 collagen, type VI, alpha 5 2.61311
SMIM47 small integral membrane protein 47 2.61311
CHLSN cholesin 2.61311
SEZ6L seizure related 6 homolog (mouse)-like 2.61311
GNA14 guanine nucleotide binding protein (G protein), alpha 14 2.61226
PRKCZ protein kinase C, zeta 2.52855
CSTB cystatin B (stefin B) 2.52313
MVB12A multivesicular body subunit 12A 2.51116
CHMP2A charged multivesicular body protein 2A 2.43885
TMEM145 transmembrane protein 145 2.43039
AAMP angio-associated, migratory cell protein 2.40365
OR4D1 olfactory receptor, family 4, subfamily D, member 1 2.39252
PRKG2 protein kinase, cGMP-dependent, type II 2.3875
ISM1 isthmin 1, angiogenesis inhibitor 2.37809
FDXR ferredoxin reductase 2.35785
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 2.35017
ACADL acyl-CoA dehydrogenase, long chain 2.34131
TMEM255A transmembrane protein 255A 2.34131
GANC glucosidase, alpha; neutral C 2.32866
MIEF2 mitochondrial elongation factor 2 2.32186
CCDC142 coiled-coil domain containing 142 2.32186
ZNF880 zinc finger protein 880 2.29694
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2.2866
TRIM8 tripartite motif containing 8 2.28153
QPRT quinolinate phosphoribosyltransferase 2.28086
CAND1 cullin-associated and neddylation-dissociated 1 2.27411
KCNMB2 potassium channel subfamily M regulatory beta subunit 2 2.27056
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39 2.26447
APLP1 amyloid beta (A4) precursor-like protein 1 2.25342
NGLY1 N-glycanase 1 2.24364
MYEF2 myelin expression factor 2 2.23234
NUP133 nucleoporin 133kDa 2.21773
PDS5A PDS5 cohesin associated factor A 2.21773
KIAA0825 KIAA0825 2.21239
CAB39L calcium binding protein 39-like 2.1944
PDZD2 PDZ domain containing 2 2.18049
RPRML reprimo-like 2.15824
BIN1 bridging integrator 1 2.11584
IK IK cytokine, down-regulator of HLA II 2.10626
EVC Ellis van Creveld protein 2.10475
PLXNA1 plexin A1 2.09642
FAM107B family with sequence similarity 107, member B 2.0927
QRICH1 glutamine-rich 1 2.08054
TRAP1 TNF receptor-associated protein 1 2.08054
FAM110C family with sequence similarity 110, member C 2.06497
DBR1 debranching RNA lariats 1 2.05915
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 2.03233
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 2.02018
TMEM268 transmembrane protein 268 2.0159
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 2.01532
RUSC2 RUN and SH3 domain containing 2 2.00656
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 2.00656

decreased expression

Symbol Name Standardized Value
SMKR1 small lysine-rich protein 1 -2.956
DPRX divergent-paired related homeobox -2.956
C11ORF96 chromosome 11 open reading frame 96 -2.956
PIH1D2 PIH1 domain containing 2 -2.956
NPAP1 nuclear pore associated protein 1 -2.956
NIPSNAP3B nipsnap homolog 3B (C. elegans) -2.956
SCN2A sodium channel, voltage gated, type II alpha subunit -2.956
BTC betacellulin -2.956
ADRB2 adrenoceptor beta 2, surface -2.956
SUSD2 sushi domain containing 2 -2.956
USP50 ubiquitin specific peptidase 50 -2.956
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -2.956
MXD1 MAX dimerization protein 1 -2.956
TRPM1 transient receptor potential cation channel, subfamily M, member 1 -2.956
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) -2.956
ANGPTL4 angiopoietin-like 4 -2.956
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma -2.956
SAXO2 stabilizer of axonemal microtubules 2 -2.956
MAP3K19 mitogen-activated protein kinase kinase kinase 19 -2.956
NR3C2 nuclear receptor subfamily 3, group C, member 2 -2.956
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -2.956
SHISAL2A shisa like 2A -2.956
GOLGA8H golgin A8 family, member H -2.956
ZSCAN31 zinc finger and SCAN domain containing 31 -2.956
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -2.956
CDKL4 cyclin-dependent kinase-like 4 -2.956
RASA4 RAS p21 protein activator 4 -2.956
IGIP IgA-inducing protein -2.956
PP2D1 protein phosphatase 2C-like domain containing 1 -2.956
AXDND1 axonemal dynein light chain domain containing 1 -2.956
RAB11FIP5 RAB11 family interacting protein 5 (class I) -2.956
BAHCC1 BAH domain and coiled-coil containing 1 -2.956
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -2.956
ZCCHC18 zinc finger, CCHC domain containing 18 -2.956
UQCRC2 ubiquinol-cytochrome c reductase core protein II -2.956
ETNK1 ethanolamine kinase 1 -2.956
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A -2.956
ERAS ES cell expressed Ras -2.956
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -2.956
CFD complement factor D (adipsin) -2.87455
IFITM2 interferon induced transmembrane protein 2 -2.85009
ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein -2.84496
FMNL2 formin-like 2 -2.83804
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -2.77973
B3GAT3 beta-1,3-glucuronyltransferase 3 -2.77973
TENM4 teneurin transmembrane protein 4 -2.75481
SCN8A sodium channel, voltage gated, type VIII alpha subunit -2.74821
CCDC71 coiled-coil domain containing 71 -2.6231
EGFLAM EGF-like, fibronectin type III and laminin G domains -2.6231
PDE7A phosphodiesterase 7A -2.62179
AK2 adenylate kinase 2 -2.61621
IRS4 insulin receptor substrate 4 -2.53582
ICA1 islet cell autoantigen 1, 69kDa -2.47183
TNNI3K TNNI3 interacting kinase -2.46957
ZBTB10 zinc finger and BTB domain containing 10 -2.46957
IKZF4 IKAROS family zinc finger 4 (Eos) -2.46364
ZNF429 zinc finger protein 429 -2.45834
NUAK1 NUAK family, SNF1-like kinase, 1 -2.45175
HARS1 histidyl-tRNA synthetase 1 -2.44406
ADM adrenomedullin -2.43227
TET1 tet methylcytosine dioxygenase 1 -2.41012
DPY19L2 dpy-19-like 2 (C. elegans) -2.40365
LOC122526780 uncharacterized LOC122526780 -2.40365
FAM120B family with sequence similarity 120B -2.40365
ZNF233 zinc finger protein 233 -2.40365
LAG3 lymphocyte-activation gene 3 -2.40365
DEF6 differentially expressed in FDCP 6 homolog (mouse) -2.40365
MMP28 matrix metallopeptidase 28 -2.40365
MRO maestro -2.40365
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 -2.40365
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa -2.3875
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase -2.34958
HBEGF heparin-binding EGF-like growth factor -2.34131
IPCEF1 interaction protein for cytohesin exchange factors 1 -2.33972
DAZAP1 DAZ associated protein 1 -2.31633
IER5 immediate early response 5 -2.29961
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -2.29961
H2BC17 H2B clustered histone 17 -2.28086
MXRA8 matrix-remodelling associated 8 -2.28086
FAM111A family with sequence similarity 111, member A -2.27411
APOLTP apolipoprotein lipid transfer particle homolog -2.27056
MIMS1 mitochondrial inner membrane scaffold 1 -2.27048
GASK1A golgi associated kinase 1A -2.26881
FZD7 frizzled class receptor 7 -2.26881
NOTCH2 notch 2 -2.26044
GPC2 glypican 2 -2.2569
MICALL1 MICAL-like 1 -2.22627
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) -2.22627
ZNF723 zinc finger protein 723 -2.22627
PDZD11 PDZ domain containing 11 -2.22183
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -2.2208
RASAL1 RAS protein activator like 1 (GAP1 like) -2.2208
H2AC13 H2A clustered histone 13 -2.2208
ZIC1 Zic family member 1 -2.20705
TACR1 tachykinin receptor 1 -2.17984
MYO5B myosin VB -2.12817
USP6 ubiquitin specific peptidase 6 -2.1192
TGFA transforming growth factor, alpha -2.10475
PNMA3 paraneoplastic Ma antigen 3 -2.10412
LMTK2 lemur tyrosine kinase 2 -2.08556
R3HDM1 R3H domain containing 1 -2.08461
THEM4 thioesterase superfamily member 4 -2.07538
BEND5 BEN domain containing 5 -2.0419
IFT43 intraflagellar transport 43 -2.0419
UBE2D1 ubiquitin-conjugating enzyme E2D 1 -2.02252
ANGPT2 angiopoietin 2 -2.0159