AKT1 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description v-akt murine thymoma viral oncogene homolog 1|The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011] (NCBI Entrez Gene Database, 207)
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Genes

100 substrates of the kinase AKT1 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
MYO1E myosin IE
KMT2A lysine (K)-specific methyltransferase 2A
HEXIM1 hexamethylene bis-acetamide inducible 1
OSBPL5 oxysterol binding protein-like 5
RRAD Ras-related associated with diabetes
IER2 immediate early response 2
TP53RK TP53 regulating kinase
TRIM17 tripartite motif containing 17
BTK Bruton agammaglobulinemia tyrosine kinase
PRICKLE3 prickle homolog 3 (Drosophila)
C11ORF30 chromosome 11 open reading frame 30
WNK1 WNK lysine deficient protein kinase 1
PLXNB1 plexin B1
SCAF1 SR-related CTD-associated factor 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
TBC1D4 TBC1 domain family, member 4
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
UBE2O ubiquitin-conjugating enzyme E2O
LEMD2 LEM domain containing 2
KIF23 kinesin family member 23
MKI67 marker of proliferation Ki-67
TRA2A transformer 2 alpha homolog (Drosophila)
PDE3A phosphodiesterase 3A, cGMP-inhibited
PDE3B phosphodiesterase 3B, cGMP-inhibited
HEATR3 HEAT repeat containing 3
TOR4A torsin family 4, member A
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
RASAL3 RAS protein activator like 3
CCDC120 coiled-coil domain containing 120
ALKBH5 AlkB family member 5, RNA demethylase
THOC5 THO complex 5
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
AIM1 absent in melanoma 1
FRMD4B FERM domain containing 4B
RPS6 ribosomal protein S6
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
CREBZF CREB/ATF bZIP transcription factor
OXR1 oxidation resistance 1
S1PR1 sphingosine-1-phosphate receptor 1
BAHD1 bromo adjacent homology domain containing 1
TRPS1 trichorhinophalangeal syndrome I
MVD mevalonate (diphospho) decarboxylase
P3H3 prolyl 3-hydroxylase 3
SOX9 SRY (sex determining region Y)-box 9
SRSF2 serine/arginine-rich splicing factor 2
NEO1 neogenin 1
ATR ATR serine/threonine kinase
ARHGAP9 Rho GTPase activating protein 9
DEPDC5 DEP domain containing 5
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
ANKRD33B ankyrin repeat domain 33B
PRKD1 protein kinase D1
PRKD3 protein kinase D3
RARA retinoic acid receptor, alpha
DUOX1 dual oxidase 1
CASC5 cancer susceptibility candidate 5
GRK7 G protein-coupled receptor kinase 7
DAPK3 death-associated protein kinase 3
GPR15 G protein-coupled receptor 15
MAP3K11 mitogen-activated protein kinase kinase kinase 11
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
AEBP2 AE binding protein 2
CHERP calcium homeostasis endoplasmic reticulum protein
KDM1A lysine (K)-specific demethylase 1A
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
CEP128 centrosomal protein 128kDa
PYGO2 pygopus family PHD finger 2
USP35 ubiquitin specific peptidase 35
CDCA2 cell division cycle associated 2
CDCA7 cell division cycle associated 7
ZFP91 ZFP91 zinc finger protein
CHKB choline kinase beta
DSP desmoplakin
RARG retinoic acid receptor, gamma
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
EI24 etoposide induced 2.4
FAM207A family with sequence similarity 207, member A
ZFC3H1 zinc finger, C3H1-type containing
FXYD1 FXYD domain containing ion transport regulator 1
TWIST1 twist family bHLH transcription factor 1
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
MAP3K2 mitogen-activated protein kinase kinase kinase 2
SETD2 SET domain containing 2
REM2 RAS (RAD and GEM)-like GTP binding 2
LARP4B La ribonucleoprotein domain family, member 4B
SETD1A SET domain containing 1A
PPP1R12A protein phosphatase 1, regulatory subunit 12A
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
CDR2L cerebellar degeneration-related protein 2-like
FAM214B family with sequence similarity 214, member B
SRRM2 serine/arginine repetitive matrix 2
PKD2 polycystic kidney disease 2 (autosomal dominant)
KCNK9 potassium channel, two pore domain subfamily K, member 9
LIMK2 LIM domain kinase 2
DGAT1 diacylglycerol O-acyltransferase 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
CDC25B cell division cycle 25B
CDC25A cell division cycle 25A
MYO1F myosin IF