AKT1 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description v-akt murine thymoma viral oncogene homolog 1|The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011] (NCBI Entrez Gene Database, 207)
External Link http://www.ncbi.nlm.nih.gov/gene/207
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Genes

180 substrates of the kinase AKT1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
ACIN1 apoptotic chromatin condensation inducer 1
ACLY ATP citrate lyase
ADRB2 adrenoceptor beta 2, surface
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT1S1 AKT1 substrate 1 (proline-rich)
ALYREF Aly/REF export factor
AR androgen receptor
ARFIP2 ADP-ribosylation factor interacting protein 2
ARHGAP22 Rho GTPase activating protein 22
ATXN1 ataxin 1
BAD BCL2-associated agonist of cell death
BCL10 B-cell CLL/lymphoma 10
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BECN1 beclin 1, autophagy related
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BTK Bruton agammaglobulinemia tyrosine kinase
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CASP9 caspase 9, apoptosis-related cysteine peptidase
CBY1 chibby homolog 1 (Drosophila)
CCDC88A coiled-coil domain containing 88A
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC25B cell division cycle 25B
CDCA7 cell division cycle associated 7
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CELF1 CUGBP, Elav-like family member 1
CFLAR CASP8 and FADD-like apoptosis regulator
CHEK1 checkpoint kinase 1
CHUK conserved helix-loop-helix ubiquitous kinase
CLK2 CDC-like kinase 2
COPS6 COP9 signalosome subunit 6
CREBBP CREB binding protein
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND2 catenin (cadherin-associated protein), delta 2
CYTH2 cytohesin 2
CYTH3 cytohesin 3
DIABLO diablo, IAP-binding mitochondrial protein
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DOCK6 dedicator of cytokinesis 6
EDC3 enhancer of mRNA decapping 3
EGFR epidermal growth factor receptor
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF4B eukaryotic translation initiation factor 4B
EP300 E1A binding protein p300
EPHA2 EPH receptor A2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ESRRG estrogen-related receptor gamma
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM129A family with sequence similarity 129, member A
FANCA Fanconi anemia, complementation group A
FLNC filamin C, gamma
FOXA2 forkhead box A2
FOXG1 forkhead box G1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
GAB2 GRB2-associated binding protein 2
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA2 GATA binding protein 2
GLI2 GLI family zinc finger 2
GOLGA3 golgin A3
GRB10 growth factor receptor-bound protein 10
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
H3F3B H3 histone, family 3B (H3.3B)
HIST1H2BB histone cluster 1, H2bb
HIST1H3A histone cluster 1, H3a
HJURP Holliday junction recognition protein
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HSPB1 heat shock 27kDa protein 1
HTRA2 HtrA serine peptidase 2
HTT huntingtin
ILF3 interleukin enhancer binding factor 3, 90kDa
IRAK1 interleukin-1 receptor-associated kinase 1
IRS1 insulin receptor substrate 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KAT6A K(lysine) acetyltransferase 6A
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KHSRP KH-type splicing regulatory protein
LMNA lamin A/C
LTB4R2 leukotriene B4 receptor 2
MAP2K4 mitogen-activated protein kinase kinase 4
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
METTL1 methyltransferase like 1
MST1R macrophage stimulating 1 receptor
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MXD1 MAX dimerization protein 1
NCF1 neutrophil cytosolic factor 1
NCOR1 nuclear receptor corepressor 1
NDRG2 NDRG family member 2
NF2 neurofibromin 2 (merlin)
NHEJ1 nonhomologous end-joining factor 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUAK1 NUAK family, SNF1-like kinase, 1
PACS2 phosphofurin acidic cluster sorting protein 2
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PALLD palladin, cytoskeletal associated protein
PCBP1 poly(rC) binding protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE3A phosphodiesterase 3A, cGMP-inhibited
PDE3B phosphodiesterase 3B, cGMP-inhibited
PEA15 phosphoprotein enriched in astrocytes 15
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHB prohibitin
PHF20 PHD finger protein 20
PIKFYVE phosphoinositide kinase, FYVE finger containing
PLCG1 phospholipase C, gamma 1
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PRPH peripherin
PTK2 protein tyrosine kinase 2
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RANBP3 RAN binding protein 3
RARA retinoic acid receptor, alpha
RGCC regulator of cell cycle
RICTOR RPTOR independent companion of MTOR, complex 2
RNF11 ring finger protein 11
RPS3 ribosomal protein S3
RPS6 ribosomal protein S6
RUNX2 runt-related transcription factor 2
S1PR1 sphingosine-1-phosphate receptor 1
SH3BP4 SH3-domain binding protein 4
SH3RF1 SH3 domain containing ring finger 1
SIK2 salt-inducible kinase 2
SKI SKI proto-oncogene
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SOX2 SRY (sex determining region Y)-box 2
SP1 Sp1 transcription factor
SRPK2 SRSF protein kinase 2
SSB Sjogren syndrome antigen B (autoantigen La)
STK3 serine/threonine kinase 3
STK4 serine/threonine kinase 4
SYTL1 synaptotagmin-like 1
TAL1 T-cell acute lymphocytic leukemia 1
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D4 TBC1 domain family, member 4
TCF3 transcription factor 3
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TERT telomerase reverse transcriptase
TIAM1 T-cell lymphoma invasion and metastasis 1
TKT transketolase
TOPBP1 topoisomerase (DNA) II binding protein 1
TP53RK TP53 regulating kinase
TSC2 tuberous sclerosis 2
TTC3 tetratricopeptide repeat domain 3
TWIST1 twist family bHLH transcription factor 1
ULK1 unc-51 like autophagy activating kinase 1
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
USP8 ubiquitin specific peptidase 8
VCP valosin containing protein
VIM vimentin
WEE1 WEE1 G2 checkpoint kinase
WNK1 WNK lysine deficient protein kinase 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YAP1 Yes-associated protein 1
YBX1 Y box binding protein 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZFP36L1 ZFP36 ring finger protein-like 1
ZYX zyxin