AKT1_knockout_210_GSE39699 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Kinase Perturbations
Category transcriptomics
Type kinase perturbation
Description kinase perturbation identified as [kinase gene symbol]_[perturbation]_[perturbation ID]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE39699
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Genes

600 genes differentially expressed following the AKT1_knockout_210_GSE39699 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

increased expression

Symbol Name Standardized Value
WNT7B wingless-type MMTV integration site family, member 7B 3.95171
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 3.92979
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 3.53464
LIMS1 LIM and senescent cell antigen-like domains 1 3.52436
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.48673
IL11RA interleukin 11 receptor, alpha 3.45648
NPHP4 nephronophthisis 4 3.33418
RPL30 ribosomal protein L30 3.31996
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 3.29899
TMEM106A transmembrane protein 106A 3.17268
ATOH8 atonal homolog 8 (Drosophila) 3.14286
ZNF7 zinc finger protein 7 3.11618
IRAK4 interleukin-1 receptor-associated kinase 4 3.09549
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 3.07606
RBM14 RNA binding motif protein 14 3.06331
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 3.03169
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 3.00734
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 2.88356
ALKBH4 alkB, alkylation repair homolog 4 (E. coli) 2.85315
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 2.82833
RPLP2 ribosomal protein, large, P2 2.8215
SORBS3 sorbin and SH3 domain containing 3 2.80202
SESTD1 SEC14 and spectrin domains 1 2.79767
UBL3 ubiquitin-like 3 2.77657
FAM92A1 family with sequence similarity 92, member A1 2.74734
NAF1 nuclear assembly factor 1 ribonucleoprotein 2.7228
SAMD8 sterile alpha motif domain containing 8 2.71221
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.70308
ZNF800 zinc finger protein 800 2.64628
CARKD carbohydrate kinase domain containing 2.63672
TRAF1 TNF receptor-associated factor 1 2.63539
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.5911
LIMD1 LIM domains containing 1 2.56255
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 2.53774
RPL27 ribosomal protein L27 2.5029
RPL38 ribosomal protein L38 2.4968
HNRNPK heterogeneous nuclear ribonucleoprotein K 2.4678
SNAP23 synaptosomal-associated protein, 23kDa 2.44355
SF3A3 splicing factor 3a, subunit 3, 60kDa 2.42734
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough 2.40541
AHCY adenosylhomocysteinase 2.39771
AXIN2 axin 2 2.3854
CCDC12 coiled-coil domain containing 12 2.38379
API5 apoptosis inhibitor 5 2.34117
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 2.32825
LHFP lipoma HMGIC fusion partner 2.32501
COL8A1 collagen, type VIII, alpha 1 2.31166
WWC1 WW and C2 domain containing 1 2.30412
SELK selenoprotein K 2.26454
APLP1 amyloid beta (A4) precursor-like protein 1 2.24738
ARMC8 armadillo repeat containing 8 2.23988
WBP11 WW domain binding protein 11 2.23555
RPS28 ribosomal protein S28 2.22279
WRNIP1 Werner helicase interacting protein 1 2.22036
RINL Ras and Rab interactor-like 2.21731
CKB creatine kinase, brain 2.2136
INO80E INO80 complex subunit E 2.19757
ARMC1 armadillo repeat containing 1 2.16006
CTSE cathepsin E 2.13764
DENND2A DENN/MADD domain containing 2A 2.13147
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 2.1301
JAK1 Janus kinase 1 2.11143
USP43 ubiquitin specific peptidase 43 2.09208
ZNF428 zinc finger protein 428 2.09043
GLIPR1 GLI pathogenesis-related 1 2.05865
LRRC41 leucine rich repeat containing 41 2.05537
RPS7 ribosomal protein S7 2.05502
MORF4L1 mortality factor 4 like 1 2.05238
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 2.04914
RBBP7 retinoblastoma binding protein 7 2.04332
GOLGA3 golgin A3 2.0366
LIG3 ligase III, DNA, ATP-dependent 2.03294
UBXN1 UBX domain protein 1 2.03187
CD300A CD300a molecule 2.03044
TM9SF2 transmembrane 9 superfamily member 2 2.0292
WIPF1 WAS/WASL interacting protein family, member 1 2.02723
MED10 mediator complex subunit 10 2.0155
PFDN2 prefoldin subunit 2 2.01074
HDGFRP2 hepatoma-derived growth factor-related protein 2 2.00967
SUMO2 small ubiquitin-like modifier 2 1.99251
CHAMP1 chromosome alignment maintaining phosphoprotein 1 1.98846
EP400 E1A binding protein p400 1.98431
PSMG4 proteasome (prosome, macropain) assembly chaperone 4 1.98041
NCF2 neutrophil cytosolic factor 2 1.97184
NACA nascent polypeptide-associated complex alpha subunit 1.96869
ZNF598 zinc finger protein 598 1.96525
OCIAD1 OCIA domain containing 1 1.96027
RPLP0 ribosomal protein, large, P0 1.9573
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 1.95656
GGT7 gamma-glutamyltransferase 7 1.95625
CWC15 CWC15 spliceosome-associated protein 1.95282
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 1.93322
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 1.9317
TRPV4 transient receptor potential cation channel, subfamily V, member 4 1.92147
KIAA1549 KIAA1549 1.91941
FOXJ2 forkhead box J2 1.91504
HAX1 HCLS1 associated protein X-1 1.91195
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 1.90283
NEK9 NIMA-related kinase 9 1.90236
KREMEN1 kringle containing transmembrane protein 1 1.90193
MEGF6 multiple EGF-like-domains 6 1.89838
CHCHD1 coiled-coil-helix-coiled-coil-helix domain containing 1 1.89802
LMNB1 lamin B1 1.89718
C1QB complement component 1, q subcomponent, B chain 1.89267
PRKCSH protein kinase C substrate 80K-H 1.88626
EDC4 enhancer of mRNA decapping 4 1.88251
RPS8 ribosomal protein S8 1.8649
ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 1.85722
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 1.85547
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 1.84673
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 1.8392
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 1.83823
PIAS2 protein inhibitor of activated STAT, 2 1.82978
NRXN2 neurexin 2 1.82463
IL4 interleukin 4 1.82223
STAR steroidogenic acute regulatory protein 1.81991
CLEC4C C-type lectin domain family 4, member C 1.79957
NTN1 netrin 1 1.79796
SLC16A11 solute carrier family 16, member 11 1.78366
OSBPL7 oxysterol binding protein-like 7 1.77559
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 1.77456
TOR1B torsin family 1, member B (torsin B) 1.77077
NINJ1 ninjurin 1 1.76991
HOXB7 homeobox B7 1.76424
FAM129A family with sequence similarity 129, member A 1.75518
CLDN3 claudin 3 1.74506
UTP23 UTP23, small subunit (SSU) processome component, homolog (yeast) 1.74142
TYMS thymidylate synthetase 1.74035
GATA6 GATA binding protein 6 1.72937
APOE apolipoprotein E 1.728
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 1.72632
ZSCAN22 zinc finger and SCAN domain containing 22 1.72597
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 1.72536
SARNP SAP domain containing ribonucleoprotein 1.72252
TFCP2L1 transcription factor CP2-like 1 1.71757
MPEG1 macrophage expressed 1 1.71692
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) 1.71584
GPKOW G patch domain and KOW motifs 1.70969
RPL13 ribosomal protein L13 1.70536
C2CD3 C2 calcium-dependent domain containing 3 1.70142
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 1.6992
NCEH1 neutral cholesterol ester hydrolase 1 1.69293
RIN1 Ras and Rab interactor 1 1.69161
ARHGAP25 Rho GTPase activating protein 25 1.68841
NCOA1 nuclear receptor coactivator 1 1.68257
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 1.68103
BICD1 bicaudal D homolog 1 (Drosophila) 1.67696
STK26 serine/threonine protein kinase 26 1.67586
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 1.67534
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 1.66447
CUL5 cullin 5 1.65883
YIPF3 Yip1 domain family, member 3 1.65354
ERI1 exoribonuclease 1 1.64556
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 1.64515
NAV1 neuron navigator 1 1.64211
WASF2 WAS protein family, member 2 1.63867
WNT11 wingless-type MMTV integration site family, member 11 1.63429
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 1.63154
UNC50 unc-50 homolog (C. elegans) 1.62903
ITM2C integral membrane protein 2C 1.62553
TRPM2 transient receptor potential cation channel, subfamily M, member 2 1.61954
RPS23 ribosomal protein S23 1.61766
TASP1 taspase, threonine aspartase, 1 1.61577
MARVELD2 MARVEL domain containing 2 1.60877
C18ORF54 chromosome 18 open reading frame 54 1.60845
GPRC5A G protein-coupled receptor, class C, group 5, member A 1.60485
SYNJ2BP synaptojanin 2 binding protein 1.59576
C1ORF43 chromosome 1 open reading frame 43 1.59547
ATF7 activating transcription factor 7 1.59311
CD2AP CD2-associated protein 1.59136
ARSA arylsulfatase A 1.58189
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 1.57888
MED21 mediator complex subunit 21 1.57613
USP6NL USP6 N-terminal like 1.57445
FAM96A family with sequence similarity 96, member A 1.57409
SSU72 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) 1.56931
IKZF5 IKAROS family zinc finger 5 (Pegasus) 1.56875
ALOX5AP arachidonate 5-lipoxygenase-activating protein 1.56655
ACVRL1 activin A receptor type II-like 1 1.55737
OVCA2 ovarian tumor suppressor candidate 2 1.55691
DAGLB diacylglycerol lipase, beta 1.54982
TMEM128 transmembrane protein 128 1.54777
ZFHX4 zinc finger homeobox 4 1.54575
C11ORF94 chromosome 11 open reading frame 94 1.54329
SEPHS2 selenophosphate synthetase 2 1.54174
GDAP1L1 ganglioside induced differentiation associated protein 1-like 1 1.53004
MED1 mediator complex subunit 1 1.52826
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa 1.52796
GARNL3 GTPase activating Rap/RanGAP domain-like 3 1.52612
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) 1.52183
ERP29 endoplasmic reticulum protein 29 1.5183
RPL35 ribosomal protein L35 1.51782
C1ORF198 chromosome 1 open reading frame 198 1.51669
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 1.51483
PAIP1 poly(A) binding protein interacting protein 1 1.51427
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 1.51377
SS18 synovial sarcoma translocation, chromosome 18 1.50845
GATA2 GATA binding protein 2 1.50734
RELT RELT tumor necrosis factor receptor 1.50724
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 1.50669
ARL5B ADP-ribosylation factor-like 5B 1.50046
RPS18 ribosomal protein S18 1.50029
ISYNA1 inositol-3-phosphate synthase 1 1.4976
ANXA3 annexin A3 1.49743
C3 complement component 3 1.49652
PGLYRP1 peptidoglycan recognition protein 1 1.49503
STARD3NL STARD3 N-terminal like 1.49492
CCDC92 coiled-coil domain containing 92 1.49225
SOAT1 sterol O-acyltransferase 1 1.48809
DOK3 docking protein 3 1.48532
CEP170B centrosomal protein 170B 1.48176
WAS Wiskott-Aldrich syndrome 1.48124
TYROBP TYRO protein tyrosine kinase binding protein 1.47416
PSMC3IP PSMC3 interacting protein 1.47406
RPL12 ribosomal protein L12 1.46475
ANKRD33B ankyrin repeat domain 33B 1.46284
MPG N-methylpurine-DNA glycosylase 1.46187
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 1.45693
ACSL1 acyl-CoA synthetase long-chain family member 1 1.45637
DNAAF2 dynein, axonemal, assembly factor 2 1.45532
EXOC3 exocyst complex component 3 1.45459
DHRS9 dehydrogenase/reductase (SDR family) member 9 1.45258
CTDNEP1 CTD nuclear envelope phosphatase 1 1.4463
MOCS3 molybdenum cofactor synthesis 3 1.44394
ARL4C ADP-ribosylation factor-like 4C 1.4405
FAM53A family with sequence similarity 53, member A 1.43746
ANXA7 annexin A7 1.435
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 1.43067
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 1.43009
LYRM4 LYR motif containing 4 1.42699
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 1.42485
UBA2 ubiquitin-like modifier activating enzyme 2 1.42412
LARP7 La ribonucleoprotein domain family, member 7 1.42397
WTIP Wilms tumor 1 interacting protein 1.42297
BLVRB biliverdin reductase B 1.41779
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 1.41561
CHIC1 cysteine-rich hydrophobic domain 1 1.4148
PRPF3 pre-mRNA processing factor 3 1.41075
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 1.40855
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 1.40645
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.40232
RBM15B RNA binding motif protein 15B 1.40097
HSF1 heat shock transcription factor 1 1.39412
CAMTA1 calmodulin binding transcription activator 1 1.39357
FAM32A family with sequence similarity 32, member A 1.38956
TMEM106B transmembrane protein 106B 1.38545
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 1.38333
ZFP37 ZFP37 zinc finger protein 1.38308
RPRD2 regulation of nuclear pre-mRNA domain containing 2 1.37873
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 1.37552
PNRC2 proline-rich nuclear receptor coactivator 2 1.37487
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 1.37267
TUBB2B tubulin, beta 2B class IIb 1.36949
ANKRD49 ankyrin repeat domain 49 1.36648
RBMS3 RNA binding motif, single stranded interacting protein 3 1.36128
ABHD15 abhydrolase domain containing 15 1.3561
PLEKHO1 pleckstrin homology domain containing, family O member 1 1.35549
CREBZF CREB/ATF bZIP transcription factor 1.35282
TRNAU1AP tRNA selenocysteine 1 associated protein 1 1.34728
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 1.34272
ZNF830 zinc finger protein 830 1.34168
EML2 echinoderm microtubule associated protein like 2 1.33925
CEP295NL CEP295 N-terminal like 1.33621
WBP5 WW domain binding protein 5 1.31922
C1ORF21 chromosome 1 open reading frame 21 1.31683
OSTM1 osteopetrosis associated transmembrane protein 1 1.31572
PTHLH parathyroid hormone-like hormone 1.31323
NCKAP1L NCK-associated protein 1-like 1.30872
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.30826
WDR25 WD repeat domain 25 1.30802
MAPK12 mitogen-activated protein kinase 12 1.30074
FOXC1 forkhead box C1 1.30014
HINT1 histidine triad nucleotide binding protein 1 1.2934
RASGEF1A RasGEF domain family, member 1A 1.29256
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 1.29228
FBXL16 F-box and leucine-rich repeat protein 16 1.29149
HCK HCK proto-oncogene, Src family tyrosine kinase 1.28971
LSR lipolysis stimulated lipoprotein receptor 1.28968
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 1.28808
CHERP calcium homeostasis endoplasmic reticulum protein 1.28613
RPL7A ribosomal protein L7a 1.28523
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 1.28158
APP amyloid beta (A4) precursor protein 1.28049
TPD52L2 tumor protein D52-like 2 1.26908
GBP2 guanylate binding protein 2, interferon-inducible 1.26821
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa 1.2666
MRPL21 mitochondrial ribosomal protein L21 1.26323
OGFRL1 opioid growth factor receptor-like 1 1.2617
PEX3 peroxisomal biogenesis factor 3 1.26053
SAMD1 sterile alpha motif domain containing 1 1.2585
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 1.25613
COBL cordon-bleu WH2 repeat protein 1.25289
CCDC127 coiled-coil domain containing 127 1.2526
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 1.25049
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 1.25007
ASB15 ankyrin repeat and SOCS box containing 15 1.24788
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 1.24492
TTI2 TELO2 interacting protein 2 1.24212
USP1 ubiquitin specific peptidase 1 1.2418
RAB7B RAB7B, member RAS oncogene family 1.24109

decreased expression

Symbol Name Standardized Value
PIGL phosphatidylinositol glycan anchor biosynthesis, class L -4.0636
FRA10AC1 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 -3.88781
CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae) -3.8598
CPEB3 cytoplasmic polyadenylation element binding protein 3 -3.84002
DROSHA drosha, ribonuclease type III -3.70444
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2 -3.50487
HDAC6 histone deacetylase 6 -3.47873
ZDHHC4 zinc finger, DHHC-type containing 4 -3.18367
OSBPL2 oxysterol binding protein-like 2 -3.12747
SSNA1 Sjogren syndrome nuclear autoantigen 1 -3.05556
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) -2.99673
GPR108 G protein-coupled receptor 108 -2.99173
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 -2.91104
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 -2.89707
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -2.88782
PTDSS1 phosphatidylserine synthase 1 -2.87129
CD99L2 CD99 molecule-like 2 -2.86864
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase -2.86057
ZMAT4 zinc finger, matrin-type 4 -2.85278
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -2.76654
ARHGAP27 Rho GTPase activating protein 27 -2.75179
CDC37 cell division cycle 37 -2.74753
SCAP SREBF chaperone -2.7339
HNF1A HNF1 homeobox A -2.6893
C10ORF32 chromosome 10 open reading frame 32 -2.67108
ZDHHC16 zinc finger, DHHC-type containing 16 -2.63882
MED25 mediator complex subunit 25 -2.63809
ABHD16A abhydrolase domain containing 16A -2.63306
TPRKB TP53RK binding protein -2.62333
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A -2.61823
NOA1 nitric oxide associated 1 -2.58461
MED14 mediator complex subunit 14 -2.56708
GLE1 GLE1 RNA export mediator -2.55889
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit -2.53714
RNF113A ring finger protein 113A -2.52695
PLCD3 phospholipase C, delta 3 -2.52601
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 -2.52582
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.52087
MAN2C1 mannosidase, alpha, class 2C, member 1 -2.50962
DDRGK1 DDRGK domain containing 1 -2.47122
USP40 ubiquitin specific peptidase 40 -2.46088
SFN stratifin -2.45417
ZDHHC7 zinc finger, DHHC-type containing 7 -2.45228
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -2.43878
AHCYL2 adenosylhomocysteinase-like 2 -2.43666
TMEM129 transmembrane protein 129, E3 ubiquitin protein ligase -2.43083
DAND5 DAN domain family member 5, BMP antagonist -2.36753
DUSP12 dual specificity phosphatase 12 -2.36364
RIMKLA ribosomal modification protein rimK-like family member A -2.34824
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) -2.3334
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) -2.33255
MKRN1 makorin ring finger protein 1 -2.32459
AKIP1 A kinase (PRKA) interacting protein 1 -2.31291
C14ORF119 chromosome 14 open reading frame 119 -2.30481
LAPTM4A lysosomal protein transmembrane 4 alpha -2.27918
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -2.23139
LMO1 LIM domain only 1 (rhombotin 1) -2.23083
EIF2D eukaryotic translation initiation factor 2D -2.22913
C14ORF166 chromosome 14 open reading frame 166 -2.22348
FAM69A family with sequence similarity 69, member A -2.21106
MRRF mitochondrial ribosome recycling factor -2.21
CEP78 centrosomal protein 78kDa -2.20841
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -2.20107
STX8 syntaxin 8 -2.16235
TMEM5 transmembrane protein 5 -2.15431
FBXL4 F-box and leucine-rich repeat protein 4 -2.14681
DGCR14 DiGeorge syndrome critical region gene 14 -2.1452
TXNL4B thioredoxin-like 4B -2.1445
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa -2.12679
SGCE sarcoglycan, epsilon -2.12491
C19ORF40 chromosome 19 open reading frame 40 -2.12325
CHRD chordin -2.11518
LAMA4 laminin, alpha 4 -2.11019
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa -2.08691
CDO1 cysteine dioxygenase type 1 -2.0737
SLC38A7 solute carrier family 38, member 7 -2.05324
WDR11 WD repeat domain 11 -2.04993
PPP6C protein phosphatase 6, catalytic subunit -2.04089
UBXN6 UBX domain protein 6 -2.03678
PCYT2 phosphate cytidylyltransferase 2, ethanolamine -2.02921
ZFAND2B zinc finger, AN1-type domain 2B -2.02685
AP3B1 adaptor-related protein complex 3, beta 1 subunit -2.01691
PABPN1 poly(A) binding protein, nuclear 1 -2.00897
CSNK1D casein kinase 1, delta -2.00413
LURAP1L leucine rich adaptor protein 1-like -1.98847
TULP3 tubby like protein 3 -1.97444
TMEM234 transmembrane protein 234 -1.96417
DOLPP1 dolichyldiphosphatase 1 -1.95297
PGRMC1 progesterone receptor membrane component 1 -1.95161
ITFG1 integrin alpha FG-GAP repeat containing 1 -1.95144
FAM3A family with sequence similarity 3, member A -1.95038
TCF25 transcription factor 25 (basic helix-loop-helix) -1.94011
NCSTN nicastrin -1.93989
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 -1.93939
PYCRL pyrroline-5-carboxylate reductase-like -1.93248
DGKD diacylglycerol kinase, delta 130kDa -1.93126
DCAF8 DDB1 and CUL4 associated factor 8 -1.92989
DCTN2 dynactin 2 (p50) -1.92573
MIER2 mesoderm induction early response 1, family member 2 -1.92541
URM1 ubiquitin related modifier 1 -1.90359
SLC26A6 solute carrier family 26 (anion exchanger), member 6 -1.90176
CCDC57 coiled-coil domain containing 57 -1.89746
FAM103A1 family with sequence similarity 103, member A1 -1.89345
GMDS GDP-mannose 4,6-dehydratase -1.89059
KIAA1456 KIAA1456 -1.89007
TMEM192 transmembrane protein 192 -1.88976
TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) -1.88607
RNF13 ring finger protein 13 -1.88524
ZNF354B zinc finger protein 354B -1.88298
PHF7 PHD finger protein 7 -1.87773
SRRD SRR1 domain containing -1.87599
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -1.86964
SEPT5 septin 5 -1.85711
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -1.85063
CDK20 cyclin-dependent kinase 20 -1.84573
C17ORF80 chromosome 17 open reading frame 80 -1.83817
RNF123 ring finger protein 123 -1.83155
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 -1.8287
MED23 mediator complex subunit 23 -1.82355
RAD51D RAD51 paralog D -1.82207
CLDN12 claudin 12 -1.82153
DDX59 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 -1.81944
IFT52 intraflagellar transport 52 -1.81634
TMEM185A transmembrane protein 185A -1.80768
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like -1.804
TRIM44 tripartite motif containing 44 -1.79998
CDC123 cell division cycle 123 -1.79621
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -1.78759
NELL1 NEL-like 1 (chicken) -1.78477
RIC8A RIC8 guanine nucleotide exchange factor A -1.78336
WDR41 WD repeat domain 41 -1.77336
KAT2A K(lysine) acetyltransferase 2A -1.76899
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) -1.76409
ZNF436 zinc finger protein 436 -1.76229
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 -1.75967
ENSA endosulfine alpha -1.75738
AKT1 v-akt murine thymoma viral oncogene homolog 1 -1.75436
RPP30 ribonuclease P/MRP 30kDa subunit -1.75431
TBC1D22B TBC1 domain family, member 22B -1.74352
TRIM26 tripartite motif containing 26 -1.74036
KIF3B kinesin family member 3B -1.73801
BBS10 Bardet-Biedl syndrome 10 -1.73377
KIAA0319L KIAA0319-like -1.72756
MAP2K7 mitogen-activated protein kinase kinase 7 -1.72684
DHRS7B dehydrogenase/reductase (SDR family) member 7B -1.71881
WIPI2 WD repeat domain, phosphoinositide interacting 2 -1.71259
ACP2 acid phosphatase 2, lysosomal -1.71152
MUM1 melanoma associated antigen (mutated) 1 -1.70538
CC2D1B coiled-coil and C2 domain containing 1B -1.70469
TMCO3 transmembrane and coiled-coil domains 3 -1.69911
TLK2 tousled-like kinase 2 -1.698
IKZF4 IKAROS family zinc finger 4 (Eos) -1.69792
ORC6 origin recognition complex, subunit 6 -1.69197
PCSK4 proprotein convertase subtilisin/kexin type 4 -1.68748
SBDS Shwachman-Bodian-Diamond syndrome -1.68489
MED31 mediator complex subunit 31 -1.67856
TPRG1L tumor protein p63 regulated 1-like -1.6765
PRF1 perforin 1 (pore forming protein) -1.67198
PON3 paraoxonase 3 -1.66521
C6ORF222 chromosome 6 open reading frame 222 -1.65907
TBC1D31 TBC1 domain family, member 31 -1.6586
UBQLN4 ubiquilin 4 -1.65358
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -1.65348
SHMT1 serine hydroxymethyltransferase 1 (soluble) -1.64708
PTH1R parathyroid hormone 1 receptor -1.64685
CHMP7 charged multivesicular body protein 7 -1.64263
FAM178B family with sequence similarity 178, member B -1.64204
L3MBTL3 l(3)mbt-like 3 (Drosophila) -1.64081
MRPL39 mitochondrial ribosomal protein L39 -1.63869
ZNF585A zinc finger protein 585A -1.63654
MRPS15 mitochondrial ribosomal protein S15 -1.63301
MLH1 mutL homolog 1 -1.63138
MAEA macrophage erythroblast attacher -1.62929
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -1.62726
C16ORF62 chromosome 16 open reading frame 62 -1.62551
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) -1.62274
TMEM259 transmembrane protein 259 -1.62189
ATP11C ATPase, class VI, type 11C -1.62073
CUL3 cullin 3 -1.61994
ENTHD2 ENTH domain containing 2 -1.61985
UBAC2 UBA domain containing 2 -1.6155
HMCES 5-hydroxymethylcytosine (hmC) binding, ES cell-specific -1.6125
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 -1.61037
MARK4 MAP/microtubule affinity-regulating kinase 4 -1.60378
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial -1.6015
NUP155 nucleoporin 155kDa -1.60092
TBC1D25 TBC1 domain family, member 25 -1.59794
ZNF773 zinc finger protein 773 -1.5918
SNX15 sorting nexin 15 -1.59164
AAMP angio-associated, migratory cell protein -1.58995
TMEM198 transmembrane protein 198 -1.58791
C9ORF142 chromosome 9 open reading frame 142 -1.58773
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -1.58714
CPQ carboxypeptidase Q -1.5869
RABGGTA Rab geranylgeranyltransferase, alpha subunit -1.58687
OR4C11 olfactory receptor, family 4, subfamily C, member 11 -1.58463
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) -1.58122
COL28A1 collagen, type XXVIII, alpha 1 -1.57831
MAPK14 mitogen-activated protein kinase 14 -1.57003
DCTN6 dynactin 6 -1.5665
NGRN neugrin, neurite outgrowth associated -1.56623
PCBP4 poly(rC) binding protein 4 -1.56047
AP3S2 adaptor-related protein complex 3, sigma 2 subunit -1.56013
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 -1.55606
MAPK9 mitogen-activated protein kinase 9 -1.55185
NDUFV3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa -1.54942
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase -1.54924
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -1.54892
DCAF5 DDB1 and CUL4 associated factor 5 -1.54807
ZBTB5 zinc finger and BTB domain containing 5 -1.54798
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) -1.54788
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD) -1.54673
WASH1 WAS protein family homolog 1 -1.54228
FIZ1 FLT3-interacting zinc finger 1 -1.54108
MTMR3 myotubularin related protein 3 -1.53835
NSUN4 NOP2/Sun domain family, member 4 -1.53806
MED30 mediator complex subunit 30 -1.53775
NHEJ1 nonhomologous end-joining factor 1 -1.53529
MAPK3 mitogen-activated protein kinase 3 -1.53203
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -1.53114
R3HDM4 R3H domain containing 4 -1.52946
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) -1.52503
KIAA0196 KIAA0196 -1.51929
PIH1D1 PIH1 domain containing 1 -1.51891
ASB1 ankyrin repeat and SOCS box containing 1 -1.5151
ATRNL1 attractin-like 1 -1.51143
PTDSS2 phosphatidylserine synthase 2 -1.51035
ANKRD46 ankyrin repeat domain 46 -1.50922
USP30 ubiquitin specific peptidase 30 -1.508
KIAA0226 KIAA0226 -1.50016
DOCK7 dedicator of cytokinesis 7 -1.49894
OR6C2 olfactory receptor, family 6, subfamily C, member 2 -1.4983
C20ORF195 chromosome 20 open reading frame 195 -1.49684
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa -1.49671
ADD1 adducin 1 (alpha) -1.49525
SFT2D2 SFT2 domain containing 2 -1.49427
AMY2A amylase, alpha 2A (pancreatic) -1.49237
PSD3 pleckstrin and Sec7 domain containing 3 -1.49195
RING1 ring finger protein 1 -1.49045
CDYL2 chromodomain protein, Y-like 2 -1.4882
STXBP2 syntaxin binding protein 2 -1.48404
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -1.4824
COPS7A COP9 signalosome subunit 7A -1.48128
THRA thyroid hormone receptor, alpha -1.47759
HDAC3 histone deacetylase 3 -1.47676
CLK3 CDC-like kinase 3 -1.47389
SPATA7 spermatogenesis associated 7 -1.4719
ERAP1 endoplasmic reticulum aminopeptidase 1 -1.471
CC2D1A coiled-coil and C2 domain containing 1A -1.46472
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide -1.46459
PHTF2 putative homeodomain transcription factor 2 -1.4636
DPT dermatopontin -1.46146
VEGFB vascular endothelial growth factor B -1.45709
SLC22A23 solute carrier family 22, member 23 -1.45434
WDR92 WD repeat domain 92 -1.45019
NDRG3 NDRG family member 3 -1.44512
C1ORF86 chromosome 1 open reading frame 86 -1.44498
ADI1 acireductone dioxygenase 1 -1.44107
NUP188 nucleoporin 188kDa -1.43842
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) -1.43664
CAMK2D calcium/calmodulin-dependent protein kinase II delta -1.43584
TTC39C tetratricopeptide repeat domain 39C -1.43004
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 -1.42792
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -1.42724
TMX3 thioredoxin-related transmembrane protein 3 -1.42704
CBR4 carbonyl reductase 4 -1.42369
CRELD1 cysteine-rich with EGF-like domains 1 -1.42304
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -1.41962
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 -1.41715
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) -1.4164
CNTF ciliary neurotrophic factor -1.41524
WDSUB1 WD repeat, sterile alpha motif and U-box domain containing 1 -1.4151
WDR20 WD repeat domain 20 -1.41316
MRPS27 mitochondrial ribosomal protein S27 -1.41153
ANAPC5 anaphase promoting complex subunit 5 -1.41122
APOOL apolipoprotein O-like -1.41058
TYSND1 trypsin domain containing 1 -1.40663
TFAP2E transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) -1.40089
RBM6 RNA binding motif protein 6 -1.39974
MAT2B methionine adenosyltransferase II, beta -1.39551
DHRS4 dehydrogenase/reductase (SDR family) member 4 -1.39551
MARK2 MAP/microtubule affinity-regulating kinase 2 -1.39216
RPAP1 RNA polymerase II associated protein 1 -1.39115
SETD5 SET domain containing 5 -1.39104
PRKDC protein kinase, DNA-activated, catalytic polypeptide -1.38915
OSGEP O-sialoglycoprotein endopeptidase -1.38897
NIPAL4 NIPA-like domain containing 4 -1.38865
PEX11B peroxisomal biogenesis factor 11 beta -1.38811
AUH AU RNA binding protein/enoyl-CoA hydratase -1.38731
POFUT1 protein O-fucosyltransferase 1 -1.38529
DPCD deleted in primary ciliary dyskinesia homolog (mouse) -1.3835
MUC20 mucin 20, cell surface associated -1.38334
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 -1.37807
NIP7 NIP7, nucleolar pre-rRNA processing protein -1.37713
MTMR14 myotubularin related protein 14 -1.37472
FAM188A family with sequence similarity 188, member A -1.37123
SRR serine racemase -1.36925
PNRC1 proline-rich nuclear receptor coactivator 1 -1.36848
USP19 ubiquitin specific peptidase 19 -1.36847
ATF1 activating transcription factor 1 -1.36768