AKT2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description v-akt murine thymoma viral oncogene homolog 2|This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 208)
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Genes

359 genes differentially expressed following the AKT2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
KLLN killin, p53-regulated DNA replication inhibitor 2.7631
ZAN zonadhesin (gene/pseudogene) 2.7631
ANKRD62 ankyrin repeat domain 62 2.7631
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.7631
TTLL9 tubulin tyrosine ligase-like family member 9 2.7631
TMEM171 transmembrane protein 171 2.7631
LOC124900192 uncharacterized LOC124900192 2.7631
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 2.7631
APOL6 apolipoprotein L, 6 2.7631
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.7631
LRRC55 leucine rich repeat containing 55 2.7631
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.7631
ZNF81 zinc finger protein 81 2.7631
GTSF1 gametocyte specific factor 1 2.7631
PRRX1 paired related homeobox 1 2.7631
IL5 interleukin 5 2.7631
RAET1G retinoic acid early transcript 1G 2.7631
MORN5 MORN repeat containing 5 2.7631
ZAR1 zygote arrest 1 2.7631
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.7631
KCNK9 potassium channel, two pore domain subfamily K, member 9 2.7631
TM4SF19 transmembrane 4 L six family member 19 2.7631
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.7631
PDILT protein disulfide isomerase-like, testis expressed 2.7631
ADAM28 ADAM metallopeptidase domain 28 2.7631
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 2.75097
TCHH trichohyalin 2.73399
HCRTR1 hypocretin (orexin) receptor 1 2.73399
PRODH2 proline dehydrogenase (oxidase) 2 2.73399
ATG10 autophagy related 10 2.73399
ASB10 ankyrin repeat and SOCS box containing 10 2.73399
SLC35G5 solute carrier family 35, member G5 2.73399
XCL1 chemokine (C motif) ligand 1 2.73399
PGBDF plakoglobin binding and degradation factor 2.73399
DDN dendrin 2.73399
MEOX1 mesenchyme homeobox 1 2.73399
GRXCR2 glutaredoxin, cysteine rich 2 2.73399
PERM1 PPARGC1 and ESRR induced regulator, muscle 1 2.73399
TLX3 T-cell leukemia homeobox 3 2.73399
TLX2 T-cell leukemia homeobox 2 2.73399
MAP3K9 mitogen-activated protein kinase kinase kinase 9 2.73399
ACY3 aminoacylase 3 2.73399
NRAP nebulin-related anchoring protein 2.73399
PRR29 proline rich 29 2.73399
RTP4 receptor (chemosensory) transporter protein 4 2.73399
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.73399
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.73399
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 2.73399
FGF4 fibroblast growth factor 4 2.73399
CPLX1 complexin 1 2.73399
TAS2R13 taste receptor, type 2, member 13 2.73399
S100A1 S100 calcium binding protein A1 2.73399
PBOV1 prostate and breast cancer overexpressed 1 2.73399
GIMAP4 GTPase, IMAP family member 4 2.73399
TNIP3 TNFAIP3 interacting protein 3 2.73399
OR51D1 olfactory receptor, family 51, subfamily D, member 1 2.73399
SP7 Sp7 transcription factor 2.73399
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 2.73399
PPIAL4G peptidylprolyl isomerase A (cyclophilin A)-like 4G 2.73399
CRX cone-rod homeobox 2.73399
DPPA3 developmental pluripotency associated 3 2.73399
PRSS21 protease, serine, 21 (testisin) 2.73399
CD1D CD1d molecule 2.73399
SPATA31H1 SPATA31 subfamily H member 1 2.73399
GBP6 guanylate binding protein family, member 6 2.73399
MGAT4D MGAT4 family, member D 2.73399
SPI1 Spi-1 proto-oncogene 2.73399
ELOVL3 ELOVL fatty acid elongase 3 2.73399
PDF peptide deformylase (mitochondrial) 2.73399
PLCZ1 phospholipase C, zeta 1 2.73399
TBC1D3L TBC1 domain family, member 3L 2.73399
FCMR Fc fragment of IgM receptor 2.73399
SPATA22 spermatogenesis associated 22 2.73399
CES4A carboxylesterase 4A 2.73399
TAFA3 TAFA chemokine like family member 3 2.73399
DUSP29 dual specificity phosphatase 29 2.73399
LY6S lymphocyte antigen 6 family member S 2.73399
NOTCH2NLC notch 2 N-terminal like C 2.73399
CIMIP3 ciliary microtubule inner protein 3 2.73399
H2BK1 H2B.K variant histone 1 2.73399
OOSP4A oocyte secreted protein family member 4A 2.73399
H4C14 H4 clustered histone 14 2.73399
H3-7 H3.7 histone (putative) 2.73399
H2BW1 H2B.W histone 1 2.73399
CATSPERZ catsper channel auxiliary subunit zeta 2.73399
OR51M1 olfactory receptor, family 51, subfamily M, member 1 2.73399
C15ORF62 chromosome 15 open reading frame 62 2.73399
FMR1NB fragile X mental retardation 1 neighbor 2.73399
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.73399
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 2.73399
ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7 2.73399
AGTR1 angiotensin II receptor, type 1 2.73399
AP5S1 adaptor-related protein complex 5, sigma 1 subunit 2.73399
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.73399
SLC26A3 solute carrier family 26 (anion exchanger), member 3 2.73399
NPPB natriuretic peptide B 2.73399
IGFL2 IGF-like family member 2 2.73399
IZUMO4 IZUMO family member 4 2.73399
LIPK lipase, family member K 2.73399
DMP1 dentin matrix acidic phosphoprotein 1 2.73399
OOSP1 oocyte secreted protein 1, pseudogene 2.73399
VCX3A variable charge, X-linked 3A 2.73399
RGS21 regulator of G-protein signaling 21 2.73399
CCR4 chemokine (C-C motif) receptor 4 2.73399
EXOC3L1 exocyst complex component 3-like 1 2.73399
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.73399
GOLGA7B golgin A7 family, member B 2.73399
CLEC3A C-type lectin domain family 3, member A 2.73399
TRIM67 tripartite motif containing 67 2.73399
KLRK1 killer cell lectin-like receptor subfamily K, member 1 2.73399
WFDC13 WAP four-disulfide core domain 13 2.73399
MAB21L3 mab-21-like 3 (C. elegans) 2.73399
EDN1 endothelin 1 2.73399
FAM135B family with sequence similarity 135, member B 2.73399
ZNF596 zinc finger protein 596 2.73399
ZNF844 zinc finger protein 844 2.73399
URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase 2.73399
ASTL astacin-like metallo-endopeptidase (M12 family) 2.73399
ZSCAN4 zinc finger and SCAN domain containing 4 2.73399
PALMD palmdelphin 2.73399
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 2.73399
FBXO38 F-box protein 38 2.73399
PLA2G4D phospholipase A2, group IVD (cytosolic) 2.73399
FCN1 ficolin (collagen/fibrinogen domain containing) 1 2.73399
IL9R interleukin 9 receptor 2.73399
ZMYND15 zinc finger, MYND-type containing 15 2.73399
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.73399
TCF21 transcription factor 21 2.73399
RUFY4 RUN and FYVE domain containing 4 2.73399
FBXO47 F-box protein 47 2.73399
LCNL1 lipocalin-like 1 2.73399
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.73399
MAB21L2 mab-21-like 2 (C. elegans) 2.73399
ODF4 outer dense fiber of sperm tails 4 2.73399
PAGE4 P antigen family, member 4 (prostate associated) 2.73399
CPA2 carboxypeptidase A2 (pancreatic) 2.73399
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.73399
CD53 CD53 molecule 2.73399
PCDHGA7 protocadherin gamma subfamily A, 7 2.73399
CCDC184 coiled-coil domain containing 184 2.73399
OLFML1 olfactomedin-like 1 2.73399
KLHL41 kelch-like family member 41 2.73399
S100Z S100 calcium binding protein Z 2.73399
MUC13 mucin 13, cell surface associated 2.73399
DSC1 desmocollin 1 2.73399
RGCC regulator of cell cycle 2.73399
UBQLNL ubiquilin-like 2.73399
EBLN1 endogenous Bornavirus-like nucleoprotein 1 2.73399
CLDN34 claudin 34 2.73399
SI sucrase-isomaltase (alpha-glucosidase) 2.73399
C9ORF50 chromosome 9 open reading frame 50 2.73399
DMRT3 doublesex and mab-3 related transcription factor 3 2.73399
DCAF5 DDB1 and CUL4 associated factor 5 2.73399
C10ORF90 chromosome 10 open reading frame 90 2.73399
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.73399
SLC38A8 solute carrier family 38, member 8 2.73399
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 2.73399
PXDN peroxidasin 2.73399
STOML3 stomatin (EPB72)-like 3 2.73399
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 2.73399
AOC1 amine oxidase, copper containing 1 2.73399
LRRN4 leucine rich repeat neuronal 4 2.73399
APOA5 apolipoprotein A-V 2.73399
CNGB1 cyclic nucleotide gated channel beta 1 2.73399
ZPBP zona pellucida binding protein 2.73399
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 2.73399
PITX2 paired-like homeodomain 2 2.73399
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.73399
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.73399
SCNN1D sodium channel, non voltage gated 1 delta subunit 2.73399
RIPPLY2 ripply transcriptional repressor 2 2.73399
TBC1D28 TBC1 domain family, member 28 2.73399
TAPBPL TAP binding protein-like 2.73399
NUTM2F NUT family member 2F 2.73399
PAGE2B P antigen family, member 2B 2.73399
POTEJ POTE ankyrin domain family, member J 2.73399
VTCN1 V-set domain containing T cell activation inhibitor 1 2.73399
FGF16 fibroblast growth factor 16 2.73399
CHAT choline O-acetyltransferase 2.73399
TUBAL3 tubulin, alpha-like 3 2.73399
CLEC9A C-type lectin domain family 9, member A 2.73399
TMEM45B transmembrane protein 45B 2.73399
CIB4 calcium and integrin binding family member 4 2.73399
LRRC31 leucine rich repeat containing 31 2.73399
SCNN1B sodium channel, non voltage gated 1 beta subunit 2.73399
CENPM centromere protein M 2.68022
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3 2.67834
OR1F1 olfactory receptor, family 1, subfamily F, member 1 2.66206
SLC4A3 solute carrier family 4 (anion exchanger), member 3 2.59629
SHOX short stature homeobox 2.5871
CLCN7 chloride channel, voltage-sensitive 7 2.5407
CYRIA CYFIP related Rac1 interactor A 2.5214
MAP3K8 mitogen-activated protein kinase kinase kinase 8 2.51447
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G 2.50084
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 2.50084
OR56A1 olfactory receptor, family 56, subfamily A, member 1 2.50084
IL1R1 interleukin 1 receptor, type I 2.50084
UNC93A unc-93 homolog A (C. elegans) 2.48578
BAG4 BCL2-associated athanogene 4 2.48484
ATP5F1A ATP synthase F1 subunit alpha 2.48129
ZNF528 zinc finger protein 528 2.46972
KIF1C kinesin family member 1C 2.435
VSNL1 visinin-like 1 2.43031
MYO5B myosin VB 2.39466
BTF3 basic transcription factor 3 2.35687
PC pyruvate carboxylase 2.3428
EGR2 early growth response 2 2.3428
GOLGA8H golgin A8 family, member H 2.3428
PHF7 PHD finger protein 7 2.33727
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 2.32772
TCEA3 transcription elongation factor A (SII), 3 2.31088
BRAT1 BRCA1-associated ATM activator 1 2.28967
AMPH amphiphysin 2.24966
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 2.22238
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 2.21777
NAP1L3 nucleosome assembly protein 1-like 3 2.21616
RGS20 regulator of G-protein signaling 20 2.19953
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 2.16184
ZDHHC11 zinc finger, DHHC-type containing 11 2.16098
CDC73 cell division cycle 73 2.15159
RC3H1 ring finger and CCCH-type domains 1 2.15159
HPS1 Hermansky-Pudlak syndrome 1 2.14187
MED4 mediator complex subunit 4 2.14187
CDKL3 cyclin-dependent kinase-like 3 2.14187
CBX5 chromobox homolog 5 2.14157
EVA1C eva-1 homolog C (C. elegans) 2.14157
MATK megakaryocyte-associated tyrosine kinase 2.14117
ZNF281 zinc finger protein 281 2.14117
SPOPL speckle-type POZ protein-like 2.12736
GFM1 G elongation factor, mitochondrial 1 2.12288
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 2.10134
DENND2D DENN/MADD domain containing 2D 2.10113
RPSA2 ribosomal protein SA 2 2.10113
ZNF319 zinc finger protein 319 2.10113
ELF1 E74-like factor 1 (ets domain transcription factor) 2.10113
MGAT4C MGAT4 family, member C 2.09725
MGAM maltase-glucoamylase 2.09153
RPS2 ribosomal protein S2 2.09122
ANKAR ankyrin and armadillo repeat containing 2.0612
NCAM1 neural cell adhesion molecule 1 2.05672
ZFYVE19 zinc finger, FYVE domain containing 19 2.05463
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 2.04343
SLMAP sarcolemma associated protein 2.03539
CPNE3 copine III 2.02332
H1-0 H1.0 linker histone 2.02115
STAP2 signal transducing adaptor family member 2 2.01532
IFT54 intraflagellar transport 54 2.00619
RSPH14 radial spoke head 14 homolog (Chlamydomonas) 2.00323
METTL14 methyltransferase like 14 2.0029

decreased expression

Symbol Name Standardized Value
ADAM32 ADAM metallopeptidase domain 32 -2.7631
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 -2.75097
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 -2.75097
DHRS2 dehydrogenase/reductase (SDR family) member 2 -2.75097
HFE hemochromatosis -2.75097
OR56B1 olfactory receptor, family 56, subfamily B, member 1 -2.73399
SLC25A41 solute carrier family 25, member 41 -2.73399
RNF222 ring finger protein 222 -2.73399
RAB8B RAB8B, member RAS oncogene family -2.73399
PTGDR prostaglandin D2 receptor (DP) -2.73399
IER5L immediate early response 5-like -2.73399
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -2.73399
AKT2 v-akt murine thymoma viral oncogene homolog 2 -2.73399
ERICH6 glutamate-rich 6 -2.73399
SNTN sentan, cilia apical structure protein -2.73399
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 -2.73399
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -2.73399
BIRC3 baculoviral IAP repeat containing 3 -2.73399
GPR20 G protein-coupled receptor 20 -2.73399
EBI3 Epstein-Barr virus induced 3 -2.73399
CCR10 chemokine (C-C motif) receptor 10 -2.73399
NLRP12 NLR family, pyrin domain containing 12 -2.73399
LPO lactoperoxidase -2.73399
POPDC2 popeye domain containing 2 -2.73399
CLNK cytokine-dependent hematopoietic cell linker -2.73399
CBY3 chibby homolog 3 (Drosophila) -2.73399
EDN3 endothelin 3 -2.73399
FAM177A1 family with sequence similarity 177, member A1 -2.73399
PNPLA5 patatin-like phospholipase domain containing 5 -2.73399
ANO3 anoctamin 3 -2.73399
RIBC1 RIB43A domain with coiled-coils 1 -2.73399
NOTCH1 notch 1 -2.73399
NPSR1 neuropeptide S receptor 1 -2.73399
C20ORF202 chromosome 20 open reading frame 202 -2.73399
ADAM17 ADAM metallopeptidase domain 17 -2.73399
ETV3L ets variant 3-like -2.73399
CRYBG1 crystallin beta-gamma domain containing 1 -2.73399
CFAP276 cilia and flagella associated protein 276 -2.73399
TSPAN16 tetraspanin 16 -2.73399
IRF4 interferon regulatory factor 4 -2.73399
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 -2.73399
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 -2.73399
AQP7 aquaporin 7 -2.73399
PIH1D2 PIH1 domain containing 2 -2.73399
UPK3B uroplakin 3B -2.73399
ZNF774 zinc finger protein 774 -2.72007
HYAL1 hyaluronoglucosaminidase 1 -2.68685
SIRT2 sirtuin 2 -2.68022
LDHAL6A lactate dehydrogenase A-like 6A -2.65218
CD79B CD79b molecule, immunoglobulin-associated beta -2.65218
HRC histidine rich calcium binding protein -2.59741
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 -2.59741
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit -2.59629
AGA aspartylglucosaminidase -2.56456
HDAC8 histone deacetylase 8 -2.50084
TTC39A tetratricopeptide repeat domain 39A -2.50084
L2HGDH L-2-hydroxyglutarate dehydrogenase -2.47274
CSRNP2 cysteine-serine-rich nuclear protein 2 -2.47274
GIPR gastric inhibitory polypeptide receptor -2.46529
C17ORF114 chromosome 17 open reading frame 114 -2.46529
BRPF1 bromodomain and PHD finger containing, 1 -2.36002
RNLS renalase, FAD-dependent amine oxidase -2.35985
NELL2 NEL-like 2 (chicken) -2.35216
CDYL chromodomain protein, Y-like -2.35216
MAP3K7 mitogen-activated protein kinase kinase kinase 7 -2.34752
FOXO4 forkhead box O4 -2.3312
FGF12 fibroblast growth factor 12 -2.32364
LMTK2 lemur tyrosine kinase 2 -2.323
GNMT glycine N-methyltransferase -2.31088
IGSF5 immunoglobulin superfamily, member 5 -2.31088
XPA xeroderma pigmentosum, complementation group A -2.29152
SORD sorbitol dehydrogenase -2.29141
NRXN3 neurexin 3 -2.24512
RFT1 RFT1 homolog (S. cerevisiae) -2.22693
B3GAT2 beta-1,3-glucuronyltransferase 2 -2.22476
SYT11 synaptotagmin XI -2.22476
RBPMS RNA binding protein with multiple splicing -2.22231
GATAD2B GATA zinc finger domain containing 2B -2.20031
C11ORF58 chromosome 11 open reading frame 58 -2.18885
SORCS3 sortilin-related VPS10 domain containing receptor 3 -2.16142
YBEY ybeY metallopeptidase (putative) -2.16098
FCHO1 FCH domain only 1 -2.14187
PROKR1 prokineticin receptor 1 -2.14187
FAM209B family with sequence similarity 209, member B -2.14187
LHX8 LIM homeobox 8 -2.14187
FAM229A family with sequence similarity 229, member A -2.14187
CCDC142 coiled-coil domain containing 142 -2.14157
GLG1 golgi glycoprotein 1 -2.14157
FOXI3 forkhead box I3 -2.14157
ZNF880 zinc finger protein 880 -2.12736
MRPL38 mitochondrial ribosomal protein L38 -2.10134
ATF5 activating transcription factor 5 -2.09358
WDFY1 WD repeat and FYVE domain containing 1 -2.09358
MEN1 multiple endocrine neoplasia I -2.08671
MKRN2OS MKRN2 opposite strand -2.08671
SCAPER S-phase cyclin A-associated protein in the ER -2.08296
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 -2.08272
CLDN7 claudin 7 -2.06326
ULK2 unc-51 like autophagy activating kinase 2 -2.04904
NPC2 Niemann-Pick disease, type C2 -2.03908
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -2.03539
RTKN2 rhotekin 2 -2.02332
SPOCD1 SPOC domain containing 1 -2.02115
FOXK2 forkhead box K2 -2.02115
ZNF446 zinc finger protein 446 -2.02115
CACNB3 calcium channel, voltage-dependent, beta 3 subunit -2.01274
TSEN34 TSEN34 tRNA splicing endonuclease subunit -2.01274
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 -2.01274
TMEM125 transmembrane protein 125 -2.01125
BANF1 barrier to autointegration factor 1 -2.00931