AKT2 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description v-akt murine thymoma viral oncogene homolog 2|This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 208)
External Link http://www.ncbi.nlm.nih.gov/gene/208
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Genes

28 substrates of the kinase AKT2 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
C2CD5 C2 calcium-dependent domain containing 5
CBY1 chibby homolog 1 (Drosophila)
CD34 CD34 molecule
CHUK conserved helix-loop-helix ubiquitous kinase
CLK2 CDC-like kinase 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
EDC3 enhancer of mRNA decapping 3
ESR1 estrogen receptor 1
EZR ezrin
FLNC filamin C, gamma
GAPDH glyceraldehyde-3-phosphate dehydrogenase
HIST1H3A histone cluster 1, H3a
HTRA2 HtrA serine peptidase 2
KHSRP KH-type splicing regulatory protein
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MYO5A myosin VA (heavy chain 12, myoxin)
PCBP1 poly(rC) binding protein 1
PITX2 paired-like homeodomain 2
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPIF peptidylprolyl isomerase F
RACGAP1 Rac GTPase activating protein 1
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SH3RF1 SH3 domain containing ring finger 1
SIK2 salt-inducible kinase 2
STXBP4 syntaxin binding protein 4
TMOD3 tropomodulin 3 (ubiquitous)
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase