AKT_UP_MTOR_DN.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/AKT_UP_MTOR_DN.V1_UP
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Genes

365 genes differentially expressed following the AKT_UP_MTOR_DN.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADAM10 ADAM metallopeptidase domain 10
ADGRG1 adhesion G protein-coupled receptor G1
ADORA2B adenosine A2b receptor
AK4 adenylate kinase 4
AKAP2 A kinase (PRKA) anchor protein 2
ALDOC aldolase C, fructose-bisphosphate
ANGPTL1 angiopoietin-like 1
ANXA13 annexin A13
APOC2 apolipoprotein C-II
ARG1 arginase 1
ARRDC4 arrestin domain containing 4
ATF3 activating transcription factor 3
BACE2 beta-site APP-cleaving enzyme 2
BCAS2 breast carcinoma amplified sequence 2
BMP8B bone morphogenetic protein 8b
BSND barttin CLCNK-type chloride channel accessory beta subunit
C3ORF52 chromosome 3 open reading frame 52
C6ORF106 chromosome 6 open reading frame 106
C9ORF89 chromosome 9 open reading frame 89
CALCB calcitonin-related polypeptide beta
CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CIR1 corepressor interacting with RBPJ, 1
CLMN calmin (calponin-like, transmembrane)
CPE carboxypeptidase E
CPNE6 copine VI (neuronal)
CRLF1 cytokine receptor-like factor 1
CTNS cystinosin, lysosomal cystine transporter
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL16 chemokine (C-X-C motif) ligand 16
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DAGLB diacylglycerol lipase, beta
DAZL deleted in azoospermia-like
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DSCAM Down syndrome cell adhesion molecule
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP8 dual specificity phosphatase 8
EDN1 endothelin 1
EFNB2 ephrin-B2
ELL elongation factor RNA polymerase II
FAM129A family with sequence similarity 129, member A
FBXL15 F-box and leucine-rich repeat protein 15
FBXO6 F-box protein 6
FKBP8 FK506 binding protein 8, 38kDa
FLT1 fms-related tyrosine kinase 1
FXR2 fragile X mental retardation, autosomal homolog 2
FXYD4 FXYD domain containing ion transport regulator 4
GAK cyclin G associated kinase
GCH1 GTP cyclohydrolase 1
GDE1 glycerophosphodiester phosphodiesterase 1
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GIPC1 GIPC PDZ domain containing family, member 1
GLDC glycine dehydrogenase (decarboxylating)
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPX8 glutathione peroxidase 8 (putative)
GSDMC gasdermin C
GUSB glucuronidase, beta
HBEGF heparin-binding EGF-like growth factor
HCK HCK proto-oncogene, Src family tyrosine kinase
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HIC2 hypermethylated in cancer 2
HIF3A hypoxia inducible factor 3, alpha subunit
HIST1H4H histone cluster 1, H4h
HIST1H4I histone cluster 1, H4i
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMCES 5-hydroxymethylcytosine (hmC) binding, ES cell-specific
HOXB3 homeobox B3
HOXB5 homeobox B5
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF1R insulin-like growth factor 1 receptor
IL1R1 interleukin 1 receptor, type I
ING2 inhibitor of growth family, member 2
JUNB jun B proto-oncogene
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3
KCNK5 potassium channel, two pore domain subfamily K, member 5
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KCTD9 potassium channel tetramerization domain containing 9
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KRT23 keratin 23, type I
LAMC2 laminin, gamma 2
LGMN legumain
LRG1 leucine-rich alpha-2-glycoprotein 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LYPD1 LY6/PLAUR domain containing 1
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene)
MAN2B2 mannosidase, alpha, class 2B, member 2
METRNL meteorin, glial cell differentiation regulator-like
MGARP mitochondria-localized glutamic acid-rich protein
MICU1 mitochondrial calcium uptake 1
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MPZL2 myelin protein zero-like 2
MSR1 macrophage scavenger receptor 1
MVP major vault protein
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYO5B myosin VB
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NIN ninein (GSK3B interacting protein)
NOL12 nucleolar protein 12
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PARM1 prostate androgen-regulated mucin-like protein 1
PDE10A phosphodiesterase 10A
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PDZD11 PDZ domain containing 11
PFDN2 prefoldin subunit 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
PLK2 polo-like kinase 2
PLSCR1 phospholipid scramblase 1
PON1 paraoxonase 1
PON2 paraoxonase 2
PPP1R3F protein phosphatase 1, regulatory subunit 3F
PRSS37 protease, serine, 37
PSCA prostate stem cell antigen
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PTGDR2 prostaglandin D2 receptor 2
PTPRJ protein tyrosine phosphatase, receptor type, J
PYGL phosphorylase, glycogen, liver
RAB3IP RAB3A interacting protein
RASAL3 RAS protein activator like 3
RASD1 RAS, dexamethasone-induced 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM4 RNA binding motif protein 4
RIMKLB ribosomal modification protein rimK-like family member B
RNF19B ring finger protein 19B
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
RUNDC3A RUN domain containing 3A
S100A8 S100 calcium binding protein A8
SAA1 serum amyloid A1
SAA2 serum amyloid A2
SEC14L2 SEC14-like 2 (S. cerevisiae)
SFTPD surfactant protein D
SGPL1 sphingosine-1-phosphate lyase 1
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SNHG11 small nucleolar RNA host gene 11
SOCS6 suppressor of cytokine signaling 6
SPHK1 sphingosine kinase 1
SPINK4 serine peptidase inhibitor, Kazal type 4
SPRR2A small proline-rich protein 2A
ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
SUCO SUN domain containing ossification factor
SUSD4 sushi domain containing 4
SYT17 synaptotagmin XVII
SYT8 synaptotagmin VIII
TACSTD2 tumor-associated calcium signal transducer 2
TESC tescalcin
TGIF1 TGFB-induced factor homeobox 1
TJP3 tight junction protein 3
TMCC3 transmembrane and coiled-coil domain family 3
TMEM186 transmembrane protein 186
TMEM40 transmembrane protein 40
TMEM56 transmembrane protein 56
TMPRSS4 transmembrane protease, serine 4
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TOR3A torsin family 3, member A
TPD52L3 tumor protein D52-like 3
TPRN taperin
TRAF3 TNF receptor-associated factor 3
TTLL1 tubulin tyrosine ligase-like family member 1
UBE2R2 ubiquitin-conjugating enzyme E2R 2
VAMP5 vesicle-associated membrane protein 5
VANGL2 VANGL planar cell polarity protein 2
VAT1 vesicle amine transport 1
VILL villin-like
WFDC12 WAP four-disulfide core domain 12
ZBTB21 zinc finger and BTB domain containing 21
ZNF746 zinc finger protein 746

decreased expression

Symbol Name
ABHD14A abhydrolase domain containing 14A
ACY1 aminoacylase 1
ADHFE1 alcohol dehydrogenase, iron containing, 1
ADORA1 adenosine A1 receptor
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AMPD2 adenosine monophosphate deaminase 2
ANGPTL4 angiopoietin-like 4
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AQP5 aquaporin 5
ASF1A anti-silencing function 1A histone chaperone
ASS1 argininosuccinate synthase 1
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BEX4 brain expressed, X-linked 4
BLVRB biliverdin reductase B
BMP7 bone morphogenetic protein 7
C11ORF71 chromosome 11 open reading frame 71
C1R complement component 1, r subcomponent
C7ORF55 chromosome 7 open reading frame 55
CADM3 cell adhesion molecule 3
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CAV2 caveolin 2
CBS cystathionine-beta-synthase
CBY1 chibby homolog 1 (Drosophila)
CD200 CD200 molecule
CD248 CD248 molecule, endosialin
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDH16 cadherin 16, KSP-cadherin
CDPF1 cysteine-rich, DPF motif domain containing 1
CELA1 chymotrypsin-like elastase family, member 1
CENPQ centromere protein Q
CHAD chondroadherin
CHN2 chimerin 2
CHRDL1 chordin-like 1
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
COIL coilin
COL17A1 collagen, type XVII, alpha 1
COL5A2 collagen, type V, alpha 2
CPLX2 complexin 2
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DPT dermatopontin
DPYD dihydropyrimidine dehydrogenase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4E3 eukaryotic translation initiation factor 4E family member 3
ERF Ets2 repressor factor
ESR2 estrogen receptor 2 (ER beta)
FAM134C family with sequence similarity 134, member C
FAM20C family with sequence similarity 20, member C
FAS Fas cell surface death receptor
FBN1 fibrillin 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FKBP10 FK506 binding protein 10, 65 kDa
FKBP11 FK506 binding protein 11, 19 kDa
FMO3 flavin containing monooxygenase 3
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
FXYD1 FXYD domain containing ion transport regulator 1
GALNT16 polypeptide N-acetylgalactosaminyltransferase 16
GAS1 growth arrest-specific 1
GATAD2B GATA zinc finger domain containing 2B
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNMT glycine N-methyltransferase
GPR83 G protein-coupled receptor 83
GSDMA gasdermin A
GSPT2 G1 to S phase transition 2
GSTA4 glutathione S-transferase alpha 4
HARS2 histidyl-tRNA synthetase 2, mitochondrial
HAUS1 HAUS augmin-like complex, subunit 1
HIC1 hypermethylated in cancer 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IBSP integrin-binding sialoprotein
IFRD2 interferon-related developmental regulator 2
IL13RA1 interleukin 13 receptor, alpha 1
IL17RC interleukin 17 receptor C
IL7 interleukin 7
IRS1 insulin receptor substrate 1
ISYNA1 inositol-3-phosphate synthase 1
ITGA6 integrin, alpha 6
ITLN1 intelectin 1 (galactofuranose binding)
ITPKB inositol-trisphosphate 3-kinase B
ITSN1 intersectin 1 (SH3 domain protein)
JPH3 junctophilin 3
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD12 potassium channel tetramerization domain containing 12
KLF1 Kruppel-like factor 1 (erythroid)
KRBA1 KRAB-A domain containing 1
KRT6B keratin 6B, type II
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LIMD1 LIM domains containing 1
LPL lipoprotein lipase
LRRC1 leucine rich repeat containing 1
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MCM6 minichromosome maintenance complex component 6
MEPE matrix extracellular phosphoglycoprotein
MERTK MER proto-oncogene, tyrosine kinase
METTL5 methyltransferase like 5
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MLPH melanophilin
MLXIPL MLX interacting protein-like
MMAA methylmalonic aciduria (cobalamin deficiency) cblA type
MOCOS molybdenum cofactor sulfurase
MRPS6 mitochondrial ribosomal protein S6
MSL2 male-specific lethal 2 homolog (Drosophila)
MSRB2 methionine sulfoxide reductase B2
MSX1 msh homeobox 1
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYB v-myb avian myeloblastosis viral oncogene homolog
MYO1G myosin IG
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NCMAP noncompact myelin associated protein
NDRG4 NDRG family member 4
NID1 nidogen 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
OGN osteoglycin
PARP2 poly (ADP-ribose) polymerase 2
PDIA5 protein disulfide isomerase family A, member 5
PDZRN3 PDZ domain containing ring finger 3
PHGR1 proline/histidine/glycine-rich 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI16 peptidase inhibitor 16
PKP1 plakophilin 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEK2 pleckstrin 2
PMPCB peptidase (mitochondrial processing) beta
PNLIPRP1 pancreatic lipase-related protein 1
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLI polymerase (DNA directed) iota
POLM polymerase (DNA directed), mu
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
PUS7 pseudouridylate synthase 7 (putative)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS19 regulator of G-protein signaling 19
RNF25 ring finger protein 25
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RTKN rhotekin
RTN1 reticulon 1
S1PR3 sphingosine-1-phosphate receptor 3
SARS2 seryl-tRNA synthetase 2, mitochondrial
SASH1 SAM and SH3 domain containing 1
SATB1 SATB homeobox 1
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SFRP5 secreted frizzled-related protein 5
SH3BGR SH3 domain binding glutamate-rich protein
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SNHG6 small nucleolar RNA host gene 6
SPATA5 spermatogenesis associated 5
STAB1 stabilin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TACR3 tachykinin receptor 3
TBCE tubulin folding cofactor E
TIPIN TIMELESS interacting protein
TM4SF1 transmembrane 4 L six family member 1
TMEM97 transmembrane protein 97
TNFRSF19 tumor necrosis factor receptor superfamily, member 19
TNNC2 troponin C type 2 (fast)
TP53I13 tumor protein p53 inducible protein 13
TPH1 tryptophan hydroxylase 1
TSPAN4 tetraspanin 4
TSPYL4 TSPY-like 4
TULP3 tubby like protein 3
TYMP thymidine phosphorylase
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
VCAN versican
VPS33B vacuolar protein sorting 33 homolog B (yeast)
WEE1 WEE1 G2 checkpoint kinase
ZC3HC1 zinc finger, C3HC-type containing 1
ZNF112 zinc finger protein 112
ZNF771 zinc finger protein 771