| Dataset | MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database) |
| External Link | http://www.broadinstitute.org/gsea/msigdb/cards/AKT_UP_MTOR_DN.V1_UP |
| Similar Terms | |
| Downloads & Tools |
365 genes differentially expressed following the AKT_UP_MTOR_DN.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
| Symbol | Name |
|---|---|
| A4GALT | alpha 1,4-galactosyltransferase |
| ABCA7 | ATP-binding cassette, sub-family A (ABC1), member 7 |
| ADAM10 | ADAM metallopeptidase domain 10 |
| ADGRG1 | adhesion G protein-coupled receptor G1 |
| ADORA2B | adenosine A2b receptor |
| AK4 | adenylate kinase 4 |
| AKAP2 | A kinase (PRKA) anchor protein 2 |
| ALDOC | aldolase C, fructose-bisphosphate |
| ANGPTL1 | angiopoietin-like 1 |
| ANXA13 | annexin A13 |
| APOC2 | apolipoprotein C-II |
| ARG1 | arginase 1 |
| ARRDC4 | arrestin domain containing 4 |
| ATF3 | activating transcription factor 3 |
| BACE2 | beta-site APP-cleaving enzyme 2 |
| BCAS2 | breast carcinoma amplified sequence 2 |
| BMP8B | bone morphogenetic protein 8b |
| BSND | barttin CLCNK-type chloride channel accessory beta subunit |
| C3ORF52 | chromosome 3 open reading frame 52 |
| C6ORF106 | chromosome 6 open reading frame 106 |
| C9ORF89 | chromosome 9 open reading frame 89 |
| CALCB | calcitonin-related polypeptide beta |
| CAMKK1 | calcium/calmodulin-dependent protein kinase kinase 1, alpha |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) |
| CDKN2B | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) |
| CEACAM21 | carcinoembryonic antigen-related cell adhesion molecule 21 |
| CIR1 | corepressor interacting with RBPJ, 1 |
| CLMN | calmin (calponin-like, transmembrane) |
| CPE | carboxypeptidase E |
| CPNE6 | copine VI (neuronal) |
| CRLF1 | cytokine receptor-like factor 1 |
| CTNS | cystinosin, lysosomal cystine transporter |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
| CXCL16 | chemokine (C-X-C motif) ligand 16 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 |
| DAGLB | diacylglycerol lipase, beta |
| DAZL | deleted in azoospermia-like |
| DHCR24 | 24-dehydrocholesterol reductase |
| DHCR7 | 7-dehydrocholesterol reductase |
| DSCAM | Down syndrome cell adhesion molecule |
| DUSP1 | dual specificity phosphatase 1 |
| DUSP10 | dual specificity phosphatase 10 |
| DUSP8 | dual specificity phosphatase 8 |
| EDN1 | endothelin 1 |
| EFNB2 | ephrin-B2 |
| ELL | elongation factor RNA polymerase II |
| FAM129A | family with sequence similarity 129, member A |
| FBXL15 | F-box and leucine-rich repeat protein 15 |
| FBXO6 | F-box protein 6 |
| FKBP8 | FK506 binding protein 8, 38kDa |
| FLT1 | fms-related tyrosine kinase 1 |
| FXR2 | fragile X mental retardation, autosomal homolog 2 |
| FXYD4 | FXYD domain containing ion transport regulator 4 |
| GAK | cyclin G associated kinase |
| GCH1 | GTP cyclohydrolase 1 |
| GDE1 | glycerophosphodiester phosphodiesterase 1 |
| GDPD2 | glycerophosphodiester phosphodiesterase domain containing 2 |
| GGA1 | golgi-associated, gamma adaptin ear containing, ARF binding protein 1 |
| GIPC1 | GIPC PDZ domain containing family, member 1 |
| GLDC | glycine dehydrogenase (decarboxylating) |
| GPD2 | glycerol-3-phosphate dehydrogenase 2 (mitochondrial) |
| GPX8 | glutathione peroxidase 8 (putative) |
| GSDMC | gasdermin C |
| GUSB | glucuronidase, beta |
| HBEGF | heparin-binding EGF-like growth factor |
| HCK | HCK proto-oncogene, Src family tyrosine kinase |
| HCN2 | hyperpolarization activated cyclic nucleotide gated potassium channel 2 |
| HIC2 | hypermethylated in cancer 2 |
| HIF3A | hypoxia inducible factor 3, alpha subunit |
| HIST1H4H | histone cluster 1, H4h |
| HIST1H4I | histone cluster 1, H4i |
| HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 |
| HMCES | 5-hydroxymethylcytosine (hmC) binding, ES cell-specific |
| HOXB3 | homeobox B3 |
| HOXB5 | homeobox B5 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 |
| IGF1R | insulin-like growth factor 1 receptor |
| IL1R1 | interleukin 1 receptor, type I |
| ING2 | inhibitor of growth family, member 2 |
| JUNB | jun B proto-oncogene |
| KCNH3 | potassium channel, voltage gated eag related subfamily H, member 3 |
| KCNK5 | potassium channel, two pore domain subfamily K, member 5 |
| KCNQ1 | potassium channel, voltage gated KQT-like subfamily Q, member 1 |
| KCTD9 | potassium channel tetramerization domain containing 9 |
| KLF10 | Kruppel-like factor 10 |
| KLF6 | Kruppel-like factor 6 |
| KRT23 | keratin 23, type I |
| LAMC2 | laminin, gamma 2 |
| LGMN | legumain |
| LRG1 | leucine-rich alpha-2-glycoprotein 1 |
| LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) |
| LYPD1 | LY6/PLAUR domain containing 1 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) |
| MAN2B2 | mannosidase, alpha, class 2B, member 2 |
| METRNL | meteorin, glial cell differentiation regulator-like |
| MGARP | mitochondria-localized glutamic acid-rich protein |
| MICU1 | mitochondrial calcium uptake 1 |
| MLLT1 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 |
| MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) |
| MPZL2 | myelin protein zero-like 2 |
| MSR1 | macrophage scavenger receptor 1 |
| MVP | major vault protein |
| MYCN | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog |
| MYO5B | myosin VB |
| NEU1 | sialidase 1 (lysosomal sialidase) |
| NFIL3 | nuclear factor, interleukin 3 regulated |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) |
| NIN | ninein (GSK3B interacting protein) |
| NOL12 | nucleolar protein 12 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 |
| PARM1 | prostate androgen-regulated mucin-like protein 1 |
| PDE10A | phosphodiesterase 10A |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 |
| PDZD11 | PDZ domain containing 11 |
| PFDN2 | prefoldin subunit 2 |
| PLAGL1 | pleiomorphic adenoma gene-like 1 |
| PLAT | plasminogen activator, tissue |
| PLK2 | polo-like kinase 2 |
| PLSCR1 | phospholipid scramblase 1 |
| PON1 | paraoxonase 1 |
| PON2 | paraoxonase 2 |
| PPP1R3F | protein phosphatase 1, regulatory subunit 3F |
| PRSS37 | protease, serine, 37 |
| PSCA | prostate stem cell antigen |
| PSMD7 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 |
| PTGDR2 | prostaglandin D2 receptor 2 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J |
| PYGL | phosphorylase, glycogen, liver |
| RAB3IP | RAB3A interacting protein |
| RASAL3 | RAS protein activator like 3 |
| RASD1 | RAS, dexamethasone-induced 1 |
| RASSF1 | Ras association (RalGDS/AF-6) domain family member 1 |
| RBM4 | RNA binding motif protein 4 |
| RIMKLB | ribosomal modification protein rimK-like family member B |
| RNF19B | ring finger protein 19B |
| RNF41 | ring finger protein 41, E3 ubiquitin protein ligase |
| RUNDC3A | RUN domain containing 3A |
| S100A8 | S100 calcium binding protein A8 |
| SAA1 | serum amyloid A1 |
| SAA2 | serum amyloid A2 |
| SEC14L2 | SEC14-like 2 (S. cerevisiae) |
| SFTPD | surfactant protein D |
| SGPL1 | sphingosine-1-phosphate lyase 1 |
| SH3BGRL2 | SH3 domain binding glutamate-rich protein like 2 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 |
| SNHG11 | small nucleolar RNA host gene 11 |
| SOCS6 | suppressor of cytokine signaling 6 |
| SPHK1 | sphingosine kinase 1 |
| SPINK4 | serine peptidase inhibitor, Kazal type 4 |
| SPRR2A | small proline-rich protein 2A |
| ST6GALNAC6 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 |
| SUCO | SUN domain containing ossification factor |
| SUSD4 | sushi domain containing 4 |
| SYT17 | synaptotagmin XVII |
| SYT8 | synaptotagmin VIII |
| TACSTD2 | tumor-associated calcium signal transducer 2 |
| TESC | tescalcin |
| TGIF1 | TGFB-induced factor homeobox 1 |
| TJP3 | tight junction protein 3 |
| TMCC3 | transmembrane and coiled-coil domain family 3 |
| TMEM186 | transmembrane protein 186 |
| TMEM40 | transmembrane protein 40 |
| TMEM56 | transmembrane protein 56 |
| TMPRSS4 | transmembrane protease, serine 4 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A |
| TOR3A | torsin family 3, member A |
| TPD52L3 | tumor protein D52-like 3 |
| TPRN | taperin |
| TRAF3 | TNF receptor-associated factor 3 |
| TTLL1 | tubulin tyrosine ligase-like family member 1 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 |
| VAMP5 | vesicle-associated membrane protein 5 |
| VANGL2 | VANGL planar cell polarity protein 2 |
| VAT1 | vesicle amine transport 1 |
| VILL | villin-like |
| WFDC12 | WAP four-disulfide core domain 12 |
| ZBTB21 | zinc finger and BTB domain containing 21 |
| ZNF746 | zinc finger protein 746 |
| Symbol | Name |
|---|---|
| ABHD14A | abhydrolase domain containing 14A |
| ACY1 | aminoacylase 1 |
| ADHFE1 | alcohol dehydrogenase, iron containing, 1 |
| ADORA1 | adenosine A1 receptor |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 |
| AMPD2 | adenosine monophosphate deaminase 2 |
| ANGPTL4 | angiopoietin-like 4 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit |
| AQP5 | aquaporin 5 |
| ASF1A | anti-silencing function 1A histone chaperone |
| ASS1 | argininosuccinate synthase 1 |
| BCS1L | BC1 (ubiquinol-cytochrome c reductase) synthesis-like |
| BDH1 | 3-hydroxybutyrate dehydrogenase, type 1 |
| BEX4 | brain expressed, X-linked 4 |
| BLVRB | biliverdin reductase B |
| BMP7 | bone morphogenetic protein 7 |
| C11ORF71 | chromosome 11 open reading frame 71 |
| C1R | complement component 1, r subcomponent |
| C7ORF55 | chromosome 7 open reading frame 55 |
| CADM3 | cell adhesion molecule 3 |
| CAMKK2 | calcium/calmodulin-dependent protein kinase kinase 2, beta |
| CAP2 | CAP, adenylate cyclase-associated protein, 2 (yeast) |
| CAV2 | caveolin 2 |
| CBS | cystathionine-beta-synthase |
| CBY1 | chibby homolog 1 (Drosophila) |
| CD200 | CD200 molecule |
| CD248 | CD248 molecule, endosialin |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) |
| CDH16 | cadherin 16, KSP-cadherin |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 |
| CELA1 | chymotrypsin-like elastase family, member 1 |
| CENPQ | centromere protein Q |
| CHAD | chondroadherin |
| CHN2 | chimerin 2 |
| CHRDL1 | chordin-like 1 |
| CHST12 | carbohydrate (chondroitin 4) sulfotransferase 12 |
| COIL | coilin |
| COL17A1 | collagen, type XVII, alpha 1 |
| COL5A2 | collagen, type V, alpha 2 |
| CPLX2 | complexin 2 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 |
| DPT | dermatopontin |
| DPYD | dihydropyrimidine dehydrogenase |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 |
| EIF4E3 | eukaryotic translation initiation factor 4E family member 3 |
| ERF | Ets2 repressor factor |
| ESR2 | estrogen receptor 2 (ER beta) |
| FAM134C | family with sequence similarity 134, member C |
| FAM20C | family with sequence similarity 20, member C |
| FAS | Fas cell surface death receptor |
| FBN1 | fibrillin 1 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) |
| FKBP10 | FK506 binding protein 10, 65 kDa |
| FKBP11 | FK506 binding protein 11, 19 kDa |
| FMO3 | flavin containing monooxygenase 3 |
| FRAT2 | frequently rearranged in advanced T-cell lymphomas 2 |
| FXYD1 | FXYD domain containing ion transport regulator 1 |
| GALNT16 | polypeptide N-acetylgalactosaminyltransferase 16 |
| GAS1 | growth arrest-specific 1 |
| GATAD2B | GATA zinc finger domain containing 2B |
| GNA14 | guanine nucleotide binding protein (G protein), alpha 14 |
| GNAT2 | guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 |
| GNMT | glycine N-methyltransferase |
| GPR83 | G protein-coupled receptor 83 |
| GSDMA | gasdermin A |
| GSPT2 | G1 to S phase transition 2 |
| GSTA4 | glutathione S-transferase alpha 4 |
| HARS2 | histidyl-tRNA synthetase 2, mitochondrial |
| HAUS1 | HAUS augmin-like complex, subunit 1 |
| HIC1 | hypermethylated in cancer 1 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) |
| IBSP | integrin-binding sialoprotein |
| IFRD2 | interferon-related developmental regulator 2 |
| IL13RA1 | interleukin 13 receptor, alpha 1 |
| IL17RC | interleukin 17 receptor C |
| IL7 | interleukin 7 |
| IRS1 | insulin receptor substrate 1 |
| ISYNA1 | inositol-3-phosphate synthase 1 |
| ITGA6 | integrin, alpha 6 |
| ITLN1 | intelectin 1 (galactofuranose binding) |
| ITPKB | inositol-trisphosphate 3-kinase B |
| ITSN1 | intersectin 1 (SH3 domain protein) |
| JPH3 | junctophilin 3 |
| KCNAB3 | potassium channel, voltage gated subfamily A regulatory beta subunit 3 |
| KCNK3 | potassium channel, two pore domain subfamily K, member 3 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 |
| KCTD12 | potassium channel tetramerization domain containing 12 |
| KLF1 | Kruppel-like factor 1 (erythroid) |
| KRBA1 | KRAB-A domain containing 1 |
| KRT6B | keratin 6B, type II |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) |
| LIMD1 | LIM domains containing 1 |
| LPL | lipoprotein lipase |
| LRRC1 | leucine rich repeat containing 1 |
| MAZ | MYC-associated zinc finger protein (purine-binding transcription factor) |
| MCM6 | minichromosome maintenance complex component 6 |
| MEPE | matrix extracellular phosphoglycoprotein |
| MERTK | MER proto-oncogene, tyrosine kinase |
| METTL5 | methyltransferase like 5 |
| MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B |
| MLPH | melanophilin |
| MLXIPL | MLX interacting protein-like |
| MMAA | methylmalonic aciduria (cobalamin deficiency) cblA type |
| MOCOS | molybdenum cofactor sulfurase |
| MRPS6 | mitochondrial ribosomal protein S6 |
| MSL2 | male-specific lethal 2 homolog (Drosophila) |
| MSRB2 | methionine sulfoxide reductase B2 |
| MSX1 | msh homeobox 1 |
| MTHFD1 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase |
| MYB | v-myb avian myeloblastosis viral oncogene homolog |
| MYO1G | myosin IG |
| NAT8 | N-acetyltransferase 8 (GCN5-related, putative) |
| NCMAP | noncompact myelin associated protein |
| NDRG4 | NDRG family member 4 |
| NID1 | nidogen 1 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 |
| OGN | osteoglycin |
| PARP2 | poly (ADP-ribose) polymerase 2 |
| PDIA5 | protein disulfide isomerase family A, member 5 |
| PDZRN3 | PDZ domain containing ring finger 3 |
| PHGR1 | proline/histidine/glycine-rich 1 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 |
| PI16 | peptidase inhibitor 16 |
| PKP1 | plakophilin 1 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) |
| PLEK2 | pleckstrin 2 |
| PMPCB | peptidase (mitochondrial processing) beta |
| PNLIPRP1 | pancreatic lipase-related protein 1 |
| POLD2 | polymerase (DNA directed), delta 2, accessory subunit |
| POLI | polymerase (DNA directed) iota |
| POLM | polymerase (DNA directed), mu |
| PPAP2B | phosphatidic acid phosphatase type 2B |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) |
| PROM1 | prominin 1 |
| PSAT1 | phosphoserine aminotransferase 1 |
| PUS7 | pseudouridylate synthase 7 (putative) |
| RAMP1 | receptor (G protein-coupled) activity modifying protein 1 |
| RGS19 | regulator of G-protein signaling 19 |
| RNF25 | ring finger protein 25 |
| RPS6KB2 | ribosomal protein S6 kinase, 70kDa, polypeptide 2 |
| RTKN | rhotekin |
| RTN1 | reticulon 1 |
| S1PR3 | sphingosine-1-phosphate receptor 3 |
| SARS2 | seryl-tRNA synthetase 2, mitochondrial |
| SASH1 | SAM and SH3 domain containing 1 |
| SATB1 | SATB homeobox 1 |
| SERPINF2 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 |
| SFRP5 | secreted frizzled-related protein 5 |
| SH3BGR | SH3 domain binding glutamate-rich protein |
| SHMT1 | serine hydroxymethyltransferase 1 (soluble) |
| SLC18A1 | solute carrier family 18 (vesicular monoamine transporter), member 1 |
| SLC22A12 | solute carrier family 22 (organic anion/urate transporter), member 12 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 |
| SLCO3A1 | solute carrier organic anion transporter family, member 3A1 |
| SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 |
| SNHG6 | small nucleolar RNA host gene 6 |
| SPATA5 | spermatogenesis associated 5 |
| STAB1 | stabilin 1 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 |
| TACR3 | tachykinin receptor 3 |
| TBCE | tubulin folding cofactor E |
| TIPIN | TIMELESS interacting protein |
| TM4SF1 | transmembrane 4 L six family member 1 |
| TMEM97 | transmembrane protein 97 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 |
| TNNC2 | troponin C type 2 (fast) |
| TP53I13 | tumor protein p53 inducible protein 13 |
| TPH1 | tryptophan hydroxylase 1 |
| TSPAN4 | tetraspanin 4 |
| TSPYL4 | TSPY-like 4 |
| TULP3 | tubby like protein 3 |
| TYMP | thymidine phosphorylase |
| TYW1 | tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) |
| UTP20 | UTP20, small subunit (SSU) processome component, homolog (yeast) |
| VCAN | versican |
| VPS33B | vacuolar protein sorting 33 homolog B (yeast) |
| WEE1 | WEE1 G2 checkpoint kinase |
| ZC3HC1 | zinc finger, C3HC-type containing 1 |
| ZNF112 | zinc finger protein 112 |
| ZNF771 | zinc finger protein 771 |
