ALK Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description anaplastic lymphoma receptor tyrosine kinase|This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011] (NCBI Entrez Gene Database, 238)
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100 substrates of the kinase ALK from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 100.0
ZCCHC3 zinc finger, CCHC domain containing 3 99.96
PADI2 peptidyl arginine deiminase, type II 99.94
RABGAP1L RAB GTPase activating protein 1-like 99.91
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 99.89
EIF1B eukaryotic translation initiation factor 1B 99.83
EIF1 eukaryotic translation initiation factor 1 99.83
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 99.8
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 99.78
FBXO9 F-box protein 9 99.74
CNOT9 CCR4-NOT transcription complex subunit 9 99.71
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 99.69
EIF3I eukaryotic translation initiation factor 3, subunit I 99.63
PTPRB protein tyrosine phosphatase, receptor type, B 99.61
LY6G6F lymphocyte antigen 6 complex, locus G6F 99.59
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 99.58
DCTN4 dynactin 4 (p62) 99.5
ESYT2 extended synaptotagmin-like protein 2 99.45
WWP2 WW domain containing E3 ubiquitin protein ligase 2 99.43
JAML junction adhesion molecule like 99.41
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 99.39
RIC1 RAB6A GEF complex partner 1 99.28
FDFT1 farnesyl-diphosphate farnesyltransferase 1 99.21
EML4 echinoderm microtubule associated protein like 4 99.19
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 99.17
PLCL2 phospholipase C-like 2 99.1
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 99.08
TRPV2 transient receptor potential cation channel, subfamily V, member 2 99.01
TEX2 testis expressed 2 98.97
IKZF3 IKAROS family zinc finger 3 (Aiolos) 98.93
N4BP3 NEDD4 binding protein 3 98.88
MCEMP1 mast cell-expressed membrane protein 1 98.86
KMT5A lysine methyltransferase 5A 98.8
TERB1 telomere repeat binding bouquet formation protein 1 98.78
CHD2 chromodomain helicase DNA binding protein 2 98.77
FCHO1 FCH domain only 1 98.73
ELP3 elongator acetyltransferase complex subunit 3 98.665
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5 98.66
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 98.45
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 98.43
MTO1 mitochondrial tRNA translation optimization 1 98.42
PLPPR4 phospholipid phosphatase related 4 98.29
FAM168A family with sequence similarity 168, member A 98.27
PM20D2 peptidase M20 domain containing 2 98.2
UBE2E2 ubiquitin-conjugating enzyme E2E 2 98.1
UBE2E3 ubiquitin-conjugating enzyme E2E 3 98.1
UBE2E1 ubiquitin-conjugating enzyme E2E 1 98.1
CNBD2 cyclic nucleotide binding domain containing 2 97.96
SHROOM1 shroom family member 1 97.94
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 97.92
ARHGAP30 Rho GTPase activating protein 30 97.88
GCSAML germinal center-associated, signaling and motility-like 97.865
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa 97.86
DPH6 diphthamine biosynthesis 6 97.83
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa 97.81
ARRDC3 arrestin domain containing 3 97.79
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 97.72
NAV1 neuron navigator 1 97.64
PHLDB3 pleckstrin homology-like domain, family B, member 3 97.59
ACE2 angiotensin I converting enzyme 2 97.53
RPS10 ribosomal protein S10 97.46
RPS10-NUDT3 RPS10-NUDT3 readthrough 97.46
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 97.425
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 97.37
TWF1 twinfilin actin binding protein 1 97.33
NOX5 NADPH oxidase, EF-hand calcium binding domain 5 97.305
RERE arginine-glutamic acid dipeptide (RE) repeats 97.26
UNG uracil-DNA glycosylase 97.24
MKNK1 MAP kinase interacting serine/threonine kinase 1 97.18
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 97.15
PRUNE2 prune homolog 2 (Drosophila) 97.09
FAF2 Fas associated factor family member 2 97.05
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 97.045
MRPS27 mitochondrial ribosomal protein S27 96.96
GREB1 growth regulation by estrogen in breast cancer 1 96.93
RGS10 regulator of G-protein signaling 10 96.89
EEIG1 estrogen-induced osteoclastogenesis regulator 1 96.83
CLMP CXADR-like membrane protein 96.72
SIPA1L1 signal-induced proliferation-associated 1 like 1 96.67
ZC3HAV1L zinc finger CCCH-type, antiviral 1-like 96.63
IRS4 insulin receptor substrate 4 96.625
TASOR2 transcription activation suppressor family member 2 96.56
UBASH3A ubiquitin associated and SH3 domain containing A 96.56
EEIG2 EEIG family member 2 96.52
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 96.45
NIT2 nitrilase family, member 2 96.35
SEC14L2 SEC14-like 2 (S. cerevisiae) 96.32
SEC14L3 SEC14-like 3 (S. cerevisiae) 96.32
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae) 96.28
CYB5R1 cytochrome b5 reductase 1 96.23
FCRL6 Fc receptor-like 6 96.23
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 96.15
GRAMD4 GRAM domain containing 4 96.13
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 96.04
SYNPO2 synaptopodin 2 96.0
KIF20A kinesin family member 20A 95.95
RALY RALY heterogeneous nuclear ribonucleoprotein 95.93
PPP1R18 protein phosphatase 1, regulatory subunit 18 95.88
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 95.82
TNN tenascin N 95.82