| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | anaplastic lymphoma receptor tyrosine kinase|This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011] (NCBI Entrez Gene Database, 238) |
| External Link | https://ncbi.nlm.nih.gov/gene/238 |
| Similar Terms | |
| Downloads & Tools |
498 genes differentially expressed following the ALK gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SCGB2A2 | secretoglobin, family 2A, member 2 | 0.0110973 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.0110502 |
| MMP1 | matrix metallopeptidase 1 | 0.0105567 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | 0.00996704 |
| S100A7 | S100 calcium binding protein A7 | 0.0092443 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | 0.00920078 |
| MYBPC1 | myosin binding protein C, slow type | 0.00909874 |
| OXTR | oxytocin receptor | 0.00899084 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.00890406 |
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | 0.00877487 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.00869709 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.00853743 |
| PTCH1 | patched 1 | 0.00842692 |
| MME | membrane metallo-endopeptidase | 0.00827328 |
| RNF167 | ring finger protein 167 | 0.00823717 |
| CXCL6 | chemokine (C-X-C motif) ligand 6 | 0.00804961 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.00802508 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.00801641 |
| KRT18 | keratin 18, type I | 0.00797093 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.00782333 |
| GALNT7 | polypeptide N-acetylgalactosaminyltransferase 7 | 0.00771571 |
| ECM1 | extracellular matrix protein 1 | 0.00770837 |
| AMDHD2 | amidohydrolase domain containing 2 | 0.00769489 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 0.00751679 |
| HSPA1A | heat shock 70kDa protein 1A | 0.00748784 |
| SMC1A | structural maintenance of chromosomes 1A | 0.00741756 |
| FABP4 | fatty acid binding protein 4, adipocyte | 0.0073265 |
| PDE4DIP | phosphodiesterase 4D interacting protein | 0.00728388 |
| SLC2A10 | solute carrier family 2 (facilitated glucose transporter), member 10 | 0.00727241 |
| ADAM12 | ADAM metallopeptidase domain 12 | 0.00722637 |
| IRS2 | insulin receptor substrate 2 | 0.00721159 |
| STOM | stomatin | 0.00720752 |
| KRT7 | keratin 7, type II | 0.00719636 |
| MSX1 | msh homeobox 1 | 0.00719098 |
| MBOAT7 | membrane bound O-acyltransferase domain containing 7 | 0.00716739 |
| ZNF586 | zinc finger protein 586 | 0.00711841 |
| TFF1 | trefoil factor 1 | 0.00711412 |
| GPM6B | glycoprotein M6B | 0.00709783 |
| ABLIM1 | actin binding LIM protein 1 | 0.00705074 |
| GOLGA8A | golgin A8 family, member A | 0.00701734 |
| AQP1 | aquaporin 1 (Colton blood group) | 0.00700456 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.00699683 |
| QPRT | quinolinate phosphoribosyltransferase | 0.00698618 |
| KLF2 | Kruppel-like factor 2 | 0.0069743 |
| TLE4 | transducin-like enhancer of split 4 | 0.00694856 |
| IL17RB | interleukin 17 receptor B | 0.00681595 |
| MAP7 | microtubule-associated protein 7 | 0.00679483 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.006741 |
| GRB7 | growth factor receptor-bound protein 7 | 0.00671567 |
| SORD | sorbitol dehydrogenase | 0.0066706 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.00664421 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.0066046 |
| EFHD1 | EF-hand domain family, member D1 | 0.00659875 |
| FMO1 | flavin containing monooxygenase 1 | 0.00658217 |
| DIO2 | deiodinase, iodothyronine, type II | 0.006574 |
| FTO | fat mass and obesity associated | 0.006546 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | 0.00652501 |
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 | 0.00652444 |
| ADAR | adenosine deaminase, RNA-specific | 0.00642481 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.00641579 |
| TPM2 | tropomyosin 2 (beta) | 0.00640644 |
| MFSD10 | major facilitator superfamily domain containing 10 | 0.00640233 |
| CPS1 | carbamoyl-phosphate synthase 1, mitochondrial | 0.0063922 |
| NES | nestin | 0.00636561 |
| S100P | S100 calcium binding protein P | 0.00636483 |
| DAXX | death-domain associated protein | 0.00633959 |
| CLU | clusterin | 0.00633571 |
| RET | ret proto-oncogene | 0.00632559 |
| AHCYL1 | adenosylhomocysteinase-like 1 | 0.00630107 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.00619988 |
| KLK6 | kallikrein-related peptidase 6 | 0.00619248 |
| CHN1 | chimerin 1 | 0.00615302 |
| NPIPB3 | nuclear pore complex interacting protein family, member B3 | 0.00614112 |
| PEBP1 | phosphatidylethanolamine binding protein 1 | 0.00611971 |
| MGLL | monoglyceride lipase | 0.0061007 |
| MYO1C | myosin IC | 0.00609854 |
| RUNX1 | runt-related transcription factor 1 | 0.00604233 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | 0.00603451 |
| CD81 | CD81 molecule | 0.0059985 |
| WEE1 | WEE1 G2 checkpoint kinase | 0.00594648 |
| UBA1 | ubiquitin-like modifier activating enzyme 1 | 0.00592268 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.00591338 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00589062 |
| ELANE | elastase, neutrophil expressed | 0.00585729 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.00585581 |
| SETD5 | SET domain containing 5 | 0.00584867 |
| TUBB2A | tubulin, beta 2A class IIa | 0.0057947 |
| GOLGA8H | golgin A8 family, member H | 0.00578749 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | 0.00578402 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | 0.00578154 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.00575489 |
| MICB | MHC class I polypeptide-related sequence B | 0.00574923 |
| FBN1 | fibrillin 1 | 0.00571689 |
| GUCY2C | guanylate cyclase 2C | 0.00570322 |
| EIF5A | eukaryotic translation initiation factor 5A | 0.00569769 |
| HOMER1 | homer scaffolding protein 1 | 0.00569317 |
| TPP1 | tripeptidyl peptidase I | 0.00567536 |
| COQ8A | coenzyme Q8A | 0.00566923 |
| ADA | adenosine deaminase | 0.00566782 |
| KLF6 | Kruppel-like factor 6 | 0.00565871 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.00564606 |
| PRF1 | perforin 1 (pore forming protein) | 0.00563854 |
| GRAMD2B | GRAM domain containing 2B | 0.00562312 |
| VCL | vinculin | 0.00562263 |
| PXDN | peroxidasin | 0.00562187 |
| ACAA1 | acetyl-CoA acyltransferase 1 | 0.00561976 |
| PENK | proenkephalin | 0.00561881 |
| GSTK1 | glutathione S-transferase kappa 1 | 0.00560716 |
| ACADVL | acyl-CoA dehydrogenase, very long chain | 0.00560409 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | 0.00559014 |
| SYT1 | synaptotagmin I | 0.00557936 |
| BAMBI | BMP and activin membrane-bound inhibitor | 0.0055514 |
| MTCL1 | microtubule crosslinking factor 1 | 0.0055463 |
| AADAC | arylacetamide deacetylase | 0.00551613 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.00551197 |
| CDIPT | CDP-diacylglycerol--inositol 3-phosphatidyltransferase | 0.00548984 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.00548476 |
| IER3 | immediate early response 3 | 0.00546798 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 0.00546703 |
| IL6 | interleukin 6 | 0.00546485 |
| DRAM1 | DNA-damage regulated autophagy modulator 1 | 0.0054611 |
| XAF1 | XIAP associated factor 1 | 0.00545566 |
| CLUH | clustered mitochondria (cluA/CLU1) homolog | 0.00544428 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | 0.00543388 |
| GPI | glucose-6-phosphate isomerase | 0.00543011 |
| PEG3 | paternally expressed 3 | 0.00542268 |
| PKD1P1 | polycystic kidney disease 1 (autosomal dominant) pseudogene 1 | 0.00541214 |
| ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 | 0.00539621 |
| VPS35 | vacuolar protein sorting 35 homolog (S. cerevisiae) | 0.00536704 |
| TFF3 | trefoil factor 3 (intestinal) | 0.00536093 |
| TBX3 | T-box 3 | 0.00534592 |
| PLA2G4C | phospholipase A2, group IVC (cytosolic, calcium-independent) | 0.00534258 |
| ETNPPL | ethanolamine-phosphate phospho-lyase | 0.00533614 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.00533048 |
| MT1E | metallothionein 1E | 0.00532984 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 0.0053136 |
| PILRB | paired immunoglobin-like type 2 receptor beta | 0.00530827 |
| AZU1 | azurocidin 1 | 0.00530514 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.00529815 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.00528804 |
| STIP1 | stress-induced phosphoprotein 1 | 0.00528329 |
| MVP | major vault protein | 0.00527356 |
| PDZD2 | PDZ domain containing 2 | 0.0052734 |
| PDZK1 | PDZ domain containing 1 | 0.00525983 |
| HMOX2 | heme oxygenase 2 | 0.00525978 |
| FIGF | c-fos induced growth factor (vascular endothelial growth factor D) | 0.00525751 |
| NPIPA1 | nuclear pore complex interacting protein family, member A1 | 0.00524319 |
| LRIG1 | leucine-rich repeats and immunoglobulin-like domains 1 | 0.00523916 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.00523667 |
| HMBOX1 | homeobox containing 1 | 0.00522441 |
| TJP2 | tight junction protein 2 | 0.00521669 |
| NCOA3 | nuclear receptor coactivator 3 | 0.00520481 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.00520367 |
| B2M | beta-2-microglobulin | 0.00519865 |
| GPR137B | G protein-coupled receptor 137B | 0.00518025 |
| GTF2H2B | general transcription factor IIH, polypeptide 2B (pseudogene) | 0.00514887 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 0.00514748 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.00513964 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 0.00512809 |
| SLC22A4 | solute carrier family 22 (organic cation/zwitterion transporter), member 4 | 0.00511415 |
| SOBP | sine oculis binding protein homolog (Drosophila) | 0.00510938 |
| QDPR | quinoid dihydropteridine reductase | 0.0050932 |
| ACKR3 | atypical chemokine receptor 3 | 0.00509147 |
| MYH10 | myosin, heavy chain 10, non-muscle | 0.00508229 |
| MT2A | metallothionein 2A | 0.00507761 |
| FUS | FUS RNA binding protein | 0.00507209 |
| FGF1 | fibroblast growth factor 1 (acidic) | 0.00506757 |
| ABCA8 | ATP-binding cassette, sub-family A (ABC1), member 8 | 0.00502753 |
| PRSS21 | protease, serine, 21 (testisin) | 0.00502573 |
| IER2 | immediate early response 2 | 0.00502544 |
| COG7 | component of oligomeric golgi complex 7 | 0.00501341 |
| GOLM1 | golgi membrane protein 1 | 0.00500653 |
| ZDHHC11 | zinc finger, DHHC-type containing 11 | 0.0050046 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.00499957 |
| CYP3A4 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 0.00499837 |
| KIAA0355 | KIAA0355 | 0.00499479 |
| SP110 | SP110 nuclear body protein | 0.00499118 |
| DHTKD1 | dehydrogenase E1 and transketolase domain containing 1 | 0.00498267 |
| VDAC1 | voltage-dependent anion channel 1 | 0.00497124 |
| USP18 | ubiquitin specific peptidase 18 | 0.00496087 |
| CAPN3 | calpain 3, (p94) | 0.00495941 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.00495547 |
| GPC4 | glypican 4 | 0.00494914 |
| HSP90B2P | heat shock protein 90kDa beta (Grp94), member 2, pseudogene | 0.00494225 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.00494099 |
| HADHB | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit | 0.00492444 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | 0.00491241 |
| P2RX4 | purinergic receptor P2X, ligand gated ion channel, 4 | 0.00490999 |
| TMEM100 | transmembrane protein 100 | 0.0049022 |
| PHF11 | PHD finger protein 11 | 0.00489948 |
| MX2 | MX dynamin-like GTPase 2 | 0.0048949 |
| PRMT1 | protein arginine methyltransferase 1 | 0.00488756 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.00488382 |
| USP11 | ubiquitin specific peptidase 11 | 0.00486895 |
| LAMA2 | laminin, alpha 2 | 0.00486732 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.00486091 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.0048539 |
| ABHD4 | abhydrolase domain containing 4 | 0.00484099 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.00483538 |
| ATP6AP1 | ATPase, H+ transporting, lysosomal accessory protein 1 | 0.00480909 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.00479575 |
| RALBP1 | ralA binding protein 1 | 0.00479509 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 0.00479492 |
| MX1 | MX dynamin-like GTPase 1 | 0.00478187 |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 | 0.00477249 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.00477207 |
| PLOD3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | 0.00476899 |
| NASP | nuclear autoantigenic sperm protein (histone-binding) | 0.00475764 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | 0.00474349 |
| RHOB | ras homolog family member B | 0.00474266 |
| RRAGD | Ras-related GTP binding D | 0.00474044 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.0047401 |
| MID1IP1 | MID1 interacting protein 1 | 0.00473123 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | 0.00472594 |
| POU4F1 | POU class 4 homeobox 1 | 0.00471994 |
| BAALC | brain and acute leukemia, cytoplasmic | 0.00471931 |
| HPD | 4-hydroxyphenylpyruvate dioxygenase | 0.00471443 |
| C9ORF91 | chromosome 9 open reading frame 91 | 0.00468694 |
| CH25H | cholesterol 25-hydroxylase | 0.00468332 |
| HSD11B1 | hydroxysteroid (11-beta) dehydrogenase 1 | 0.00467995 |
| FCGR3B | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | 0.00465668 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 0.00463714 |
| MT1F | metallothionein 1F | 0.00462279 |
| FLT3 | fms-related tyrosine kinase 3 | 0.00461547 |
| F12 | coagulation factor XII (Hageman factor) | 0.00461482 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | 0.00461452 |
| KIF14 | kinesin family member 14 | 0.00461375 |
| BIN1 | bridging integrator 1 | 0.00459524 |
| CDR2L | cerebellar degeneration-related protein 2-like | 0.0045818 |
| SPRR2B | small proline-rich protein 2B | 0.00457984 |
| MPDZ | multiple PDZ domain protein | 0.00456933 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | 0.00455043 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.00452048 |
| ZYX | zyxin | 0.0045173 |
| HOXC6 | homeobox C6 | 0.00450823 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | 0.00450453 |
| DGLUCY | D-glutamate cyclase | 0.00449591 |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 | 0.00449482 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.00448868 |
| G0S2 | G0/G1 switch 2 | 0.00447555 |
| GPM6A | glycoprotein M6A | 0.00447193 |
| CERS2 | ceramide synthase 2 | 0.00445872 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.00445461 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.00445436 |
| FBLN5 | fibulin 5 | 0.00445328 |
| STX4 | syntaxin 4 | 0.00445181 |
| FRY | furry homolog (Drosophila) | 0.0044511 |
| STX16 | syntaxin 16 | 0.00444946 |
| HOXA5 | homeobox A5 | 0.00443699 |
| RAB29 | RAB29, member RAS oncogene family | 0.00442059 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -0.0191218 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.011777 |
| LPAR6 | lysophosphatidic acid receptor 6 | -0.011391 |
| PCP4 | Purkinje cell protein 4 | -0.0109807 |
| HTRA1 | HtrA serine peptidase 1 | -0.0109304 |
| TMEM14B | transmembrane protein 14B | -0.0108187 |
| TPSAB1 | tryptase alpha/beta 1 | -0.0105728 |
| CA12 | carbonic anhydrase XII | -0.0103096 |
| FCGBP | Fc fragment of IgG binding protein | -0.0101632 |
| CNPY3 | canopy FGF signaling regulator 3 | -0.00985395 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | -0.00984833 |
| RNASE6 | ribonuclease, RNase A family, k6 | -0.00977753 |
| NPTX2 | neuronal pentraxin II | -0.00973464 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.00954914 |
| JCHAIN | joining chain of multimeric IgA and IgM | -0.0095292 |
| PFDN4 | prefoldin subunit 4 | -0.00950093 |
| JAG1 | jagged 1 | -0.00887067 |
| IPO13 | importin 13 | -0.00886531 |
| CTSH | cathepsin H | -0.00848443 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | -0.00834153 |
| KCTD12 | potassium channel tetramerization domain containing 12 | -0.00814511 |
| PTK2B | protein tyrosine kinase 2 beta | -0.00810695 |
| THAP12 | THAP domain containing 12 | -0.00808187 |
| GNAO1 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O | -0.00806928 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.00802761 |
| MAOA | monoamine oxidase A | -0.00793597 |
| EVI2A | ecotropic viral integration site 2A | -0.00774432 |
| CCR2 | chemokine (C-C motif) receptor 2 | -0.00764904 |
| REG1B | regenerating islet-derived 1 beta | -0.0075982 |
| RCBTB2 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 | -0.00759381 |
| MUC4 | mucin 4, cell surface associated | -0.00757544 |
| CD1E | CD1e molecule | -0.00753344 |
| CPE | carboxypeptidase E | -0.00749148 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0074504 |
| RSL24D1 | ribosomal L24 domain containing 1 | -0.00740188 |
| RAP2A | RAP2A, member of RAS oncogene family | -0.00736393 |
| C1QA | complement component 1, q subcomponent, A chain | -0.00733377 |
| HOMER2 | homer scaffolding protein 2 | -0.00731603 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | -0.00731301 |
| SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1 | -0.00729307 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.00728396 |
| LCN2 | lipocalin 2 | -0.00722665 |
| GNG10 | guanine nucleotide binding protein (G protein), gamma 10 | -0.00718891 |
| GPX3 | glutathione peroxidase 3 | -0.00716397 |
| CD48 | CD48 molecule | -0.00708069 |
| COMMD8 | COMM domain containing 8 | -0.00707174 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.00707145 |
| FRZB | frizzled-related protein | -0.00702886 |
| DUOX2 | dual oxidase 2 | -0.00701003 |
| MPZL2 | myelin protein zero-like 2 | -0.00700351 |
| IFT57 | intraflagellar transport 57 | -0.00699982 |
| RPS17 | ribosomal protein S17 | -0.00699957 |
| IL18 | interleukin 18 | -0.00698186 |
| C1QB | complement component 1, q subcomponent, B chain | -0.00697328 |
| TGFA | transforming growth factor, alpha | -0.00696436 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | -0.00695853 |
| LY96 | lymphocyte antigen 96 | -0.00695097 |
| MS4A6A | membrane-spanning 4-domains, subfamily A, member 6A | -0.00691533 |
| MEA1 | male-enhanced antigen 1 | -0.00691313 |
| CYBB | cytochrome b-245, beta polypeptide | -0.00691266 |
| CSTA | cystatin A (stefin A) | -0.00689374 |
| CLEC7A | C-type lectin domain family 7, member A | -0.0068702 |
| FGL2 | fibrinogen-like 2 | -0.00686733 |
| MARCHF1 | membrane associated ring-CH-type finger 1 | -0.00684463 |
| YME1L1 | YME1-like 1 ATPase | -0.00684384 |
| CP | ceruloplasmin (ferroxidase) | -0.0068188 |
| CPB1 | carboxypeptidase B1 (tissue) | -0.00680886 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -0.00679386 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.00676795 |
| ODC1 | ornithine decarboxylase 1 | -0.00676786 |
| CLCA1 | chloride channel accessory 1 | -0.00675706 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | -0.00670495 |
| CTSZ | cathepsin Z | -0.00661861 |
| UGT2B17 | UDP glucuronosyltransferase 2 family, polypeptide B17 | -0.00660723 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | -0.0065645 |
| RWDD1 | RWD domain containing 1 | -0.00656105 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.00649769 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | -0.00648507 |
| CD4 | CD4 molecule | -0.00646921 |
| PARM1 | prostate androgen-regulated mucin-like protein 1 | -0.00645953 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | -0.00644149 |
| PDGFC | platelet derived growth factor C | -0.00643015 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.00642893 |
| CEACAM7 | carcinoembryonic antigen-related cell adhesion molecule 7 | -0.00642305 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.00639574 |
| HIST1H2BD | histone cluster 1, H2bd | -0.00639421 |
| MET | MET proto-oncogene, receptor tyrosine kinase | -0.0063926 |
| METTL5 | methyltransferase like 5 | -0.00637215 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | -0.00637154 |
| RAP2B | RAP2B, member of RAS oncogene family | -0.00630997 |
| DPYD | dihydropyrimidine dehydrogenase | -0.00628357 |
| GPX2 | glutathione peroxidase 2 | -0.00625244 |
| DPM3 | dolichyl-phosphate mannosyltransferase polypeptide 3 | -0.00624743 |
| PLN | phospholamban | -0.00623894 |
| HLA-DQB2 | major histocompatibility complex, class II, DQ beta 2 | -0.00620394 |
| REG1A | regenerating islet-derived 1 alpha | -0.0061653 |
| MS4A12 | membrane-spanning 4-domains, subfamily A, member 12 | -0.00616465 |
| CLCA4 | chloride channel accessory 4 | -0.00615656 |
| RPS27L | ribosomal protein S27-like | -0.00614959 |
| ZNF124 | zinc finger protein 124 | -0.00614949 |
| PAK1IP1 | PAK1 interacting protein 1 | -0.00614294 |
| ADAMDEC1 | ADAM-like, decysin 1 | -0.00612282 |
| PRKCI | protein kinase C, iota | -0.00612208 |
| ZG16 | zymogen granule protein 16 | -0.00611814 |
| LST1 | leukocyte specific transcript 1 | -0.00607073 |
| TPRKB | TP53RK binding protein | -0.00607047 |
| ZFAND1 | zinc finger, AN1-type domain 1 | -0.00606624 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.00605681 |
| CMAHP | cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene | -0.00604655 |
| MGAT2 | mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase | -0.00604082 |
| RTN1 | reticulon 1 | -0.00600644 |
| GGH | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | -0.00597469 |
| EAPP | E2F-associated phosphoprotein | -0.00596909 |
| DENND1B | DENN/MADD domain containing 1B | -0.00595118 |
| CLEC2B | C-type lectin domain family 2, member B | -0.00595026 |
| ELOC | elongin C | -0.00591208 |
| HMGN4 | high mobility group nucleosomal binding domain 4 | -0.00589785 |
| CCNE2 | cyclin E2 | -0.0058975 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | -0.00588577 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | -0.00588037 |
| RGS10 | regulator of G-protein signaling 10 | -0.00584701 |
| TMEM70 | transmembrane protein 70 | -0.00583882 |
| RAB2A | RAB2A, member RAS oncogene family | -0.00582163 |
| RBX1 | ring-box 1, E3 ubiquitin protein ligase | -0.00579255 |
| STAB1 | stabilin 1 | -0.00578611 |
| MDFIC | MyoD family inhibitor domain containing | -0.00577333 |
| SNRPG | small nuclear ribonucleoprotein polypeptide G | -0.00576026 |
| AOC1 | amine oxidase, copper containing 1 | -0.00575245 |
| NMU | neuromedin U | -0.00574464 |
| CD86 | CD86 molecule | -0.00572859 |
| NELL2 | NEL-like 2 (chicken) | -0.00572005 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | -0.00571602 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -0.00570823 |
| ARMC1 | armadillo repeat containing 1 | -0.00570138 |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | -0.00569738 |
| PTPRO | protein tyrosine phosphatase, receptor type, O | -0.00569136 |
| COPS4 | COP9 signalosome subunit 4 | -0.00567606 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.00566144 |
| GTF2A2 | general transcription factor IIA, 2, 12kDa | -0.00564356 |
| FAM13A | family with sequence similarity 13, member A | -0.00562592 |
| TYROBP | TYRO protein tyrosine kinase binding protein | -0.00562097 |
| COX17 | COX17 cytochrome c oxidase copper chaperone | -0.00561948 |
| WFDC2 | WAP four-disulfide core domain 2 | -0.00558779 |
| CCND2 | cyclin D2 | -0.00558011 |
| CCL19 | chemokine (C-C motif) ligand 19 | -0.00557675 |
| AHR | aryl hydrocarbon receptor | -0.0055497 |
| ATF1 | activating transcription factor 1 | -0.00554253 |
| PSMA2 | proteasome (prosome, macropain) subunit, alpha type, 2 | -0.00553675 |
| CD177 | CD177 molecule | -0.00553111 |
| EXT1 | exostosin glycosyltransferase 1 | -0.00551546 |
| THOC7 | THO complex 7 | -0.0055051 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.00550097 |
| CD1D | CD1d molecule | -0.00549562 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | -0.00548741 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 | -0.00548369 |
| TADA2A | transcriptional adaptor 2A | -0.00547883 |
| TWF1 | twinfilin actin binding protein 1 | -0.00547428 |
| SUN1 | Sad1 and UNC84 domain containing 1 | -0.00546604 |
| GPA33 | glycoprotein A33 (transmembrane) | -0.00544139 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | -0.00543904 |
| EPHB2 | EPH receptor B2 | -0.00543449 |
| PDE9A | phosphodiesterase 9A | -0.0054341 |
| UCHL3 | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) | -0.00542979 |
| CD9 | CD9 molecule | -0.00542694 |
| INAVA | innate immunity activator | -0.00542176 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | -0.00540979 |
| MRPL13 | mitochondrial ribosomal protein L13 | -0.0054062 |
| RFK | riboflavin kinase | -0.00540297 |
| LXN | latexin | -0.0053841 |
| CD3D | CD3d molecule, delta (CD3-TCR complex) | -0.00538314 |
| CD14 | CD14 molecule | -0.00537991 |
| FCGR2B | Fc fragment of IgG, low affinity IIb, receptor (CD32) | -0.00537857 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.00537375 |
| CLEC10A | C-type lectin domain family 10, member A | -0.00536823 |
| NELL1 | NEL-like 1 (chicken) | -0.00536723 |
| TMEM126B | transmembrane protein 126B | -0.0053509 |
| CAPG | capping protein (actin filament), gelsolin-like | -0.00534445 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | -0.00533805 |
| FAM162A | family with sequence similarity 162, member A | -0.00533479 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | -0.00530964 |
| CDHR1 | cadherin-related family member 1 | -0.00530543 |
| LGALS2 | lectin, galactoside-binding, soluble, 2 | -0.0052933 |
| PDCD10 | programmed cell death 10 | -0.00528238 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 | -0.00524724 |
| CCNB2 | cyclin B2 | -0.00522906 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.00521475 |
| MRPL3 | mitochondrial ribosomal protein L3 | -0.0052026 |
| CD163 | CD163 molecule | -0.00520025 |
| HPGDS | hematopoietic prostaglandin D synthase | -0.0051559 |
| S100A4 | S100 calcium binding protein A4 | -0.00515332 |
| PID1 | phosphotyrosine interaction domain containing 1 | -0.00514517 |
| RPA3 | replication protein A3, 14kDa | -0.00514072 |
| FST | follistatin | -0.00513636 |
| GIMAP6 | GTPase, IMAP family member 6 | -0.00512662 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | -0.00510555 |
| NCKAP1 | NCK-associated protein 1 | -0.00510277 |
| LAMTOR3 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 | -0.00510215 |
| ASGR2 | asialoglycoprotein receptor 2 | -0.00510214 |
| VEGFA | vascular endothelial growth factor A | -0.00510087 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | -0.00509225 |
| GALNT3 | polypeptide N-acetylgalactosaminyltransferase 3 | -0.0050666 |
| MTARC1 | mitochondrial amidoxime reducing component 1 | -0.00506584 |
| CCNI | cyclin I | -0.00504845 |
| ADORA2B | adenosine A2b receptor | -0.0050349 |
| WTAP | Wilms tumor 1 associated protein | -0.00503075 |
| FZD6 | frizzled class receptor 6 | -0.00502008 |
| FOXG1 | forkhead box G1 | -0.00501757 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | -0.00501199 |
| RYK | receptor-like tyrosine kinase | -0.00500863 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.00499736 |
| MIOS | missing oocyte, meiosis regulator, homolog (Drosophila) | -0.0049949 |
| AP5M1 | adaptor-related protein complex 5, mu 1 subunit | -0.0049885 |
| ZC3H15 | zinc finger CCCH-type containing 15 | -0.00496569 |
| NTAQ1 | N-terminal glutamine amidase 1 | -0.00495896 |
| GLB1L2 | galactosidase, beta 1-like 2 | -0.0049501 |
| AIF1 | allograft inflammatory factor 1 | -0.00493931 |
| NPC2 | Niemann-Pick disease, type C2 | -0.00493516 |
| TOB1 | transducer of ERBB2, 1 | -0.00492598 |
| LRRC40 | leucine rich repeat containing 40 | -0.00491082 |
| CYCS | cytochrome c, somatic | -0.00489626 |
| CNIH4 | cornichon family AMPA receptor auxiliary protein 4 | -0.00487613 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.00487358 |
| SPINK4 | serine peptidase inhibitor, Kazal type 4 | -0.00487328 |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | -0.0048707 |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) | -0.00486313 |
| NUP54 | nucleoporin 54kDa | -0.00483781 |
| MCUB | mitochondrial calcium uniporter dominant negative subunit beta | -0.00482144 |
| PPP1R14D | protein phosphatase 1, regulatory (inhibitor) subunit 14D | -0.00477302 |
| HDAC2 | histone deacetylase 2 | -0.00477117 |
| MTFR1 | mitochondrial fission regulator 1 | -0.00476699 |
| GTF2H5 | general transcription factor IIH, polypeptide 5 | -0.00476589 |
| CXADR | coxsackie virus and adenovirus receptor | -0.00476347 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | -0.00475782 |
| RBBP8 | retinoblastoma binding protein 8 | -0.00474608 |
| ATP5MG | ATP synthase membrane subunit g | -0.00474235 |
| ESR1 | estrogen receptor 1 | -0.00474066 |
| ZDHHC4 | zinc finger, DHHC-type containing 4 | -0.0047399 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.00473435 |
| PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | -0.0047333 |
| HES1 | hes family bHLH transcription factor 1 | -0.00473176 |
| IL10RA | interleukin 10 receptor, alpha | -0.00472846 |
| LYPLA1 | lysophospholipase I | -0.00472655 |
| TSPAN6 | tetraspanin 6 | -0.0047255 |
| FXYD2 | FXYD domain containing ion transport regulator 2 | -0.00471408 |
| SUMO1 | small ubiquitin-like modifier 1 | -0.00471091 |
| LEF1 | lymphoid enhancer-binding factor 1 | -0.0047084 |
| NUAK1 | NUAK family, SNF1-like kinase, 1 | -0.00469027 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -0.00468551 |
