ALK Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description anaplastic lymphoma receptor tyrosine kinase|This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011] (NCBI Entrez Gene Database, 238)
External Link http://www.ncbi.nlm.nih.gov/gene/238
Similar Terms
Downloads & Tools

Genes

110 interacting proteins for ALK from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACAD11 acyl-CoA dehydrogenase family, member 11
ACVR1 activin A receptor, type I
ARHGAP9 Rho GTPase activating protein 9
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
AURKA aurora kinase A
AURKB aurora kinase B
AXL AXL receptor tyrosine kinase
AZI2 5-azacytidine induced 2
BMP2K BMP2 inducible kinase
CDK13 cyclin-dependent kinase 13
CENPF centromere protein F, 350/400kDa
DGKZ diacylglycerol kinase, zeta
EIF4B eukaryotic translation initiation factor 4B
EPHA1 EPH receptor A1
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
EPHB4 EPH receptor B4
ERRFI1 ERBB receptor feedback inhibitor 1
FER fer (fps/fes related) tyrosine kinase
FN3K fructosamine 3 kinase
GAK cyclin G associated kinase
GRB2 growth factor receptor-bound protein 2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
INSL6 insulin-like 6
IRAK1 interleukin-1 receptor-associated kinase 1
IRF7 interferon regulatory factor 7
IRS1 insulin receptor substrate 1
IRS4 insulin receptor substrate 4
ITK IL2-inducible T-cell kinase
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
KRT18 keratin 18, type I
KRT74 keratin 74, type II
LIMK1 LIM domain kinase 1
LIMK2 LIM domain kinase 2
LMNB1 lamin B1
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MARK1 MAP/microtubule affinity-regulating kinase 1
MDK midkine (neurite growth-promoting factor 2)
MEP1B meprin A, beta
MERTK MER proto-oncogene, tyrosine kinase
MST1R macrophage stimulating 1 receptor
MTIF2 mitochondrial translational initiation factor 2
MYBPC3 myosin binding protein C, cardiac
MYLK myosin light chain kinase
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NUAK1 NUAK family, SNF1-like kinase, 1
PDLIM5 PDZ and LIM domain 5
PDX1 pancreatic and duodenal homeobox 1
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PKM pyruvate kinase, muscle
PLCB2 phospholipase C, beta 2
PLCG1 phospholipase C, gamma 1
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRKD2 protein kinase D2
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTN pleiotrophin
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRB protein tyrosine phosphatase, receptor type, B
PTPRG protein tyrosine phosphatase, receptor type, G
PTPRJ protein tyrosine phosphatase, receptor type, J
PTPRK protein tyrosine phosphatase, receptor type, K
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAB35 RAB35, member RAS oncogene family
RAD17 RAD17 homolog (S. pombe)
RIPK2 receptor-interacting serine-threonine kinase 2
SFPQ splicing factor proline/glutamine-rich
SH3GL3 SH3-domain GRB2-like 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SLK STE20-like kinase
SMC6 structural maintenance of chromosomes 6
SOCS1 suppressor of cytokine signaling 1
SOCS5 suppressor of cytokine signaling 5
SRCIN1 SRC kinase signaling inhibitor 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK4 serine/threonine kinase 4
TANK TRAF family member-associated NFKB activator
TBK1 TANK-binding kinase 1
TBKBP1 TBK1 binding protein 1
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNK2 tyrosine kinase, non-receptor, 2
TRAF2 TNF receptor-associated factor 2
TYK2 tyrosine kinase 2
UBASH3A ubiquitin associated and SH3 domain containing A
VASP vasodilator-stimulated phosphoprotein
VAV3 vav 3 guanine nucleotide exchange factor
ZC3HC1 zinc finger, C3HC-type containing 1