ALK Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description anaplastic lymphoma receptor tyrosine kinase|This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011] (NCBI Entrez Gene Database, 238)
External Link http://www.ncbi.nlm.nih.gov/gene/238
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Genes

8 substrates of the kinase ALK from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ALK anaplastic lymphoma receptor tyrosine kinase
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
GRB2 growth factor receptor-bound protein 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
SFPQ splicing factor proline/glutamine-rich
SRCIN1 SRC kinase signaling inhibitor 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
VASP vasodilator-stimulated phosphoprotein