ALKBH3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description alkB, alkylation repair homolog 3 (E. coli)|The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008] (NCBI Entrez Gene Database, 221120)
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Genes

356 genes differentially expressed following the ALKBH3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
BPIFA2 BPI fold containing family A, member 2 3.60795
SLC26A9 solute carrier family 26 (anion exchanger), member 9 3.60795
HPCAL4 hippocalcin like 4 3.60795
IL22RA1 interleukin 22 receptor, alpha 1 3.60795
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 3.60795
PCDHB7 protocadherin beta 7 3.60795
TM4SF20 transmembrane 4 L six family member 20 3.60795
NRAP nebulin-related anchoring protein 3.60795
SLC25A41 solute carrier family 25, member 41 3.60795
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 3.60795
WDR87 WD repeat domain 87 3.60795
USP26 ubiquitin specific peptidase 26 3.60795
FGD2 FYVE, RhoGEF and PH domain containing 2 3.60795
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1 3.60795
RAET1E retinoic acid early transcript 1E 3.60795
HNF4A hepatocyte nuclear factor 4, alpha 3.60795
CFHR5 complement factor H-related 5 3.60795
GJA3 gap junction protein, alpha 3, 46kDa 3.60795
FOLR1 folate receptor 1 (adult) 3.60795
CD5 CD5 molecule 3.60795
ZACN zinc activated ligand-gated ion channel 3.60795
RASL10A RAS-like, family 10, member A 3.60795
OPRL1 opiate receptor-like 1 3.60795
LBP lipopolysaccharide binding protein 3.60795
MFAP5 microfibrillar associated protein 5 3.60795
DRGX dorsal root ganglia homeobox 3.60795
OR5V1 olfactory receptor, family 5, subfamily V, member 1 3.60795
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 3.60795
OXT oxytocin/neurophysin I prepropeptide 3.60795
ATOH1 atonal homolog 1 (Drosophila) 3.60795
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.60795
TSHZ1 teashirt zinc finger homeobox 1 3.60795
ASGR2 asialoglycoprotein receptor 2 3.60795
ETV7 ets variant 7 3.60795
TTLL8 tubulin tyrosine ligase-like family member 8 3.60795
SPNS2 spinster homolog 2 (Drosophila) 3.60795
TDRD9 tudor domain containing 9 3.60795
C19ORF67 chromosome 19 open reading frame 67 3.60795
SHCBP1L SHC SH2-domain binding protein 1-like 3.60795
CA6 carbonic anhydrase VI 3.60795
REN renin 3.60795
POSTN periostin, osteoblast specific factor 3.60795
SFTPB surfactant protein B 3.60795
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 3.60795
MYPN myopalladin 3.60795
TDRD6 tudor domain containing 6 3.60795
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 3.60795
SPMAP2L sperm microtubule associated protein 2 like 3.60795
SIM1 single-minded family bHLH transcription factor 1 3.60795
DUSP9 dual specificity phosphatase 9 3.60795
TMPRSS7 transmembrane protease, serine 7 3.60795
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 3.60795
TREX2 three prime repair exonuclease 2 3.60795
MAGIX MAGI family member, X-linked 3.60795
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 3.60795
CCDC42 coiled-coil domain containing 42 3.60795
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus 3.60795
AVPR1B arginine vasopressin receptor 1B 3.60795
ROPN1B rhophilin associated tail protein 1B 3.60795
UNC93A unc-93 homolog A (C. elegans) 3.60795
PRR20G proline rich 20G 3.60795
PRRT1B proline rich transmembrane protein 1B 3.60795
GLYATL1B glycine-N-acyltransferase like 1B 3.60795
UBE2L5 ubiquitin conjugating enzyme E2 L5 3.60795
ODAPH odontogenesis associated phosphoprotein 3.60795
CBY2 chibby family member 2 3.60795
CFAP206 cilia and flagella associated protein 206 3.60795
H2AP H2A.P histone 3.60795
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 3.60795
SAMD15 sterile alpha motif domain containing 15 3.60795
VCX3B variable charge, X-linked 3B 3.60795
C7 complement component 7 3.60795
CKM creatine kinase, muscle 3.60795
TEX101 testis expressed 101 3.60795
PCDHB10 protocadherin beta 10 3.60795
WDR38 WD repeat domain 38 3.60795
GGT5 gamma-glutamyltransferase 5 3.60795
RHOXF2 Rhox homeobox family, member 2 3.60795
ATP13A4 ATPase type 13A4 3.60795
PTTG2 pituitary tumor-transforming 2 3.60795
ELAVL4 ELAV like neuron-specific RNA binding protein 4 3.60795
UROC1 urocanate hydratase 1 3.60795
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 3.60795
TLR4 toll-like receptor 4 3.60795
SASH3 SAM and SH3 domain containing 3 3.60795
S100B S100 calcium binding protein B 3.60795
S100G S100 calcium binding protein G 3.60795
CDSN corneodesmosin 3.60795
EXOC3L1 exocyst complex component 3-like 1 3.60795
EXOC3L4 exocyst complex component 3-like 4 3.60795
NPFF neuropeptide FF-amide peptide precursor 3.60795
MIA melanoma inhibitory activity 3.60795
LEF1 lymphoid enhancer-binding factor 1 3.60795
HHEX hematopoietically expressed homeobox 3.60795
MCIDAS multiciliate differentiation and DNA synthesis associated cell cycle protein 3.60795
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3.60795
TPSB2 tryptase beta 2 (gene/pseudogene) 3.60795
FAM177B family with sequence similarity 177, member B 3.60795
CPA4 carboxypeptidase A4 3.60795
CYS1 cystin 1 3.60795
C2CD4B C2 calcium-dependent domain containing 4B 3.60795
IFNL4 interferon, lambda 4 (gene/pseudogene) 3.60795
NUPR1 nuclear protein, transcriptional regulator, 1 3.60795
CCL19 chemokine (C-C motif) ligand 19 3.60795
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 3.60795
CALHM1 calcium homeostasis modulator 1 3.60795
CALHM3 calcium homeostasis modulator 3 3.60795
CYSLTR2 cysteinyl leukotriene receptor 2 3.60795
FNDC8 fibronectin type III domain containing 8 3.60795
ZSCAN4 zinc finger and SCAN domain containing 4 3.60795
MR1 major histocompatibility complex, class I-related 3.60795
CNTF ciliary neurotrophic factor 3.60795
RAD51AP2 RAD51 associated protein 2 3.60795
EHF ets homologous factor 3.60795
NKX6-2 NK6 homeobox 2 3.60795
C11ORF96 chromosome 11 open reading frame 96 3.60795
ARR3 arrestin 3, retinal (X-arrestin) 3.60795
DPRX divergent-paired related homeobox 3.60795
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B 3.60795
THBD thrombomodulin 3.60795
ZCCHC12 zinc finger, CCHC domain containing 12 3.60795
LY6G6D lymphocyte antigen 6 complex, locus G6D 3.60795
SLC25A34 solute carrier family 25, member 34 3.60795
GFY golgi-associated, olfactory signaling regulator 3.60795
KLHDC1 kelch domain containing 1 3.60795
MEPE matrix extracellular phosphoglycoprotein 3.60795
CCDC78 coiled-coil domain containing 78 3.60795
TTC24 tetratricopeptide repeat domain 24 3.60795
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 3.60795
ZNF835 zinc finger protein 835 3.60795
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 3.60795
OR13G1 olfactory receptor, family 13, subfamily G, member 1 3.60795
NXF2B nuclear RNA export factor 2B 3.60795
SH2D1B SH2 domain containing 1B 3.60795
COL6A5 collagen, type VI, alpha 5 3.60795
KLK4 kallikrein-related peptidase 4 3.60795
C8B complement component 8, beta polypeptide 3.60795
SPHKAP SPHK1 interactor, AKAP domain containing 3.60795
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 3.60795
OTOP2 otopetrin 2 3.60795
PENK proenkephalin 3.60795
DAW1 dynein assembly factor with WDR repeat domains 1 3.60795
PGR progesterone receptor 3.60795
TMPPE transmembrane protein with metallophosphoesterase domain 3.60795
PDK4 pyruvate dehydrogenase kinase, isozyme 4 3.60795
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 3.60795
FGF10 fibroblast growth factor 10 3.60795
OR3A3 olfactory receptor, family 3, subfamily A, member 3 3.60795
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 3.60795
APOL3 apolipoprotein L, 3 3.60795
TGM6 transglutaminase 6 3.60795
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 3.60795
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 3.60795
NPC1L1 NPC1-like 1 3.60795
CD226 CD226 molecule 3.60795
NLRP9 NLR family, pyrin domain containing 9 3.60795
C1ORF141 chromosome 1 open reading frame 141 3.60795
NR2F1 nuclear receptor subfamily 2, group F, member 1 3.60795
CLEC2B C-type lectin domain family 2, member B 3.60795
LEP leptin 3.60795
FGF7 fibroblast growth factor 7 3.60795
PCDHGA11 protocadherin gamma subfamily A, 11 3.60795
SOST sclerostin 3.60795
NPAS4 neuronal PAS domain protein 4 3.60795
WFDC11 WAP four-disulfide core domain 11 3.60795
CHRM1 cholinergic receptor, muscarinic 1 3.60795
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 3.60795
TMTC3 transmembrane and tetratricopeptide repeat containing 3 3.49679
SYBU syntabulin (syntaxin-interacting) 3.06441
LEMD2 LEM domain containing 2 2.71722
SGK2 serum/glucocorticoid regulated kinase 2 2.61517
GREB1L growth regulation by estrogen in breast cancer-like 2.61322
CATSPERQ catsper channel auxiliary subunit theta 2.58405
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 2.57465
DPP6 dipeptidyl-peptidase 6 2.5416
MTMR3 myotubularin related protein 3 2.5416
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 2.50963
JADE2 jade family PHD finger 2 2.49054
RBM14 RNA binding motif protein 14 2.49054
S100A14 S100 calcium binding protein A14 2.43609
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 2.43609
NOD2 nucleotide-binding oligomerization domain containing 2 2.43609
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 2.43609
KCNG3 potassium channel, voltage gated modifier subfamily G, member 3 2.43609
TCEA3 transcription elongation factor A (SII), 3 2.43609
MFAP4 microfibrillar-associated protein 4 2.43609
PMF1 polyamine-modulated factor 1 2.43133
PIM3 Pim-3 proto-oncogene, serine/threonine kinase 2.4279
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) 2.40786
ZEB2 zinc finger E-box binding homeobox 2 2.39955
TEX9 testis expressed 9 2.39955
RNF10 ring finger protein 10 2.35222
WNK1 WNK lysine deficient protein kinase 1 2.34951
MYO3B myosin IIIB 2.34951
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 2.30078
MRNIP MRN complex interacting protein 2.27839
LHFPL6 LHFPL tetraspan subfamily member 6 2.27839
TMX3 thioredoxin-related transmembrane protein 3 2.27839
UBL4A ubiquitin-like 4A 2.27586
THSD1 thrombospondin, type I, domain containing 1 2.24098
FBXO34 F-box protein 34 2.23251
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 2.23101
BVES blood vessel epicardial substance 2.22322
LTF lactotransferrin 2.22322
FADS6 fatty acid desaturase 6 2.22322
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.22322
MINDY2 MINDY lysine 48 deubiquitinase 2 2.20569
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 2.19448
DLG1 discs, large homolog 1 (Drosophila) 2.19448
PTCD2 pentatricopeptide repeat domain 2 2.19278
LRRN3 leucine rich repeat neuronal 3 2.18698
ARLN allregulin 2.18242
C11ORF71 chromosome 11 open reading frame 71 2.14808
NMT1 N-myristoyltransferase 1 2.11845
EPM2AIP1 EPM2A (laforin) interacting protein 1 2.10423
MEA1 male-enhanced antigen 1 2.10379
MECR mitochondrial trans-2-enoyl-CoA reductase 2.10379
ACTR5 ARP5 actin-related protein 5 homolog (yeast) 2.08051
TPD52 tumor protein D52 2.06161
ANKRD18A ankyrin repeat domain 18A 2.05686
DACT3 dishevelled-binding antagonist of beta-catenin 3 2.0486
RDH13 retinol dehydrogenase 13 (all-trans/9-cis) 2.04189
RASSF4 Ras association (RalGDS/AF-6) domain family member 4 2.0347
EPB41L5 erythrocyte membrane protein band 4.1 like 5 2.01817
SS18 synovial sarcoma translocation, chromosome 18 2.016
NEXMIF neurite extension and migration factor 2.00918
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 2.00891
ZBTB32 zinc finger and BTB domain containing 32 2.00418

decreased expression

Symbol Name Standardized Value
SEC24C SEC24 family member C -3.60795
SFXN3 sideroflexin 3 -3.60795
CD300A CD300a molecule -3.60795
COL16A1 collagen, type XVI, alpha 1 -3.60795
FAM90A1 family with sequence similarity 90, member A1 -3.60795
ZNF703 zinc finger protein 703 -3.60795
DNAH10 dynein, axonemal, heavy chain 10 -3.60795
SSTR1 somatostatin receptor 1 -3.60795
AKR1C2 aldo-keto reductase family 1, member C2 -3.60795
LRRTM1 leucine rich repeat transmembrane neuronal 1 -3.60795
RPL3L ribosomal protein L3-like -3.60795
MEIKIN meiotic kinetochore factor -3.60795
ZMYND12 zinc finger, MYND-type containing 12 -3.60795
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -3.60795
DNAH2 dynein, axonemal, heavy chain 2 -3.60795
FAM216B family with sequence similarity 216, member B -3.60795
SYTL4 synaptotagmin-like 4 -3.60795
CHAD chondroadherin -3.60795
RNF222 ring finger protein 222 -3.60795
POTEF POTE ankyrin domain family, member F -3.60795
IFI16 interferon, gamma-inducible protein 16 -3.60795
PTGDS prostaglandin D2 synthase 21kDa (brain) -3.60795
UPK3B uroplakin 3B -3.60795
ADORA1 adenosine A1 receptor -3.60795
SCRG1 stimulator of chondrogenesis 1 -3.60795
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 -3.60795
PTPN20 protein tyrosine phosphatase, non-receptor type 20 -3.60795
ITGA10 integrin, alpha 10 -3.60795
C1QL3 complement component 1, q subcomponent-like 3 -3.60795
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 -3.60795
GATA4 GATA binding protein 4 -3.60795
NSG2 neuronal vesicle trafficking associated 2 -3.60795
SLC49A3 solute carrier family 49 member 3 -3.60795
DRC7 dynein regulatory complex subunit 7 -3.60795
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 -3.60795
TACSTD2 tumor-associated calcium signal transducer 2 -3.60795
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B -3.60795
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma -3.60795
F11 coagulation factor XI -3.60795
CCDC17 coiled-coil domain containing 17 -3.60795
EMP1 epithelial membrane protein 1 -3.60795
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) -3.60795
WNT16 wingless-type MMTV integration site family, member 16 -3.60795
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 -3.60795
CATSPERD catsper channel auxiliary subunit delta -3.60795
MROH7 maestro heat-like repeat family member 7 -3.60795
H3C13 H3 clustered histone 13 -3.60795
HYAL3 hyaluronoglucosaminidase 3 -3.57622
UGT8 UDP glycosyltransferase 8 -3.19383
NBPF10 neuroblastoma breakpoint family, member 10 -3.15374
RPL19 ribosomal protein L19 -3.15023
RPS6KL1 ribosomal protein S6 kinase-like 1 -3.12034
DNAH5 dynein, axonemal, heavy chain 5 -3.06575
S1PR3 sphingosine-1-phosphate receptor 3 -2.95565
AMD1 adenosylmethionine decarboxylase 1 -2.90298
UBTD1 ubiquitin domain containing 1 -2.8765
SLC38A12 solute carrier family 38 member 12 -2.83708
ERV3-1-ZNF117 ERV3-1-ZNF117 readthrough -2.78339
SWI5 SWI5 recombination repair homolog (yeast) -2.74925
UBE2A ubiquitin-conjugating enzyme E2A -2.73001
ZNF746 zinc finger protein 746 -2.6949
PXMP2 peroxisomal membrane protein 2, 22kDa -2.6254
NTF4 neurotrophin 4 -2.61322
ALOX12B arachidonate 12-lipoxygenase, 12R type -2.61322
PADI3 peptidyl arginine deiminase, type III -2.61322
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 -2.61322
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 -2.6083
RAB40B RAB40B, member RAS oncogene family -2.57465
SKAP1 src kinase associated phosphoprotein 1 -2.53067
SYNPO synaptopodin -2.50345
MBLAC1 metallo-beta-lactamase domain containing 1 -2.50345
CDNF cerebral dopamine neurotrophic factor -2.50345
FAM78A family with sequence similarity 78, member A -2.50345
MTARC2 mitochondrial amidoxime reducing component 2 -2.46698
METTL23 methyltransferase like 23 -2.44722
SMIM14 small integral membrane protein 14 -2.43678
HDAC6 histone deacetylase 6 -2.43133
F8A1 coagulation factor VIII-associated 1 -2.41324
SPIB Spi-B transcription factor (Spi-1/PU.1 related) -2.41143
ING2 inhibitor of growth family, member 2 -2.39955
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase -2.39563
PCDHA6 protocadherin alpha 6 -2.39553
ABI3BP ABI family, member 3 (NESH) binding protein -2.36782
BMX BMX non-receptor tyrosine kinase -2.36782
CERS3 ceramide synthase 3 -2.36782
DPH6 diphthamine biosynthesis 6 -2.36719
HDAC9 histone deacetylase 9 -2.3486
CEND1 cell cycle exit and neuronal differentiation 1 -2.34157
MRPL44 mitochondrial ribosomal protein L44 -2.27839
SMIM30 small integral membrane protein 30 -2.26685
MFAP3L microfibrillar-associated protein 3-like -2.23985
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -2.23691
MDP1 magnesium-dependent phosphatase 1 -2.22966
AIRIM AFG2 interacting ribosome maturation factor -2.22404
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 -2.20569
EHD1 EH-domain containing 1 -2.20569
MBD4 methyl-CpG binding domain protein 4 -2.20569
SPATA45 spermatogenesis associated 45 -2.19278
TSHR thyroid stimulating hormone receptor -2.19278
WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules -2.18298
C9ORF78 chromosome 9 open reading frame 78 -2.17363
ADAT1 adenosine deaminase, tRNA-specific 1 -2.17269
MATK megakaryocyte-associated tyrosine kinase -2.16636
CCDC127 coiled-coil domain containing 127 -2.16636
PEX12 peroxisomal biogenesis factor 12 -2.16636
RBM39 RNA binding motif protein 39 -2.14404
INTS6 integrator complex subunit 6 -2.13197
RBM47 RNA binding motif protein 47 -2.12843
ZNF134 zinc finger protein 134 -2.11845
H3-3A H3.3 histone A -2.10379
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 -2.09778
RPL21 ribosomal protein L21 -2.08165
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa -2.07406
CEP250 centrosomal protein 250kDa -2.0706
STRIP2 striatin interacting protein 2 -2.06161
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit -2.04184
SAYSD1 SAYSVFN motif domain containing 1 -2.03052
PDZD11 PDZ domain containing 11 -2.03052
CALM2 calmodulin 2 (phosphorylase kinase, delta) -2.03049
ZNF740 zinc finger protein 740 -2.02528
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.00742
NOXRED1 NADP-dependent oxidoreductase domain containing 1 -2.00742
MRO maestro -2.00742
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit -2.00742
KIAA1143 KIAA1143 -2.00742
FILIP1 filamin A interacting protein 1 -2.0071
SOD3 superoxide dismutase 3, extracellular -2.0071
TTK TTK protein kinase -2.00163