ALK_DN.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/ALK_DN.V1_UP
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Genes

286 genes differentially expressed following the ALK_DN.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ACTL6B actin-like 6B
ADAM12 ADAM metallopeptidase domain 12
ADAM28 ADAM metallopeptidase domain 28
AIF1 allograft inflammatory factor 1
AMELY amelogenin, Y-linked
ANGPT2 angiopoietin 2
ANGPTL4 angiopoietin-like 4
AQP7 aquaporin 7
AQP9 aquaporin 9
ARHGAP4 Rho GTPase activating protein 4
ASNS asparagine synthetase (glutamine-hydrolyzing)
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BDKRB2 bradykinin receptor B2
BEGAIN brain-enriched guanylate kinase-associated
BMPR1B bone morphogenetic protein receptor, type IB
BST1 bone marrow stromal cell antigen 1
C8ORF4 chromosome 8 open reading frame 4
CA2 carbonic anhydrase II
CA3 carbonic anhydrase III
CARD9 caspase recruitment domain family, member 9
CATSPERG catsper channel auxiliary subunit gamma
CBS cystathionine-beta-synthase
CCL19 chemokine (C-C motif) ligand 19
CCL20 chemokine (C-C motif) ligand 20
CCNK cyclin K
CCR7 chemokine (C-C motif) receptor 7
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CES1P1 carboxylesterase 1 pseudogene 1
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CH25H cholesterol 25-hydroxylase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLSPN claspin
CRYGA crystallin, gamma A
CSTA cystatin A (stefin A)
CTH cystathionine gamma-lyase
CTRB2 chymotrypsinogen B2
CXCL5 chemokine (C-X-C motif) ligand 5
CXCR5 chemokine (C-X-C motif) receptor 5
DDIT4 DNA-damage-inducible transcript 4
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DLX6 distal-less homeobox 6
DMP1 dentin matrix acidic phosphoprotein 1
EIF3FP2 eukaryotic translation initiation factor 3, subunit F pseudogene 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
ETV1 ets variant 1
FABP2 fatty acid binding protein 2, intestinal
FAM110D family with sequence similarity 110, member D
FAM188A family with sequence similarity 188, member A
FAP fibroblast activation protein, alpha
FBXL8 F-box and leucine-rich repeat protein 8
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FGF21 fibroblast growth factor 21
FJX1 four jointed box 1 (Drosophila)
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FMO1 flavin containing monooxygenase 1
FOXP3 forkhead box P3
GALK1 galactokinase 1
GDF15 growth differentiation factor 15
GDF5 growth differentiation factor 5
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GRM1 glutamate receptor, metabotropic 1
GRPR gastrin-releasing peptide receptor
HIST3H3 histone cluster 3, H3
HLA-DMB major histocompatibility complex, class II, DM beta
HMGB3P1 high mobility group box 3 pseudogene 1
IGLL1 immunoglobulin lambda-like polypeptide 1
IL1R2 interleukin 1 receptor, type II
IL6 interleukin 6
INHBE inhibin, beta E
KRT81 keratin 81, type II
KYNU kynureninase
LIN28A lin-28 homolog A (C. elegans)
LMX1B LIM homeobox transcription factor 1, beta
LOC440792 proline dehydrogenase (oxidase) 1 pseudogene
LTC4S leukotriene C4 synthase
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MPO myeloperoxidase
MRAS muscle RAS oncogene homolog
MT1H metallothionein 1H
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NNAT neuronatin
NOD2 nucleotide-binding oligomerization domain containing 2
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OLFML3 olfactomedin-like 3
OR10H3 olfactory receptor, family 10, subfamily H, member 3
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDZD7 PDZ domain containing 7
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PNOC prepronociceptin
PRDM1 PR domain containing 1, with ZNF domain
PROL1 proline rich, lacrimal 1
PSAT1 phosphoserine aminotransferase 1
PYGB phosphorylase, glycogen; brain
PYY2 peptide YY, 2 (pseudogene)
RAB9BP1 RAB9B, member RAS oncogene family pseudogene 1
RBM17 RNA binding motif protein 17
RIBC2 RIB43A domain with coiled-coils 2
RRAS related RAS viral (r-ras) oncogene homolog
SAA1 serum amyloid A1
SCGB1D1 secretoglobin, family 1D, member 1
SCN1A sodium channel, voltage gated, type I alpha subunit
SCN9A sodium channel, voltage gated, type IX alpha subunit
SLAMF7 SLAM family member 7
SLC12A8 solute carrier family 12, member 8
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMPX small muscle protein, X-linked
SPACA1 sperm acrosome associated 1
SPP1 secreted phosphoprotein 1
SPRR2C small proline-rich protein 2C (pseudogene)
STC2 stanniocalcin 2
STEAP4 STEAP family member 4
STMN2 stathmin 2
TBL1Y transducin (beta)-like 1, Y-linked
TBX2 T-box 2
TDO2 tryptophan 2,3-dioxygenase
TFEC transcription factor EC
THAP3 THAP domain containing, apoptosis associated protein 3
TREM1 triggering receptor expressed on myeloid cells 1
TRIB3 tribbles pseudokinase 3
TTLL2 tubulin tyrosine ligase-like family member 2
UBQLN3 ubiquilin 3
UNC13A unc-13 homolog A (C. elegans)
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VNN2 vanin 2
VSTM4 V-set and transmembrane domain containing 4
XBP1 X-box binding protein 1
ZNF639 zinc finger protein 639
ZNRF4 zinc and ring finger 4

decreased expression

Symbol Name
ABHD8 abhydrolase domain containing 8
ADCY2 adenylate cyclase 2 (brain)
ADORA3 adenosine A3 receptor
AGRP agouti related neuropeptide
ANGPTL7 angiopoietin-like 7
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
AQP3 aquaporin 3 (Gill blood group)
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
BCO1 beta-carotene oxygenase 1
C16ORF59 chromosome 16 open reading frame 59
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CASQ2 calsequestrin 2 (cardiac muscle)
CCDC81 coiled-coil domain containing 81
CCR8 chemokine (C-C motif) receptor 8
CD300C CD300c molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEP41 centrosomal protein 41kDa
CHRM4 cholinergic receptor, muscarinic 4
CIC capicua transcriptional repressor
CIDEB cell death-inducing DFFA-like effector b
CLCA1 chloride channel accessory 1
CMKLR1 chemerin chemokine-like receptor 1
CNTNAP2 contactin associated protein-like 2
COL9A3 collagen, type IX, alpha 3
CRYAB crystallin, alpha B
CST4 cystatin S
CTF1 cardiotrophin 1
CTRC chymotrypsin C (caldecrin)
DIO2 deiodinase, iodothyronine, type II
DKFZP434C153 DKFZP434C153 protein
DLGAP2 discs, large (Drosophila) homolog-associated protein 2
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNASE1L2 deoxyribonuclease I-like 2
DOC2A double C2-like domains, alpha
DOK3 docking protein 3
DPEP1 dipeptidase 1 (renal)
EFHD1 EF-hand domain family, member D1
EFNA2 ephrin-A2
EGFL6 EGF-like-domain, multiple 6
ESRP1 epithelial splicing regulatory protein 1
FAM215A family with sequence similarity 215, member A (non-protein coding)
FGL2 fibrinogen-like 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXA1 forkhead box A1
FXYD6 FXYD domain containing ion transport regulator 6
FZD8 frizzled class receptor 8
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GCKR glucokinase (hexokinase 4) regulator
GPA33 glycoprotein A33 (transmembrane)
GPR162 G protein-coupled receptor 162
GPR45 G protein-coupled receptor 45
GPX2 glutathione peroxidase 2
GRB7 growth factor receptor-bound protein 7
GRM2 glutamate receptor, metabotropic 2
GSG1 germ cell associated 1
GYPE glycophorin E (MNS blood group)
HDAC9 histone deacetylase 9
HPX hemopexin
HSPA1L heat shock 70kDa protein 1-like
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IGFBP6 insulin-like growth factor binding protein 6
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRF9 interferon regulatory factor 9
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KAZN kazrin, periplakin interacting protein
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0408 KIAA0408
KIAA0509 uncharacterized LOC57242
LCN1 lipocalin 1
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LECT1 leukocyte cell derived chemotaxin 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LINC00260 long intergenic non-protein coding RNA 260
LOC100288903
LOC145678 uncharacterized LOC145678
LPA lipoprotein, Lp(a)
LPAR2 lysophosphatidic acid receptor 2
MAEA macrophage erythroblast attacher
MGC2889 uncharacterized protein MGC2889
MIA melanoma inhibitory activity
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MX1 MX dynamin-like GTPase 1
MYH1 myosin, heavy chain 1, skeletal muscle, adult
MYL10 myosin, light chain 10, regulatory
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NDRG2 NDRG family member 2
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NRDE2 NRDE-2, necessary for RNA interference, domain containing
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OLFM4 olfactomedin 4
OPRD1 opioid receptor, delta 1
OR10J1 olfactory receptor, family 10, subfamily J, member 1
OR1D2 olfactory receptor, family 1, subfamily D, member 2
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2
PAX1 paired box 1
PCDH8 protocadherin 8
PENK proenkephalin
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRDM14 PR domain containing 14
PRODH proline dehydrogenase (oxidase) 1
PROZ protein Z, vitamin K-dependent plasma glycoprotein
PRPH peripherin
PSORS1C1 psoriasis susceptibility 1 candidate 1
PTK2B protein tyrosine kinase 2 beta
PTPRF protein tyrosine phosphatase, receptor type, F
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PYY peptide YY
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like
RHO rhodopsin
RPL23AP7 ribosomal protein L23a pseudogene 7
RTP4 receptor (chemosensory) transporter protein 4
RXRG retinoid X receptor, gamma
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SLA Src-like-adaptor
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2
SLMO1 slowmo homolog 1 (Drosophila)
SPTB spectrin, beta, erythrocytic
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TCP10 t-complex 10
TEX13A testis expressed 13A
THSD4 thrombospondin, type I, domain containing 4
TIAM1 T-cell lymphoma invasion and metastasis 1
TRIM17 tripartite motif containing 17
TTC38 tetratricopeptide repeat domain 38
UNC93B1 unc-93 homolog B1 (C. elegans)
USP46 ubiquitin specific peptidase 46
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
ZBED2 zinc finger, BED-type containing 2
ZFYVE26 zinc finger, FYVE domain containing 26