| Dataset | MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database) |
| External Link | http://www.broadinstitute.org/gsea/msigdb/cards/ALK_DN.V1_UP |
| Similar Terms | |
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286 genes differentially expressed following the ALK_DN.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
| Symbol | Name |
|---|---|
| ACTL6B | actin-like 6B |
| ADAM12 | ADAM metallopeptidase domain 12 |
| ADAM28 | ADAM metallopeptidase domain 28 |
| AIF1 | allograft inflammatory factor 1 |
| AMELY | amelogenin, Y-linked |
| ANGPT2 | angiopoietin 2 |
| ANGPTL4 | angiopoietin-like 4 |
| AQP7 | aquaporin 7 |
| AQP9 | aquaporin 9 |
| ARHGAP4 | Rho GTPase activating protein 4 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) |
| B3GALT4 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 |
| BDKRB2 | bradykinin receptor B2 |
| BEGAIN | brain-enriched guanylate kinase-associated |
| BMPR1B | bone morphogenetic protein receptor, type IB |
| BST1 | bone marrow stromal cell antigen 1 |
| C8ORF4 | chromosome 8 open reading frame 4 |
| CA2 | carbonic anhydrase II |
| CA3 | carbonic anhydrase III |
| CARD9 | caspase recruitment domain family, member 9 |
| CATSPERG | catsper channel auxiliary subunit gamma |
| CBS | cystathionine-beta-synthase |
| CCL19 | chemokine (C-C motif) ligand 19 |
| CCL20 | chemokine (C-C motif) ligand 20 |
| CCNK | cyclin K |
| CCR7 | chemokine (C-C motif) receptor 7 |
| CEBPG | CCAAT/enhancer binding protein (C/EBP), gamma |
| CES1P1 | carboxylesterase 1 pseudogene 1 |
| CFTR | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) |
| CH25H | cholesterol 25-hydroxylase |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) |
| CHST8 | carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 |
| CLSPN | claspin |
| CRYGA | crystallin, gamma A |
| CSTA | cystatin A (stefin A) |
| CTH | cystathionine gamma-lyase |
| CTRB2 | chymotrypsinogen B2 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 |
| CXCR5 | chemokine (C-X-C motif) receptor 5 |
| DDIT4 | DNA-damage-inducible transcript 4 |
| DECR2 | 2,4-dienoyl CoA reductase 2, peroxisomal |
| DLX6 | distal-less homeobox 6 |
| DMP1 | dentin matrix acidic phosphoprotein 1 |
| EIF3FP2 | eukaryotic translation initiation factor 3, subunit F pseudogene 2 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 |
| ENTPD3 | ectonucleoside triphosphate diphosphohydrolase 3 |
| EPAS1 | endothelial PAS domain protein 1 |
| EREG | epiregulin |
| ETV1 | ets variant 1 |
| FABP2 | fatty acid binding protein 2, intestinal |
| FAM110D | family with sequence similarity 110, member D |
| FAM188A | family with sequence similarity 188, member A |
| FAP | fibroblast activation protein, alpha |
| FBXL8 | F-box and leucine-rich repeat protein 8 |
| FBXW4P1 | F-box and WD repeat domain containing 4 pseudogene 1 |
| FGF21 | fibroblast growth factor 21 |
| FJX1 | four jointed box 1 (Drosophila) |
| FLVCR2 | feline leukemia virus subgroup C cellular receptor family, member 2 |
| FMO1 | flavin containing monooxygenase 1 |
| FOXP3 | forkhead box P3 |
| GALK1 | galactokinase 1 |
| GDF15 | growth differentiation factor 15 |
| GDF5 | growth differentiation factor 5 |
| GNA15 | guanine nucleotide binding protein (G protein), alpha 15 (Gq class) |
| GNAT2 | guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 |
| GRM1 | glutamate receptor, metabotropic 1 |
| GRPR | gastrin-releasing peptide receptor |
| HIST3H3 | histone cluster 3, H3 |
| HLA-DMB | major histocompatibility complex, class II, DM beta |
| HMGB3P1 | high mobility group box 3 pseudogene 1 |
| IGLL1 | immunoglobulin lambda-like polypeptide 1 |
| IL1R2 | interleukin 1 receptor, type II |
| IL6 | interleukin 6 |
| INHBE | inhibin, beta E |
| KRT81 | keratin 81, type II |
| KYNU | kynureninase |
| LIN28A | lin-28 homolog A (C. elegans) |
| LMX1B | LIM homeobox transcription factor 1, beta |
| LOC440792 | proline dehydrogenase (oxidase) 1 pseudogene |
| LTC4S | leukotriene C4 synthase |
| LYL1 | lymphoblastic leukemia associated hematopoiesis regulator 1 |
| MLC1 | megalencephalic leukoencephalopathy with subcortical cysts 1 |
| MPO | myeloperoxidase |
| MRAS | muscle RAS oncogene homolog |
| MT1H | metallothionein 1H |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
| NFKBIL1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 |
| NNAT | neuronatin |
| NOD2 | nucleotide-binding oligomerization domain containing 2 |
| NTRK1 | neurotrophic tyrosine kinase, receptor, type 1 |
| OLFML3 | olfactomedin-like 3 |
| OR10H3 | olfactory receptor, family 10, subfamily H, member 3 |
| P2RX3 | purinergic receptor P2X, ligand gated ion channel, 3 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
| PDZD7 | PDZ domain containing 7 |
| PIK3CG | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma |
| PNOC | prepronociceptin |
| PRDM1 | PR domain containing 1, with ZNF domain |
| PROL1 | proline rich, lacrimal 1 |
| PSAT1 | phosphoserine aminotransferase 1 |
| PYGB | phosphorylase, glycogen; brain |
| PYY2 | peptide YY, 2 (pseudogene) |
| RAB9BP1 | RAB9B, member RAS oncogene family pseudogene 1 |
| RBM17 | RNA binding motif protein 17 |
| RIBC2 | RIB43A domain with coiled-coils 2 |
| RRAS | related RAS viral (r-ras) oncogene homolog |
| SAA1 | serum amyloid A1 |
| SCGB1D1 | secretoglobin, family 1D, member 1 |
| SCN1A | sodium channel, voltage gated, type I alpha subunit |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit |
| SLAMF7 | SLAM family member 7 |
| SLC12A8 | solute carrier family 12, member 8 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 |
| SLC1A5 | solute carrier family 1 (neutral amino acid transporter), member 5 |
| SLC6A9 | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 |
| SMPX | small muscle protein, X-linked |
| SPACA1 | sperm acrosome associated 1 |
| SPP1 | secreted phosphoprotein 1 |
| SPRR2C | small proline-rich protein 2C (pseudogene) |
| STC2 | stanniocalcin 2 |
| STEAP4 | STEAP family member 4 |
| STMN2 | stathmin 2 |
| TBL1Y | transducin (beta)-like 1, Y-linked |
| TBX2 | T-box 2 |
| TDO2 | tryptophan 2,3-dioxygenase |
| TFEC | transcription factor EC |
| THAP3 | THAP domain containing, apoptosis associated protein 3 |
| TREM1 | triggering receptor expressed on myeloid cells 1 |
| TRIB3 | tribbles pseudokinase 3 |
| TTLL2 | tubulin tyrosine ligase-like family member 2 |
| UBQLN3 | ubiquilin 3 |
| UNC13A | unc-13 homolog A (C. elegans) |
| VEGFA | vascular endothelial growth factor A |
| VEGFC | vascular endothelial growth factor C |
| VNN2 | vanin 2 |
| VSTM4 | V-set and transmembrane domain containing 4 |
| XBP1 | X-box binding protein 1 |
| ZNF639 | zinc finger protein 639 |
| ZNRF4 | zinc and ring finger 4 |
| Symbol | Name |
|---|---|
| ABHD8 | abhydrolase domain containing 8 |
| ADCY2 | adenylate cyclase 2 (brain) |
| ADORA3 | adenosine A3 receptor |
| AGRP | agouti related neuropeptide |
| ANGPTL7 | angiopoietin-like 7 |
| AP1G2 | adaptor-related protein complex 1, gamma 2 subunit |
| AQP3 | aquaporin 3 (Gill blood group) |
| ARID3B | AT rich interactive domain 3B (BRIGHT-like) |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 |
| BCO1 | beta-carotene oxygenase 1 |
| C16ORF59 | chromosome 16 open reading frame 59 |
| CAMK2A | calcium/calmodulin-dependent protein kinase II alpha |
| CASQ2 | calsequestrin 2 (cardiac muscle) |
| CCDC81 | coiled-coil domain containing 81 |
| CCR8 | chemokine (C-C motif) receptor 8 |
| CD300C | CD300c molecule |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) |
| CEACAM7 | carcinoembryonic antigen-related cell adhesion molecule 7 |
| CEP41 | centrosomal protein 41kDa |
| CHRM4 | cholinergic receptor, muscarinic 4 |
| CIC | capicua transcriptional repressor |
| CIDEB | cell death-inducing DFFA-like effector b |
| CLCA1 | chloride channel accessory 1 |
| CMKLR1 | chemerin chemokine-like receptor 1 |
| CNTNAP2 | contactin associated protein-like 2 |
| COL9A3 | collagen, type IX, alpha 3 |
| CRYAB | crystallin, alpha B |
| CST4 | cystatin S |
| CTF1 | cardiotrophin 1 |
| CTRC | chymotrypsin C (caldecrin) |
| DIO2 | deiodinase, iodothyronine, type II |
| DKFZP434C153 | DKFZP434C153 protein |
| DLGAP2 | discs, large (Drosophila) homolog-associated protein 2 |
| DNAJA4 | DnaJ (Hsp40) homolog, subfamily A, member 4 |
| DNASE1L2 | deoxyribonuclease I-like 2 |
| DOC2A | double C2-like domains, alpha |
| DOK3 | docking protein 3 |
| DPEP1 | dipeptidase 1 (renal) |
| EFHD1 | EF-hand domain family, member D1 |
| EFNA2 | ephrin-A2 |
| EGFL6 | EGF-like-domain, multiple 6 |
| ESRP1 | epithelial splicing regulatory protein 1 |
| FAM215A | family with sequence similarity 215, member A (non-protein coding) |
| FGL2 | fibrinogen-like 2 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog |
| FOXA1 | forkhead box A1 |
| FXYD6 | FXYD domain containing ion transport regulator 6 |
| FZD8 | frizzled class receptor 8 |
| GABRG2 | gamma-aminobutyric acid (GABA) A receptor, gamma 2 |
| GCKR | glucokinase (hexokinase 4) regulator |
| GPA33 | glycoprotein A33 (transmembrane) |
| GPR162 | G protein-coupled receptor 162 |
| GPR45 | G protein-coupled receptor 45 |
| GPX2 | glutathione peroxidase 2 |
| GRB7 | growth factor receptor-bound protein 7 |
| GRM2 | glutamate receptor, metabotropic 2 |
| GSG1 | germ cell associated 1 |
| GYPE | glycophorin E (MNS blood group) |
| HDAC9 | histone deacetylase 9 |
| HPX | hemopexin |
| HSPA1L | heat shock 70kDa protein 1-like |
| IFI27 | interferon, alpha-inducible protein 27 |
| IFI44L | interferon-induced protein 44-like |
| IFI6 | interferon, alpha-inducible protein 6 |
| IGFBP6 | insulin-like growth factor binding protein 6 |
| INPP5D | inositol polyphosphate-5-phosphatase, 145kDa |
| IRF9 | interferon regulatory factor 9 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 |
| KAZN | kazrin, periplakin interacting protein |
| KCNC3 | potassium channel, voltage gated Shaw related subfamily C, member 3 |
| KCNJ9 | potassium channel, inwardly rectifying subfamily J, member 9 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 |
| KIAA0408 | KIAA0408 |
| KIAA0509 | uncharacterized LOC57242 |
| LCN1 | lipocalin 1 |
| LDLRAD4 | low density lipoprotein receptor class A domain containing 4 |
| LECT1 | leukocyte cell derived chemotaxin 1 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 |
| LILRA6 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 |
| LINC00260 | long intergenic non-protein coding RNA 260 |
| LOC100288903 | |
| LOC145678 | uncharacterized LOC145678 |
| LPA | lipoprotein, Lp(a) |
| LPAR2 | lysophosphatidic acid receptor 2 |
| MAEA | macrophage erythroblast attacher |
| MGC2889 | uncharacterized protein MGC2889 |
| MIA | melanoma inhibitory activity |
| MTHFR | methylenetetrahydrofolate reductase (NAD(P)H) |
| MX1 | MX dynamin-like GTPase 1 |
| MYH1 | myosin, heavy chain 1, skeletal muscle, adult |
| MYL10 | myosin, light chain 10, regulatory |
| NAT2 | N-acetyltransferase 2 (arylamine N-acetyltransferase) |
| NDRG2 | NDRG family member 2 |
| NMNAT2 | nicotinamide nucleotide adenylyltransferase 2 |
| NRDE2 | NRDE-2, necessary for RNA interference, domain containing |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa |
| OLFM4 | olfactomedin 4 |
| OPRD1 | opioid receptor, delta 1 |
| OR10J1 | olfactory receptor, family 10, subfamily J, member 1 |
| OR1D2 | olfactory receptor, family 1, subfamily D, member 2 |
| P2RX2 | purinergic receptor P2X, ligand gated ion channel, 2 |
| PAX1 | paired box 1 |
| PCDH8 | protocadherin 8 |
| PENK | proenkephalin |
| PPP2R1A | protein phosphatase 2, regulatory subunit A, alpha |
| PRDM14 | PR domain containing 14 |
| PRODH | proline dehydrogenase (oxidase) 1 |
| PROZ | protein Z, vitamin K-dependent plasma glycoprotein |
| PRPH | peripherin |
| PSORS1C1 | psoriasis susceptibility 1 candidate 1 |
| PTK2B | protein tyrosine kinase 2 beta |
| PTPRF | protein tyrosine phosphatase, receptor type, F |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 |
| PYY | peptide YY |
| RBPJL | recombination signal binding protein for immunoglobulin kappa J region-like |
| RHO | rhodopsin |
| RPL23AP7 | ribosomal protein L23a pseudogene 7 |
| RTP4 | receptor (chemosensory) transporter protein 4 |
| RXRG | retinoid X receptor, gamma |
| SEMA3E | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E |
| SEMA7A | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) |
| SERPINF2 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 |
| SERPINI2 | serpin peptidase inhibitor, clade I (pancpin), member 2 |
| SLA | Src-like-adaptor |
| SLC10A1 | solute carrier family 10 (sodium/bile acid cotransporter), member 1 |
| SLC28A2 | solute carrier family 28 (concentrative nucleoside transporter), member 2 |
| SLMO1 | slowmo homolog 1 (Drosophila) |
| SPTB | spectrin, beta, erythrocytic |
| ST8SIA3 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase |
| TCP10 | t-complex 10 |
| TEX13A | testis expressed 13A |
| THSD4 | thrombospondin, type I, domain containing 4 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 |
| TRIM17 | tripartite motif containing 17 |
| TTC38 | tetratricopeptide repeat domain 38 |
| UNC93B1 | unc-93 homolog B1 (C. elegans) |
| USP46 | ubiquitin specific peptidase 46 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked |
| VAV1 | vav 1 guanine nucleotide exchange factor |
| VAV2 | vav 2 guanine nucleotide exchange factor |
| VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) |
| ZBED2 | zinc finger, BED-type containing 2 |
| ZFYVE26 | zinc finger, FYVE domain containing 26 |
