ALX1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description ALX homeobox 1|The specific function of this gene has yet to be determined in humans; however, in rodents, it is necessary for survival of the forebrain mesenchyme and may also be involved in development of the cervix. Mutations in the mouse gene lead to neural tube defects such as acrania and meroanencephaly. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8092)
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Genes

347 genes differentially expressed following the ALX1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GUCA1C guanylate cyclase activator 1C 2.43293
TSGA13 testis specific, 13 2.43293
CELA3B chymotrypsin-like elastase family, member 3B 2.43293
HORMAD1 HORMA domain containing 1 2.43293
DSTYK dual serine/threonine and tyrosine protein kinase 2.43293
SLC25A45 solute carrier family 25, member 45 2.43293
GJB5 gap junction protein, beta 5, 31.1kDa 2.43293
TKTL1 transketolase-like 1 2.43293
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.43293
PAX5 paired box 5 2.43293
PLCH2 phospholipase C, eta 2 2.43293
PLIN1 perilipin 1 2.43293
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.43293
FABP9 fatty acid binding protein 9, testis 2.43293
PDILT protein disulfide isomerase-like, testis expressed 2.43293
COL19A1 collagen, type XIX, alpha 1 2.43293
NDRG1 N-myc downstream regulated 1 2.43293
COL20A1 collagen, type XX, alpha 1 2.43293
MYBPHL myosin binding protein H-like 2.43293
LRRD1 leucine-rich repeats and death domain containing 1 2.43293
CARD18 caspase recruitment domain family, member 18 2.43293
FAM180A family with sequence similarity 180, member A 2.43293
DUXB double homeobox B 2.43293
OLIG1 oligodendrocyte transcription factor 1 2.43293
SSMEM1 serine-rich single-pass membrane protein 1 2.43293
BMP5 bone morphogenetic protein 5 2.43293
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) 2.43293
NMUR2 neuromedin U receptor 2 2.43293
FAM9B family with sequence similarity 9, member B 2.43293
KIAA1755 KIAA1755 2.43293
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 2.43293
FGF7 fibroblast growth factor 7 2.43293
FGF9 fibroblast growth factor 9 2.43293
TPRX1 tetra-peptide repeat homeobox 1 2.43293
DSPP dentin sialophosphoprotein 2.43293
TREML1 triggering receptor expressed on myeloid cells-like 1 2.43293
HBZ hemoglobin, zeta 2.43293
ASB10 ankyrin repeat and SOCS box containing 10 2.43293
GYPB glycophorin B (MNS blood group) 2.43293
HCRTR2 hypocretin (orexin) receptor 2 2.43293
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.43293
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 2.43293
C1ORF141 chromosome 1 open reading frame 141 2.43293
C9ORF152 chromosome 9 open reading frame 152 2.43293
GMFG glia maturation factor, gamma 2.43293
SPP2 secreted phosphoprotein 2, 24kDa 2.43293
OCSTAMP osteoclast stimulatory transmembrane protein 2.43293
WFDC11 WAP four-disulfide core domain 11 2.43293
ZNF99 zinc finger protein 99 2.43293
SPMIP11 sperm microtubule inner protein 11 2.43293
GPX5 glutathione peroxidase 5 2.43293
GPR35 G protein-coupled receptor 35 2.43293
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 2.43293
ACER1 alkaline ceramidase 1 2.43293
RD3 retinal degeneration 3 2.43293
MLN motilin 2.43293
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.43293
OR52E5 olfactory receptor, family 52, subfamily E, member 5 2.43293
MAGIX MAGI family member, X-linked 2.43293
MAP6D1 MAP6 domain containing 1 2.43293
OPRM1 opioid receptor, mu 1 2.43293
GBP3 guanylate binding protein 3 2.43293
SPEGNB SPEG neighbor 2.43293
TBC1D3I TBC1 domain family member 3I 2.43293
SYT15B synaptotagmin 15B 2.43293
MYMK myomaker, myoblast fusion factor 2.43293
GARIN4 golgi associated RAB2 interactor family member 4 2.43293
LORICRIN loricrin cornified envelope precursor protein 2.43293
NSG2 neuronal vesicle trafficking associated 2 2.43293
SELE selectin E 2.43293
HAO2 hydroxyacid oxidase 2 (long chain) 2.43293
OTOS otospiralin 2.43293
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 2.43293
F5 coagulation factor V (proaccelerin, labile factor) 2.43293
RUNX3 runt-related transcription factor 3 2.43293
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 2.43293
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 2.43293
LIX1 Lix1 homolog (chicken) 2.43293
GAST gastrin 2.43293
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.43293
TEX101 testis expressed 101 2.43293
IRF5 interferon regulatory factor 5 2.43293
CLDN2 claudin 2 2.43293
PTPRQ protein tyrosine phosphatase, receptor type, Q 2.43293
C1QTNF1 C1q and tumor necrosis factor related protein 1 2.43293
C9 complement component 9 2.43293
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 2.43293
GATA2 GATA binding protein 2 2.43293
PRDM7 PR domain containing 7 2.43293
SYT15 synaptotagmin XV 2.43293
LRRN4CL LRRN4 C-terminal like 2.43293
SOAT2 sterol O-acyltransferase 2 2.43293
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.43293
PXDC1 PX domain containing 1 2.43293
LGSN lengsin, lens protein with glutamine synthetase domain 2.43293
SAMD11 sterile alpha motif domain containing 11 2.43293
FOXD1 forkhead box D1 2.43293
TEKT5 tektin 5 2.43293
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.43293
CT55 cancer/testis antigen 55 2.43293
RBMXL3 RNA binding motif protein, X-linked-like 3 2.43293
TMEM132D transmembrane protein 132D 2.43293
GLYATL2 glycine-N-acyltransferase-like 2 2.43293
LY9 lymphocyte antigen 9 2.43293
GOLGA6D golgin A6 family, member D 2.43293
FNDC1 fibronectin type III domain containing 1 2.43293
GAL3ST2 galactose-3-O-sulfotransferase 2 2.43293
PCDHGB5 protocadherin gamma subfamily B, 5 2.43293
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 2.43293
VAX2 ventral anterior homeobox 2 2.43293
MORC1 MORC family CW-type zinc finger 1 2.43293
OR7G2 olfactory receptor, family 7, subfamily G, member 2 2.43293
GPR62 G protein-coupled receptor 62 2.43293
ANKRD62 ankyrin repeat domain 62 2.43293
CTSS cathepsin S 2.43293
ZNF703 zinc finger protein 703 2.43293
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 2.43293
C11ORF96 chromosome 11 open reading frame 96 2.43293
IFITM5 interferon induced transmembrane protein 5 2.43293
BAHCC1 BAH domain and coiled-coil containing 1 2.43293
TTC9B tetratricopeptide repeat domain 9B 2.43293
EGR2 early growth response 2 2.43293
CLEC4D C-type lectin domain family 4, member D 2.43293
PAGE4 P antigen family, member 4 (prostate associated) 2.43293
LY96 lymphocyte antigen 96 2.43293
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.43293
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.43293
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.43293
ANKRD53 ankyrin repeat domain 53 2.43293
SMIM17 small integral membrane protein 17 2.43293
HELZ helicase with zinc finger 2.43293
PLET1 placenta expressed transcript 1 2.43293
MAGED4B melanoma antigen family D4B 2.43293
CRYBB3 crystallin, beta B3 2.43293
SYNGR4 synaptogyrin 4 2.43293
SOSTDC1 sclerostin domain containing 1 2.43293
CD22 CD22 molecule 2.43293
FOXG1 forkhead box G1 2.43293
MEIOB meiosis specific with OB domains 2.43293
GOLGA8N golgin A8 family, member N 2.43293
TMEM213 transmembrane protein 213 2.43293
GPRC5D G protein-coupled receptor, class C, group 5, member D 2.43293
TTC24 tetratricopeptide repeat domain 24 2.43293
KCNK15 potassium channel, two pore domain subfamily K, member 15 2.43293
OR52N1 olfactory receptor, family 52, subfamily N, member 1 2.43293
MZB1 marginal zone B and B1 cell-specific protein 2.43293
LPA lipoprotein, Lp(a) 2.43293
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.43293
GPRASP2 G protein-coupled receptor associated sorting protein 2 2.43293
IRX3 iroquois homeobox 3 2.43293
PASD1 PAS domain containing 1 2.43293
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 2.43293
ART1 ADP-ribosyltransferase 1 2.43293
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.43293
ASCL3 achaete-scute family bHLH transcription factor 3 2.43293
TRAF3IP3 TRAF3 interacting protein 3 2.43293
HLA-DMB major histocompatibility complex, class II, DM beta 2.43293
CSF1R colony stimulating factor 1 receptor 2.43293
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.43293
RNF224 ring finger protein 224 2.43293
UBXN10 UBX domain protein 10 2.43293
CLPSL1 colipase-like 1 2.43293
CLCA1 chloride channel accessory 1 2.43293
ITPKA inositol-trisphosphate 3-kinase A 2.43293
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 2.43293
TRPM5 transient receptor potential cation channel, subfamily M, member 5 2.43293
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 2.43293
CIB3 calcium and integrin binding family member 3 2.43293
RFWD3 ring finger and WD repeat domain 3 2.42421
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa 2.38602
SAMD14 sterile alpha motif domain containing 14 2.35808
LRRC19 leucine rich repeat containing 19 2.35808
C20ORF203 chromosome 20 open reading frame 203 2.35808
KLHDC1 kelch domain containing 1 2.35808
EXTL2 exostosin-like glycosyltransferase 2 2.35329
DYNLT1 dynein, light chain, Tctex-type 1 2.3268
VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae) 2.31727
HSPA1B heat shock 70kDa protein 1B 2.30978
DOLK dolichol kinase 2.29629
SLC30A1 solute carrier family 30 (zinc transporter), member 1 2.2923
POLR3B polymerase (RNA) III (DNA directed) polypeptide B 2.28405
RAB5IF RAB5 interacting factor 2.27672
SIVA1 SIVA1, apoptosis-inducing factor 2.23201
INAFM2 InaF-motif containing 2 2.20386
TXNDC9 thioredoxin domain containing 9 2.20273
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease 2.19148
ZNF224 zinc finger protein 224 2.17632
TRAPPC2B trafficking protein particle complex 2B 2.17366
DHRS7B dehydrogenase/reductase (SDR family) member 7B 2.17282
ERI1 exoribonuclease 1 2.17282
BORCS6 BLOC-1 related complex subunit 6 2.17282
TMEM234 transmembrane protein 234 2.17282
MROH1 maestro heat-like repeat family member 1 2.17282
PMVK phosphomevalonate kinase 2.17282
PLAA phospholipase A2-activating protein 2.17282
SF3B5 splicing factor 3b, subunit 5, 10kDa 2.16872
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 2.16809
EGFR epidermal growth factor receptor 2.16809
MLYCD malonyl-CoA decarboxylase 2.16809
CEP70 centrosomal protein 70kDa 2.15554
KIF5C kinesin family member 5C 2.15554
CDC27 cell division cycle 27 2.15554
MAPK6 mitogen-activated protein kinase 6 2.15554
GRID2 glutamate receptor, ionotropic, delta 2 2.15554
RNF25 ring finger protein 25 2.15554
HPS6 Hermansky-Pudlak syndrome 6 2.15554
SLC38A2 solute carrier family 38, member 2 2.15554
SNX1 sorting nexin 1 2.14591
ZBTB44 zinc finger and BTB domain containing 44 2.12298
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 2.10754
ELF2 E74-like factor 2 (ets domain transcription factor) 2.10022
STX12 syntaxin 12 2.09579
AAAS achalasia, adrenocortical insufficiency, alacrimia 2.09541
PPOX protoporphyrinogen oxidase 2.08784
TIGAR TP53 induced glycolysis regulatory phosphatase 2.08526
UBE2I ubiquitin-conjugating enzyme E2I 2.085
WDR17 WD repeat domain 17 2.0799
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 2.07709
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 2.07581
KDM4A lysine (K)-specific demethylase 4A 2.07536
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 2.07012
CEP89 centrosomal protein 89kDa 2.07012
OBI1 ORC ubiquitin ligase 1 2.06329
RCAN3 RCAN family member 3 2.06329
TBRG1 transforming growth factor beta regulator 1 2.06329
FOXJ3 forkhead box J3 2.05679
ASB2 ankyrin repeat and SOCS box containing 2 2.05213
RPLP0 ribosomal protein, large, P0 2.03705
CAPRIN2 caprin family member 2 2.03313
MACF1 microtubule-actin crosslinking factor 1 2.03313
DPF2 D4, zinc and double PHD fingers family 2 2.03305
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2.02073
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 2.00971
SWSAP1 SWIM-type zinc finger 7 associated protein 1 2.00314
HAPLN3 hyaluronan and proteoglycan link protein 3 2.00196
FNDC5 fibronectin type III domain containing 5 2.00165
FBXL15 F-box and leucine-rich repeat protein 15 2.00165
CEP250 centrosomal protein 250kDa 2.00165
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 2.00165
SDF2L1 stromal cell-derived factor 2-like 1 2.00165
GOSR2 golgi SNAP receptor complex member 2 2.00165
TLR3 toll-like receptor 3 2.00165

decreased expression

Symbol Name Standardized Value
TMEM200B transmembrane protein 200B -2.43293
PCDHGA8 protocadherin gamma subfamily A, 8 -2.43293
CBX4 chromobox homolog 4 -2.43293
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -2.43293
SAXO2 stabilizer of axonemal microtubules 2 -2.43293
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 -2.43293
GSTM3 glutathione S-transferase mu 3 (brain) -2.43293
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) -2.43293
FEZF1 FEZ family zinc finger 1 -2.43293
ACAN aggrecan -2.43293
DISP2 dispatched homolog 2 (Drosophila) -2.43293
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 -2.43293
CFAP20 cilia and flagella associated protein 20 -2.43293
PRMT8 protein arginine methyltransferase 8 -2.43293
NOPCHAP1 NOP protein chaperone 1 -2.43293
NIBAN3 niban apoptosis regulator 3 -2.43293
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -2.43293
MYH14 myosin, heavy chain 14, non-muscle -2.43293
ANAPC2 anaphase promoting complex subunit 2 -2.43293
MTMR1 myotubularin related protein 1 -2.43293
E2F8 E2F transcription factor 8 -2.43293
FLT3 fms-related tyrosine kinase 3 -2.43293
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 -2.43293
ITLN2 intelectin 2 -2.43293
CRYBG2 crystallin beta-gamma domain containing 2 -2.41987
KCNK17 potassium channel, two pore domain subfamily K, member 17 -2.35808
TELO2 telomere maintenance 2 -2.34416
TMEM52 transmembrane protein 52 -2.33311
CARMIL3 capping protein regulator and myosin 1 linker 3 -2.32201
ORC2 origin recognition complex, subunit 2 -2.30978
NRBF2 nuclear receptor binding factor 2 -2.26932
NECAP2 NECAP endocytosis associated 2 -2.23234
HSPA12B heat shock 70kD protein 12B -2.21736
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -2.20579
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -2.19148
SPATA2L spermatogenesis associated 2-like -2.17734
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -2.17507
MAPKAP1 mitogen-activated protein kinase associated protein 1 -2.17282
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 -2.16044
ANGPT4 angiopoietin 4 -2.15554
ZNF586 zinc finger protein 586 -2.15554
PRR35 proline rich 35 -2.15554
MUC6 mucin 6, oligomeric mucus/gel-forming -2.15554
PTGDR2 prostaglandin D2 receptor 2 -2.15554
FBXL22 F-box and leucine-rich repeat protein 22 -2.15554
MINDY4B MINDY family member 4B -2.15554
RIBC1 RIB43A domain with coiled-coils 1 -2.15554
MINAR2 membrane integral NOTCH2 associated receptor 2 -2.15554
ETV3L ets variant 3-like -2.15554
TMOD4 tropomodulin 4 (muscle) -2.15554
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 -2.15554
WDR64 WD repeat domain 64 -2.15554
TRPA1 transient receptor potential cation channel, subfamily A, member 1 -2.15554
RNF181 ring finger protein 181 -2.15554
SLC18B1 solute carrier family 18, subfamily B, member 1 -2.15554
LY6G6D lymphocyte antigen 6 complex, locus G6D -2.15554
TLR2 toll-like receptor 2 -2.15554
PCDH8 protocadherin 8 -2.15554
EDN3 endothelin 3 -2.15554
PITX2 paired-like homeodomain 2 -2.15554
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) -2.15554
BIN2 bridging integrator 2 -2.15554
SYTL5 synaptotagmin-like 5 -2.15554
SERTM1 serine-rich and transmembrane domain containing 1 -2.15554
GPR179 G protein-coupled receptor 179 -2.15554
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -2.15554
TSLP thymic stromal lymphopoietin -2.15554
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 -2.15554
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 -2.15554
MPL MPL proto-oncogene, thrombopoietin receptor -2.15554
ECM1 extracellular matrix protein 1 -2.15554
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 -2.15554
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) -2.15554
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -2.10857
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -2.09579
JAK3 Janus kinase 3 -2.09579
TTLL4 tubulin tyrosine ligase-like family member 4 -2.09579
CAPN1 calpain 1, (mu/I) large subunit -2.09541
MAPK15 mitogen-activated protein kinase 15 -2.08526
SYCP3 synaptonemal complex protein 3 -2.08526
SERF1B small EDRK-rich factor 1B (centromeric) -2.08526
HPRT1 hypoxanthine phosphoribosyltransferase 1 -2.08526
SRD5A3 steroid 5 alpha-reductase 3 -2.08301
ARHGAP12 Rho GTPase activating protein 12 -2.0799
MOGAT1 monoacylglycerol O-acyltransferase 1 -2.07536
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 -2.07536
ATG10 autophagy related 10 -2.07012
MMD monocyte to macrophage differentiation-associated -2.07012
ATP10A ATPase, class V, type 10A -2.06842
ZNF709 zinc finger protein 709 -2.06842
SMIM30 small integral membrane protein 30 -2.06258
IGSF5 immunoglobulin superfamily, member 5 -2.06258
TMEM123 transmembrane protein 123 -2.03313
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit -2.03313
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 -2.03313
KDM1A lysine (K)-specific demethylase 1A -2.02885
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -2.0143
LGALS8 lectin, galactoside-binding, soluble, 8 -2.00971
RNF7 ring finger protein 7 -2.00971
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 -2.00251
CCSAP centriole, cilia and spindle-associated protein -2.00165
RHBG Rh family, B glycoprotein (gene/pseudogene) -2.00165
GAA glucosidase, alpha; acid -2.00165
LYPLAL1 lysophospholipase-like 1 -2.00165
SPATA16 spermatogenesis associated 16 -2.00165