ALX4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description ALX homeobox 4|This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart. [provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 60529)
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Genes

333 genes differentially expressed following the ALX4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SHD Src homology 2 domain containing transforming protein D 3.689
HBA2 hemoglobin, alpha 2 3.689
PTPRQ protein tyrosine phosphatase, receptor type, Q 3.689
C9ORF57 chromosome 9 open reading frame 57 3.689
SV2B synaptic vesicle glycoprotein 2B 3.689
SCML4 sex comb on midleg-like 4 (Drosophila) 3.689
PLEK2 pleckstrin 2 3.689
EGR2 early growth response 2 3.689
RHCG Rh family, C glycoprotein 3.689
TEX11 testis expressed 11 3.689
CSF3R colony stimulating factor 3 receptor (granulocyte) 3.689
SIX1 SIX homeobox 1 3.689
RSPH1 radial spoke head 1 homolog (Chlamydomonas) 3.689
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 3.689
ACRBP acrosin binding protein 3.689
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 3.689
HES4 hes family bHLH transcription factor 4 3.689
IRX1 iroquois homeobox 1 3.689
PLIN1 perilipin 1 3.689
GGN gametogenetin 3.689
RXFP2 relaxin/insulin-like family peptide receptor 2 3.689
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 3.689
GOLGA6L7 golgin A6 family like 7 3.689
POU2AF2 POU class 2 homeobox associating factor 2 3.689
MOS v-mos Moloney murine sarcoma viral oncogene homolog 3.689
PLA2G5 phospholipase A2, group V 3.689
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 3.689
RBBP8NL RBBP8 N-terminal like 3.689
HK3 hexokinase 3 (white cell) 3.689
SLCO1B3 solute carrier organic anion transporter family, member 1B3 3.60578
IL22RA1 interleukin 22 receptor, alpha 1 3.60578
CD19 CD19 molecule 3.60578
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 3.60578
IZUMO3 IZUMO family member 3 3.60578
SCARA5 scavenger receptor class A, member 5 3.60578
SLC26A4 solute carrier family 26 (anion exchanger), member 4 3.60578
FAM180B family with sequence similarity 180, member B 3.60578
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 3.60578
CD93 CD93 molecule 3.60578
SLC22A10 solute carrier family 22, member 10 3.60578
CAMKV CaM kinase-like vesicle-associated 3.60578
SIX6 SIX homeobox 6 3.60578
PEAK3 PEAK family member 3 3.60578
GJA3 gap junction protein, alpha 3, 46kDa 3.60578
ACP7 acid phosphatase 7, tartrate resistant (putative) 3.60578
LRRC8C-DT LRRC8C divergent transcript 3.60578
OC90 otoconin 90 3.60578
CD68 CD68 molecule 3.60578
MGARP mitochondria-localized glutamic acid-rich protein 3.60578
SPATA31H1 SPATA31 subfamily H member 1 3.60578
THRSP thyroid hormone responsive 3.60578
SPANXB1 SPANX family, member B1 3.60578
CIMIP4 ciliary microtubule inner protein 4 3.60578
ASPA aspartoacylase 3.60578
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 3.60578
FOLR3 folate receptor 3 (gamma) 3.60578
EPCIP exosomal polycystin 1 interacting protein 3.60578
C6ORF58 chromosome 6 open reading frame 58 3.60578
OR2J3 olfactory receptor, family 2, subfamily J, member 3 3.60578
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 3.60578
CIMIP7 ciliary microtubule inner protein 7 3.60578
SLC16A11 solute carrier family 16, member 11 3.60578
STRIT1 small transmembrane regulator of ion transport 1 3.60578
LRRIQ4 leucine-rich repeats and IQ motif containing 4 3.60578
CLIP4 CAP-GLY domain containing linker protein family, member 4 3.60578
SPACA9 sperm acrosome associated 9 3.60578
TAS1R1 taste receptor, type 1, member 1 3.60578
CCDC198 coiled-coil domain containing 198 3.60578
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 3.60578
BEST3 bestrophin 3 3.60578
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 3.60578
IL16 interleukin 16 3.60578
TSPAN1 tetraspanin 1 3.60578
SAG S-antigen; retina and pineal gland (arrestin) 3.60578
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.60578
OTOR otoraplin 3.60578
STYXL2 serine/threonine/tyrosine interacting like 2 3.60578
SQOR sulfide quinone oxidoreductase 3.60578
PLN phospholamban 3.60578
GPX5 glutathione peroxidase 5 3.60578
EFNB1 ephrin-B1 3.60578
OR1R1 olfactory receptor family 1 subfamily R member 1 3.60578
VCX3B variable charge, X-linked 3B 3.60578
RGS21 regulator of G-protein signaling 21 3.60578
CFAP107 cilia and flagella associated protein 107 3.60578
TBX20 T-box 20 3.60578
FPR2 formyl peptide receptor 2 3.60578
GRXCR1 glutaredoxin, cysteine rich 1 3.60578
PVRIG poliovirus receptor related immunoglobulin domain containing 3.60578
OR5H1 olfactory receptor, family 5, subfamily H, member 1 3.60578
TERB1 telomere repeat binding bouquet formation protein 1 3.60578
PTPRC protein tyrosine phosphatase, receptor type, C 3.60578
ARL5C ADP-ribosylation factor-like 5C 3.60578
EDAR ectodysplasin A receptor 3.60578
TMEM235 transmembrane protein 235 3.60578
NPIPB9 nuclear pore complex interacting protein family, member B9 3.60578
LRTM3 leucine rich repeat transmembrane protein 3 3.60578
C12ORF54 chromosome 12 open reading frame 54 3.60578
KASH5 KASH domain containing 5 3.60578
PRR4 proline rich 4 (lacrimal) 3.60578
CCR4 chemokine (C-C motif) receptor 4 3.60578
GBP2 guanylate binding protein 2, interferon-inducible 3.60578
S100A5 S100 calcium binding protein A5 3.60578
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 3.60578
FBXO39 F-box protein 39 3.60578
VHLL von Hippel-Lindau tumor suppressor-like 3.60578
LRRC43 leucine rich repeat containing 43 3.60578
CH25H cholesterol 25-hydroxylase 3.60578
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 3.60578
TCEANC transcription elongation factor A (SII) N-terminal and central domain containing 3.60578
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 3.60578
C11ORF91 chromosome 11 open reading frame 91 3.60578
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 3.60578
PRSS55 protease, serine, 55 3.60578
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 3.60578
TMEM86A transmembrane protein 86A 3.60578
HHIPL2 HHIP-like 2 3.60578
OR9A4 olfactory receptor, family 9, subfamily A, member 4 3.60578
MT1A metallothionein 1A 3.60578
AMER3 APC membrane recruitment protein 3 3.60578
ACKR2 atypical chemokine receptor 2 3.60578
PRSS54 protease, serine, 54 3.60578
HAVCR1 hepatitis A virus cellular receptor 1 3.60578
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 3.60578
GCGR glucagon receptor 3.60578
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 3.60578
C1ORF105 chromosome 1 open reading frame 105 3.60578
RIPK3 receptor-interacting serine-threonine kinase 3 3.60578
ETV3L ets variant 3-like 3.60578
DKK1 dickkopf WNT signaling pathway inhibitor 1 3.60578
NLRP14 NLR family, pyrin domain containing 14 3.60578
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 3.60578
SLC38A8 solute carrier family 38, member 8 3.60578
ASTL astacin-like metallo-endopeptidase (M12 family) 3.60578
TRADD TNFRSF1A-associated via death domain 3.60578
C16ORF78 chromosome 16 open reading frame 78 3.60578
CRHBP corticotropin releasing hormone binding protein 3.60578
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 3.60578
PCDHGA7 protocadherin gamma subfamily A, 7 3.60578
TEX19 testis expressed 19 3.60578
CDRT15L2 CMT1A duplicated region transcript 15-like 2 3.60578
SST somatostatin 3.60578
LRRC31 leucine rich repeat containing 31 3.60578
THEM5 thioesterase superfamily member 5 3.60578
TRPC5OS TRPC5 opposite strand 3.60578
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 3.60578
R3HDML R3H domain containing-like 3.60578
ASCL2 achaete-scute family bHLH transcription factor 2 3.60578
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 3.60578
GRM6 glutamate receptor, metabotropic 6 3.60578
CD33 CD33 molecule 3.60578
APCDD1 adenomatosis polyposis coli down-regulated 1 3.60578
OR5A1 olfactory receptor, family 5, subfamily A, member 1 3.60578
PODN podocan 3.60578
SHISA3 shisa family member 3 3.60578
ATOH8 atonal homolog 8 (Drosophila) 3.60578
COL15A1 collagen, type XV, alpha 1 3.60578
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 3.60578
ADAM20 ADAM metallopeptidase domain 20 3.60578
ANGPTL6 angiopoietin-like 6 3.60578
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 3.60578
NKPD1 NTPase, KAP family P-loop domain containing 1 3.60578
KRTAP4-9 keratin associated protein 4-9 3.60578
SMIM10 small integral membrane protein 10 3.41185
REC8 REC8 meiotic recombination protein 3.24944
RND3 Rho family GTPase 3 2.78472
RSF1 remodeling and spacing factor 1 2.78265
KIAA0408 KIAA0408 2.76541
UBE2A ubiquitin-conjugating enzyme E2A 2.741
ANKRD11 ankyrin repeat domain 11 2.74066
CDH12 cadherin 12, type 2 (N-cadherin 2) 2.67519
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39 2.65219
CPQ carboxypeptidase Q 2.65219
HSH2D hematopoietic SH2 domain containing 2.61578
FAM209B family with sequence similarity 209, member B 2.61578
CCDC92 coiled-coil domain containing 92 2.61578
PDF peptide deformylase (mitochondrial) 2.61578
SPATA16 spermatogenesis associated 16 2.61578
PCDHA1 protocadherin alpha 1 2.61578
MEIOB meiosis specific with OB domains 2.61578
EGFL6 EGF-like-domain, multiple 6 2.61578
SMIM18 small integral membrane protein 18 2.61578
FAM186A family with sequence similarity 186, member A 2.55159
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.51571
PHF14 PHD finger protein 14 2.50533
DNASE2 deoxyribonuclease II, lysosomal 2.50533
ETFA electron-transfer-flavoprotein, alpha polypeptide 2.49482
BAHD1 bromo adjacent homology domain containing 1 2.48461
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 2.48445
SCAMP1 secretory carrier membrane protein 1 2.45558
SH2B2 SH2B adaptor protein 2 2.44639
ZBTB42 zinc finger and BTB domain containing 42 2.41458
MROH5 maestro heat-like repeat family member 5 2.40756
RAB36 RAB36, member RAS oncogene family 2.40756
DOHH deoxyhypusine hydroxylase/monooxygenase 2.39334
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 2.38361
IL18R1 interleukin 18 receptor 1 2.37313
RGS8 regulator of G-protein signaling 8 2.37313
PPP1R26 protein phosphatase 1, regulatory subunit 26 2.37313
SIX3 SIX homeobox 3 2.37313
PBLD phenazine biosynthesis-like protein domain containing 2.36848
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.36801
FASTKD3 FAST kinase domains 3 2.3675
HCFC1 host cell factor C1 2.36147
SCYL1 SCY1-like 1 (S. cerevisiae) 2.35981
ABHD13 abhydrolase domain containing 13 2.35398
FBXO2 F-box protein 2 2.35346
ZNF174 zinc finger protein 174 2.33575
EXO1 exonuclease 1 2.31285
BAX BCL2-associated X protein 2.24485
MED14 mediator complex subunit 14 2.24424
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 2.20897
CRK v-crk avian sarcoma virus CT10 oncogene homolog 2.19553
SF3B3 splicing factor 3b, subunit 3, 130kDa 2.18152
SDE2 SDE2 telomere maintenance homolog (S. pombe) 2.1733
CCDC6 coiled-coil domain containing 6 2.17205
TSLIG3A tRNA splicing ligase complex subunit 3A 2.1657
MBNL3 muscleblind-like splicing regulator 3 2.15274
NDFIP1 Nedd4 family interacting protein 1 2.15163
C15ORF40 chromosome 15 open reading frame 40 2.12862
PUS7 pseudouridylate synthase 7 (putative) 2.12862
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 2.1233
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 2.09833
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 2.09564
TMEM33 transmembrane protein 33 2.09062
MFAP2 microfibrillar-associated protein 2 2.07785
CLEC9A C-type lectin domain family 9, member A 2.07503
DOLPP1 dolichyldiphosphatase 1 2.05521
PILRB paired immunoglobin-like type 2 receptor beta 2.02314
MLH3 mutL homolog 3 2.01543
NEURL1 neuralized E3 ubiquitin protein ligase 1 2.01271
KLHL3 kelch-like family member 3 2.01088
SETD6 SET domain containing 6 2.00078

decreased expression

Symbol Name Standardized Value
PAQR6 progestin and adipoQ receptor family member VI -3.64182
MAGEA4 melanoma antigen family A4 -3.64182
EVA1A eva-1 homolog A (C. elegans) -3.64182
SERTM1 serine-rich and transmembrane domain containing 1 -3.64182
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 -3.64182
ZNF688 zinc finger protein 688 -3.60578
STMND1 stathmin domain containing 1 -3.50524
PRB2 proline-rich protein BstNI subfamily 2 -3.50524
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 -3.50524
EBF4 early B-cell factor 4 -3.50524
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) -3.50524
CXCR5 chemokine (C-X-C motif) receptor 5 -3.50524
RGPD3 RANBP2-like and GRIP domain containing 3 -3.50524
COL19A1 collagen, type XIX, alpha 1 -3.50524
GPRC5D G protein-coupled receptor, class C, group 5, member D -3.50524
LRRTM1 leucine rich repeat transmembrane neuronal 1 -3.50524
PLK5 polo-like kinase 5 -3.50524
IL2RB interleukin 2 receptor, beta -3.50524
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 -3.50524
VWC2L von Willebrand factor C domain containing protein 2-like -3.50524
CLNK cytokine-dependent hematopoietic cell linker -3.50524
TSSK6 testis-specific serine kinase 6 -3.50524
TMEM215 transmembrane protein 215 -3.50524
ITPKA inositol-trisphosphate 3-kinase A -3.50524
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -3.50524
CRHR1 corticotropin releasing hormone receptor 1 -3.50524
CDK20 cyclin-dependent kinase 20 -3.50524
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 -3.50524
PLAC8 placenta-specific 8 -3.50524
HUS1B HUS1 checkpoint homolog b (S. pombe) -3.50524
NUPR1 nuclear protein, transcriptional regulator, 1 -3.50524
FGR FGR proto-oncogene, Src family tyrosine kinase -3.50524
UBXN10 UBX domain protein 10 -3.50524
ZNF835 zinc finger protein 835 -3.50524
CNTD1 cyclin N-terminal domain containing 1 -3.50524
POMC proopiomelanocortin -3.37103
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 -3.37103
GOLGA8B golgin A8 family, member B -3.16597
YIPF5 Yip1 domain family, member 5 -3.16576
ZNF816 zinc finger protein 816 -3.10322
TERF2 telomeric repeat binding factor 2 -3.02425
SPATC1 spermatogenesis and centriole associated 1 -2.96868
POFUT2 protein O-fucosyltransferase 2 -2.96075
ALKBH7 alkB, alkylation repair homolog 7 (E. coli) -2.90738
CDCA5 cell division cycle associated 5 -2.87364
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 -2.7688
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -2.7688
RAP1B RAP1B, member of RAS oncogene family -2.75686
RAB10 RAB10, member RAS oncogene family -2.72528
GRB7 growth factor receptor-bound protein 7 -2.70211
COL4A4 collagen, type IV, alpha 4 -2.62953
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 -2.54619
LRRC8A leucine rich repeat containing 8 family, member A -2.51838
TRIML2 tripartite motif family-like 2 -2.51571
CKB creatine kinase, brain -2.50024
ORC4 origin recognition complex, subunit 4 -2.50024
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -2.48461
CFAP74 cilia and flagella associated protein 74 -2.4457
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 -2.4457
DCAF12L1 DDB1 and CUL4 associated factor 12-like 1 -2.4457
PDHB pyruvate dehydrogenase (lipoamide) beta -2.44177
MRAS muscle RAS oncogene homolog -2.43158
KRT18 keratin 18, type I -2.41967
SMAD1 SMAD family member 1 -2.41047
YAE1 YAE1 maturation factor of ABCE1 -2.38347
PARM1 prostate androgen-regulated mucin-like protein 1 -2.37313
H2AC25 H2A clustered histone 25 -2.37262
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -2.33886
DEUP1 deuterosome assembly protein 1 -2.32381
JHY junctional cadherin complex regulator -2.32374
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 -2.32374
WDR91 WD repeat domain 91 -2.3118
ZNF524 zinc finger protein 524 -2.3118
TRIM47 tripartite motif containing 47 -2.3118
RLN1 relaxin 1 -2.3118
PYY peptide YY -2.3118
ADAM33 ADAM metallopeptidase domain 33 -2.3118
KIAA1549 KIAA1549 -2.27601
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -2.22984
GTF3A general transcription factor IIIA -2.1985
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -2.19553
FAM133A family with sequence similarity 133, member A -2.18152
TBC1D14 TBC1 domain family, member 14 -2.17205
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 -2.1657
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) -2.163
RPL5 ribosomal protein L5 -2.163
CLUH clustered mitochondria (cluA/CLU1) homolog -2.14147
FANCC Fanconi anemia, complementation group C -2.12202
CMTR2 cap methyltransferase 2 -2.07591
GRAMD2B GRAM domain containing 2B -2.06993
CASTOR1 cytosolic arginine sensor for mTORC1 subunit 1 -2.05849
YEATS2 YEATS domain containing 2 -2.05498
PDLIM1 PDZ and LIM domain 1 -2.02887
RPL24 ribosomal protein L24 -2.02566
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -2.02272
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) -2.02041
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B -2.01088
CAMK2N2 calcium/calmodulin-dependent protein kinase II inhibitor 2 -2.01088
MMS22L MMS22-like, DNA repair protein -2.01038
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -2.01038