AMER1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description APC membrane recruitment protein 1|The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS). [provided by RefSeq, May 2010] (NCBI Entrez Gene Database, 139285)
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Genes

357 genes differentially expressed following the AMER1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TBX20 T-box 20 3.30565
PIRT phosphoinositide-interacting regulator of transient receptor potential channels 3.30565
NHLH1 nescient helix loop helix 1 3.30565
LPO lactoperoxidase 3.30565
MYL10 myosin, light chain 10, regulatory 3.30565
TRIM15 tripartite motif containing 15 3.30565
PTH parathyroid hormone 3.30565
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 3.30565
LRRIQ3 leucine-rich repeats and IQ motif containing 3 3.30565
TBX3 T-box 3 3.30565
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 3.30565
BHLHA9 basic helix-loop-helix family, member a9 3.30565
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 3.30565
HAPLN2 hyaluronan and proteoglycan link protein 2 3.30565
TMEM236 transmembrane protein 236 3.30565
CMTM1 CKLF-like MARVEL transmembrane domain containing 1 3.30565
GJA5 gap junction protein, alpha 5, 40kDa 3.30565
BTBD19 BTB (POZ) domain containing 19 3.30565
OCM oncomodulin 3.30565
RPS21-DT RPS21 divergent transcript 3.30565
KLHDC1 kelch domain containing 1 3.30565
CLXN calaxin 3.30565
OPTC opticin 3.30565
C2ORF78 chromosome 2 open reading frame 78 3.30565
MFAP5 microfibrillar associated protein 5 3.30565
ADRA2A adrenoceptor alpha 2A 3.30565
FAM86B2 family with sequence similarity 86, member B2 3.30565
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 3.30565
LITAFD LITAF domain containing 3.30565
SCN2B sodium channel, voltage gated, type II beta subunit 3.18516
IGFL3 IGF-like family member 3 3.18516
IZUMO3 IZUMO family member 3 3.18516
GOT1L1 glutamic-oxaloacetic transaminase 1-like 1 3.18516
TAS2R30 taste receptor, type 2, member 30 3.18516
ZNF98 zinc finger protein 98 3.18516
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 3.18516
DRGX dorsal root ganglia homeobox 3.18516
DLX4 distal-less homeobox 4 3.18516
RNF17 ring finger protein 17 3.18516
COL20A1 collagen, type XX, alpha 1 3.18516
INHBB inhibin, beta B 3.18516
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 3.18516
NAPSA napsin A aspartic peptidase 3.18516
KCNIP3 Kv channel interacting protein 3, calsenilin 3.18516
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 3.18516
ASB12 ankyrin repeat and SOCS box containing 12 3.18516
CD300A CD300a molecule 3.18516
CD209 CD209 molecule 3.18516
EP300 E1A binding protein p300 3.18516
GRIA2 glutamate receptor, ionotropic, AMPA 2 3.18516
SKOR1 SKI family transcriptional corepressor 1 3.18516
PEAR1 platelet endothelial aggregation receptor 1 3.18516
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 3.18516
TNNI2 troponin I type 2 (skeletal, fast) 3.18516
GMFG glia maturation factor, gamma 3.18516
PON1 paraoxonase 1 3.18516
DNASE1L2 deoxyribonuclease I-like 2 3.18516
TEX13B testis expressed 13B 3.18516
PGAM2 phosphoglycerate mutase 2 (muscle) 3.18516
GJB4 gap junction protein, beta 4, 30.3kDa 3.18516
SP7 Sp7 transcription factor 3.18516
NFAM1 NFAT activating protein with ITAM motif 1 3.18516
ISM2 isthmin 2 3.18516
CATSPERT catsper channel auxiliary subunit tau 3.18516
HBG2 hemoglobin, gamma G 3.18516
KRT86 keratin 86, type II 3.18516
C20ORF202 chromosome 20 open reading frame 202 3.18516
ACSL5 acyl-CoA synthetase long-chain family member 5 3.18516
CCDC198 coiled-coil domain containing 198 3.18516
MIOX myo-inositol oxygenase 3.18516
TTR transthyretin 3.18516
WNT16 wingless-type MMTV integration site family, member 16 3.18516
LTB4R2 leukotriene B4 receptor 2 3.18516
UNC93A unc-93 homolog A (C. elegans) 3.18516
OR10H3 olfactory receptor, family 10, subfamily H, member 3 3.18516
CATSPERH catsper channel auxiliary subunit eta 3.18516
OOSP4B oocyte secreted protein family member 4B 3.18516
CFAP299 cilia and flagella associated protein 299 3.18516
CCDC190 coiled-coil domain containing 190 3.18516
BNIP5 BCL2 interacting protein 5 3.18516
TMEM275 transmembrane protein 275 3.18516
H1-6 H1.6 linker histone, cluster member 3.18516
ARX aristaless related homeobox 3.18516
GRAP GRB2-related adaptor protein 3.18516
HNF1A HNF1 homeobox A 3.18516
LRRC72 leucine rich repeat containing 72 3.18516
SCN10A sodium channel, voltage gated, type X alpha subunit 3.18516
GAST gastrin 3.18516
IRF5 interferon regulatory factor 5 3.18516
DMP1 dentin matrix acidic phosphoprotein 1 3.18516
RHOXF2 Rhox homeobox family, member 2 3.18516
KLHL33 kelch-like family member 33 3.18516
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 3.18516
PCDHA8 protocadherin alpha 8 3.18516
CATSPER3 cation channel, sperm associated 3 3.18516
C1ORF162 chromosome 1 open reading frame 162 3.18516
DMBX1 diencephalon/mesencephalon homeobox 1 3.18516
FRK fyn-related Src family tyrosine kinase 3.18516
DDTL D-dopachrome tautomerase-like 3.18516
ARHGAP15 Rho GTPase activating protein 15 3.18516
SBSN suprabasin 3.18516
NPFF neuropeptide FF-amide peptide precursor 3.18516
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 3.18516
RUNX3 runt-related transcription factor 3 3.18516
ZNF575 zinc finger protein 575 3.18516
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 3.18516
TMEM121 transmembrane protein 121 3.18516
CCL27 chemokine (C-C motif) ligand 27 3.18516
GPBAR1 G protein-coupled bile acid receptor 1 3.18516
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 3.18516
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 3.18516
BPI bactericidal/permeability-increasing protein 3.18516
RTN4RL1 reticulon 4 receptor-like 1 3.18516
TSKS testis-specific serine kinase substrate 3.18516
CIB4 calcium and integrin binding family member 4 3.18516
TRIM55 tripartite motif containing 55 3.18516
DIAPH1 diaphanous-related formin 1 3.18516
NELL1 NEL-like 1 (chicken) 3.18516
PADI6 peptidyl arginine deiminase, type VI 3.18516
PCDHGA3 protocadherin gamma subfamily A, 3 3.18516
SHISA8 shisa family member 8 3.18516
PATE1 prostate and testis expressed 1 3.18516
SPATA31E1 SPATA31 subfamily E, member 1 3.18516
LST1 leukocyte specific transcript 1 3.18516
RORC RAR-related orphan receptor C 3.18516
AKR1B15 aldo-keto reductase family 1, member B15 3.18516
PRSS55 protease, serine, 55 3.18516
MRLN myoregulin 3.18516
OXGR1 oxoglutarate (alpha-ketoglutarate) receptor 1 3.18516
TNR tenascin R 3.18516
PRR15L proline rich 15-like 3.18516
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 3.18516
KLHL1 kelch-like family member 1 3.18516
GAGE10 G antigen 10 3.18516
AMER3 APC membrane recruitment protein 3 3.18516
C11ORF91 chromosome 11 open reading frame 91 3.18516
AQP6 aquaporin 6, kidney specific 3.18516
RP1 retinitis pigmentosa 1 (autosomal dominant) 3.18516
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 3.18516
TEKT2 tektin 2 (testicular) 3.18516
MRC1 mannose receptor, C type 1 3.18516
MYO1A myosin IA 3.18516
LYPD5 LY6/PLAUR domain containing 5 3.18516
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 3.18516
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 3.18516
OPALIN oligodendrocytic myelin paranodal and inner loop protein 3.18516
CLEC18A C-type lectin domain family 18, member A 3.18516
DRC1 dynein regulatory complex subunit 1 3.18516
DRC7 dynein regulatory complex subunit 7 3.18516
TMEM255A transmembrane protein 255A 3.18516
PDK4 pyruvate dehydrogenase kinase, isozyme 4 3.18516
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 3.18516
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 3.18516
MMP12 matrix metallopeptidase 12 3.18516
GYS2 glycogen synthase 2 (liver) 3.18516
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa 3.18516
PENK proenkephalin 3.18516
PATE4 prostate and testis expressed 4 3.18516
VPREB3 pre-B lymphocyte 3 3.18516
COL6A5 collagen, type VI, alpha 5 3.18516
TF transferrin 3.18516
ANKRD55 ankyrin repeat domain 55 3.18516
MEIG1 meiosis/spermiogenesis associated 1 3.18516
NRSN1 neurensin 1 3.18516
NYX nyctalopin 3.18516
NR5A2 nuclear receptor subfamily 5, group A, member 2 3.18516
ERAP2 endoplasmic reticulum aminopeptidase 2 3.18516
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 3.18516
TMEM31 transmembrane protein 31 3.18516
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 3.18516
CASS4 Cas scaffolding protein family member 4 3.112
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) 3.08943
BMF Bcl2 modifying factor 3.06767
VAT1L vesicle amine transport 1-like 3.00766
KCNK10 potassium channel, two pore domain subfamily K, member 10 3.00662
SAMD1 sterile alpha motif domain containing 1 2.95347
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 2.81162
CCNK cyclin K 2.81162
JAKMIP2 janus kinase and microtubule interacting protein 2 2.75971
CMSS1 cms1 ribosomal small subunit homolog (yeast) 2.67229
STARD9 StAR-related lipid transfer (START) domain containing 9 2.60309
TBCA tubulin folding cofactor A 2.59188
SNW1 SNW domain containing 1 2.58549
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 2.51043
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 2.48776
IGIP IgA-inducing protein 2.46869
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 2.46834
SRGN serglycin 2.458
CLEC4G C-type lectin domain family 4, member G 2.458
LIF leukemia inhibitory factor 2.43811
COG3 component of oligomeric golgi complex 3 2.42953
ADA adenosine deaminase 2.42678
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 2.41158
RUNDC1 RUN domain containing 1 2.40639
GSTM3 glutathione S-transferase mu 3 (brain) 2.39714
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 2.39488
TNNC2 troponin C type 2 (fast) 2.39488
TOP1 topoisomerase (DNA) I 2.3904
KAT2B K(lysine) acetyltransferase 2B 2.38699
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 2.38541
CCDC125 coiled-coil domain containing 125 2.38541
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 2.38317
NEBL nebulette 2.34532
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 2.31218
SRCIN1 SRC kinase signaling inhibitor 1 2.29767
CCDC149 coiled-coil domain containing 149 2.24479
TMLHE trimethyllysine hydroxylase, epsilon 2.24038
ZFP64 ZFP64 zinc finger protein 2.24038
CBY1 chibby homolog 1 (Drosophila) 2.23329
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 2.22254
MTFP1 mitochondrial fission process 1 2.22254
DPF3 D4, zinc and double PHD fingers, family 3 2.22254
CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 2.22254
DENND6B DENN/MADD domain containing 6B 2.22254
CDHR4 cadherin-related family member 4 2.22254
HAPSTR1 HUWE1 associated protein modifying stress responses 2.21483
CCDC110 coiled-coil domain containing 110 2.21037
SPART spartin 2.21037
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 2.20979
ITPKB inositol-trisphosphate 3-kinase B 2.20901
UBXN2B UBX domain protein 2B 2.20472
PFDN2 prefoldin subunit 2 2.16409
KRABD4 KRAB domain containing 4 2.142
PPP4R3A protein phosphatase 4 regulatory subunit 3A 2.13578
FDXR ferredoxin reductase 2.13447
XNDC1N XRCC1 N-terminal domain containing 1, N-terminal like 2.11829
TRIM28 tripartite motif containing 28 2.11829
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 2.11519
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 2.10754
ABI3BP ABI family, member 3 (NESH) binding protein 2.10754
NQO2 NAD(P)H dehydrogenase, quinone 2 2.10229
ARL8A ADP-ribosylation factor-like 8A 2.07231
LAMA1 laminin, alpha 1 2.07231
AFF4 AF4/FMR2 family, member 4 2.06845
HAX1 HCLS1 associated protein X-1 2.05082
FAM107B family with sequence similarity 107, member B 2.05082
VPS26B vacuolar protein sorting 26 homolog B (S. pombe) 2.0482
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 2.04287
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2.03878
LRRC8C leucine rich repeat containing 8 family, member C 2.03719
NSUN5 NOP2/Sun domain family, member 5 2.02936
GMPR2 guanosine monophosphate reductase 2 2.02936
WSB1 WD repeat and SOCS box containing 1 2.02748
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 2.02004
SHOC1 shortage in chiasmata 1 2.01568
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 2.01568
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 2.00887
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 2.00716

decreased expression

Symbol Name Standardized Value
SOX10 SRY (sex determining region Y)-box 10 -3.30565
ECE2 endothelin converting enzyme 2 -3.30565
CREG2 cellular repressor of E1A-stimulated genes 2 -3.23442
PCDHB10 protocadherin beta 10 -3.23442
PABPC4L poly(A) binding protein, cytoplasmic 4-like -3.23442
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 -3.23442
BTBD6 BTB (POZ) domain containing 6 -3.18516
FAM133A family with sequence similarity 133, member A -3.18516
HMCN1 hemicentin 1 -3.18516
EXOC1 exocyst complex component 1 -3.18516
CCDC25 coiled-coil domain containing 25 -3.18067
IRF7 interferon regulatory factor 7 -3.10723
CYGB cytoglobin -3.10723
TUBA3D tubulin, alpha 3d -3.10723
CCR6 chemokine (C-C motif) receptor 6 -3.10723
APOA1 apolipoprotein A-I -3.10723
TRAF3IP3 TRAF3 interacting protein 3 -3.10723
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -3.10723
PCDHB4 protocadherin beta 4 -3.10723
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 -3.10723
CCNB3 cyclin B3 -3.10723
TUBB1 tubulin, beta 1 class VI -3.10723
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) -3.10723
C11ORF87 chromosome 11 open reading frame 87 -3.10723
CBX8 chromobox homolog 8 -3.10723
S100Z S100 calcium binding protein Z -3.10723
SCRT2 scratch family zinc finger 2 -3.10723
CXCL13 chemokine (C-X-C motif) ligand 13 -3.10723
IKBIP IKBKB interacting protein -3.10723
RGS4 regulator of G-protein signaling 4 -3.10723
CEBPZOS CEBPZ opposite strand -3.10723
BDKRB2 bradykinin receptor B2 -3.10723
VSTM1 V-set and transmembrane domain containing 1 -3.10723
SYT15 synaptotagmin XV -3.10723
FBXO40 F-box protein 40 -3.10723
CALHM2 calcium homeostasis modulator 2 -3.10723
PCDHGA2 protocadherin gamma subfamily A, 2 -3.10723
SPATS1 spermatogenesis associated, serine-rich 1 -3.10723
B2M beta-2-microglobulin -3.09123
NBPF20 neuroblastoma breakpoint family, member 20 -2.993
CPN1 carboxypeptidase N, polypeptide 1 -2.98427
EXOSC4 exosome component 4 -2.97115
ERBB4 erb-b2 receptor tyrosine kinase 4 -2.95714
MORN4 MORN repeat containing 4 -2.85003
TXK TXK tyrosine kinase -2.70575
MYO15A myosin XVA -2.63584
DENND1A DENN/MADD domain containing 1A -2.6203
ISYNA1 inositol-3-phosphate synthase 1 -2.61935
TACC1 transforming, acidic coiled-coil containing protein 1 -2.61308
ZNF547 zinc finger protein 547 -2.61178
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7 -2.61102
SDK2 sidekick cell adhesion molecule 2 -2.5945
ZNF559 zinc finger protein 559 -2.52577
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 -2.51662
ATXN7 ataxin 7 -2.48522
NUDT17 nudix (nucleoside diphosphate linked moiety X)-type motif 17 -2.47409
UBC ubiquitin C -2.47409
ARC activity-regulated cytoskeleton-associated protein -2.47409
ARL4A ADP-ribosylation factor-like 4A -2.4292
NALF1 NALCN channel auxiliary factor 1 -2.38545
CDCP1 CUB domain containing protein 1 -2.35506
ZIM3 zinc finger, imprinted 3 -2.34667
GSN gelsolin -2.33574
BUD31 BUD31 homolog (S. cerevisiae) -2.31301
KMT5A lysine methyltransferase 5A -2.31301
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -2.28733
STRIP1 striatin interacting protein 1 -2.28592
EGLN1 egl-9 family hypoxia-inducible factor 1 -2.24479
STXBP5L syntaxin binding protein 5-like -2.23605
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 -2.23402
BET1 Bet1 golgi vesicular membrane trafficking protein -2.23002
N4BP2 NEDD4 binding protein 2 -2.22254
MVK mevalonate kinase -2.21483
CCDC159 coiled-coil domain containing 159 -2.21037
LIG3 ligase III, DNA, ATP-dependent -2.20979
PNRC1 proline-rich nuclear receptor coactivator 1 -2.20901
BTBD17 BTB (POZ) domain containing 17 -2.18187
FAM78A family with sequence similarity 78, member A -2.18187
SNTG2 syntrophin, gamma 2 -2.18187
KIFAP3 kinesin-associated protein 3 -2.18185
DCST2 DC-STAMP domain containing 2 -2.18185
CRACDL CRACD like -2.18185
TTLL9 tubulin tyrosine ligase-like family member 9 -2.18185
TK1 thymidine kinase 1, soluble -2.17753
NRK Nik related kinase -2.17091
CAMKMT calmodulin-lysine N-methyltransferase -2.11829
WDR90 WD repeat domain 90 -2.10916
LUC7L3 LUC7-like 3 (S. cerevisiae) -2.10754
MRPL28 mitochondrial ribosomal protein L28 -2.10754
MOG myelin oligodendrocyte glycoprotein -2.08327
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.0786
DDRGK1 DDRGK domain containing 1 -2.05767
EFCAB13 EF-hand calcium binding domain 13 -2.04287
MICALL2 MICAL-like 2 -2.03958
MAPK6 mitogen-activated protein kinase 6 -2.03878
AMER1 APC membrane recruitment protein 1 -2.03878
H2AJ H2A.J histone -2.03855
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) -2.03586
PMP22 peripheral myelin protein 22 -2.03012
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 -2.03012
GHR growth hormone receptor -2.03012
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 -2.03012
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 -2.03012
GTF2A1L general transcription factor IIA, 1-like -2.03012
MAT2B methionine adenosyltransferase II, beta -2.02936
TRPM4 transient receptor potential cation channel, subfamily M, member 4 -2.01568
TRIM44 tripartite motif containing 44 -2.0087
NFE2L3 nuclear factor, erythroid 2-like 3 -2.00578
MME membrane metallo-endopeptidase -2.00342