| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/24957182 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in AMG 487 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CCDC73 | coiled-coil domain containing 73 | 1.76 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.89 |
| BANF1 | barrier to autointegration factor 1 | 0.76 |
| ZNRF2 | zinc and ring finger 2, E3 ubiquitin protein ligase | 0.59 |
| RFXANK | regulatory factor X-associated ankyrin-containing protein | 0.56 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.55 |
| NALCN | sodium leak channel, non selective | 0.5 |
| ANKRD24 | ankyrin repeat domain 24 | 0.49 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | 0.47 |
| CACNA1E | calcium channel, voltage-dependent, R type, alpha 1E subunit | 0.47 |
| BBS2 | Bardet-Biedl syndrome 2 | 0.46 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.46 |
| ARHGEF35 | Rho guanine nucleotide exchange factor (GEF) 35 | 0.45 |
| SLC35F3 | solute carrier family 35, member F3 | 0.45 |
| H2AZ1 | H2A.Z variant histone 1 | 0.43 |
| AGFG2 | ArfGAP with FG repeats 2 | 0.42 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.42 |
| ZNF616 | zinc finger protein 616 | 0.42 |
| MT1F | metallothionein 1F | 0.42 |
| BSDC1 | BSD domain containing 1 | 0.4 |
| ACTBL2 | actin, beta-like 2 | 0.4 |
| SH3RF2 | SH3 domain containing ring finger 2 | 0.39 |
| SPPL3 | signal peptide peptidase like 3 | 0.39 |
| VIM | vimentin | 0.38 |
| TOR2A | torsin family 2, member A | 0.38 |
| FANCD2 | Fanconi anemia, complementation group D2 | 0.38 |
| AMOT | angiomotin | 0.38 |
| USP33 | ubiquitin specific peptidase 33 | 0.37 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 0.37 |
| KLF2 | Kruppel-like factor 2 | 0.37 |
| CASZ1 | castor zinc finger 1 | 0.36 |
| ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | 0.36 |
| FGFR1OP2 | FGFR1 oncogene partner 2 | 0.36 |
| AGPAT2 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | 0.36 |
| SLC35B1 | solute carrier family 35, member B1 | 0.36 |
| TPM1 | tropomyosin 1 (alpha) | 0.35 |
| SOX13 | SRY (sex determining region Y)-box 13 | 0.35 |
| RCAN1 | regulator of calcineurin 1 | 0.35 |
| ARL6IP6 | ADP-ribosylation factor-like 6 interacting protein 6 | 0.35 |
| ZCCHC24 | zinc finger, CCHC domain containing 24 | 0.35 |
| TMEM263 | transmembrane protein 263 | 0.34 |
| CALU | calumenin | 0.34 |
| YAF2 | YY1 associated factor 2 | 0.34 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.33 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.33 |
| KCTD21 | potassium channel tetramerization domain containing 21 | 0.33 |
| SLC35A1 | solute carrier family 35 (CMP-sialic acid transporter), member A1 | 0.33 |
| SDR16C5 | short chain dehydrogenase/reductase family 16C, member 5 | 0.33 |
| ABHD2 | abhydrolase domain containing 2 | 0.32 |
| BCORL1 | BCL6 corepressor-like 1 | 0.32 |
| TMEM62 | transmembrane protein 62 | 0.32 |
| RASA4 | RAS p21 protein activator 4 | 0.32 |
| DNAH1 | dynein, axonemal, heavy chain 1 | 0.32 |
| MCRIP1 | MAPK regulated corepressor interacting protein 1 | 0.32 |
| PUM1 | pumilio RNA-binding family member 1 | 0.31 |
| ZNF7 | zinc finger protein 7 | 0.31 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | 0.31 |
| SP4 | Sp4 transcription factor | 0.31 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.31 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.31 |
| GRHL1 | grainyhead-like 1 (Drosophila) | 0.3 |
| ST5 | suppression of tumorigenicity 5 | 0.3 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.3 |
| CCDC167 | coiled-coil domain containing 167 | 0.3 |
| TRIM7 | tripartite motif containing 7 | 0.3 |
| FSD1L | fibronectin type III and SPRY domain containing 1-like | 0.3 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.3 |
| PPP1R3D | protein phosphatase 1, regulatory subunit 3D | 0.29 |
| SS18 | synovial sarcoma translocation, chromosome 18 | 0.29 |
| DNAJB5 | DnaJ (Hsp40) homolog, subfamily B, member 5 | 0.29 |
| MYH15 | myosin, heavy chain 15 | 0.29 |
| SLC16A6 | solute carrier family 16, member 6 | 0.29 |
| APOB | apolipoprotein B | 0.29 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 0.29 |
| RPL26 | ribosomal protein L26 | 0.29 |
| FANCF | Fanconi anemia, complementation group F | 0.28 |
| UBC | ubiquitin C | 0.28 |
| TRIM8 | tripartite motif containing 8 | 0.28 |
| TPGS2 | tubulin polyglutamylase complex subunit 2 | 0.28 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.28 |
| REXO5 | RNA exonuclease 5 | 0.28 |
| BCL3 | B-cell CLL/lymphoma 3 | 0.28 |
| SLC66A2 | solute carrier family 66 member 2 | 0.27 |
| RAB6B | RAB6B, member RAS oncogene family | 0.27 |
| NOTCH3 | notch 3 | 0.27 |
| VSNL1 | visinin-like 1 | 0.27 |
| DOCK11 | dedicator of cytokinesis 11 | 0.27 |
| DVL3 | dishevelled segment polarity protein 3 | 0.27 |
| ZFP62 | ZFP62 zinc finger protein | 0.27 |
| TANK | TRAF family member-associated NFKB activator | 0.27 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.27 |
| PMPCA | peptidase (mitochondrial processing) alpha | 0.27 |
| ZNF584 | zinc finger protein 584 | 0.27 |
| R3HDM4 | R3H domain containing 4 | 0.26 |
| TMEM189 | transmembrane protein 189 | 0.26 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | 0.26 |
| MYLK | myosin light chain kinase | 0.26 |
| ERG28 | ergosterol biosynthesis 28 homolog | 0.26 |
| JUN | jun proto-oncogene | 0.26 |
| SYT17 | synaptotagmin XVII | 0.26 |
| Symbol | Name | Standardized Value |
|---|---|---|
| THAP9 | THAP domain containing 9 | -1.57 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -1.21 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | -1.0 |
| SPAG17 | sperm associated antigen 17 | -0.91 |
| CCDC57 | coiled-coil domain containing 57 | -0.87 |
| NF1 | neurofibromin 1 | -0.78 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.75 |
| AAMDC | adipogenesis associated, Mth938 domain containing | -0.72 |
| TFCP2L1 | transcription factor CP2-like 1 | -0.64 |
| TTPA | tocopherol (alpha) transfer protein | -0.6 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.6 |
| C2CD4C | C2 calcium-dependent domain containing 4C | -0.55 |
| NPHP3 | nephronophthisis 3 (adolescent) | -0.53 |
| TLE5 | TLE family member 5, transcriptional modulator | -0.51 |
| SIDT2 | SID1 transmembrane family, member 2 | -0.5 |
| ZNF697 | zinc finger protein 697 | -0.49 |
| MEGF6 | multiple EGF-like-domains 6 | -0.48 |
| EPHA4 | EPH receptor A4 | -0.47 |
| SUMO2 | small ubiquitin-like modifier 2 | -0.47 |
| SLC25A39 | solute carrier family 25, member 39 | -0.47 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.45 |
| ATP6V1E2 | ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2 | -0.44 |
| SKIL | SKI-like proto-oncogene | -0.42 |
| PDRG1 | p53 and DNA-damage regulated 1 | -0.42 |
| REX1BD | required for excision 1-B domain containing | -0.41 |
| PLIN2 | perilipin 2 | -0.41 |
| CEP112 | centrosomal protein 112kDa | -0.41 |
| GTF2A2 | general transcription factor IIA, 2, 12kDa | -0.41 |
| DTD2 | D-tyrosyl-tRNA deacylase 2 (putative) | -0.4 |
| OTC | ornithine carbamoyltransferase | -0.39 |
| BCAM | basal cell adhesion molecule (Lutheran blood group) | -0.38 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | -0.37 |
| ROBO3 | roundabout, axon guidance receptor, homolog 3 (Drosophila) | -0.37 |
| NADK | NAD kinase | -0.36 |
| HGFAC | HGF activator | -0.35 |
| NEB | nebulin | -0.35 |
| SERF2 | small EDRK-rich factor 2 | -0.35 |
| FRS2 | fibroblast growth factor receptor substrate 2 | -0.34 |
| CDC25B | cell division cycle 25B | -0.34 |
| RHBDD1 | rhomboid domain containing 1 | -0.34 |
| CHCHD1 | coiled-coil-helix-coiled-coil-helix domain containing 1 | -0.34 |
| OXNAD1 | oxidoreductase NAD-binding domain containing 1 | -0.34 |
| C1ORF109 | chromosome 1 open reading frame 109 | -0.34 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.34 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.33 |
| SPATA2 | spermatogenesis associated 2 | -0.33 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | -0.33 |
| STARD3NL | STARD3 N-terminal like | -0.32 |
| NKAPD1 | NKAP domain containing 1 | -0.3 |
| ENTR1 | endosome associated trafficking regulator 1 | -0.3 |
| PDGFRL | platelet-derived growth factor receptor-like | -0.3 |
| AMN1 | antagonist of mitotic exit network 1 homolog (S. cerevisiae) | -0.3 |
| FSTL1 | follistatin-like 1 | -0.3 |
| ZNF805 | zinc finger protein 805 | -0.29 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.29 |
| TSPAN4 | tetraspanin 4 | -0.29 |
| DCAF4 | DDB1 and CUL4 associated factor 4 | -0.29 |
| FJX1 | four jointed box 1 (Drosophila) | -0.29 |
| WASHC3 | WASH complex subunit 3 | -0.29 |
| RGPD8 | RANBP2-like and GRIP domain containing 8 | -0.29 |
| PPP1R14C | protein phosphatase 1, regulatory (inhibitor) subunit 14C | -0.28 |
| SMCR8 | Smith-Magenis syndrome chromosome region, candidate 8 | -0.28 |
| NDUFAF6 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 | -0.28 |
| FTL | ferritin, light polypeptide | -0.28 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.28 |
| TTC30B | tetratricopeptide repeat domain 30B | -0.27 |
| ZNF608 | zinc finger protein 608 | -0.27 |
| ADM | adrenomedullin | -0.27 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.27 |
| CPA4 | carboxypeptidase A4 | -0.27 |
| C19ORF44 | chromosome 19 open reading frame 44 | -0.27 |
| PTCD2 | pentatricopeptide repeat domain 2 | -0.27 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.27 |
| HOXA7 | homeobox A7 | -0.27 |
| PRMT2IP | PRMT2 interacting protein | -0.26 |
| NHLRC3 | NHL repeat containing 3 | -0.26 |
| CCDC158 | coiled-coil domain containing 158 | -0.26 |
| B4GALT2 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 | -0.26 |
| ZG16B | zymogen granule protein 16B | -0.26 |
| SESN2 | sestrin 2 | -0.26 |
| POLR2K | polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa | -0.26 |
| E2F2 | E2F transcription factor 2 | -0.26 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | -0.26 |
| SPNS1 | spinster homolog 1 (Drosophila) | -0.26 |
| PPIE | peptidylprolyl isomerase E (cyclophilin E) | -0.26 |
| TMEM161A | transmembrane protein 161A | -0.25 |
| HSPA8 | heat shock 70kDa protein 8 | -0.25 |
| FGB | fibrinogen beta chain | -0.25 |
| SLC15A4 | solute carrier family 15 (oligopeptide transporter), member 4 | -0.25 |
| LAMA3 | laminin, alpha 3 | -0.25 |
| CCDC102A | coiled-coil domain containing 102A | -0.25 |
| DOP1A | DOP1 leucine zipper like protein A | -0.24 |
| CENPL | centromere protein L | -0.24 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.24 |
| ABCD4 | ATP-binding cassette, sub-family D (ALD), member 4 | -0.24 |
| C15ORF41 | chromosome 15 open reading frame 41 | -0.24 |
| ASB8 | ankyrin repeat and SOCS box containing 8 | -0.24 |
| IL10RB | interleukin 10 receptor, beta | -0.24 |
| LIX1L | Lix1 homolog (chicken) like | -0.24 |
